Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression.

Jan Kornfeld; Stephanie Meder; M Wohlberg; Reinhard Friedrich; Thomas Rau; L Riethdorf; Thomas Löning; Klaus Pantel; Sabine Riethdorf

doi:10.1038/sj.bjc.6606017

Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression.

Jan Kornfeld
Stephanie Meder
M Wohlberg
Reinhard Friedrich
Thomas Rau
L Riethdorf
Thomas Löning
Klaus Pantel
Sabine Riethdorf

Related Research units

Department of Tumor Biology
Department of Oral and Maxillofacial Surgery
Institute of Experimental Pharmacology and Toxicology
Institute of Pathology

Abstract

TACE/ADAM17 is a transmembranous protease that cleaves membrane-bound growth factors like EGFR ligands. TACE-dependent proteolysis is regulated by its inhibitor, tissue inhibitor of metalloproteinases 3 (TIMP3). This study analyses the role of TACE and TIMP3 mRNA expression in squamous cell carcinomas of the head and neck (HNSCCs).

Bibliographical data

Original language	English
Article number	1
ISSN	0007-0920
DOIs	https://doi.org/10.1038/sj.bjc.6606017
Publication status	Published - 04.01.2011