Research ExplorerResearch UnitsInstitute of Experimental Pharmacology and Toxicology Publications

Institute of Experimental Pharmacology and Toxicology

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Publications

  1. 2012

  2. Calciumantagonisten

    Eschenhagen, T., 2012, Arzneiverordnungs-Report 2012. Springer Berlin Heidelberg, p. 515-524 10 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  3. cMyBP-C as a promiscuous substrate: phosphorylation by non-PKA kinases and its potential significance.

    Bardswell, S. C., Cuello, F., Kentish, J. C. & Avkiran, M., 2012, In: J MUSCLE RES CELL M. 33, 1, p. 53-60 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Complex interactions between human myoblasts and the surrounding 3D fibrin-based matrix.

    Chiron, S., Tomczak, C., Duperray, A., Lainé, J., Bonne, G., Eder, A., Hansen, A., Eschenhagen, T., Verdier, C. & Coirault, C., 2012, In: PLOS ONE. 7, 4, p. 36173 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function.

    Dijk, V., Sabine, J., Paalberends, E. R., Najafi, A., Michels, M., Carrier, L., Carrier, L., Boontje, N. M., Kuster, D. W. D., van Slegtenhorst, M., Dooijes, D., Cris, D. R., Cate, T., Folkert, J., Stienen, G. J. M. & van der Velden, J., 2012, In: CIRC-HEART FAIL. 5, 1, p. 36-46 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy.

    Schlossarek, S., Englmann, D. R., Sultan, K. R., Sauer, M., Eschenhagen, T. & Carrier, L., 2012, In: BASIC RES CARDIOL. 107, 1, p. 235 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death.

    Bertrand, A. T., Renou, L., Papadopoulos, A., Beuvin, M., Lacène, E., Massart, C., Ottolenghi, C., Decostre, V., Maron, S., Schlossarek, S., Cattin, M-E., Carrier, L., Malissen, M., Arimura, T. & Bonne, G., 2012, In: HUM MOL GENET. 21, 5, p. 1037-1048 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Engineered Heart Tissue

    Eschenhagen, T. & Zimmermann, W-H., 2012, Heart Regeneration: Stem Cells and Beyond. World Scientific Publishing Company, p. 299-326 28 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  9. Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy.

    Friedrich, F., Wilding, B. R., Reischmann, S., Crocini, C., Lang, P., Charron, P., Müller, O. J., McGrath, M. J., Vollert, I., Hansen, A., Linke, W. A., Hengstenberg, C., Bonne, G., Morner, S., Wichter, T., Madeira, H., Arbustini, E., Eschenhagen, T., Mitchell, C. A., Isnard, R. & Carrier, L., 2012, In: HUM MOL GENET. 21, 14, p. 3237-3254 14.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Genetics of hypertrophic and dilated cardiomyopathy.

    Friedrich, F. & Carrier, L., 2012, In: CURR PHARM BIOTECHNO. 13, 13, p. 2467-2476 13.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Herztherapeutika

    Eschenhagen, T., 2012, Arzneiverordnungs-Report 2012. Springer Berlin Heidelberg, p. 633-652 20 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  12. How do MYBPC3 mutations cause hypertrophic cardiomyopathy?

    Marston, S., Copeland, ON., Gehmlich, K., Schlossarek, S. & Carrier, L., 2012, In: J MUSCLE RES CELL M. 33, 1, p. 75-80 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Impact of AT2 receptor deficiency on postnatal cardiovascular development.

    Biermann, D., Heilmann, A., Didié, M., Schlossarek, S., Wahab, A., Grimm, M., Römer, M., Reichenspurner, H., Sultan, K., Steenpass, A., Ergün, S., Donzelli, S., Carrier, L., Ehmke, H., Zimmermann, W. H., Hein, L., Böger, R. & Benndorf, R. A., 2012, In: PLOS ONE. 7, 10, p. 47916 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Impact of the β1-adrenoceptor Arg389Gly polymorphism on heart-rate responses to bisoprolol and carvedilol in heart-failure patients.

    Rau, T., Düngen, H-D., Edelmann, F., Waagstein, F., Lainščak, M., Dimković, S., Apostolović, S., Nešković, A. N., Haverkamp, W., Gelbrich, G. & Eschenhagen, T., 2012, In: CLIN PHARMACOL THER. 92, 1, p. 21-28 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Increased afterload induces pathological cardiac hypertrophy: a new in vitro model.

    Hirt, M., Sörensen, N. A., Bartholdt, L. M., Boeddinghaus, J., Schaaf, S., Eder, A., Vollert, I., Stöhr, A., Schulze, T., Witten, A., Stoll, M., Hansen, A. & Eschenhagen, T., 2012, In: BASIC RES CARDIOL. 107, 6, p. 307 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.

    Fredersdorf, S., Thumann, C., Zimmermann, W. H., Vetter, R., Graf, T., Luchner, A., Riegger, G. A., Schunkert, H., Eschenhagen, T. & Weil, J., 2012, In: CARDIOVASC DIABETOL. 11, p. 57

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice.

    Fraysse, B., Weinberger, F., Bardswell, S. C., Cuello, F., Vignier, N., Geertz, B., Starbatty, J., Krämer, E., Coirault, C., Eschenhagen, T., Kentish, J. C., Avkiran, M. & Carrier, L., 2012, In: J MOL CELL CARDIOL. 52, 6, p. 1299-1307 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart.

    Weinberger, F., Mehrkens, D., Friedrich, F., Stubendorff, M., Hua, X., Müller, J. C., Schrepfer, S., Evans, S. M., Carrier, L. & Eschenhagen, T., 2012, In: CIRC RES. 110, 10, p. 1303-1310 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Multi-Well Engineered Heart Tissue for Drug Screening and Predictive Toxicology

    Eder, A., Hansen, A. & Eschenhagen, T., 2012, Toxicity and Drug Testing. InTech, p. 71-90 20 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  20. Myeloperoxidase deficiency preserves vasomotor function in humans.

    Rudolph, T. K., Wipper, S., Reiter, B., Rudolph, V., Coym, A., Detter, C., Lau, D., Klinke, A., Friedrichs, K., Rau, T., Pekarova, M., Russ, D., Knöll, K., Stubendorff, M., Schroeder, B., Wegscheider, K., Andresen, H., Schwedhelm, E., Böger, R., Ehmke, H. & Baldus, S., 2012, In: EUR HEART J. 33, 13, p. 1625-1634 13.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms.

    Haworth, R. S., Stathopoulou, K., Candasamy, A. J. & Avkiran, M., 2012, In: CIRC RES. 110, 12, p. 1585-1595 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Physiological aspects of cardiac tissue engineering.

    Eschenhagen, T., Eder, A., Vollert, I. & Hansen, A., 2012, In: AM J PHYSIOL-HEART C. 303, 2, p. 133-143 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Progesterone receptor variants associated with the PROGINS haplotype exhibit functional properties similar to those of wild-type progesterone receptor.

    Stenzig, J., Schweikert, A., Piasecki, A., Höppner, G., Eschenhagen, T. & Rau, T., 2012, In: PHARMACOGENET GENOM. 22, 8, p. 629-641 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. Protein kinase D increases maximal Ca2+-activated tension of cardiomyocyte contraction by phosphorylation of cMyBP-C-Ser315.

    Dirkx, E., Cazorla, O., Schwenk, R. W., Lorenzen-Schmidt, I., Sadayappan, S., Johan, V. L., Carrier, L., Eys, V., Guillaume, J. J. M., Glatz, J. F. C. & Luiken, J. J. F. P., 2012, In: AM J PHYSIOL-HEART C. 303, 3, p. 323-331 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. Succinate reverses in-vitro platelet inhibition by acetylsalicylic acid and P2Y receptor antagonists.

    Spath, B., Hansen, A., Bokemeyer, C. & Langer, F., 2012, In: PLATELETS. 23, 1, p. 60-68 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. The German Centre for Cardiovascular Research.

    Prendergast, B., Coope, L. T., Crijns, H., Falkenstein, E., Fölsch, U., Halvorsen, S., Janssens, S., Jokinen, E., Kroemer, H. K., Lücke, A., Murer, H., Nagel, E., Neyses, L., Perk, J., Probst-Hensch, N., Rietschel, E. T., Rütten, H., Steingen, C., Tedgui, A., van Gilst, W., Eschenhagen, T. & Kristensen, S. D., 2012, In: EUR HEART J. 33, 9, p. 1033-1036 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.

    Ucar, A., Gupta, S. K., Fiedler, J., Erikci, E., Kardasinski, M., Batkai, S., Dangwal, S., Kumarswamy, R., Bang, C., Holzmann, A., Remke, J., Caprio, M., Jentzsch, C., Engelhardt, S., Geisendorf, S., Glas, C., Hofmann, T. G., Nessling, M., Richter, K., Schiffer, M., Carrier, L., Napp, L. C., Bauersachs, J., Chowdhury, K. & Thum, T., 2012, In: NAT COMMUN. 3, p. 1078

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. 2011

  29. Cardiac myosin-binding protein C in hypertrophic cardiomyopathy: Mechanisms and therapeutic opportunities.

    Schlossarek, S., Mearini, G. & Carrier, L., 01.04.2011, In: J MOL CELL CARDIOL. 50, 4, p. 613-620 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium

    Boontje, N. M., Merkus, D., Zaremba, R., Versteilen, A., Waard, D., Mearini, G., Mearini, G., Carrier, L., Vincent, J., Carrier, L., Walker, L. A., Niessen, H. W. M., Dobrev, D., Stienen, G. J. M., Duncker, D. J. & van der Velden, J., 01.03.2011, In: J MOL CELL CARDIOL. 50, 3, p. 487-499 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression.

    Kornfeld, J., Meder, S., Wohlberg, M., Friedrich, R., Rau, T., Riethdorf, L., Löning, T., Pantel, K. & Riethdorf, S., 04.01.2011, In: BRIT J CANCER. 104, 1, p. 138-145 8 p., 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology.

    Eschenhagen, T., Force, T., Ewer, M. S., Keulenaer, D., Gilles, W., Suter, T. M., Anker, S. D., Avkiran, M., de Azambuja, E., Balligand, J-L., Brutsaert, D. L., Hansen, A., Hansen, A., Heymans, S., Hill, J. A., Hirsch, E., Hilfiker-Kleiner, D., Janssens, S., de Jong, S., Neubauer, G., Pieske, B., Ponikowski, P., Pirmohamed, M., Rauchhaus, M., Sawyer, D., Sugden, P. H., Wojta, J., Zannad, F. & Shah, A. M., 01.01.2011, In: EUR J HEART FAIL. 13, 1, p. 1-10 10 p., 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT).

    Conradi, L., Pahrmann, C., Schmidt, S., Deuse, T., Hansen, A., Eder, A., Reichenspurner, H., Robbins, R. C., Eschenhagen, T. & Schrepfer, S., 2011, In: JOVE-J VIS EXP. 52, p. 2605

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Distinction Between Two Populations of Islet-1-Positive Cells in Hearts of Different Murine Strains.

    Khattar, P., Friedrich, F., Bonne, G., Carrier, L., Eschenhagen, T., Evans, S. M., Schwartz, K., Fiszman, M. Y. & Vilquin, J-T., 2011, In: STEM CELLS DEV. 20, 6, p. 1043-1052 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels.

    Naito, H., Tojo, T., Kimura, M., Dohi, Y., Zimmermann, W-H., Eschenhagen, T. & Taniguchi, S., 2011, In: INTERACT CARDIOV TH. 12, 2, p. 156-161 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Follistatin-like 1 in chronic systolic heart failure: a marker of left ventricular remodeling.

    El-Armouche, A., Ouchi, N., Tanaka, K., Doros, G., Wittköpper, K., Schulze, T., Eschenhagen, T., Walsh, K. & Sam, F., 2011, In: CIRC-HEART FAIL. 4, 5, p. 621-627 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology.

    Schaaf, S., Shibamiya, A., Mewe, M., Eder, A., Stöhr, A., Hirt, M., Rau, T., Zimmermann, W-H., Conradi, L., Eschenhagen, T. & Hansen, A., 2011, In: PLOS ONE. 6, 10, p. 26397 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Hypertrophic cardiomyopathy

    Christiaans, I. & Carrier, L., 2011, Clinical Cardiogenetics. Springer Berlin Heidelberg, p. 47-62 16 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  39. Oral antiplatelet agents in ACS: from pharmacology to clinical differences.

    Agewall, S., Badimon, L., Drouet, L., Eschenhagen, T., Husted, S., Simon, T. & Steg, G., 2011, In: FUND CLIN PHARMACOL. 25, 5, p. 564-571 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Phosphatase-1-inhibitor-1 in physiological and pathological {beta}-adrenoceptor signaling.

    Wittköpper, K., Dobrev, D., Eschenhagen, T. & El-Armouche, A., 2011, In: CARDIOVASC RES. 91, 3, p. 392-401 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue.

    Tiburcy, M., Didié, M., Boy, O., Christalla, P., Döker, S., Naito, H., Karikkineth, B. C., El-Armouche, A., Grimm, M., Nose, M., Eschenhagen, T., Zieseniss, A., Katschinksi, D. M., Hamdani, N., Linke, W. A., Yin, X., Mayr, M. & Zimmermann, W-H., 2011, In: CIRC RES. 109, 10, p. 1105-1114 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. The beat goes on: human heart muscle from pluripotent stem cells.

    Eschenhagen, T., 2011, In: CIRC RES. 109, 1, p. 2-4 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. The effect of mesenchymal stem cell osteoblastic differentiation on the mechanical properties of engineered bone-like tissue.

    Naito, H., Dohi, Y., Zimmermann, W-H., Tojo, T., Takasawa, S., Eschenhagen, T. & Taniguchi, S., 2011, In: TISSUE ENG PT A. 17, 17-18, p. 2321-2329 17-18.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. The ubiquitin-proteasome system in cardiomyopathies.

    Schlossarek, S. & Carrier, L., 2011, In: CURR OPIN CARDIOL. 26, 3, p. 190-195 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Titration to target dose of bisoprolol vs. carvedilol in elderly patients with heart failure: the CIBIS-ELD trial.

    Düngen, H-D., Apostolovic, S., Inkrot, S., Tahirovic, E., Töpper, A., Mehrhof, F., Prettin, C., Putnikovic, B., Neskovic, A. N., Krotin, M., Sakac, D., Lainscak, M., Edelmann, F., Wachter, R., Rau, T., Eschenhagen, T., Doehner, W., Anker, S. D., Waagstein, F., Herrmann-Lingen, C., Gelbrich, G., Dietz, R., Investigators, CIBIS-ELD. & Failure, P. M. T. I. T. C. N. H., 2011, In: EUR J HEART FAIL. 13, 6, p. 670-680 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Ubiquitin C-terminal hydrolase-l1 activity induces polyubiquitin accumulation in podocytes and increases proteinuria in rat membranous nephropathy.

    Meyer-Schwesinger, C., Meyer, T., Sievert, H., Hoxha, E., Sachs, M., Klupp, E-M., Münster, S., Balabanov, S., Carrier, L., Helmchen, U., Thaiss, F. & Stahl, R. A. K., 2011, In: AM J PATHOL. 178, 5, p. 2044-2057 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. 2010

  48. Too much of a good thing is bad: proteasome inhibition induces stressed hearts to fail.

    Carrier, L., 01.12.2010, In: CARDIOVASC RES. 88, 3, p. 389-390 2 p., 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes

    El-Armouche, A., Wahab, A., Wittköpper, K., Schulze, T., Böttcher, F., Pohlmann, L., King, S. B., DuMond, J. F., Gerloff, C., Böger, R. H., Eschenhagen, T., Carrier, L. & Donzelli, S., 12.11.2010, In: BIOCHEM BIOPH RES CO. 402, 2, p. 340-344 5 p., 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. Sorafenib

    Hansen, A. & Eschenhagen, T., 01.09.2010, In: DEUT MED WOCHENSCHR. 135, 37, p. 1819-1822 4 p., 37.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. Vernakalant: Ein neues Antiarrhythmikum zur Akutbehandlung von Vorhofflimmern

    Hirt, M. N. & Eschenhagen, T., 01.05.2010, In: DEUT MED WOCHENSCHR. 135, 19, p. 971-6 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms.

    Mearini, G., Hornung, C., Schlossarek, S., Witt, C. C., Krämer, E., Cao, P., Gomes, M. D., Lecker, S. H., Labeit, S., Willis, M. S., Eschenhagen, T. & Carrier, L., 2010, In: CARDIOVASC RES. 85, 2, p. 357-366 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  53. Common microRNA signatures in cardiac hypertrophic and atrophic remodeling induced by changes in hemodynamic load.

    El-Armouche, A., Schwoerer, A., Neuber, C., Emmons, J., Biermann, D., Christalla, T., Grundhoff, A., Eschenhagen, T., Zimmermann, W-H. & Ehmke, H., 2010, In: PLOS ONE. 5, 12, p. 14263 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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