Institute of Experimental Pharmacology and Toxicology

Publications

  1. 2008
  2. Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice.

    Jacobi, J., Maas, R., Cordasic, N., Koch, K., Schmieder, R. E., Böger, R. & Hilgers, K. F., 2008, In: AM J PHYSIOL-HEART C. 294, 2, p. 1058-1066 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  3. Simultaneous assessment of endothelial function, nitric oxide synthase activity, nitric oxide-mediated signaling, and oxidative stress in individuals with and without hypercholesterolemia.

    Maas, R., Schwedhelm, E., Kahl, L., Li, H., Benndorf, R., Lüneburg, N., Förstermann, U. & Böger, R., 2008, In: CLIN CHEM. 54, 2, p. 292-300 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  4. The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms.

    Kockskämper, J., von Lewinski, D., Khafaga, M., Elgner, A., Grimm, M., Eschenhagen, T., Gottlieb, P. A., Sachs, F. & Pieske, B., 2008, In: PROG BIOPHYS MOL BIO. 97, 2-3, p. 250-267 2-3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  5. The ubiquitin-proteasome system in cardiac dysfunction.

    Mearini, G., Schlossarek, S., Willis, M. S. & Carrier, L., 2008, In: BBA-MOL BASIS DIS. 1782, 12, p. 749-763 12.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  6. Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/ AKT pathway.

    Krüger, M., Sachse, C., Zimmermann, W-H., Eschenhagen, T., Klede, S. & Linke, W. A., 2008, In: CIRC RES. 102, 4, p. 439-447 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  7. Ubiquitin-proteasome system impairment caused by a missense cardiac myosin-binding protein C mutation and associated with cardiac dysfunction in hypertrophic cardiomyopathy.

    Bahrudin, U., Morisaki, H., Morisaki, T., Ninomiya, H., Higaki, K., Nanba, E., Igawa, O., Takashima, S., Mizuta, E., Miake, J., Yamamoto, Y., Shirayoshi, Y., Kitakaze, M., Carrier, L. & Hisatome, I., 2008, In: J MOL BIOL. 384, 4, p. 896-907 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  8. Unloaded rat hearts in vivo express a hypertrophic phenotype of cardiac repolarization.

    Schwoerer, A., Melnychenko, I., Goltz, D., Hedinger, N., Broichhausen, I., El-Armouche, A., Eschenhagen, T., Volk, T. & Ehmke, H., 2008, In: J MOL CELL CARDIOL. 45, 5, p. 633-641 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  9. 2007
  10. Acute effects of various fast-food meals on vascular function and cardiovascular disease risk markers: the Hamburg Burger Trial.

    Rudolph, T. K., Ruempler, K., Schwedhelm, E., Tan-Andresen, J., Riederer, U., Böger, R. & Maas, R., 2007, In: AM J CLIN NUTR. 86, 2, p. 334-340 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  11. Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue.

    El-Armouche, A., Singh, J., Naito, H., Wittköpper, K., Didié, M., Laatsch, A., Zimmermann, W-H. & Eschenhagen, T., 2007, In: J MOL CELL CARDIOL. 43, 3, p. 371-376 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  12. An additive effect of endothelial nitric oxide synthase gene polymorphisms contributes to the severity of atherosclerosis in patients on dialysis.

    Spoto, B., Benedetto, F. A., Testa, A., Tripepi, G., Mallamaci, F., Maas, R., Boeger, R. H. & Zoccali, C., 2007, In: AM J HYPERTENS. 20, 7, p. 758-763 7.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  13. Arterial wave reflections and determinants of endothelial function a hypothesis based on peripheral mode of action.

    Weber, T., Maas, R., Auer, J., Lamm, G., Lassnig, E., Rammer, M., O'Rourke, M. F., Böger, R. & Eber, B., 2007, In: AM J HYPERTENS. 20, 3, p. 256-262 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  14. A stable-isotope based technique for the determination of dimethylarginine dimethylaminohydrolase (DDAH) activity in mouse tissue.

    Maas, R., Tan-Andreesen, J., Schwedhelm, E., Schulze, F. & Böger, R., 2007, In: J CHROMATOGR B. 851, 1-2, p. 220-228 1-2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  15. Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia.

    Maas, R., Quitzau, K., Schwedhelm, E., Spieker, L., Rafflenbeul, W., Steenpass, A., Lüscher, T. F. & Böger, R., 2007, In: ATHEROSCLEROSIS. 191, 1, p. 211-219 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  16. Asymmetric dimethyl-arginine (ADMA) response to inflammation in acute infections.

    Zoccali, C., Maas, R., Cutrupi, S., Pizzini, P., Finocchiaro, P., Cambareri, F., Panuccio, V., Martorano, C., Schulze, F., Enia, G., Tripepi, G. & Böger, R., 2007, In: NEPHROL DIAL TRANSPL. 22, 3, p. 801-806 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  17. Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: Effect of combination with oral L-arginine.

    Böger, G. I., Rudolph, T. K., Maas, R., Schwedhelm, E., Dumbadze, E., Bierend, A., Benndorf, R. & Böger, R., 2007, In: J AM COLL CARDIOL. 49, 23, p. 2274-2282 23.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  18. Asymmetric dimethylarginine is associated with parameters of glucose metabolism in Caucasian but not in African women from South Africa.

    Reimann, M., Schutte, A. E., Malan, N. T., Schwarz, P. E. H., Benndorf, R., Schulze, F. & Böger, R., 2007, In: EXP CLIN ENDOCR DIAB. 115, 9, p. 600-605 9.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  19. AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease.

    Warnholtz, A., Ostad, M. A., Heitzer, T., Thuneke, F., Fröhlich, M., Tschentscher, P., Schwedhelm, E., Böger, R., Meinertz, T. & Munzel, T., 2007, In: ATHEROSCLEROSIS. 194, 2, p. 439-445 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  20. Attenuation of cardiac remodelling by endocardial injection of erythropoietin: ultrasonic strain-rate imaging in a model of hibernating myocardium.

    Schneider, C., Jaquet, K., Malisius, R., Geidel, S., Bahlmann, E., Boczor, S., Rau, T., Antz, M., Kuck, K-H. & Krause, K., 2007, In: EUR HEART J. 28, 4, p. 499-509 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  21. Cardiac myosin-binding protein C in the heart.

    Carrier, L., 2007, In: Arch Mal Coeur Vaiss. 100, 3, p. 238-243 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  22. Cardiac myosin-binding protein C is required for complete relaxation in intact myocytes.

    Pohlmann, L., Kröger, I., Vignier, N., Schlossarek, S., Krämer, E., Coirault, C., Sultan, K., El-Armouche, A., Winegrad, S., Eschenhagen, T. & Carrier, L., 2007, In: CIRC RES. 101, 9, p. 928-938 9.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  23. Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure.

    El-Armouche, A., Pohlmann, L., Schlossarek, S., Starbatty, J., Yeh, Y-H., Nattel, S., Dobrev, D., Eschenhagen, T. & Carrier, L., 2007, In: J MOL CELL CARDIOL. 43, 2, p. 223-229 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  24. Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system.

    Riethdorf, S., Fritsche, H., Müller, V., Rau, T., Schindlbeck, C., Rack, B., Janni, W., Coith, C., Beck, K., Jänicke, F., Jackson, S., Gornet, T., Cristofanilli, M. & Pantel, K., 2007, In: CLIN CANCER RES. 13, 3, p. 920-928 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  25. Development of a biological ventricular assist device: preliminary data from a small animal model.

    Yildirim, Y., Naito, H., Didié, M., Karikkineth, B., Biermann, D., Eschenhagen, T. & Zimmermann, W-H., 2007, In: CIRCULATION. 116, 11, p. 16-23 11.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  26. [Dopamine: less important in emergency medicine?]

    El-Armouche, A. & Eschenhagen, T., 2007, In: DEUT MED WOCHENSCHR. 132, 49, p. 2654 49.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  27. Elevated plasma concentrations of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine predict adverse events in patients undergoing noncardiac surgery.

    Maas, R., Dentz, L., Schwedhelm, E., Thoms, W., Kuß, O., Hiltmeyer, N., Haddad, M., Klöss, T., Standl, T. & Böger, R., 2007, In: CRIT CARE MED. 35, 8, p. 1876-1881 8.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  28. Embryonic stem cells for cardiac muscle engineering.

    Zimmermann, W-H. & Eschenhagen, T., 2007, In: TRENDS CARDIOVAS MED. 17, 4, p. 134-140 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  29. High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma.

    Schwedhelm, E., Maas, R., Tan-Andresen, J., Schulze, F., Riederer, U. & Böger, R., 2007, In: J CHROMATOGR B. 851, 1-2, p. 211-219 1-2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  30. Impact of atorvastatin treatment on platelet-activating factor acetylhydrolase and 15-F(2trans)-isoprostane in hypercholesterolaemic patients.

    Kom, G. D., Schwedhelm, E., Maas, R., Schneider, L., Benndorf, R. & Böger, R., 2007, In: BRIT J CLIN PHARMACO. 63, 6, p. 672-679 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  31. Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?

    Schrepfer, S., Deuse, T., Sultan, K., Haddad, M., Böger, R., Münzel, T., Schäfer, H., Pelletier, M. P., Robbins, R. C. & Reichenspurner, H., 2007, In: CARDIOLOGY. 108, 2, p. 128-137 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  32. Long-term beta-adrenergic stimulation leads to downregulation of protein phosphatase inhibitor-1 in the heart.

    El-Armouche, A., Gocht, F., Jaeckel, E., Wittköpper, K., Peeck, M. & Eschenhagen, T., 2007, In: EUR J HEART FAIL. 9, 11, p. 1077-1080 11.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  33. Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective.

    Tousoulis, D., Böger, R., Antoniades, C., Siasos, G., Stefanadi, E. & Stefanadis, C., 2007, In: NAT CLIN PRACT CARD. 4, 5, p. 274-283 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  34. Mobilization of putative high-proliferative-potential endothelial colony-forming cells during antihypertensive treatment in patients with essential hypertension.

    Benndorf, R., Gehling, U., Appel, D., Maas, R., Schwedhelm, E., Schlagner, K., Silberhorn, E., Hossfeld, D. K., Rogiers, X. & Böger, R., 2007, In: STEM CELLS DEV. 16, 2, p. 329-338 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  35. Pharmacokinetics of oral doses of telmisartan and nisoldipine, given alone and in combination, in patients with essential hypertension.

    Bajcetic, M., Benndorf, R., Appel, D., Schwedhelm, E., Schulze, F., Riekhof, D., Maas, R. & Böger, R., 2007, In: J CLIN PHARMACOL. 47, 3, p. 295-304 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  36. Plasma concentrations of asymmetric dimethylarginine (ADMA) in metabolic syndrome.

    Garcia, R. G., Perez, M., Maas, R., Schwedhelm, E., Böger, R. & López-Jaramillo, P., 2007, In: INT J CARDIOL. 122, 2, p. 176-178 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  37. Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition.

    Grimm, M., El-Armouche, A., Zhang, R., Anderson, M. E. & Eschenhagen, T., 2007, In: J MOL CELL CARDIOL. 42, 3, p. 643-652 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  38. Regulation of cardiac cAMP synthesis and contractility by nucleoside diphosphate kinase B/G protein beta gamma dimer complexes.

    Hippe, H-J., Luedde, M., Lutz, S., Koehler, H., Eschenhagen, T., Frey, N., Katus, H. A., Wieland, T. & Niroomand, F., 2007, In: CIRC RES. 100, 8, p. 1191-1199 8.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  39. Reproducibility of transthoracic echocardiography in small animals using clinical equipment.

    Wasmeier, G. H., Melnychenko, I., Voigt, J-U., Zimmermann, W-H., Eschenhagen, T., Schineis, N., Reulbach, U., Flachskampf, F. A., Daniel, W. G. & Nixdorff, U., 2007, In: CORONARY ARTERY DIS. 18, 4, p. 283-291 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  40. Telmisartan improves endothelial function in patients with essential hypertension.

    Benndorf, R., Appel, D., Maas, R., Schwedhelm, E., Wenzel, U. & Böger, R., 2007, In: J CARDIOVASC PHARM. 50, 4, p. 367-371 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  41. The effect of the volatile oil from ginger rhizomes (Zingiber officinale), its fractions and isolated compounds on the 5-HT3 receptor complex and the serotoninergic system of the rat ileum.

    Riyazi, A., Hensel, A., Bauer, K., Geissler, N., Schaaf, S. & Verspohl, E. J., 2007, In: PLANTA MED. 73, 4, p. 355-362 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  42. The pharmacodynamics of L-arginine.

    Böger, R., 2007, In: J NUTR. 137(6 Suppl 2)

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  43. Toxicological and analytical investigations of noni (Morinda citrifolia) fruit juice.

    Westendorf, J., Harms-Effenberger, K., Iznaguen, H. & Basar, S., 2007, In: J AGR FOOD CHEM. 55, 2, p. 529-537 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  44. 2006
  45. Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter Coronary Artery Risk Determination investigating the Influence of ADMA Concentration (CARDIAC) study.

    Schulze, F., Lenzen, H., Hanefeld, C., Bartling, A., Osterziel, K. J., Goudeva, L., Schmidt-Lucke, C., Kusus, M., Maas, R., Schwedhelm, E., Strödter, D., Simon, B. C., Mügge, A., Daniel, W. G., Tillmanns, H., Maisch, B., Streichert, T. & Böger, R. H., 2006, In: AM HEART J. 152, 3, p. 1-8 3.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  46. A technique for locating implant abutment screws of posterior cement-retained metal-ceramic restorations with ceramic occlusal surfaces.

    Schwedhelm, E. & Raigrodski, A. J., 2006, In: J PROSTHET DENT. 95, 2, p. 165-167 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  47. Atorvastatin desensitizes beta-adrenergic signaling in cardiac myocytes via reduced isoprenylation of G-protein gamma-subunits.

    Mühlhäuser, U., Zolk, O., Rau, T., Münzel, F., Wieland, T. & Eschenhagen, T., 2006, In: FASEB J. 20, 6, p. 785-787 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  48. Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effects.

    Heitzer, T., Rudolph, V., Schwedhelm, E., Karstens, M., Sydow, K., Ortak, M., Tschentscher, P., Meinertz, T., Böger, R. & Baldus, S., 2006, In: ARTERIOSCL THROM VAS. 26, 7, p. 1648-1652 7.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  49. Comparison of HPLC method and commercial ELISA assay for asymmetric dimethylarginine (ADMA) determination in human serum.

    Schulze, F., Schwedhelm, E., Maas, R. & Böger, R. H., 2006, In: J CHROMATOGR B. 831, 1-2, p. 333 1-2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  50. Complications of non-compaction of the left ventricular myocardium in a paediatric population: a prospective study.

    Lilje, C., Rázek, V., Joyce, J. J., Rau, T., Finckh, B., Weiss, F., Habermann, C. R., Rice, J. C. & Weil, J., 2006, In: EUR HEART J. 27, 15, p. 1855-1860 15.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  51. Direct technique for the fabrication of acrylic provisional restorations.

    Schwedhelm, E., 2006, In: J Contemp Dent Pract. 7, 1, p. 157-173 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  52. Event-recorder monitoring in the diagnosis of atrial fibrillation in symptomatic patients: subanalysis of the SOPAT trial.

    Patten-Hamel, M., Maas, R., Karim, A., Müller, H-W., Simonovsky, R. & Meinertz, T., 2006, In: J CARDIOVASC ELECTR. 17, 11, p. 1216-1220 11.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review