A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies.

  • Carolyn G Marsden
  • Mary Jo Wright
  • Lucie Carrier
  • Krzysztof Moroz
  • Radhika Pochampally
  • Brian G Rowan

Abstract

The study of breast cancer metastasis depends on the use of established breast cancer cell lines that do not accurately represent the heterogeneity and complexity of human breast tumors. A tumor model was developed using primary breast tumor-initiating cells isolated from patient core biopsies that would more accurately reflect human breast cancer metastasis.

Bibliographical data

Original languageEnglish
ISSN1471-2407
Publication statusPublished - 2012
pubmed 22233382