Institute of Experimental Pharmacology and Toxicology
Publications
- 2019
DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs
Hoff, K., Lemme, M., Kahlert, A-K., Runde, K., Audain, E., Schuster, D., Scheewe, J., Attmann, T., Pickardt, T., Caliebe, A., Siebert, R., Kramer, H-H., Milting, H., Hansen, A., Ammerpohl, O. & Hitz, M-P., 11.06.2019, In: CLIN EPIGENETICS. 11, 1, p. 89Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
DPP10 is a new regulator of Nav1.5 channels in human heart
Belau, F., Metzner, K., Christ, T., Ravens, U., Schaefer, M., Künzel, S., Li, W., Wettwer, E., Dobrev, D., El-Armouche, A. & Kämmerer, S., 01.06.2019, In: INT J CARDIOL. 284, p. 68-73 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Dissecting hiPSC-CM pacemaker function in a cardiac organoid model
Schulze, M. L., Lemoine, M. D., Fischer, A. W., Scherschel, K., David, R., Riecken, K., Hansen, A., Eschenhagen, T. & Ulmer, B. M., 06.2019, In: BIOMATERIALS. 206, p. 133-145 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management
Thomas, D., Christ, T., Fabritz, L., Goette, A., Hammwöhner, M., Heijman, J., Kockskämper, J., Linz, D., Odening, K. E., Schweizer, P. A., Wakili, R. & Voigt, N., 06.2019, In: CLIN RES CARDIOL. 108, 6, p. 577-599 23 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Cardiac glial cells release neurotrophic S100B upon catheter-based treatment of atrial fibrillation
Scherschel, K., Hedenus, K., Jungen, C., Lemoine, M. D., Rübsamen, N., Veldkamp, M. W., Klatt, N., Lindner, D., Westermann, D., Casini, S., Kuklik, P., Eickholt, C., Klöcker, N., Shivkumar, K., Christ, T., Zeller, T., Willems, S. & Meyer, C., 22.05.2019, In: SCI TRANSL MED. 11, 493Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cardiomyopathy phenotypes in human induced pluripotent stem cell-derived cardiomyocytes – a systematic review
Eschenhagen, T. & Carrier, L., 05.2019, In: PFLUG ARCH EUR J PHY. 471, 5, p. 755-768 14 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Gene therapy strategies in the treatment of hypertrophic cardiomyopathy
Prondzynski, M., Mearini, G. & Carrier, L., 05.2019, In: PFLUG ARCH EUR J PHY. 471, 5, p. 807-815 9 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors
Längle, D., Werner, T. R., Wesseler, F., Reckzeh, E., Schaumann, N., Drowley, L., Polla, M., Plowright, A. T., Hirt, M. N., Eschenhagen, T. & Schade, D., 17.04.2019, In: CHEMMEDCHEM. 14, 8, p. 810-822 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Analysis of fibrosis in control or pressure overloaded rat hearts after mechanical unloading by heterotopic heart transplantation
Schaefer, A., Schneeberger, Y., Schulz, S., Krasemann, S., Werner, T., Piasecki, A., Höppner, G., Müller, C., Morhenn, K., Lorenz, K., Wieczorek, D., Schwoerer, A. P., Eschenhagen, T., Ehmke, H., Reichenspurner, H., Stenzig, J. & Cuello, F., 05.04.2019, In: SCI REP-UK. 9, 1, p. 5710Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF2α in patients with myocardial infarction in the randomized RIMINI-Trial
Schwemer, T. F., Deutscher, N., Diermann, N., Böger, R., Schwedhelm, E., Blankenberg, S. & Friedrich, F. W., 05.04.2019, In: SCI REP-UK. 9, 1, p. 5708Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Incidence and outcomes of unstable angina compared with non-ST-elevation myocardial infarction.
Puelacher, C., Gugala, M., Adamson, PD., Shah, A., Chapman, AR., Anand, A., Sabti, Z., Boeddinghaus, J., Nestelberger, T., Twerenbold, R., Wildi, K., Badertscher, P. & Mueller, C., 04.2019, In: HEART.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Implantation of hiPSC-derived Cardiac-muscle Patches after Myocardial Injury in a Guinea Pig Model
Castro, L., Geertz, B., Reinsch, M., Aksehirlioglu, B., Hansen, A., Eschenhagen, T., Reichenspurner, H., Weinberger, F. & Pecha, S., 18.03.2019, In: JOVE-J VIS EXP. 145Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Heart Repair With Myocytes: Why not take your own?
Eschenhagen, T. & Weinberger, F., 15.03.2019, In: CIRC RES. 124, 6, p. 843-845 3 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure
Madonna, R., Van Laake, L. W., Botker, H. E., Davidson, S. M., De Caterina, R., Engel, F. B., Eschenhagen, T., Fernandez-Aviles, F., Hausenloy, D. J., Hulot, J-S., Lecour, S., Leor, J., Menasché, P., Pesce, M., Perrino, C., Prunier, F., Van Linthout, S., Ytrehus, K., Zimmermann, W-H., Ferdinandy, P. & Sluijter, J. P. G., 01.03.2019, In: CARDIOVASC RES. 115, 3, p. 488-500 13 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Predicting Acute Myocardial Infarction with a Single Blood Draw
APACE Investigators, 03.2019, In: CLIN CHEM. 65, 3, p. 437-450 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Modified HEART Score and High-Sensitivity Cardiac Troponin in Patients With Suspected Acute Myocardial Infarction
APACE Investigators, 26.02.2019, In: J AM COLL CARDIOL. 73, 7, p. 873-875 3 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
B-Type Natriuretic Peptides and Cardiac Troponins for Diagnosis and Risk-Stratification of Syncope
du Fay de Lavallaz, J., Badertscher, P., Nestelberger, T., Zimmermann, T., Miró, Ò., Salgado, E., Christ, M., Geigy, N., Cullen, L., Than, M., Martin-Sanchez, F. J., Di Somma, S., Peacock, W. F., Morawiec, B., Walter, J., Twerenbold, R., Puelacher, C., Wussler, D., Boeddinghaus, J., Koechlin, L., Strebel, I., Keller, D. I., Lohrmann, J., Michou, E., Kühne, M., Reichlin, T. & Mueller, C., 25.02.2019, In: CIRCULATION.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling
Eiringhaus, J., Herting, J., Schatter, F., Nikolaev, V. O., Sprenger, J., Wang, Y., Köhn, M., Zabel, M., El-Armouche, A., Hasenfuss, G., Sossalla, S. & Fischer, T. H., 20.02.2019, In: BASIC RES CARDIOL. 114, 2, p. 13Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
External Validation of the MEESSI Acute Heart Failure Risk Score: A Cohort Study
Wussler, D., Kozhuharov, N., Sabti, Z., Walter, J., Strebel, I., Scholl, L., Miró, O., Rossello, X., Martín-Sánchez, F. J., Pocock, S. J., Nowak, A., Badertscher, P., Twerenbold, R., Wildi, K., Puelacher, C., du Fay de Lavallaz, J., Shrestha, S., Strauch, O., Flores, D., Nestelberger, T., Boeddinghaus, J., Schumacher, C., Goudev, A., Pfister, O., Breidthardt, T. & Mueller, C., 19.02.2019, In: ANN INTERN MED. 170, 4, p. 248-256 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cysteine-Based Redox Sensing and Its Role in Signaling by Cyclic Nucleotide-Dependent Kinases in the Cardiovascular System
Cuello, F. & Eaton, P., 10.02.2019, In: ANNU REV PHYSIOL. 81, p. 63-87 25 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
A newly generated neuronal cell model of CLN7 disease reveals aberrant lysosome motility and impaired cell survival.
von Kleist, L., Ariunbat, K., Braren, I., Stauber, T., Storch, S. & Danyukova, T., 02.2019, In: MOL GENET METAB. 126, 2, p. 196-205 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inflammatory Biomarkers and Clinical Judgment in the Emergency Diagnosis of Urgent Abdominal Pain
BASEL VII Investigators, 02.2019, In: CLIN CHEM. 65, 2, p. 302-312 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy
Morhenn, K., Quentin, T., Wichmann, H., Steinmetz, M., Prondzynski, M., Söhren, K-D., Christ, T., Geertz, B., Schröder, S., Schöndube, F. A., Hasenfuss, G., Schlossarek, S., Zimmermann, W. H., Carrier, L., Eschenhagen, T., Cardinaux, J-R., Lutz, S. & Oetjen, E., 02.2019, In: J MOL CELL CARDIOL. 127, p. 31-43 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
PKG1α oxidation negatively regulates food seeking behaviour and reward
Duraffourd, C., Huckstepp, R. T. R., Braren, I., Fernandes, C., Brock, O., Delogu, A., Prysyazhna, O., Burgoyne, J. & Eaton, P., 02.2019, In: REDOX BIOL. 21, p. 101077Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM
Piroddi, N., Witjas-Paalberends, E. R., Ferrara, C., Ferrantini, C., Vitale, G., Scellini, B., Wijnker, P. J. M., Sequiera, V., Dooijes, D., Dos Remedios, C., Schlossarek, S., Leung, M. C., Messer, A., Ward, D. G., Biggeri, A., Tesi, C., Carrier, L., Redwood, C. S., Marston, S. B., van der Velden, J. & Poggesi, C., 07.01.2019, In: J GEN PHYSIOL. 151, 1, p. 18-29 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Effect of Ranolazine on Ischemic Myocardium IN Patients With Acute Cardiac Ischemia (RIMINI-Trial): A Randomized Controlled Pilot Trial
Schwemer, T. F., Radziwolek, L., Deutscher, N., Diermann, N., Sehner, S., Blankenberg, S. & Friedrich, F. W., 01.2019, In: J CARDIOVASC PHARM T. 24, 1, p. 62-69 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impact of Food and Drug Administration Regulatory Approach on the 0/2-Hour Algorithm for Rapid Triage of Suspected Myocardial Infarction
Wildi, K., Nestelberger, T., Wussler, D., Boeddinghaus, J., Badertscher, P., Koechlin, L., Duwe, P., Rubini Gimenez, M., Twerenbold, R. & Mueller, C., 01.2019, In: CIRC-CARDIOVASC QUAL. 12, 1, p. e005188Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Piezo-bending actuators for isometric or auxotonic contraction analysis of engineered heart tissue
Mannhardt, I., Warncke, C., Trieu, H. K., Müller, J. & Eschenhagen, T., 01.2019, In: J TISSUE ENG REGEN M. 13, 1, p. 3-11 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue
Kresin, N., Stücker, S., Krämer, E., Flenner, F., Mearini, G., Münch, J., Patten, M., Redwood, C., Carrier, L. & Friedrich, F. W., 2019, In: FRONT PHYSIOL. 10, p. 239Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Biallelic mutation in MYH7 and MYBPC3 leads to severe cardiomyopathy with left ventricular non-compaction phenotype
Kolokotronis, K., Kühnisch, J., Klopocki, E., Dartsch, J., Rost, S., Huculak, C., Mearini, G., Störk, S., Carrier, L., Klaassen, S. & Gerull, B., 2019, In: HUM MUTAT.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium
Trautsch, I., Heta, E., Soong, P. L., Levent, E., Nikolaev, V. O., Bogeski, I., Katschinski, D. M., Mayr, M. & Zimmermann, W-H., 2019, In: FRONT PHYSIOL. 10, p. 272Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Evidence for Minimal Cardiogenic Potential of Stem Cell Antigen 1-Positive Cells in the Adult Mouse Heart
Neidig, L. E., Weinberger, F., Palpant, N. J., Mignone, J., Martinson, A. M., Sorensen, D. W., Bender, I., Nemoto, N., Reinecke, H., Pabon, L., Molkentin, J. D., Murry, C. E. & van Berlo, J. H., 18.12.2018, In: CIRCULATION. 138, 25, p. 2960-2962 3 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Atrial-like Engineered Heart Tissue: An In Vitro Model of the Human Atrium
Lemme, M., Ulmer, B. M., Lemoine, M. D., Zech, A. T. L., Flenner, F., Ravens, U., Reichenspurner, H., Rol-Garcia, M., Smith, G., Hansen, A., Christ, T. & Eschenhagen, T., 11.12.2018, In: STEM CELL REP. 11, 6, p. 1378-1390 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Normalization of force to muscle cross-sectional area: A helpful attempt to reduce data scattering in contractility studies?
Pecha, S., Koivumäki, J., Geelhoed, B., Kempe, R., Berk, E., Engel, A., Reichenspurner, H., Eschenhagen, T., Ravens, U., Kaumann, A. & Christ, T., 12.2018, In: ACTA PHYSIOL. 224, 4, p. e13202Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Correction: Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue
Jacob, F., Yonis, A. Y., Cuello, F., Luther, P., Schulze, T., Eder, A., Streichert, T., Mannhardt, I., Hirt, M. N., Schaaf, S., Stenzig, J., Force, T., Eschenhagen, T. & Hansen, A., 27.11.2018, In: PLOS ONE. 13, 11, p. e0208342Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy
Mosqueira, D., Mannhardt, I., Bhagwan, J., Lis-Slimak, K., Katili, P., Scott, E., Hassan, M., Prondzynski, M., Harmer, S., Tinker, A., Smith, J. G. W., Carrier, L., Williams, P. M., Gaffney, D., Eschenhagen, T., Hansen, A. & Denning, C. N., 14.11.2018, In: EUR HEART J. 39, 43, p. 3879-3892 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTCI E99K Mutation Unveil Differential Functional Deficits
Smith, J. G. W., Owen, T., Bhagwan, J. R., Mosqueira, D., Scott, E., Mannhardt, I., Patel, A., Barriales-Villa, R., Monserrat, L., Hansen, A., Eschenhagen, T., Harding, S. E., Marston, S. & Denning, C., 13.11.2018, In: STEM CELL REP. 11, 5, p. 1226-1243 18 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Oxidation of cardiac myofilament proteins: Priming for dysfunction?
Cuello, F., Wittig, I., Lorenz, K. & Eaton, P., 10.2018, In: MOL ASPECTS MED. 63, SI, p. 47-58Research output: SCORING: Contribution to journal › SCORING: Review article › Research
S100A4 as a target of the E3-ligase Asb2β and its effect on engineered heart tissue
Braumann, S., Thottakara, T., Stücker, S., Reischmann-Düsener, S., Krämer, E., Groß, J., Hirt, M., Doroudgar, S., Carrier, L. & Friedrich, F., 19.09.2018, In: FRONT PHYSIOL. 9, p. 1292Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Satellite cells delivered in their niche efficiently generate functional myotubes in three-dimensional cell culture
Prüller, J., Mannhardt, I., Eschenhagen, T., Zammit, P. S. & Figeac, N., 17.09.2018, In: PLOS ONE. 13, 9, p. e0202574Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Rat atrial engineered heart tissue: a new in vitro model to study atrial biology
Krause, J., Löser, A., Lemoine, M. D., Christ, T., Scherschel, K., Meyer, C., Blankenberg, S., Zeller, T., Eschenhagen, T. & Stenzig, J., 03.09.2018, In: BASIC RES CARDIOL. 113, 5, p. 41Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A Fragment of Adhesion Molecule L1 Binds to Nuclear Receptors to Regulate Synaptic Plasticity and Motor Coordination
Kraus, K., Kleene, R., Henis, M., Braren, I., Kataria, H., Sharaf, A., Loers, G., Schachner, M. & Lutz, D., 09.2018, In: MOL NEUROBIOL. 55, 9, p. 7164-7178Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
From basic science to high performance medicine
Eschenhagen, T., 21.08.2018, In: EUR HEART J. 39, 32, p. 2919-2921 3 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Novel DNA Methylation Sites Influence Expression in Relation to Smoking
Haase, T., Müller, C., Krause, J., Röthemeier, C., Stenzig, J., Kunze, S., Waldenberger, M., Münzel, T., Pfeiffer, N., Wild, P. S., Michal, M., Marini, F., Karakas, M., Lackner, K. J., Blankenberg, S. & Zeller, T., 20.08.2018, In: BIOMOLECULES. 8, 3, p. E74Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Effect of L. Fruit Juice on the Blood Sugar Level and Other Serum Parameters in Patients with Diabetes Type 2
Algenstaedt, P., Stumpenhagen, A. & Westendorf, J., 06.08.2018, In: EVID-BASED COMPL ALT. 2018, p. 3565427Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Response by Kaier et al to Letter Regarding Article, "Direct Comparison of Cardiac Myosin-Binding Protein C With Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction"
Kaier, T. E., Twerenbold, R., Puelacher, C., Marjot, J., Imambaccus, N., Boeddinghaus, J., Nestelberger, T., Badertscher, P., Sabti, Z., Rubini Giménez, M., Wildi, K., Hillinger, P., Grimm, K., Loeffel, S., Shrestha, S., Flores Widmer, D., Cupa, J., Kozhuharov, N., Miró, Ò., Martín-Sánchez, F. J., Morawiec, B., Rentsch, K., Lohrmann, J., Kloos, W., Osswald, S., Reichlin, T., Weber, E., Marber, M. & Mueller, C., 31.07.2018, In: CIRCULATION. 138, 5, p. 544-545 2 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
How accurate is clinical assessment of neck veins in the estimation of central venous pressure in acute heart failure? Insights from a prospective study
Breidthardt, T., Moreno-Weidmann, Z., Uthoff, H., Sabti, Z., Aeppli, S., Puelacher, C., Stallone, F., Twerenbold, R., Wildi, K., Kozhuharov, N., Wussler, D., Flores, D., Shrestha, S., Badertscher, P., Boeddinghaus, J., Nestelberger, T., Gimenez, M. R., Staub, D., Aschwanden, M., Lohrmann, J., Pfister, O., Osswald, S. & Mueller, C., 07.2018, In: EUR J HEART FAIL. 20, 7, p. 1160-1162 3 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers
Lemoine, M. D., Krause, T., Koivumäki, J. T., Prondzynski, M., Schulze, M. L., Girdauskas, E., Willems, S., Hansen, A., Eschenhagen, T. & Christ, T., 07.2018, In: CIRC-ARRHYTHMIA ELEC. 11, 7, p. e006035Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pharmacological inhibition of DNA methylation attenuates pressure overload-induced cardiac hypertrophy in rats.
Stenzig, J., Schneeberger, Y., Löser, A., Peters, B., Schäfer, A., Zhao, R., Ng, S. L., Höppner, G., Geertz, B., Hirt, M., Tan, W., Wong, E., Reichenspurner, H., Foo, R. & Eschenhagen, T., 07.2018, In: J MOL CELL CARDIOL. 120, p. 53-63 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clonal dynamics studied in cultured induced pluripotent stem cells reveal major growth imbalances within a few weeks
Brenière-Letuffe, D., Domke-Shibamiya, A., Hansen, A., Eschenhagen, T., Fehse, B., Riecken, K. & Stenzig, J., 18.06.2018, In: STEM CELL RES THER. 9, 1, p. 165Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review