Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression.

Jan Kornfeld; Stephanie Meder; M Wohlberg; Reinhard Friedrich; Thomas Rau; L Riethdorf; Thomas Löning; Klaus Pantel; Sabine Riethdorf

doi:10.1038/sj.bjc.6606017

Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression.

Jan Kornfeld
Stephanie Meder
M Wohlberg
Reinhard Friedrich
Thomas Rau
L Riethdorf
Thomas Löning
Klaus Pantel
Sabine Riethdorf

Beteiligte Einrichtungen

Institut für Tumorbiologie
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
Institut für Experimentelle Pharmakologie und Toxikologie
Institut für Pathologie

Abstract

TACE/ADAM17 is a transmembranous protease that cleaves membrane-bound growth factors like EGFR ligands. TACE-dependent proteolysis is regulated by its inhibitor, tissue inhibitor of metalloproteinases 3 (TIMP3). This study analyses the role of TACE and TIMP3 mRNA expression in squamous cell carcinomas of the head and neck (HNSCCs).

Bibliografische Daten

Originalsprache	Englisch
Aufsatznummer	1
ISSN	0007-0920
DOIs	https://doi.org/10.1038/sj.bjc.6606017
Status	Veröffentlicht - 04.01.2011