Research ExplorerResearch UnitsInstitute of Experimental Pharmacology and Toxicology Publications

Institute of Experimental Pharmacology and Toxicology

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Publications

  1. 2014

  2. Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

    Mearini, G., Stimpel, D., Geertz, B., Weinberger, F., Krämer, E., Schlossarek, S., Mourot-Filiatre, J., Stoehr, A., Dutsch, A., Wijnker, P. J. M., Braren, I., Katus, H. A., Müller, O. J., Voit, T., Eschenhagen, T. & Carrier, L., 01.01.2014, In: NAT COMMUN. 5, p. 5515

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy

    Schlossarek, S., Singh, S. R., Geertz, B., Schulz, H., Reischmann, S., Hübner, N. & Carrier, L., 01.01.2014, In: FRONT PHYSIOL. 5, p. 484

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Calciumantagonisten

    Eschenhagen, T., 2014, Arzneiverordnungsreport 2014. Schwabe, U. & Paffrath, D. (eds.). 1 ed. Springer-Verlag Berlin, Heidelberg, p. 561-570 9 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Education

  5. Generation of Strip-Format Fibrin-Based Engineered Heart Tissue (EHT)

    Schaaf, S., Eder, A., Vollert, I., Stöhr, A., Hansen, A. & Eschenhagen, T., 2014, Cardiac Tissue Engineering: Methods and Protocols . Radisic, M. & Black III, L. D. (eds.). 1 ed. New York: Springer Science+Business Media New York, Vol. 1181. p. 121-129 9 p. (Methods in Molecular Biology ; vol. 1181).

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  6. Herztherapeutika

    Eschenhagen, T., 2014, Arzneiverordnungsreport 2014. 1 ed. Springer-Verlag Berlin, Heidelberg, p. 681-701 19 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Education

  7. Origin and characteristics of high Shannon entropy at the pivot of locally stable rotors: insights from computational simulation

    Ganesan, A. N., Kuklik, P., Gharaviri, A., Brooks, A., Chapman, D., Lau, D. H., Roberts-Thomson, K. C. & Sanders, P., 2014, In: PLOS ONE. 9, 11, p. e110662

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Prostaglandin E2 does not attenuate adrenergic-induced cardiac contractile response

    Pecha, S., Mudersbach, E., Söhren, K-D., Hakmi, S., Reichenspurner, H., Eschenhagen, T. & Christ, T., 2014, In: N-S ARCH PHARMACOL. 387, 10, p. 963-968

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. 2013

  10. Enhanced Ca²+ influx through cardiac L-type Ca²+ channels maintains the systolic Ca²+ transient in early cardiac atrophy induced by mechanical unloading

    Schwoerer, A., Neef, S., Broichhausen, I., Jacubeit, J., Tiburcy, M., Wagner, M., Biermann, D., Didié, M., Vettel, C., Maier, L. S., Zimmermann, W. H., Carrier, L., Eschenhagen, T., Volk, T., El-Armouche, A. & Ehmke, H., 01.12.2013, In: PFLUG ARCH EUR J PHY. 465, 12, p. 1763-73 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase

    Holland, R. J., Paulisch, R., Cao, Z., Keefer, L. K., Saavedra, J. E. & Donzelli, S., 30.11.2013, In: NITRIC OXIDE-BIOL CH. 35, p. 131-6 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Functional MicroRNA Library Screening Identifies the HypoxaMiR MiR-24 as a Potent Regulator of Smooth Muscle Cell Proliferation and Vascularization

    Fiedler, J., Stöhr, A., Gupta, S. K., Hartmann, D., Holzmann, A., Just, A., Hansen, A., Hilfiker-Kleiner, D., Eschenhagen, T. & Thum, T., 19.11.2013, In: ANTIOXID REDOX SIGN.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Mit Stammzell-Modellen Herzkrankheiten besser verstehen

    Eschenhagen, T., 01.11.2013, In: DEUT MED WOCHENSCHR. 138, 46, p. 2381-2 2 p.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  14. Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure

    Dirkx, E., Gladka, M. M., Philippen, L. E., Armand, A-S., Kinet, V., Leptidis, S., El Azzouzi, H., Salic, K., Bourajjaj, M., da Silva, G. J. J., Olieslagers, S., van der Nagel, R., de Weger, R., Bitsch, N., Kisters, N., Seyen, S., Morikawa, Y., Chanoine, C., Heymans, S., Volders, P. G. A., Thum, T., Dimmeler, S., Cserjesi, P., Eschenhagen, T., da Costa Martins, P. A. & De Windt, L. J., 01.11.2013, In: NAT CELL BIOL. 15, 11, p. 1282-93 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Extracellular matrix secretion by cardiac fibroblasts Role of microRNA-29b and microRNA-30c

    Abonnenc, M., Nabeebaccus, A. A., Mayr, U., Barallobre-Barreiro, J., Dong, X., Cuello, F., Sur, S., Drozdov, I., Langley, S. R., Lu, R., Stathopoulou, K., Didangelos, A., Yin, X., Zimmermann, W-H., Shah, A. M., Zampetaki, A. & Mayr, M., 25.10.2013, In: CIRC RES. 113, 10, p. 1138-47 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes

    Mehel, H., Emons, J., Vettel, C., Wittköpper, K., Seppelt, D., Dewenter, M., Lutz, S., Sossalla, S., Maier, L. S., Lechêne, P., Leroy, J., Lefebvre, F., Varin, A., Eschenhagen, T., Nattel, S., Dobrev, D., Zimmermann, W-H., Nikolaev, V. O., Vandecasteele, G., Fischmeister, R. & El-Armouche, A., 22.10.2013, In: J AM COLL CARDIOL. 62, 17, p. 1596-606 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia

    Harder, L., Eschenburg, G., Zech, A., Kriebitzsch, N., Otto, B., Streichert, T., Behlich, A-S., Dierck, K., Klingler, B., Hansen, A., Stanulla, M., Zimmermann, M., Kremmer, E., Stocking, C. & Horstmann, M. A., 21.10.2013, In: J EXP MED. 210, 11, p. 2289-304 16 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice

    Stöhr, A., Friedrich, F. W., Flenner, F., Geertz, B., Eder, A., Schaaf, S., Hirt, M. N., Uebeler, J., Schlossarek, S., Carrier, L., Hansen, A. & Eschenhagen, T., 01.10.2013, In: J MOL CELL CARDIOL. 63, p. 189-98 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Development of a colorimetric and a fluorescence phosphatase-inhibitor assay suitable for drug discovery approaches

    Sotoud, H., Gribbon, P., Ellinger, B., Reinshagen, J., Boknik, P., Kattner, L., El-Armouche, A. & Eschenhagen, T., 01.09.2013, In: Journal of biomolecular screening. 18, 8, p. 899-909 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. The expression of podocyte-specific proteins in parietal epithelial cells is regulated by protein degradation

    Guhr, S. SO., Sachs, M., Wegner, A., Becker, J. U., Meyer, T. N., Kietzmann, L., Schlossarek, S., Carrier, L., Balabanov, M., Jat, P. S., Stahl, R. A. K. & Meyer-Schwesinger, C., 01.09.2013, In: KIDNEY INT. 84, 3, p. 532-44 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity

    Cattin, M-E., Bertrand, A. T., Schlossarek, S., Le Bihan, M-C., Skov Jensen, S., Neuber, C., Crocini, C., Maron, S., Lainé, J., Mougenot, N., Varnous, S., Fromes, Y., Hansen, A., Eschenhagen, T., Decostre, V., Carrier, L. & Bonne, G., 01.08.2013, In: HUM MOL GENET. 22, 15, p. 3152-64 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Rescue of cardiomyopathy through U7snRNA-mediated exon skipping in Mybpc3-targeted knock-in mice

    Hornung, C., Behrens, V., Reischmann, S., Geertz, B., Stimpel, D., Weinberger, F., Schlossarek, S., Précigout, G., Braren, I., Eschenhagen, T., Mearini, G., Lorain, S., Voit, T., Dreyfus, P. A., Garcia, L. & Carrier, L., 01.07.2013, In: EMBO MOL MED. 5, 7, p. 1060-77 18 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. BSE-associated prion-amyloid cardiomyopathy in primates

    Krasemann, S., Mearini, G., Krämer, E., Wagenführ, K., Schulz-Schaeffer, W., Neumann, M., Bodemer, W., Kaup, F-J., Beekes, M., Carrier, L., Aguzzi, A. & Glatzel, M., 01.06.2013, In: EMERG INFECT DIS. 19, 6, p. 985-8 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. PDE4 in the human heart - major player or little helper?

    Eschenhagen, T., 01.06.2013, In: BRIT J PHARMACOL. 169, 3, p. 524-7 4 p.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  25. Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation

    Nebel, M., Schwoerer, A. P., Warszta, D., Siebrands, C. C., Limbrock, A-C., Swarbrick, J. M., Fliegert, R., Weber, K., Bruhn, S., Hohenegger, M., Geisler, A., Herich, L., Schlegel, S., Carrier, L., Eschenhagen, T., Potter, B. V. L., Ehmke, H. & Guse, A. H., 31.05.2013, In: J BIOL CHEM. 288, 22, p. 16017-30 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Perturbed length-dependent activation in human hypertrophic cardiomyopathy with missense sarcomeric gene mutations

    Sequeira, V., Wijnker, P. J. M., Nijenkamp, L. L. A. M., Kuster, D. W. D., Najafi, A., Witjas-Paalberends, E. R., Regan, J. A., Boontje, N., Ten Cate, F. J., Germans, T., Carrier, L., Sadayappan, S., van Slegtenhorst, M. A., Zaremba, R., Foster, D. B., Murphy, A. M., Poggesi, C., Dos Remedios, C., Stienen, G. J. M., Ho, C. Y., Michels, M. & van der Velden, J., 24.05.2013, In: CIRC RES. 112, 11, p. 1491-505 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. A novel genetic variant in the transcription factor Islet-1 exerts gain of function on myocyte enhancer factor 2C promoter activity

    Friedrich, F. W., Dilanian, G., Khattar, P., Juhr, D., Gueneau, L., Charron, P., Fressart, V., Vilquin, J-T., Isnard, R., Gouya, L., Richard, P., Hammoudi, N., Komajda, M., Bonne, G., Eschenhagen, T., Dubourg, O., Villard, E. & Carrier, L., 01.03.2013, In: EUR J HEART FAIL. 15, 3, p. 267-76 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. Parthenogenetic stem cells for tissue-engineered heart repair

    Didié, M., Christalla, P., Rubart, M., Muppala, V., Döker, S., Unsöld, B., El-Armouche, A., Rau, T., Eschenhagen, T., Schwoerer, A. P., Ehmke, H., Schumacher, U., Fuchs, S., Lange, C., Becker, A., Tao, W., Scherschel, J. A., Soonpaa, M. H., Yang, T., Lin, Q., Zenke, M., Han, D-W., Schöler, H. R., Rudolph, C., Steinemann, D., Schlegelberger, B., Kattman, S., Witty, A., Keller, G., Field, L. J. & Zimmermann, W-H., 01.03.2013, In: J CLIN INVEST. 123, 3, p. 1285-98 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. GSK3β phosphorylates newly identified site in the proline-alanine-rich region of cardiac myosin-binding protein C and alters cross-bridge cycling kinetics in human: short communication

    Kuster, D. W. D., Sequeira, V., Najafi, A., Boontje, N. M., Wijnker, P. J. M., Witjas-Paalberends, E. R., Marston, S. B., Dos Remedios, C. G., Carrier, L., Demmers, J. A. A., Redwood, C., Sadayappan, S. & van der Velden, J., 15.02.2013, In: CIRC RES. 112, 4, p. 633-9 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Personalisierte Therapie in der Kardiologie. Biomarker, Pharmakogenetik und Therapie monogener Erkrankungen

    Eschenhagen, T. & Blankenberg, S., 01.02.2013, In: INTERNIST. 54, 2, p. 147-8, 150-2, 154

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Pharmacological characterization of 1-nitrosocyclohexyl acetate, a long-acting nitroxyl donor that shows vasorelaxant and antiaggregatory effects

    Donzelli, S., Fischer, G., King, B. S., Niemann, C., DuMond, J. F., Heeren, J., Wieboldt, H., Baldus, S., Gerloff, C., Eschenhagen, T., Carrier, L., Böger, R. H. & Espey, M. G., 01.02.2013, In: J PHARMACOL EXP THER. 344, 2, p. 339-47 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. A frequent gene polymorphism affecting the heart-rate response to carvedilol

    Eschenhagen, T., 01.01.2013, In: PHARMACOGENOMICS. 14, 2, p. 115-8 4 p.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  33. Distinctive serum miRNA profile in mouse models of striated muscular pathologies

    Vignier, N., Amor, F., Fogel, P., Duvallet, A., Poupiot, J., Charrier, S., Arock, M., Montus, M., Nelson, I., Richard, I., Carrier, L., Servais, L., Voit, T., Bonne, G. & Israeli, D., 01.01.2013, In: PLOS ONE. 8, 2, p. e55281

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue

    Crocini, C., Arimura, T., Reischmann, S., Eder, A., Braren, I., Hansen, A., Eschenhagen, T., Kimura, A. & Carrier, L., 01.01.2013, In: BASIC RES CARDIOL. 108, 3, p. 349

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. New tissue for failing hearts

    Eschenhagen, T., 01.01.2013, In: EUR J HEART FAIL. 15, 1, p. 1-2 2 p.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  36. Repair of Mybpc3 mRNA by 5'-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy

    Mearini, G., Stimpel, D., Krämer, E., Geertz, B., Braren, I., Hornung, C., Précigout, G., Müller, O. J., Katus, H. A., Eschenhagen, T., Voit, T., Garcia, L., Lorain, S. & Carrier, L., 01.01.2013, In: MOL THER-NUCL ACIDS. 2, p. e102

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. Herzprobleme unter Neuroleptika

    Hirt, M. & Oetjen, E., 01.2013, In: Herz Heute.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Education

  38. B-scan ultrasonographic monitoring of orthotopic xenografted plexiform neurofibroma in mice

    Gleiss, J., Demestre, M., Spyra, M., Eschenhagen, T., Hagel, C., Mautner, V-F., Kluwe, L. & Friedrich, R. E., 2013, In: IN VIVO. 27, 6, p. 723-7 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Calciumantagonisten

    Eschenhagen, T., 2013, Arzneiverordnungsreport 2013. Schwabe, U. & Paffrath, D. (eds.). Springer-Verlag Berlin, Heidelberg, p. 503-512 10 p. 20

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  40. Herz-Kreislaufsystem

    Eschenhagen, T. & Zolk, O., 2013, Toxikologie . Marquardt, H., Schäfer, S. G. & Barth, H. (eds.). 3 ed. Stuttgart: Wissenschaftliche Verlagsgesellschaft, p. 569-592 24 p. 24

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Education › peer-review

  41. Herztherapeutika

    Eschenhagen, T., 2013, Arzneiverordnungsreport 2013. Springer-Verlag Berlin, Heidelberg, p. 621-639 19 p. 27

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  42. Medikamente zur Therapie der Herzinsuffizienz: Wie wirkt Relaxin?

    Eschenhagen, T. & Weinberger, F., 2013, In: Cardio News. 5, p. 14-15 2 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

  43. Pharmakologie des kardiovaskulären Systems - das Herz

    Eschenhagen, T., 2013, Allgemeine und spezielle Pharmakologie und Toxikologie . Aktories, K., Förstermann, U., Hofmann, F. & Starke, K. (eds.). 11 ed. München: Urban & Fischer, p. 381-435 55 p. 17

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Education › peer-review

  44. Tissue-Engineered Cardiovascular Products

    Eschenhagen, T. & Zimmermann, W-H., 2013, Principles of Tissue Engineering, 4th Edition . Lanza, R., Langer, R. & Vacanti, J. (eds.). 4 ed. London: Academic Press, p. 1745–1764 20 p. Chapter 84

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  45. Vernakalant

    Hirt, M. & Eschenhagen, T., 2013, In: Internistische Praxis. 53, 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

  46. Warnung vor Diclofenac: Was nun?

    Stenzig, J. & Oetjen, E., 2013, In: Herz Heute. 33, 4, p. 18-21 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Transfer

  47. Wie wichtig sind Medikamente?

    Eschenhagen, T. & Zimmermann, W-H., 2013, Das schwache Herz: Diagnose und Therapie der Herzinsuffizienz heute. Frankfurt a. M.: Deutsche Herzstiftung e.V., p. 47-54 8 p. 8

    Research output: SCORING: Contribution to book/anthology › Other › Research

  48. Wie wirkt L-Arginin?

    Eschenhagen, T. & Weinberger, F., 2013, In: Herz Heute. 3, p. 44-45 2 p.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  49. 2012

  50. Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice

    Schlossarek, S., Schürmann, F., Geertz, B., Mearini, G., Eschenhagen, T. & Carrier, L., 01.05.2012, In: J MUSCLE RES CELL M. 33, 1, p. 5-15 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. Aldosterone inhibits antifibrotic factors in mouse hypertensive heart

    Azibani, F., Benard, L., Schlossarek, S., Merval, R., Tournoux, F., Fazal, L., Polidano, E., Launay, J-M., Carrier, L., Chatziantoniou, C., Samuel, J-L. & Delcayre, C., 2012, In: HYPERTENSION. 59, 6, p. 1179-1187 9 p., 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. Aldosterone inhibits the fetal program and increases hypertrophy in the heart of hypertensive mice

    Azibani, F., Devaux, Y., Coutance, G., Schlossarek, S., Polidano, E., Fazal, L., Merval, R., Carrier, L., Solal, A. C., Chatziantoniou, C., Launay, J-M., Samuel, J-L. & Delcayre, C., 2012, In: PLOS ONE. 7, 5, p. e38197 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  53. A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies.

    Marsden, C. G., Wright, M. J., Carrier, L., Moroz, K., Pochampally, R. & Rowan, B. G., 2012, In: BMC CANCER. 12, p. 10

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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