Research ExplorerResearch UnitsInstitute of Experimental Pharmacology and Toxicology Publications

Institute of Experimental Pharmacology and Toxicology

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Publications

  1. 2006

  2. High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations.

    Rau, T., Erney, B., Göres, R., Eschenhagen, T., Beck, J. & Langer, T., 2006, In: CLIN PHARMACOL THER. 80, 5, p. 468-476 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Increased urinary excretion of 8-iso-prostaglandin F2alpha in patients with HFE-related hemochromatosis: a case-control study.

    Kom, G. D., Schwedhelm, E., Nielsen, P. & Böger, R. H., 2006, In: FREE RADICAL BIO MED. 40, 7, p. 1194-1200 7.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation.

    El-Armouche, A., Boknik, P., Eschenhagen, T., Carrier, L., Knaut, M., Ravens, U. & Dobrev, D., 2006, In: CIRCULATION. 114, 7, p. 670-680 7.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Noni juice is not hepatotoxic.

    West, B-J., Jensen, C-J. & Westendorf, J., 2006, In: WORLD J GASTROENTERO. 12, 22, p. 3616-3619 22.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Noni juice protects the liver.

    Jensen, C. J., Westendorf, J., Wang, M-Y. & Wadsworth, D. P., 2006, In: EUR J GASTROEN HEPAT. 18, 5, p. 575-577 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Obesity is associated with a slower response to initial phenprocoumon therapy whereas CYP2C9 genotypes are not.

    Schwabedissen, Z., Meyer, C., Mevissen, V., Schmitz, F., Woodruff, S., Rau, T., Rau, T., Zerres, K., Hoffmann, R. & Ortlepp, J. R., 2006, In: EUR J CLIN PHARMACOL. 62, 9, p. 713-720 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Phosphorylation of protein phosphatase inhibitor-1 by protein kinase C.

    Sahin, B., Shu, H., Fernandez, J., El-Armouche, A., Molkentin, J. D., Nairn, A. C. & Bibb, J. A., 2006, In: J BIOL CHEM. 281, 34, p. 24322-24335 34.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Postocclusive reactive hyperemia inversely correlates with urinary 15-F2t-isoprostane levels in systemic sclerosis.

    Cracowski, J-L., Kom, G. D., Salvat-Melis, M., Renversez, J-C., McCord, G., Boignard, A., Carpentier, P. H. & Schwedhelm, E., 2006, In: FREE RADICAL BIO MED. 40, 10, p. 1732-1737 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Quantification of hormone-induced atrophy of large myotubes from C2C12 and L6 cells: atrophy-inducible and atrophy-resistant C2C12 myotubes.

    Sultan, K., Henkel, B., Terlou, M. & Haagsman, H. P., 2006, In: AM J PHYSIOL-CELL PH. 290, 2, p. 650-659 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.

    El-Armouche, A., Bednorz, A., Pamminger, T., Ditz, D., Didié, M., Dobrev, D. & Eschenhagen, T., 2006, In: BIOCHEM BIOPH RES CO. 346, 3, p. 700-706 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension.

    Benndorf, R. A., Rudolph, T. K., Appel, D., Schwedhelm, E., Maas, R., Schulze, F., Silberhorn, E. & Böger, R. H., 2006, In: METABOLISM. 55, 9, p. 1159-1164 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. The 2988G>A polymorphism affects splicing of a CYP2D6 minigene.

    Rau, T., Diepenbruck, S., Diepenbruck, I. & Eschenhagen, T., 2006, In: CLIN PHARMACOL THER. 80, 5, p. 555-560 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. The MLCK-mediated alpha1-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCepsilon signaling.

    Grimm, M., Mahnecke, N., Soja, F., El-Armouche, A., Haas, P., Treede, H., Reichenspurner, H. & Eschenhagen, T., 2006, In: BRIT J PHARMACOL. 148, 7, p. 991-1000 7.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. 2005

  16. Plasma concentrations of N-terminal brain natriuretic peptide in healthy children, adolescents, and young adults: effect of age and gender.

    Mir, T. S., Flato, M., Falkenberg, J., Haddad, M., Budden, R., Weil, J., Albers, S. & Laer, S., 01.09.2005, In: PEDIATR CARDIOL. 27, 1, p. 73-77 5 p., 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. ADMA and oxidative stress may relate to the progression of renal disease: rationale and design of the VIVALDI study.

    Böger, R. H., Schwedhelm, E., Maas, R., Quispe-Bravo, S. & Skamira, C., 2005, In: VASC MED. 10, 1, p. 97-102 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Asymmetric dimethylarginine, L-arginine, and endothelial dysfunction in essential hypertension.

    Perticone, F., Sciacqua, A., Maio, R., Perticone, M., Maas, R., Boger, R. H., Tripepi, G., Sesti, G. & Zoccali, C., 2005, In: J AM COLL CARDIOL. 46, 3, p. 518-523 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease.

    Spoto, B., Benedetto, F. A., Testa, A., Tripepi, G., Mallamaci, F., Maas, R., Boeger, R. H., Zoccali, C., Parlongo, R. M. & Pisano, A., 2005, In: AM J HYPERTENS. 18(12 Pt 1), p. 1549-1555

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  20. Bioavailability of diclofenac potassium at low doses.

    Hinz, B., Chevts, J., Renner, B., Wuttke, H., Rau, T., Schmidt, A., Szelenyi, I., Brune, K. & Werner, U., 2005, In: BRIT J CLIN PHARMACO. 59, 1, p. 80-84 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells.

    Willipinski-Stapelfeldt, B., Riethdorf, S., Assmann, V., Woelfle, U., Rau, T., Sauter, G., Heukeshoven, J. & Pantel, K., 2005, In: CLIN CANCER RES. 11, 22, p. 8006-8014 22.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity.

    Müller, V., Stahmann, N., Riethdorf, S., Rau, T., Zabel, T., Goetz, A., Jänicke, F. & Pantel, K., 2005, In: CLIN CANCER RES. 11, 10, p. 3678-3685 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Determination of a reference value for N(G), N(G)-dimethyl-L-arginine in 500 subjects.

    Schulze, F., Maas, R., Freese, R., Schwedhelm, E., Silberhorn, E. & Böger, R. H., 2005, In: EUR J CLIN INVEST. 35, 10, p. 622-626 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. Effect of syncope-related traumatic injuries on the diagnostic evaluation and syncope recurrence of patients with syncope and apparently normal hearts.

    Schuchert, A., Maas, R., Mortensen, K., Aydin, M. A., Kretzschmar, C. & Meinertz, T., 2005, In: AM J CARDIOL. 95, 9, p. 1101-1103 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality.

    Böger, R. H., Maas, R., Schulze, F. & Schwedhelm, E., 2005, In: CLIN CHEM LAB MED. 43, 10, p. 1124-1129 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Elevation of asymmetrical dimethylarginine (ADMA) and coronary artery disease in men with erectile dysfunction.

    Maas, R., Wenske, S., Zabel, M., Ventura, R., Schwedhelm, E., Steenpass, A., Klemm, H., Noldus, J. & Böger, R. H., 2005, In: EUR UROL. 48, 6, p. 1002-1004 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. Elevation of asymmetric dimethylarginine in patients with unstable angina and recurrent cardiovascular events.

    Krempl, T. K., Maas, R., Sydow, K., Meinertz, T., Böger, R. H. & Kähler, J., 2005, In: EUR HEART J. 26, 18, p. 1846-1851 18.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation.

    Deuse, T., Schrepfer, S., Koch-Nolte, F., Haddad, M., Schwedhelm, E., Böger, R., Schäfer, H., Detter, C. & Reichenspurner, H., 2005, In: J HEART LUNG TRANSPL. 24, 11, p. 1844-1854 11.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. Identification of adverse drug reactions by evaluation of a prescription database, demonstrated for "risk of bleeding".

    Gaus, W., Westendorf, J., Diebow, R. & Kieser, M., 2005, In: METHOD INFORM MED. 44, 5, p. 697-703 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium.

    Grimm, M., Haas, P., Willipinski-Stapelfeldt, B., Zimmermann, W-H., Rau, T., Pantel, K., Weyand, M. & Eschenhagen, T., 2005, In: CARDIOVASC RES. 65, 1, p. 211-220 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma.

    Schwedhelm, E., Tan-Andresen, J., Maas, R., Riederer, U., Schulze, F. & Böger, R. H., 2005, In: CLIN CHEM. 51, 7, p. 1268-1271 7.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Pharmacotherapies and their influence on asymmetric dimethylargine (ADMA).

    Maas, R., 2005, In: VASC MED. 10, 1, p. 49-57 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Quantification of ADMA: analytical approaches.

    Schwedhelm, E., 2005, In: VASC MED. 10, 1, p. 89-95 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.

    Effenberger, K. E., Johnsen, S. A., Monroe, D. G., Spelsberg, T. C. & Westendorf, J., 2005, In: J STEROID BIOCHEM. 96, 5, p. 387-399 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. The GLU298ASP variant of nitric oxide synthase interacts with asymmetric dimethyl arginine in determining cardiovascular mortality in patients with end-stage renal disease.

    Testa, A., Spoto, B., Tripepi, G., Mallamaci, F., Malatino, L., Fatuzzo, P., Maas, R., Boeger, R. & Zoccali, C., 2005, In: J HYPERTENS. 23, 10, p. 1825-1830 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Unusual collision-induced dissociation of fluorated and non-fluorated alpha-nitrotoluene analogs in a gas chromatograph triple-stage quadrupole mass spectrometer under electron-capturing negative-ion chemical ionization conditions.

    Tsikas, D., Schwedhelm, E. & Frölich, J. C., 2005, In: J CHROMATOGR A. 1067, 1-2, p. 337-345 1-2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. 2004

  38. Acetylsalicylic acid inhibits monocyte adhesion to endothelial cells by an antioxidative mechanism.

    Eisele, G., Schwedhelm, E., Schieffer, B., Tsikas, D. & Böger, R. H., 2004, In: J CARDIOVASC PHARM. 43, 4, p. 514-521 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Analysis of the relationship between norepinephrine and asymmetric dimethyl arginine levels among patients with end-stage renal disease.

    Mallamaci, F., Tripepi, G., Maas, R., Malatino, L., Böger, R. & Zoccali, C., 2004, In: J AM SOC NEPHROL. 15, 2, p. 435-441 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. Association of progesterone receptor polymorphism with recurrent abortions.

    Schweikert, A., Rau, T., Berkholz, A., Allera, A., Daufeldt, S. & Wildt, L., 2004, In: EUR J OBSTET GYN R B. 113, 1, p. 67-72 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. [Beta blockers in cardiac insufficiency. When, how much and which substance]

    Wuttke, H., Rau, T. & Eschenhagen, T., 2004, In: Med Monatsschr Pharm. 27, 12, p. 412-415 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. [Biomarkers as prognostic factors in pulmonary arterial hypertension. Rationale and study design]

    Cracowski, J. L., Yaici, A., Sitbon, O., Reynaud-Gaubert, M., Renversez, J. C., Pison, C., Faure, P., Cracowski, C., Chouri, N., Chaouat, A., Chabot, F., Schwedhelm, E., Maas, R., Degano, B., Mornex, J. F. & Humbert, M., 2004, In: REV MAL RESPIR. 21(6 Pt 1), p. 1137-1143

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. Comparative effects of AT1-antagonism and angiotensin-converting enzyme inhibition on markers of inflammation and platelet aggregation in patients with coronary artery disease.

    Schieffer, B., Bünte, C., Witte, J., Hoeper, K., Böger, R. H., Schwedhelm, E. & Drexler, H., 2004, In: J AM COLL CARDIOL. 44, 2, p. 362-368 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. CYP2D6 genotype: impact on adverse effects and nonresponse during treatment with antidepressants-a pilot study.

    Rau, T., Wohlleben, G., Wuttke, H., Thuerauf, N., Lunkenheimer, J., Lanczik, M. & Eschenhagen, T., 2004, In: CLIN PHARMACOL THER. 75, 5, p. 386-393 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Decreased protein and phosphorylation level of the protein phosphatase inhibitor-1 in failing human hearts.

    El-Armouche, A., Pamminger, T., Ditz, D., Zolk, O. & Eschenhagen, T., 2004, In: CARDIOVASC RES. 61, 1, p. 87-93 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay.

    Schulze, F., Wesemann, R., Schwedhelm, E., Sydow, K., Albsmeier, J., Cooke, J. P. & Böger, R. H., 2004, In: CLIN CHEM LAB MED. 42, 12, p. 1377-1383 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. Determination of NG,NG-dimethyl-L-arginine, an endogenous NO synthase inhibitor, by gas chromatography-mass spectrometry.

    Albsmeier, J., Schwedhelm, E., Schulze, F., Kastner, M. & Böger, R. H., 2004, In: J CHROMATOGR B. 809, 1, p. 59-65 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies.

    Deuse, T., Schrepfer, S., Schäfer, H., Koch-Nolte, F., Schwedhelm, E., Böger, R. H. & Reichenspurner, H., 2004, In: TRANSPLANTATION. 78, 1, p. 71-77 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. Formation of molecular complexes by N-methyl-D-aspartate receptor subunit NR2B and ryanodine receptor 2 in neonatal rat myocard.

    Seeber, S., Humeny, A., Herkert, M., Rau, T., Eschenhagen, T. & Becker, C-M., 2004, In: J BIOL CHEM. 279, 20, p. 21062-21068 20.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. [Genetic polymorphisms in drug metabolizing enzymes--impact on treatment with beta-blockers]

    Wuttke, H., Rau, T. & Eschenhagen, T., 2004, In: DEUT MED WOCHENSCHR. 129, 15, p. 831-835 15.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties.

    Keller, D. I., Coirault, C., Rau, T., Cheav, T., Weyand, M., Amann, K., Lecarpentier, Y., Richard, P., Eschenhagen, T. & Carrier, L., 2004, In: J MOL CELL CARDIOL. 36, 3, p. 355-362 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. Ouabain treatment is associated with upregulation of phosphatase inhibitor-1 and Na+/Ca(2+)-exchanger and beta-adrenergic sensitization in rat hearts.

    El-Armouche, A., Jaeckel, E., Boheler, K. R., Boknik, P., Hertle, B., Neumann, J. & Eschenhagen, T., 2004, In: BIOCHEM BIOPH RES CO. 318, 1, p. 219-226 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  53. Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia.

    Maas, R., Böger, R. H., Schwedhelm, E., Casas, J. P., López-Jaramillo, P., Serrano, N. & Díaz, L. A., 2004, In: JAMA-J AM MED ASSOC. 291, 7, p. 823-824 7.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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