Research ExplorerResearch UnitsInstitute of Experimental Pharmacology and Toxicology Publications

Institute of Experimental Pharmacology and Toxicology

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Publications

  1. 2009

  2. Nonsense-mediated mRNA decay and ubiquitin-proteasome system regulate cardiac myosin-binding protein C mutant levels in cardiomyopathic mice.

    Vignier, N., Schlossarek, S., Fraysse, B., Mearini, G., Krämer, E., Pointu, H., Mougenot, N., Guiard, J., Reimer, R., Hohenberg, H., Schwartz, K., Vernet, M., Eschenhagen, T. & Carrier, L., 2009, In: CIRC RES. 105, 3, p. 239-248 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. Pharmacogenetic characteristics of patients with complicated phenprocoumon dosing.

    Werner, D., Werner, U., Wuerfel, A., Grosch, A., Lestin, H., Eschenhagen, T. & Rau, T., 2009, In: EUR J CLIN PHARMACOL.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  4. Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community.

    Böger, R., Sullivan Lisa, M., Schwedhelm, E., Wang, T. J., Maas, R., Benjamin, E. J., Schulze, F., Xanthakis, V., Benndorf, R. & Vasan, R. S., 2009, In: CIRCULATION. 119, 12, p. 1592-1600 12.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Plasma asymmetric dimethylarginine, L-arginine and left ventricular structure and function in a community-based sample.

    Lieb, W., Benndorf, R., Benjamin, E. J., Sullivan Lisa, M., Maas, R., Xanthakis, V., Schwedhelm, E., Aragam, J., Schulze, F., Böger, R. & Vasan, R. S., 2009, In: ATHEROSCLEROSIS. 204, 1, p. 282-287 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Plasminogen activator inhibitor type 1 up-regulation is associated with skeletal muscle atrophy and associated fibrosis.

    Naderi, J., Bernreuther, C., Grabinski, N., Putman, C. T., Henkel, B., Bell, G., Glatzel, M. & Sultan, K., 2009, In: AM J PATHOL. 175, 2, p. 763-771 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension.

    Maas, R., Erdmann, J., Lüneburg, N., Stritzke, J., Schwedhelm, E., Meisinger, C., Peters, A., Weil, J., Schunkert, H., Böger, R. & Lieb, W., 2009, In: PHARMACOL RES. 60, 6, p. 488-493 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Predicting recurrence of vasovagal syncope: a simple risk score for the clinical routine.

    Aydin, M. A., Maas, R., Mortensen, K., Steinig, T., Klemm, H., Risius, T., Meinertz, T., Willems, S., Morillo, C. A. & Ventura, R., 2009, In: J CARDIOVASC ELECTR. 20, 4, p. 416-421 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling.

    Duncker, D. J., Boontje, N. M., Merkus, D., Versteilen, A., Krysiak, J., Mearini, G., El-Armouche, A., Beer, D., Vincent, J., Carrier, L., Carrier, L., Walker, L. A., Linke, W. A., Stienen, G. J. M. & van der Velden, J., 2009, In: CIRC-HEART FAIL. 2, 3, p. 233-242 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. Quantification of arginine and its mono- and dimethylated analogs NMMA, ADMA and SDMA in biological fluids by LC-MS/MS: Is LC superfluous?

    Martens-Lobenhoffer, J., Schwedhelm, E. & Tsikas, D., 2009, In: J CHROMATOGR B. 877, 27, p. 3261-3266 27.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  11. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer.

    Johnsen, S. A., Güngör, C., Prenzel, T., Riethdorf, S., Riethdorf, L., Taniguchi-Ishigaki, N., Rau, T., Tursun, B., Furlow, J. D., Sauter, G., Scheffner, M., Pantel, K., Gannon, F. & Bach, I., 2009, In: CANCER RES. 69, 1, p. 128-136 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. Renal resistance index in renal allograft recipients: a role for ADMA.

    Bergmann, I. P., Böger, R., Marti, E., Frey, F. J., Schwedhelm, E. & Eisenberger, U., 2009, In: AM J KIDNEY DIS.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  13. The benefits of noni juice: an epidemiological evaluation in Europe

    Westendorf, J. & Mettlich, C., 2009, In: J Med Food Plants. 1, 2, p. 64-67 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. The neuropeptide calcitonin gene-related peptide (CGRP) prevents inflammatory liver injury in mice.

    Kroeger, I., Erhardt, A., Abt, D., Fischer, M., Biburger, M., Rau, T., Neuhuber, W. L. & Tiegs, G., 2009, In: J HEPATOL. 51, 2, p. 342-353 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Transplantation of bone marrow-derived stem cells improves myocardial diastolic function: strain rate imaging in a model of hibernating myocardium.

    Schneider, C., Jaquet, K., Geidel, S., Rau, T., Malisius, R., Boczor, S., Zienkiewicz, T., Kuck, K-H. & Krause, K., 2009, In: J AM SOC ECHOCARDIOG. 22, 10, p. 1180-1189 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Treatment with atorvastatin partially protects the rat heart from harmful catecholamine effects.

    Schmechel, A., Grimm, M., El-Armouche, A., Höppner, G., Schwoerer, A., Ehmke, H. & Eschenhagen, T., 2009, In: CARDIOVASC RES. 82, 1, p. 100-106 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. Urinary excretion of biomarkers of oxidatively damaged DNA and RNA in hereditary hemochromatosis.

    Broedbaek, K., Poulsen, H. E., Weimann, A., Kom, G. D., Schwedhelm, E., Nielsen, P. & Böger, R., 2009, In: FREE RADICAL BIO MED. 47, 8, p. 1230-1233 8.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  18. Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine.

    Hu, X., Xu, X., Zhu, G., Atzler, D., Kimoto, M., Chen, J., Schwedhelm, E., Lüneburg, N., Böger, R., Zhang, P. & Chen, Y., 2009, In: CIRCULATION. 120, 22, p. 2222-2229 22.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  19. 2008

  20. Olanzapin

    Wittköpper, K., El-Armouche, A. & Eschenhagen, T., 01.09.2008, In: DEUT MED WOCHENSCHR. 133, 39, p. 1958-62 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure

    Albers, S., Meibohm, B., Mir, T. S. & Läer, S., 04.2008, In: BRIT J CLIN PHARMACO. 65, 4, p. 511-522 12 p., 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. [25 years of progress in pharmacology: many innovations--are you up to date?]

    Eschenhagen, T. & Rau, T., 2008, In: MMW Fortschr Med. 150, 48, p. 130, 132, 134 48.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Activation of negative regulators of the hypoxia-inducible factor (HIF) pathway in human end-stage heart failure.

    Zolk, O., Solbach, T. F., Eschenhagen, T., Weidemann, A. & Fromm, M. F., 2008, In: BIOCHEM BIOPH RES CO. 376, 2, p. 315-320 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  24. Altered carnitine homeostasis is associated with decreased mitochondrial function and altered nitric oxide signaling in lambs with pulmonary hypertension.

    Sharma, S., Sud, N., Wiseman, D. A., Carter, A. L., Kumar, S., Hou, Y., Rau, T., Wilham, J., Harmon, C., Oishi, P., Fineman, J. R. & Black, S. M., 2008, In: AM J PHYSIOL-LUNG C. 294, 1, p. 46-56 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  25. Altered myocardial gene expression reveals possible maladaptive processes in heterozygous and homozygous cardiac myosin-binding protein C knockout mice.

    Eijssen, L. M. T., van den Bosch, B. J. C., Vignier, N., Lindsey, P. J., van den Burg, C. M. M., Carrier, L., Doevendans, P. A., van der Vusse, G. J. & Smeets, H. J. M., 2008, In: GENOMICS. 91, 1, p. 52-60 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium.

    Kockskämper, J., Khafaga, M., Grimm, M., Elgner, A., Walther, S., Kockskämper, A., von Lewinski, D., Post, H., Grossmann, M., Dörge, H., Gottlieb, P. A., Sachs, F., Eschenhagen, T., Schöndube, F. A. & Pieske, B., 2008, In: CARDIOVASC RES. 79, 4, p. 642-651 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. Antiproteinuric effects of angiotensin receptor blockers: telmisartan versus valsartan in hypertensive patients with type 2 diabetes mellitus and overt nephropathy.

    Galle, J., Schwedhelm, E., Pinnetti, S., Böger, R. & Wanner, C., 2008, In: NEPHROL DIAL TRANSPL. 23, 10, p. 3174-3183 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  28. Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease.

    Arlt, S., Schulze, F., Eichenlaub, M., Maas, R., Lehmbeck, J., Schwedhelm, E., Jahn, H. & Böger, R., 2008, In: DEMENT GERIATR COGN. 26, 1, p. 58-64 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  29. ATP-binding cassette transporters in human heart failure.

    Solbach, T. F., Paulus, B., Weyand, M., Eschenhagen, T., Zolk, O. & Fromm, M. F., 2008, In: N-S ARCH PHARMACOL. 377, 3, p. 231-243 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. Beta-adrenergic signaling in heart failure-adapt or die.

    Eschenhagen, T., 2008, In: NAT MED. 14, 5, p. 485-487 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Bisoprolol vs. carvedilol in elderly patients with heart failure: rationale and design of the CIBIS-ELD trial.

    Düngen, H-D., Apostolovi, S., Inkrot, S., Tahirovi, E., Krackhardt, F., Pavlovi, M., Putnikovi, B., Lainscak, M., Gelbrich, G., Edelmann, F., Wachter, R., Eschenhagen, T., Waagstein, F., Follath, F., Rauchhaus, M., Haverkamp, W., Osterziel, K-J. & Dietz, R., 2008, In: CLIN RES CARDIOL. 97, 9, p. 578-586 9.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Cardiac Myosin-binding protein C modulates the tuning of the molecular motor in the heart.

    Lecarpentier, Y., Vignier, N., Oliviero, P., Guellich, A., Carrier, L. & Coirault, C., 2008, In: BIOPHYS J. 95, 2, p. 720-728 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Effects of moderate hyperhomocysteinaemia induced by 4 weeks methionine-enriched diet on metabolite profile and mesenteric artery function in rats.

    Pexa, A., Böger, R., Henle, T., Schwedhelm, E. & Deussen, A., 2008, In: BRIT J NUTR. 99, 5, p. 993-999 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Expression and distribution of heat shock proteins in the heart of transported pigs.

    Bao, E., Sultan, K., Nowak, B. & Hartung, J., 2008, In: CELL STRESS CHAPERON. 13, 4, p. 459-466 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Hindbrain administration of estradiol inhibits feeding and activates estrogen receptor-alpha-expressing cells in the nucleus tractus solitarius of ovariectomized rats.

    Thammacharoen, S., Lutz, T., Geary, N. & Asarian, L., 2008, In: ENDOCRINOLOGY. 149, 4, p. 1609-1617 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins.

    Huellner, M. W., Schrepfer, S., Weyand, M., Weiner, H., Rau, I., Eschenhagen, T. & Rau, T., 2008, In: FASEB J. 22, 7, p. 2561-2568 7.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  37. Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.

    Grote-Wessels, S., Baba, H. A., Boknik, P., El-Armouche, A., Fabritz, L., Gillmann, H-J., Kucerova, D., Matus, M., Müller, F. U., Neumann, J., Schmitz, M., Stümpel, F., Theilmeier, G., Wohlschlaeger, J., Schmitz, W. & Kirchhefer, U., 2008, In: CARDIOVASC RES. 79, 3, p. 464-471 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  38. Intramyocardial transplantation of bone marrow-derived stem cells: ultrasonic strain rate imaging in a model of hibernating myocardium.

    Schneider, C., Krause, K., Jaquet, K., Geidel, S., Malisius, R., Boczor, S., Rau, T., Zienkiewicz, T., Hennig, D. & Kuck, K-H., 2008, In: J CARD FAIL. 14, 10, p. 861-872 10.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  39. Introducing the first polymer-free leflunomide eluting stent.

    Deuse, T., Erben, R. G., Ikeno, F., Behnisch, B., Böger, R., Connolly, A. J., Reichenspurner, H., Bergow, C., Pelletier, M. P., Robbins, R. C. & Schrepfer, S., 2008, In: ATHEROSCLEROSIS. 200, 1, p. 126-134 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. L-Arginine therapy in cardiovascular pathologies: beneficial or dangerous?

    Böger, R., 2008, In: CURR OPIN CLIN NUTR. 11, 1, p. 55-61 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  41. Long-term effect on body composition and metabolic parameters after treatment with recombinant human growth hormone (r-hGH) in HIV-1 infected patients with lipodystrophy.

    Bickel, M., Zangos, S., Lutz, T., Eisen, J., Knecht, G., Goebel, F. D., Crespi, C. M., Jacobi, V., Staszewski, S. & Klauke, S., 2008, In: SCAND J INFECT DIS. 40, 1, p. 36-39 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. Mechanical unloading of the rat heart involves marked changes in the protein kinase-phosphatase balance.

    Schwoerer, A., Neuber, C., Schmechel, A., Melnychenko, I., Mearini, G., Boknik, P., Kirchhefer, U., Schmitz, W., Ehmke, H., Eschenhagen, T. & El-Armouche, A., 2008, In: J MOL CELL CARDIOL. 45, 6, p. 846-852 6.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  43. [Olanzapine]

    Wittköpper, K., El-Armouche, A. & Eschenhagen, T., 2008, In: DEUT MED WOCHENSCHR. 133, 39, p. 1958-1962 39.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Opioids and the management of chronic severe pain in the elderly: consensus statement of an International Expert Panel with focus on the six clinically most often used World Health Organization Step III opioids (buprenorphine, fentanyl, hydromorphone, methadone, morphine, oxycodone).

    Pergolizzi, J., Böger, R., Budd, K., Dahan, A., Erdine, S., Hans, G., Kress, H-G., Langford, R., Likar, R., Raffa, R. B. & Sacerdote, P., 2008, In: PAIN PRACT. 8, 4, p. 287-313 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease.

    Bierend, A., Rau, T., Maas, R., Schwedhelm, E. & Böger, R., 2008, In: BRIT J CLIN PHARMACO. 65, 4, p. 540-547 4.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.

    Schwedhelm, E., Maas, R., Freese, R., Jung, D., Lukacs, Z., Jambrecina, A., Spickler, W., Schulze, F. & Böger, R., 2008, In: BRIT J CLIN PHARMACO. 65, 1, p. 51-59 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy.

    El-Armouche, A., Wittköpper, K., Degenhardt, F., Weinberger, F., Didié, M., Melnychenko, I., Grimm, M., Peeck, M., Zimmermann, W-H., Unsöld, B., Hasenfuss, G., Dobrev, D. & Eschenhagen, T., 2008, In: CARDIOVASC RES. 80, 3, p. 396-406 3.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. Pleiotropic effects of telmisartan: still more to come?

    Benndorf, R. & Böger, R., 2008, In: J HYPERTENS. 26, 5, p. 854-856 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  49. Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment.

    Köllermann, J., Weikert, S., Schostak, M., Kempkensteffen, C., Kleinschmidt, K., Rau, T. & Pantel, K., 2008, In: J CLIN ONCOL. 26, 30, p. 4928-4933 30.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. Rapid development of severe end-organ damage in C57BL/6 mice by combining DOCA salt and angiotensin II.

    Kirchhoff, F., Krebs, C., Abdulhag, U. N., Meyer-Schwesinger, C., Maas, R., Helmchen, U., Hilgers, K. F., Wolf, G., Stahl, R. A. K. & Wenzel, U., 2008, In: KIDNEY INT. 73, 5, p. 643-650 5.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. Real-time myocardial contrast echocardiography for assessing perfusion and function in healthy and infarcted wistar rats.

    Wasmeier, G. H., Zimmermann, W-H., Schineis, N., Melnychenko, I., Voigt, J-U., Eschenhagen, T., Flachskampf, F. A., Daniel, W. G. & Nixdorff, U., 2008, In: ULTRASOUND MED BIOL. 34, 1, p. 47-55 1.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. Reduced phospholamban phosphorylation is associated with impaired relaxation in left ventricular myocytes from neuronal NO synthase-deficient mice.

    Zhang, Y. H., Zhang, M. H., Sears, C. E., Emanuel, K., Redwood, C., El-Armouche, A., Kranias, E. G. & Casadei, B., 2008, In: CIRC RES. 102, 2, p. 242-249 2.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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