Research ExplorerResearch UnitsInstitute of Experimental Pharmacology and Toxicology Publications

Institute of Experimental Pharmacology and Toxicology

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Publications

  1. 2015

  2. LQT1-phenotypes in hiPSC: Are we measuring the right thing?

    Christ, T., Horvath, A. & Eschenhagen, T., 21.04.2015, In: P NATL ACAD SCI USA. 112, 16, p. E1968

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  3. Engineering Cardiovascular Regeneration

    Vollert, I., Eder, A., Hansen, A. & Eschenhagen, T., 03.04.2015, In: CURR STEM CELL REP. 1, 2, p. 67-78 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Animal and in silico models for the study of sarcomeric cardiomyopathies

    Duncker, D. J., Bakkers, J., Brundel, B. J., Robbins, J., Tardiff, J. C. & Carrier, L., 01.04.2015, In: CARDIOVASC RES. 105, 4, p. 439-48 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Deciphering the microRNA signature of pathological cardiac hypertrophy by engineered heart tissue- and sequencing-technology

    Hirt, M. N., Werner, T., Indenbirken, D., Alawi, M., Demin, P., Kunze, A-C., Stenzig, J., Starbatty, J., Hansen, A., Fiedler, J., Thum, T. & Eschenhagen, T., 01.04.2015, In: J MOL CELL CARDIOL. 81, p. 1-9 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes

    Eschenhagen, T., Mummery, C. & Knollmann, B. C., 01.04.2015, In: CARDIOVASC RES. 105, 4, p. 424-38 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Research priorities in sarcomeric cardiomyopathies

    van der Velden, J., Ho, C. Y., Tardiff, J. C., Olivotto, I., Knollmann, B. C. & Carrier, L., 01.04.2015, In: CARDIOVASC RES. 105, 4, p. 449-56 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Targets for therapy in sarcomeric cardiomyopathies

    Tardiff, J. C., Carrier, L., Bers, D. M., Poggesi, C., Ferrantini, C., Coppini, R., Maier, L. S., Ashrafian, H., Huke, S. & van der Velden, J., 01.04.2015, In: CARDIOVASC RES. 105, 4, p. 457-70 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Prolonged action potentials in HCM-derived iPSC - biology or artefact?

    Christ, T., Koivumäki, J. T. & Eschenhagen, T., 04.2015, In: CARDIOVASC RES. 106, 1, p. 6

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  10. Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1

    Sotoud, H., Borgmeyer, U., Schulze, C., El-Armouche, A. & Eschenhagen, T., 01.03.2015, In: N-S ARCH PHARMACOL. 388, 3, p. 283-93 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Interaction of DPP10a with Kv4.3 channel complex results in a sustained current component of human transient outward current Ito

    Turnow, K., Metzner, K., Cotella, D., Morales, M. J., Schaefer, M., Christ, T., Ravens, U., Wettwer, E. & Kämmerer, S., 03.2015, In: BASIC RES CARDIOL. 110, 2, p. Art. 5

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy

    Gehmlich, K., Dodd, M. S., Allwood, J. W., Kelly, M., Bellahcene, M., Lad, H. V., Stockenhuber, A., Hooper, C., Ashrafian, H., Redwood, C. S., Carrier, L. & Dunn, W. B., 02.2015, In: MOL BIOSYST. 11, 2, p. 564-73 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Assessment of DNA synthesis in Islet-1⁺ cells in the adult murine heart

    Weinberger, F., Mehrkens, D., Starbatty, J., Nicol, P. & Eschenhagen, T., 02.01.2015, In: BIOCHEM BIOPH RES CO. 456, 1, p. 294-7 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Cardiac Arrhythmias Introduction: Action potentials and membrane currents

    Jost, N., Muntean, D. & Christ, T., 2015, Pathophysiology and Pharmcotherapy of Cardiovascular Dieseases . 26 ed. Cham Heidelberg New York Dordrecht London: Springer, Vol. 1.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  15. Cardiac Arrhythmias: Introduction, Electrophysiology of the Heart, Action Potential and Membrane Currents

    Jost, N., Muntean, D. & Christ, T., 2015, Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Jagadeesh, G., Balakumar, P. & Maung-U, K. (eds.). 1 ed. Adis, p. 977 - 1002 26 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  16. Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology

    Carrier, L., Mearini, G., Stathopoulou, K. & Cuello, F., 2015, In: GENE. 573, 2, p. 188-197

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Protection by the NO-Donor SNAP and BNP against Hypoxia/Reoxygenation in Rat Engineered Heart Tissue

    Görbe, A., Eder, A., Varga, Z. V., Pálóczi, J., Hansen, A., Ferdinandy, P. & Eschenhagen, T., 2015, In: PLOS ONE. 10, 7, p. e0132186

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Targeted Mybpc3 knock-out mice with cardiac hypertrophy exhibit structural mitral valve abnormalities

    Judge, D. P., Neamatalla, H., Norris, R. A., Levine, R. L., Butcher, J. T., Vignier, N., Kang, K. H., Nguyen, Q., Bruneval, P., Perier, M-C., Messas, E., Jeunemaitre, X., de Vlaming, A., Markwald, R., Carrier, L. & Hagège, A. A., 2015, In: J CARDIOVASC DEV DIS. 2, 2, p. 48-65

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Treatment of Atrial Flutter and Atrial Fibrillation

    Christ, T., Pecha, S. U. & Jost, N., 2015, Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Jagadeesh, G., Balakumar, P. & Maung-U, K. (eds.). 1 ed. Adis, p. 1059 - 1079 21 p. 50

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review

  20. 2014

  21. The continuum of personalized cardiovascular medicine: a position paper of the European Society of Cardiology

    Kirchhof, P., Sipido, K. R., Cowie, M. R., Eschenhagen, T., Fox, K. A. A., Katus, H., Schroeder, S., Schunkert, H., Priori, S. & ESC CRT R&D and European Affairs Work Shop on Personalized Medicine, 07.12.2014, In: EUR HEART J. 35, 46, p. 3250-3257 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes

    Tanaka, A., Yuasa, S., Mearini, G., Egashira, T., Seki, T., Kodaira, M., Kusumoto, D., Kuroda, Y., Okata, S., Suzuki, T., Inohara, T., Arimura, T., Makino, S., Kimura, K., Kimura, A., Furukawa, T., Carrier, L., Node, K. & Fukuda, K., 01.12.2014, In: J AM HEART ASSOC. 3, 6, p. e001263

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. GeSRU-Jahresüberblick 2015: Weiterbilden, Netzwerken und Karriereplanen

    Meyer, C., Beyer, B., Arnold, H., Borgmann, H. & Salem, J., 12.2014, In: UROLOGE. 53, 12, p. 1817-9 3 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Education

  24. Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue

    Eder, A., Hansen, A., Uebeler, J., Schulze, T., Neuber, C., Schaaf, S., Yuan, L., Christ, T., Vos, M. A. & Eschenhagen, T., 01.11.2014, In: BASIC RES CARDIOL. 109, 6, p. 436

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. FHL2 expression and variants in hypertrophic cardiomyopathy

    Friedrich, F. W., Reischmann, S., Schwalm, A., Unger, A., Ramanujam, D., Münch, J., Müller, O. J., Hengstenberg, C., Galve, E., Charron, P., Linke, W. A., Engelhardt, S., Patten-Hamel, M., Richard, P., van der Velden, J., Eschenhagen, T., Isnard, R. & Carrier, L., 01.11.2014, In: BASIC RES CARDIOL. 109, 6, p. 451

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Redox state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis

    Cuello, F., Shankar-Hari, M., Mayr, U., Yin, X., Marshall, M., Suna, G., Willeit, P., Langley, S. R., Jayawardhana, T., Zeller, T., Terblanche, M., Shah, A. M. & Mayr, M., 01.10.2014, In: MOL CELL PROTEOMICS. 13, 10, p. 2545-57 13 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. Arrhythmias, elicited by catecholamines and serotonin, vanish in human chronic atrial fibrillation

    Christ, T., Rozmaritsa, N., Engel, A., Berk, E., Knaut, M., Metzner, K., Canteras, M., Ravens, U. & Kaumann, A., 29.07.2014, In: P NATL ACAD SCI USA. 111, 30, p. 11193-8 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. P368Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes

    Neuber, C., Uebeler, J., Schulze, T., Sotoud, H., El-Armouche, A. & Eschenhagen, T., 15.07.2014, In: CARDIOVASC RES. 103 Suppl 1, p. S67 P368.

    Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review

  29. P425Cytoprotection by the NO-donor SNAP and BNP against ischemia/reperfusion injury in rat engineered heart tissue

    Gorbe, A., Eder, A., Varga, Z., Paloczi, J., Hansen, A., Ferdinandy, P. & Eschenhagen, T., 15.07.2014, In: CARDIOVASC RES. 103 Suppl 1, p. S78

    Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review

  30. P635Proarrhythmic drugs exert hERG-independent slowing of relaxation and irregular beating in rat engineered heart tissue

    Eder, A., Hansen, A., Neuber, C., Schaaf, S., Vos, M. & Eschenhagen, T., 15.07.2014, In: CARDIOVASC RES. 103 Suppl 1, p. S115

    Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review

  31. P778Physiological and pharmacological characterization of human engineered heart tissue

    Vollert, I., Schaaf, S., Neuber, C., Letuffe-Breniere, D., Breckwoldt, K., Shibamiya, A., Stimpel, D., Eder, A., Eschenhagen, T. & Hansen, A., 15.07.2014, In: CARDIOVASC RES. 103 Suppl 1, p. S143

    Research output: SCORING: Contribution to journal › Conference abstract in journal › Research › peer-review

  32. Small-conductance calcium-activated potassium (SK) channels contribute to action potential repolarization in human atria

    Skibsbye, L., Poulet, C., Diness, J. G., Bentzen, B. H., Yuan, L., Kappert, U., Matschke, K., Wettwer, E., Ravens, U., Grunnet, M., Christ, T. & Jespersen, T., 01.07.2014, In: CARDIOVASC RES. 103, 1, p. 156-167

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Guanabenz Interferes with ER Stress and Exerts Protective Effects in Cardiac Myocytes

    Neuber, C., Uebeler, J., Schulze, T., Sotoud, H., El-Armouche, A. & Eschenhagen, T., 03.06.2014, In: PLOS ONE. 9, 6, p. e98893

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. AT1 blockade abolishes left ventricular hypertrophy in heterozygous cMyBP-C null mice: role of FHL1

    Vignier, N., Le Corvoisier, P., Blard, C., Sambin, L., Azibani, F., Schlossarek, S., Delcayre, C., Carrier, L., Hittinger, L. & Su, J. B., 01.06.2014, In: FUND CLIN PHARMACOL. 28, 3, p. 249-256 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Heart failure-specific changes in protein kinase signalling

    Lorenz, K., Stathopoulou, K., Schmid, E., Eder, P. & Cuello, F., 01.06.2014, In: PFLUG ARCH EUR J PHY. 466, 6, p. 1151-1162 12 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Ubiquitin-proteasome system and hereditary cardiomyopathies

    Schlossarek, S., Frey, N. & Carrier, L., 01.06.2014, In: J MOL CELL CARDIOL. 71, p. 25-31 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury

    Deuse, T., Hua, X., Wang, D., Maegdefessel, L., Heeren, J., Scheja, L., Bolaños, J. P., Rakovic, A., Spin, J. M., Stubbendorff, M., Ikeno, F., Länger, F., Zeller, T., Schulte-Uentrop, L., Stoehr, A., Itagaki, R., Haddad, F., Eschenhagen, T., Blankenberg, S., Kiefmann, R., Reichenspurner, H., Velden, J., Klein, C., Yeung, A., Robbins, R. C., Tsao, P. S. & Schrepfer, S., 29.05.2014, In: NATURE. 509, 7502, p. 641-644 4 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation

    Hirt, M. N., Boeddinghaus, J., Mitchell, A., Schaaf, S., Börnchen, C., Müller, C., Schulz, H., Hubner, N., Stenzig, J., Stoehr, A., Neuber, C., Eder, A., Luther, P. K., Hansen, A. & Eschenhagen, T., 19.05.2014, In: J MOL CELL CARDIOL. 74C, p. 151-161 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Automated analysis of contractile force and Ca2+ transients in engineered heart tissue

    Stoehr, A., Neuber, C., Baldauf, C., Vollert, I., Friedrich, F. W., Flenner, F., Carrier, L., Eder, A., Schaaf, S., Hirt, M. N., Aksehirlioglu, B., Tong, C. W., Moretti, A., Eschenhagen, T. & Hansen, A., 01.05.2014, In: AM J PHYSIOL-HEART C. 306, 9, p. H1353-H1363

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Myelin basic protein cleaves cell adhesion molecule l1 and promotes neuritogenesis and cell survival.

    Lutz, D., Loers, G., Kleene, R., Oezen, I., Kataria, H., Katagihallimath, N., Braren, I., Harauz, G. & Schachner, M., 05.2014, In: J BIOL CHEM. 289, 19, p. 13503-13518 16 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. Paradoxical effects on force generation after efficient β1-adrenoceptor knockdown in reconstituted heart tissue

    Neuber, C., Müller, O. J., Hansen, F., Eder, A., Witten, A., Rühle, F., Stoll, M., Katus, H. A., Eschenhagen, T. & El-Armouche, A., 01.04.2014, In: J PHARMACOL EXP THER. 349, 1, p. 39-46 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. Attenuated response of L-type calcium current to nitric oxide in atrial fibrillation

    Rozmaritsa, N., Christ, T., Van Wagoner, D. R., Haase, H., Stasch, J-P., Matschke, K. & Ravens, U., 01.03.2014, In: CARDIOVASC RES. 101, 3, p. 533-542 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. Cytoprotection by the NO-donor SNAP against ischemia/reoxygenation injury in mouse embryonic stem cell-derived cardiomyocytes

    Görbe, A., Varga, Z. V., Pálóczi, J., Rungarunlert, S., Klincumhom, N., Pirity, M. K., Madonna, R., Eschenhagen, T., Dinnyés, A., Csont, T. & Ferdinandy, P., 01.03.2014, In: NAT BIOTECHNOL. 56, 3, p. 258-264 7 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Myocardial tissue Engineering: in vitro models

    Vunjak Novakovic, G., Eschenhagen, T. & Mummery, C., 01.03.2014, In: CSH PERSPECT MED. 4, 3

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Hamburger Pharmakologie-Repetitorium: Eine Übersicht klinisch relevanter arzneitherapeutischer Fakten

    Wuttke, A. H., Eschenhagen, T., Hirt, M., Hansen, A., Stenzig, J., Weinberger, F., Werner, U., Friedrich, F., Schwedhelm, E., Lüneburg, N. & Anderssohn, M., 04.02.2014, Hamburger Pharmakologie-Repetitorium: Eine Übersicht klinisch relevanter arzneitherapeutischer Fakten. Wuttke, A. H. & Eschenhagen, T. (eds.). 3 ed. Hamburg: Eigenverlag, 197 p.

    Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Education

  46. Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

    Stathopoulou, K., Cuello, F., Candasamy, A. J., Kemp, E. M., Ehler, E., Haworth, R. S. & Avkiran, M., 01.02.2014, In: BIOCHEM J. 457, 3, p. 451-461 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. In vitro perfusion of engineered heart tissue through endothelialized channels

    Vollert, I., Seiffert, M., Bachmair, J., Sander, M., Eder, A., Conradi, L., Vogelsang, A., Schulze, T., Uebeler, J., Holnthoner, W., Redl, H., Reichenspurner, H., Hansen, A. & Eschenhagen, T., 01.02.2014, In: TISSUE ENG PT A. 20, 3-4, p. 854-63 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. MYBPC3 in hypertrophic cardiomyopathy: from mutation identification to RNA-based correction

    Behrens-Gawlik, V., Mearini, G., Gedicke-Hornung, C., Richard, P. & Carrier, L., 01.02.2014, In: PFLUG ARCH EUR J PHY. 466, 2, p. 215-223 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. Cardiac Tissue Engineering State of the Art

    Hirt, M. N., Hansen, A. & Eschenhagen, T., 17.01.2014, In: CIRC RES. 114, 2, p. 354-367 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. Atrial-selective antiarrhythmic activity by vernakalant fact or fiction?

    Christ, T., 01.01.2014, In: J CARDIOVASC PHARM. 63, 1, p. 23-24 2 p.

    Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

  51. Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation

    Mesirca, P., Alig, J., Torrente, A. G., Müller, J. C., Marger, L., Rollin, A., Marquilly, C., Vincent, A., Dubel, S., Bidaud, I., Fernandez, A., Seniuk, A., Engeland, B., Singh, J., Miquerol, L., Ehmke, H., Eschenhagen, T., Nargeot, J., Wickman, K., Isbrandt, D. & Mangoni, M. E., 01.01.2014, In: NAT COMMUN. 5, p. 4664

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

    Unsöld, B., Kaul, A., Sbroggiò, M., Schubert, C., Regitz-Zagrosek, V., Brancaccio, M., Damilano, F., Hirsch, E., Van Bilsen, M., Munts, C., Sipido, K., Bito, V., Detre, E., Wagner, N. M., Schäfer, K., Seidler, T., Vogt, J., Neef, S., Bleckmann, A., Maier, L. S., Balligand, J. L., Bouzin, C., Ventura-Clapier, R., Garnier, A., Eschenhagen, T., El-Armouche, A., Knöll, R., Tarone, G. & Hasenfuß, G., 01.01.2014, In: CARDIOVASC RES. 101, 1, p. 97-107 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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