Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.

Sabine Fredersdorf; Christian Thumann; Wolfram H Zimmermann; Roland Vetter; Tobias Graf; Andreas Luchner; Günter Aj Riegger; Heribert Schunkert; Thomas Eschenhagen; Joachim Weil

doi:10.1186/1475-2840-11-57

Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.

Sabine Fredersdorf
Christian Thumann
Wolfram H Zimmermann
Roland Vetter
Tobias Graf
Andreas Luchner
Günter Aj Riegger
Heribert Schunkert
Thomas Eschenhagen
Joachim Weil

Related Research units

Institute of Experimental Pharmacology and Toxicology

Abstract

Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).

Bibliographical data

Original language	English
ISSN	1475-2840
DOIs	https://doi.org/10.1186/1475-2840-11-57
Publication status	Published - 2012

pubmed	22621761