Institute of Experimental Pharmacology and Toxicology
Publications
- 2000
Influence of treatment modality on angiographic outcome after coronary stenting in diabetic patients: a controlled study.
Schofer, J., Schlüter, M., Rau, T., Hammer, F., Haag, N. & Mathey, D. G., 2000, In: J AM COLL CARDIOL. 35, 6, p. 1554-1559 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Nebivolol decreases systemic oxidative stress in healthy volunteers.
Troost, R., Schwedhelm, E., Rojczyk, S., Tsikas, D. & Frölich, J. C., 2000, In: BRIT J CLIN PHARMACO. 50, 4, p. 377-379 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Normal oxidative stress and enhanced lipoprotein resistance to in vitro oxidation in hypertriglyceridemia: effects of bezafibrate therapy.
de Man, F. H., Jonkers, I. J., Schwedhelm, E., Smelt, A. H., Onkenhout, W., VanDDuyvenvoorde, W., Buytenhek, R., Leuven, J. A., Troost, R., van Der Laarse, A. & Princen, H. M., 2000, In: ARTERIOSCL THROM VAS. 20, 11, p. 2434-2440 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Tandem mass spectrometric quantification of 8-iso-prostaglandin F2alpha and its metabolite 2,3-dinor-5,6-dihydro-8-iso-prostaglandin F2alpha in human urine.
Schwedhelm, E., Tsikas, D., Durand, T., Gutzki, F. M., Guy, A., Rossi, J. C. & Frölich, J. C., 2000, In: J CHROMATOGR B. 744, 1, p. 99-112 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Transient expression of NMDA receptor subunit NR2B in the developing rat heart.
Seeber, S., Becker, K., Rau, T., Eschenhagen, T., Becker, C. M. & Herkert, M., 2000, In: J NEUROCHEM. 75, 6, p. 2472-2477 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
UDS induction by an array of standard carcinogens in human and rodent hepatocytes: effect of cryopreservation.
Schehrer, L., Regan, J. D. & Westendorf, J., 2000, In: TOXICOLOGY. 147, 3, p. 177-191 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1999
Enhanced expression of CTLA-4 (CD152) on CD4+ T cells in HIV infection.
Steiner, K., Waase, I., Rau, T., Dietrich, M., Fleischer, B. & Bröker, B. M., 1999, In: CLIN EXP IMMUNOL. 115, 3, p. 451-457 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Muscle LIM protein: expressed in slow muscle and induced in fast muscle by enhanced contractile activity.
Schneider, A. G., Sultan, K. & Pette, D., 1999, In: AM J PHYSIOL-HEART C. 276(4 Pt 1), p. 900-906Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pharmacological characterization of protein phosphatase activities in preparations from failing human hearts.
Neumann, J., Maas, R., Bokník, P., Jones, L. R., Zimmermann, N. & Scholz, H., 1999, In: J PHARMACOL EXP THER. 289, 1, p. 188-193 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Restenosis after stenting of matched occluded and non-occluded coronary arteries. Should there be a difference?
Schofer, J., Rau, T., Schlüter, M. & Mathey, D. G., 1999, In: EUR HEART J. 20, 16, p. 1175-1181 16.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Time-dependent changes in myosin heavy chain mRNA and protein isoforms in unloaded soleus muscle of rat.
Stevens, L., Sultan, K., Peuker, H., Gohlsch, B., Mounier, Y. & Pette, D., 1999, In: AM J PHYSIOL-HEART C. 277(6 Pt 1), p. 1044-1049Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1998
[Liver organ systems: valuation by gene expression]
Sultan, K., Hartumg, J. & Bade Ernesto, G., 1998, In: ALTEX-ALTERN TIEREXP. 15, 1, p. 9-17 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Stenting of nonacute total coronary occlusions: predictors of late angiographic outcome.
Rau, T., Schofer, J., Schlüter, M., Seidensticker, A., Berger, J. & Mathey, D. G., 1998, In: J AM COLL CARDIOL. 31, 2, p. 275-280 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1997
Comparison of immediate and intermediate-term results of intravascular ultrasound versus angiography-guided Palmaz-Schatz stent implantation in matched lesions.
Albiero, R., Rau, T., Schlüter, M., Di Mario, C., Reimers, B., Mathey, D. G., Tobis, J. M., Schofer, J. & Colombo, A., 1997, In: CIRCULATION. 96, 9, p. 2997-3005 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genotoxicity assessment of suspended particulate matter in the Elbe river: comparison of Salmonella microsome test, arabinose resistance test, and umu-test.
Vahl, H. H., Karbe, L. & Westendorf, J., 1997, In: MUTAT RES-FUND MOL M. 394, 1-3, p. 81-93 1-3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Short-term results and intermediate-term follow-up of laser wire recanalization of chronic coronary artery occlusions: a single-center experience.
Schofer, J., Rau, T., Schlüter, M. & Mathey, D. G., 1997, In: J AM COLL CARDIOL. 30, 7, p. 1722-1728 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Uptake and metabolism of benzo(a)pyrene absorbed to sediment by the freshwater invertebrate species Chironomus riparius and Sphaerium corneum.
Borchert, J., Karbe, L. & Westendorf, J., 1997, In: B ENVIRON CONTAM TOX. 58, 1, p. 158-165 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1996
[Holiday heart syndrome]
Rau, T. & Mathey, D., 1996, In: DEUT MED WOCHENSCHR. 121, 36, p. 1108 36.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hormone- and endotoxin-modulated gene expression of a long-term organ culture system of adult rat liver.
Sultan, K., Hartung, J. & Bade E, G., 1996, In: FEBS LETT. 394, 1, p. 51-54 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mechanisms of the contractile effects of 2,3-butanedione-monoxime in the mammalian heart.
Zimmermann, N., Boknik, P., Gams, E., Gsell, S., Jones, L. R., Maas, R., Neumann, J. & Scholz, H., 1996, In: N-S ARCH PHARMACOL. 354, 4, p. 431-436 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pharmacological and toxicological aspects of new imidazoacridinone antitumor agents.
Berger, B., Marquardt, H. & Westendorf, J., 1996, In: CANCER RES. 56, 9, p. 2094-2104 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Recanalization of chronic coronary artery occlusions using laser followed by balloon angioplasty.
Schofer, J., Kresser, J., Rau, T., Kunze, K. P., Kühn, C. R. & Mathey, D. G., 1996, In: AM J CARDIOL. 78, 7, p. 836-838 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1993
Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye.
Steinhorst, U. H., Chen, E. P., Hatchell, D. L., Samsa, G. P., Saloupis, P. T., Westendorf, J. & Machemer, R., 1993, In: INVEST OPHTH VIS SCI. 34, 5, p. 1753-1760 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Decreased resistance to N,N-dimethylated anthracyclines in multidrug-resistant Friend erythroleukemia cells.
Schaefer, A., Westendorf, J., Lingelbach, K., Schmidt, C. A., Mihalache, D. L., Reymann, A. & Marquardt, H., 1993, In: CANCER CHEMOTH PHARM. 31, 4, p. 301-307 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1992
Formation of genotoxic metabolites from anthraquinone glycosides, present in Rubia tinctorum L.
Blömeke, B., Poginsky, B., Schmutte, C., Marquardt, H. & Westendorf, J., 1992, In: MUTAT RES-FUND MOL M. 265, 2, p. 263-272 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mutagenicity testing of imidazole and related compounds.
Forster, R., Blowers, S. D., Cinelli, S., Marquardt, H. & Westendorf, J., 1992, In: MUTAT RES-FUND MOL M. 298, 2, p. 71-79 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Two-dimensional nuclear magnetic resonance studies of an intercalation complex between the novel semisynthetic anthracycline 3'-deamino-3'-(2-methoxy-4-morpholinyl)-doxorubicin and the hexanucleotide duplex d(CGTACG).
Odefey, C., Westendorf, J., Dieckmann, T. & Oschkinat, H., 1992, In: CHEM-BIOL INTERACT. 85, 2-3, p. 117-126 2-3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1991
Evaluation of DNA-binding activity of hydroxyanthraquinones occurring in Rubia tinctorum L.
Poginsky, B., Westendorf, J., Blömeke, B., Marquardt, H., Hewer, A., Grover, P. L. & Phillips, D. H., 1991, In: CARCINOGENESIS. 12, 7, p. 1265-1271 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1990
Genotoxicity of naturally occurring hydroxyanthraquinones.
Westendorf, J., Marquardt, H., Poginsky, B., Dominiak, M. & Schmidt, J., 1990, In: MUTAT RES-FUND MOL M. 240, 1, p. 1-12 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes.
Wölfle, D., Schmutte, C., Westendorf, J. & Marquardt, H., 1990, In: CANCER RES. 50, 20, p. 6540-6544 20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food.
Piasecki, A., Ruge, A. & Marquardt, H., 1990, In: ARZNEIMITTEL-FORSCH. 40, 9, p. 1054-1055 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1989
Mechanistic aspects of DNA damage by morpholinyl and cyanomorpholinyl anthracyclines.
Westendorf, J., Aydin, M., Groth, G., Weller, O. & Marquardt, H., 1989, In: CANCER RES. 49, 19, p. 5262-5266 19.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Proliferation of fetal rat hepatocytes in response to growth factors and hormones in primary culture.
Hoffmann, B., Piasecki, A. & Paul, D., 1989, In: J CELL PHYSIOL. 139, 3, p. 654-662 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1988
Altered growth factor requirements and cell cycle control in rat hepatoma cells versus adult rat hepatocytes in culture.
Paul, D., Piasecki, A., Baisch, H. & Begemann, M., 1988, In: EUR J CELL BIOL. 46, 2, p. 270-274 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Immortalized differentiated hepatocyte lines derived from transgenic mice harboring SV40 T-antigen genes.
Paul, D., Höhne, M., Pinkert, C., Piasecki, A., Ummelmann, E. & Brinster, R. L., 1988, In: EXP CELL RES. 175, 2, p. 354-362 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Induction of erythroid differentiation by the anthracycline antitumor antibiotic pyrromycin.
Steinheider, G., Schaefer, A., Westendorf, J. & Marquardt, H., 1988, In: CELL BIOL TOXICOL. 4, 1, p. 123-133 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Inhibition of amino acid uptake and incorporation into proteins in Friend erythroleukemia cells by the anthracycline antitumor antibiotic aclacinomycin A.
Schaefer, A., Boldt, J., Westendorf, J., Steinheider, G. & Marquardt, H., 1988, In: BIOCHEM PHARMACOL. 37, 7, p. 1377-1382 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mutagenic and antimutagenic effects of 5-substituted 2'-deoxyuridines depending on the nature of the 5-substituent.
Marquardt, H., Westendorf, J., Schaefer, A., Boldt, J. & De Clercq, E., 1988, In: ARZNEIMITTEL-FORSCH. 38, 12, p. 1820-1824 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Possible carcinogenicity of anthraquinone-containing medical plants.
Westendorf, J., Poginsky, B., Marquardt, H. & Kraus, L., 1988, In: PLANTA MED. 54, 6, p. 562 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts.
Westendorf, J., Poginsky, B., Marquardt, H. & Groth, G., 1988, In: CELL BIOL TOXICOL. 4, 2, p. 225-239 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1987
Induction of chromosomal aberrations by the anthracycline antitumor antibiotics N,N-dimethyldaunomycin and aclacinomycin A.
Steinheider, G., Westendorf, J. & Marquardt, H., 1987, In: Experientia. 43, 5, p. 586-588 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Induction of malignant transformation in vitro and mammary tumors in rats by two new potent anthracycline antitumor antibiotics, morpholinodaunomycin and cyanomorpholinoadriamycin.
Westendorf, J., Mohr, U. & Marquardt, H., 1987, In: CELL BIOL TOXICOL. 3, 1, p. 17-21 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Transformation of differentiated neonatal rat hepatocytes in primary culture by polyoma virus early region sequences.
Höhne, M., Piasecki, A., Ummelmann, E. & Paul, D., 1987, In: ONCOGENE. 1, 4, p. 337-345 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1986
DNA interaction and mutagenicity of the plastic stabilizer di-n-octyltin dichloride.
Westendorf, J. & Marquardt, H., 1986, In: ARZNEIMITTEL-FORSCH. 36, 8, p. 1263-1264 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Induction of erythroid differentiation by the anthracycline antitumor antibiotics, aclacinomycin A, musettamycin and marcellomycin.
Steinheider, G., Westendorf, J. & Marquardt, H., 1986, In: LEUKEMIA RES. 10, 10, p. 1233-1239 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1985
Formation of DNA-adducts and induction of DNA-crosslinks and chromosomal aberrations by the new potent anthracycline antitumor antibiotics: morpholinodaunomycin, cyanomorpholinodaunomycin and cyanomorpholinoadriamycin.
Westendorf, J., Groth, G., Steinheider, G. & Marquardt, H., 1985, In: CELL BIOL TOXICOL. 1, 2, p. 87-101 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes.
Marquardt, H., Westendorf, J. & De Clercq, E., 1985, In: CARCINOGENESIS. 6, 8, p. 1207-1209 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1984
[Biotransformation of monolinuron (N-(4-chlorophenyl)-N'-methyl-N'methoxyurea) in isolated perfused chicken liver].
Westphal, D., Lucas, K., Hilbig, V., Mechler, U. & Piasecki, A., 1984, In: FOOD CHEM TOXICOL. 22, 7, p. 521-528 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Rat platelets contain growth factor(s) distinct from PDGF which stimulate DNA synthesis in primary adult rat hepatocyte cultures.
Paul, D. & Piasecki, A., 1984, In: EXP CELL RES. 154, 1, p. 95-100 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Structure-activity relationship of anthracycline-induced genotoxicity in vitro.
Westendorf, J. & Marquardt, H., 1984, In: CANCER RES. 44(12 Pt 1), p. 5599-5604Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review