Research ExplorerResearch UnitsInstitute of Experimental Pharmacology and Toxicology Publications

Institute of Experimental Pharmacology and Toxicology

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Publications

  1. 2010

  2. Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging.

    Wittköpper, K., Fabritz, L., Neef, S., Ort, K. R., Grefe, C., Unsöld, B., Kirchhof, P., Maier, L. S., Hasenfuss, G., Dobrev, D., Eschenhagen, T. & El-Armouche, A., 2010, In: J CLIN INVEST. 120, 2, p. 617-626 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial.

    Riethdorf, S., Müller, V., Zhang, L., Rau, T., Loibl, S., Komor, M., Roller, M., Huober, J., Fehm, T., Schrader, I., Hilfrich, J., Holms, F., Tesch, H., Eidtmann, H., Untch, M., von Minckwitz, G. & Pantel, K., 2010, In: CLIN CANCER RES. 16, 9, p. 2634-2645 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Development of a drug screening platform based on engineered heart tissue.

    Hansen, A., Eder, A., Bönstrup, M., Flato, M., Mewe, M., Schaaf, S., Aksehirlioglu, B., Schwoerer, A., Uebeler, J. & Eschenhagen, T., 2010, In: CIRC RES. 107, 1, p. 35-44 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Effects of chronic atrial fibrillation on active and passive force generation in human atrial myofibrils.

    Belus, A., Nicoletta, P., Ferrantini, C., Tesi, C., Cazorla, O., Toniolo, L., Drost, M., Mearini, G., Carrier, L., Rossi, A., Mugelli, A., Cerbai, E., van der Velden, J. & Poggesi, C., 2010, In: CIRC RES. 107, 1, p. 144-152 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Gender is an important determinant of the disposition of the loop diuretic torasemide.

    Werner, U., Werner, D., Heinbüchner, S., Graf, B., Ince, H., Kische, S., Thürmann, P., König, J., Fromm, M. F. & Zolk, O., 2010, In: J CLIN PHARMACOL. 50, 2, p. 160-168 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure?

    Eschenhagen, T., 2010, In: J CLIN INVEST. 120, 12, p. 4197-4203 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling.

    Martins, D. C., Paula, A., Salic, K., Gladka, M. M., Armand, A-S., Leptidis, S., Hansen, A., Hansen, A., Roo, C., Christina, J., Bierhuizen, M. F., van der Nagel, R., van Kuik, J., de Weger, R., de Bruin, A., Eschenhagen, T., Arbones, M. L., Eschenhagen, T., Windt, D. & Leon, J., 2010, In: NAT CELL BIOL. 12, 12, p. 1220-1227 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation.

    Rudolph, V., Andrié, R. P., Rudolph, T. K., Friedrichs, K., Klinke, A., Hirsch-Hoffmann, B., Schwoerer, A., Lau, D., Fu, X., Klingel, K., Sydow, K., Didié, M., Seniuk, A., von Leitner, E-C., Szöcs, K., Schrickel, J. W., Treede, H., Wenzel, U., Lewalter, T., Nickenig, G., Zimmermann, W-H., Meinertz, T., Böger, R., Reichenspurner, H., Freeman, B. A., Eschenhagen, T., Ehmke, H., Hazen, S. L., Willems, S. & Baldus, S., 2010, In: NAT MED. 16, 4, p. 470-474 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing.

    Will, R. D., Eden, M., Just, S., Hansen, A., Eder, A., Frank, D., Kuhn, C., Seeger, T. S., Oehl, U., Wiemann, S., Korn, B., Koegl, M., Rottbauer, W., Eschenhagen, T., Katus, H. A. & Frey, N., 2010, In: CIRC RES. 107, 10, p. 1253-1264 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Phosphatase-1-inhibitor-1: amplifier or attenuator of catecholaminergic stress?

    Wittköpper, K., Eschenhagen, T. & El-Armouche, A., 2010, In: BASIC RES CARDIOL. 105, 5, p. 569-571 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Regional diastolic and systolic function by strain rate imaging for the detection of intramural viability during dobutamine stress echocardiography in a porcine model of myocardial infarction.

    Schneider, C., Jaquet, K., Geidel, S., Malisius, R., Boczor, S., Rau, T., Zienkiewicz, T., Hennig, D., Kuck, K-H. & Krause, K., 2010, In: ECHOCARDIOGR-J CARD. 27, 5, p. 552-562 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. Stoppt Bremse des Proteinabbaus die Hypertrophie?

    Carrier, L. & Schlossarek, S., 2010, In: Cardio News. 13, 3, p. 22-23 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. The angiotensin II type 2 receptor in renal disease.

    Wenzel, U., Krebs, C. & Benndorf, R., 2010, In: J RENIN-ANGIO-ALDO S. 11, 1, p. 37-41 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy.

    Carrier, L., Schlossarek, S., Willis, M. S. & Eschenhagen, T., 2010, In: CARDIOVASC RES. 85, 2, p. 330-338 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. [Vernakalant: a novel antiarrhythmic drug for the rapid conversion of atrial fibrillation to sinus rhythm].

    Hirt, M. & Eschenhagen, T., 2010, In: DEUT MED WOCHENSCHR. 135, 19, p. 971-976 19.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. 2009

  18. Beta-adrenergic stimulation and myocardial function in the failing heart

    El-Armouche, A. & Eschenhagen, T., 01.12.2009, In: HEART FAIL REV. 14, 4, p. 225-41 17 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Fingolimod - ein neuer Immunmodulator

    Friedrich, F. W. & Eschenhagen, T., 01.10.2009, In: DEUT MED WOCHENSCHR. 134, 42, p. 2127-31 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity

    Choe, C., Lewerenz, J., Fischer, G., Uliasz, T. F., Espey, M. G., Hummel, F. C., King, S. B., Schwedhelm, E., Böger, R. H., Gerloff, C., Hewett, S. J., Magnus, T. & Donzelli, S., 01.09.2009, In: J NEUROCHEM. 110, 6, p. 1766-73 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Comparing the chemical biology of NO and HNO

    Flores-Santana, W., Switzer, C., Ridnour, L. A., Basudhar, D., Mancardi, D., Donzelli, S., Thomas, D. D., Miranda, K. M., Fukuto, J. M. & Wink, D. A., 01.08.2009, In: ARCH PHARM RES. 32, 8, p. 1139-53 15 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Impact of the CYP2D6 genotype on the clinical effects of metoprolol: a prospective longitudinal study.

    Rau, T., Wuttke, H., Michels, L. M., Werner, U., Bergmann, K., Kreft, M., Fromm, M. F. & Eschenhagen, T., 01.03.2009, In: CLIN PHARMACOL THER. 85, 3, p. 269-272 4 p., 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. ADMA and the role of the genes: Lessons from genetically modified animals and human gene polymorphisms.

    Maas, R., Böger, R. & Lüneburg, N., 2009, In: PHARMACOL RES. 60, 6, p. 475-480 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. A Double-Blind Clinical Safety Study of Noni Fruit Juice

    West, B. J., White, L. D., Palu, A. K., Westendorf, J. & Westendorf, J., 2009, In: Pacific Health Dial. 15, 2, p. 21-32 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. A myeloperoxidase promoter polymorphism is independently associated with mortality in patients with impaired left ventricular function.

    Rudolph, V., Rudolph, T. K., Kubala, L., Clauberg, N., Maas, R., Pekarova, M., Klinke, A., Lau, D., Szöcs, K., Meinertz, T., Böger, R. & Baldus, S., 2009, In: FREE RADICAL BIO MED. 47, 11, p. 1584-1590 11.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Analgesic and antiinflammatory activity of Morinda citrifolia L. (Noni) fruit.

    Basar, S., Uhlenhut, K., Högger, P., Schöne, F. & Westendorf, J., 2009, In: PHYTOTHER RES.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. A new polymorphism in human calmodulin III gene promoter is a potential modifier gene for familial hypertrophic cardiomyopathy.

    Friedrich, F., Bausero, P., Sun, Y., Treszl, A., Krämer, E., Juhr, D., Richard, P., Wegscheider, K., Schwartz, K., Brito, D., Arbustini, E., Waldenström, A., Isnard, R., Komajda, M., Eschenhagen, T. & Carrier, L., 2009, In: EUR HEART J. 30, 13, p. 1648-1655 13.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. Angiotensin II type 2 receptor deficiency aggravates renal injury and reduces survival in chronic kidney disease in mice.

    Benndorf, R., Krebs, C., Hirsch-Hoffmann, B., Schwedhelm, E., Cieslar, G., Schmidt-Haupt, R., Steinmetz, O., Meyer-Schwesinger, C., Thaiss, F., Haddad, M., Fehr, S., Heilmann, A., Helmchen, U., Hein, L., Ehmke, H., Stahl, R. A. K., Böger, R. & Wenzel, U., 2009, In: KIDNEY INT. 75, 10, p. 1039-1049 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study.

    Pikula, A., Böger, R., Beiser, A. S., Maas, R., DeCarli, C., Schwedhelm, E., Himali, J. J., Schulze, F., Au, R., Kelly-Hayes, M., Kase, C. S., Vasan, R. S., Wolf, P. A. & Seshadri, S., 2009, In: STROKE. 40, 9, p. 2959-2964 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Association of the Endogenous Nitric Oxide Synthase Inhibitor ADMA With Carotid Artery Intimal Media Thickness in the Framingham Heart Study Offspring Cohort.

    Maas, R., Xanthakis, V., Polak, J. F., Schwedhelm, E., Sullivan Lisa, M., Benndorf, R., Schulze, F., Vasan, R. S., Wolf, P. A., Böger, R. & Seshadri, S., 2009, In: STROKE. 40, 8, p. 2715-2719 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuria.

    Sibal, L., Agarwal, S. C., Schwedhelm, E., Lüneburg, N., Böger, R. & Home, P. D., 2009, In: CARDIOVASC DIABETOL. 8, p. 27

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Asymmetric dimethylarginine (ADMA) as a prospective marker of cardiovascular disease and mortality-An update on patient populations with a wide range of cardiovascular risk.

    Böger, R., Maas, R., Schulze, F. & Schwedhelm, E., 2009, In: PHARMACOL RES. 60, 6, p. 481-487 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Asymmetric dimethylarginine predicts outcome and time of stay in hospital in patients attending an internal medicine emergency room.

    Schulze, F., Vollert, J., Maas, R., Müller, R., Schwedhelm, E., Müller, C., Böger, R. & Möckel, M., 2009, In: CLIN CHIM ACTA. 401, 1-2, p. 20-24 1-2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Asymmetric dimethylarginine reference intervals determined with liquid chromatography-tandem mass spectrometry: results from the Framingham offspring cohort.

    Schwedhelm, E., Xanthakis, V., Maas, R., Sullivan Lisa, M., Schulze, F., Riederer, U., Benndorf, R., Böger, R. & Vasan, R. S., 2009, In: CLIN CHEM.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Asymmetric dimethylarginine: Understanding the physiology, genetics, and clinical relevance of this novel biomarker Proceedings of the 4th International Symposium on ADMA.

    Böger, R., 2009, In: PHARMACOL RES. 60, 6, p. 447 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Capturing adenylyl cyclases as potential drug targets.

    Pierre, S., Eschenhagen, T., Geisslinger, G. & Scholich, K., 2009, In: NAT REV DRUG DISCOV. 8, 4, p. 321-335 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction.

    Dijk, V., Sabine, J., Dooijes, D., Cris, D. R., Michels, M., Lamers, J. M. J., Schlossarek, S., Schlossarek, S., Carrier, L., Cate, T., Folkert, J., Stienen, G. J. M. & van der Velden, J., 2009, In: CIRCULATION. 119, 11, p. 1473-1483 11.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Correlation of biomarkers of endothelium dysfunction and matrix remodeling in patients with systemic sclerosis.

    Blaise, S., Maas, R., Trocme, C., Kom, G. D., Roustit, M., Carpentier, P. H. & Cracowski, J-L., 2009, In: J RHEUMATOL. 36, 5, p. 984-988 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. [Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous]

    Brune, K., Renner, B. & Maas, R., 2009, In: DEUT MED WOCHENSCHR. 134, 36, p. 1771-1773 36.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Development and validation of an RP-HPLC method for the analysis of anthraquinones in noni fruits and leaves

    Shixin, D., Jarakae Jensen, C., Basar, S., Westendorf, J. & Westendorf, J., 2009, In: FOOD CHEM. 116, 2, p. 505-508 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischemic stroke.

    Leypoldt, F., Choe, C-U., Gelderblom, M., von Leitner, E-C., Atzler, D., Schwedhelm, E., Gerloff, C., Sydow, K., Böger, R. & Magnus, T., 2009, In: PLOS ONE. 4, 10, p. 7337 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.

    Greiser, M., Neuberger, H-R., Harks, E., El-Armouche, A., Boknik, P., de Haan, S., Verheyen, F., Verheule, S., Schmitz, W., Ravens, U., Nattel, S., Allessie, M. A., Dobrev, D. & Schotten, U., 2009, In: J MOL CELL CARDIOL. 46, 3, p. 385-394 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. Ethnic-specific correlations of visfatin with circulating markers of endothelial inflammation and function.

    Reimann, M., Ziemssen, T., Huisman, H. W., Schutte, R., Malan, L., Rooyen, V., Böger, R., Böger, R. H., Malan, N. T. & Schutte, A. E., 2009, In: OBESITY. 17, 12, p. 2210-2215 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Expression of heat shock proteins in tissues from young pigs exposed to transport stress.

    Bao, E., Sultan, K., Bernhard, N. & Hartung, J., 2009, In: Dtsch Tierarztl Wochenschr. 116, 9, p. 321-325 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Extensive characterization of the human DDAH1 transgenic mice.

    Schwedhelm, E., von Leitner, E-C., Atzler, D., Schmitz, C., Jacobi, J., Meinertz, T., Münzel, T., Baldus, S., Cooke, J. P., Böger, R., Maas, R. & Sydow, K., 2009, In: PHARMACOL RES. 60, 6, p. 494-502 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. [Fingolimod - a new immunomodulator]

    Friedrich, F. & Eschenhagen, T., 2009, In: DEUT MED WOCHENSCHR. 134, 42, p. 2127-2131 42.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. Flow-mediated dilation in patients with coronary artery disease is enhanced by high dose atorvastatin compared to combined low dose atorvastatin and ezetimibe: results of the CEZAR study.

    Ostad, M. A., Eggeling, S., Tschentscher, P., Schwedhelm, E., Böger, R., Wenzel, P., Meinertz, T., Munzel, T. & Warnholtz, A., 2009, In: ATHEROSCLEROSIS. 205, 1, p. 227-232 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.

    Deuse, T., Peter, C., Fedak, P. W. M., Doyle, T., Reichenspurner, H., Zimmermann, W. H., Eschenhagen, T., Stein, W., Wu, J. C., Robbins, R. C. & Schrepfer, S., 2009, In: CIRCULATION. 120, 11, p. 247-254 11.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. HNO exacerbates ischemic cerebral injury and oxidative neurotoxicity.

    Choe, C-U., Lewerenz, J., Fischer, G., Uliasz, T. F., Espey, M. G., Hummel, F., Bruce King, S., Schwedhelm, E., Böger, R., Gerloff, C., Hewett, S. J., Magnus, T. & Donzelli, S., 2009, In: J NEUROCHEM.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. Interaction of thiazolidinediones (glitazones) with the ATP-binding cassette transporters P-glycoprotein and breast cancer resistance protein.

    Weiss, J., Sauer, A., Herzog, M., Böger, R., Haefeli, W. E. & Benndorf, R., 2009, In: PHARMACOLOGY. 84, 5, p. 264-270 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides.

    Schulze, F., Glos, S., Petruschka, D., Altenburg, C., Maas, R., Benndorf, R., Schwedhelm, E., Beil, U. & Böger, R., 2009, In: NUTR RES. 29, 5, p. 291-297 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. Methylarginines and mortality in patients with end stage renal disease: a prospective cohort study.

    Aucella, F., Maas, R., Vigilante, M., Tripepi, G., Schwedhelm, E., Margaglione, M., Gesualdo, L., Boeger, R. & Zoccali, C., 2009, In: ATHEROSCLEROSIS.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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