Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.

Sabine Fredersdorf; Christian Thumann; Wolfram H Zimmermann; Roland Vetter; Tobias Graf; Andreas Luchner; Günter Aj Riegger; Heribert Schunkert; Thomas Eschenhagen; Joachim Weil

doi:10.1186/1475-2840-11-57

Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.

Standard

Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. / Fredersdorf, Sabine; Thumann, Christian; Zimmermann, Wolfram H; Vetter, Roland; Graf, Tobias; Luchner, Andreas; Riegger, Günter Aj; Schunkert, Heribert; Eschenhagen, Thomas; Weil, Joachim.

In: CARDIOVASC DIABETOL, Vol. 11, 2012, p. 57.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fredersdorf, S, Thumann, C, Zimmermann, WH, Vetter, R, Graf, T, Luchner, A, Riegger, GA, Schunkert, H, Eschenhagen, T & Weil, J 2012, 'Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.', CARDIOVASC DIABETOL, vol. 11, pp. 57. https://doi.org/10.1186/1475-2840-11-57

APA

Fredersdorf, S., Thumann, C., Zimmermann, W. H., Vetter, R., Graf, T., Luchner, A., Riegger, G. A., Schunkert, H., Eschenhagen, T., & Weil, J. (2012). Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. CARDIOVASC DIABETOL, 11, 57. https://doi.org/10.1186/1475-2840-11-57

Vancouver

Fredersdorf S, Thumann C, Zimmermann WH, Vetter R, Graf T, Luchner A et al. Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. CARDIOVASC DIABETOL. 2012;11:57. https://doi.org/10.1186/1475-2840-11-57

Bibtex

@article{edf8d0de628643a6b33cfacd7ded5045,

title = "Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.",

abstract = "Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).",

keywords = "Animals, Male, Time Factors, Cells, Cultured, Disease Models, Animal, Up-Regulation, Rats, Blotting, Northern, Rats, Wistar, Phosphorylation, Blotting, Western, Animals, Newborn, Polymerase Chain Reaction, Calcium/metabolism, RNA, Messenger/metabolism, Proto-Oncogene Proteins c-akt, Insulin/*pharmacology, Calcium-Binding Proteins/genetics/metabolism, Diabetes Mellitus, Type 2/blood/*drug therapy/enzymology/genetics/physiopathology, Gene Expression Regulation, Enzymologic/drug effects, Hypoglycemic Agents/*pharmacology, Myocardial Contraction/drug effects, Myocardium/*enzymology, Myocytes, Cardiac/*drug effects/enzymology, Rats, Zucker, Sarcoplasmic Reticulum/enzymology, Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics/*metabolism, Animals, Male, Time Factors, Cells, Cultured, Disease Models, Animal, Up-Regulation, Rats, Blotting, Northern, Rats, Wistar, Phosphorylation, Blotting, Western, Animals, Newborn, Polymerase Chain Reaction, Calcium/metabolism, RNA, Messenger/metabolism, Proto-Oncogene Proteins c-akt, Insulin/*pharmacology, Calcium-Binding Proteins/genetics/metabolism, Diabetes Mellitus, Type 2/blood/*drug therapy/enzymology/genetics/physiopathology, Gene Expression Regulation, Enzymologic/drug effects, Hypoglycemic Agents/*pharmacology, Myocardial Contraction/drug effects, Myocardium/*enzymology, Myocytes, Cardiac/*drug effects/enzymology, Rats, Zucker, Sarcoplasmic Reticulum/enzymology, Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics/*metabolism",

author = "Sabine Fredersdorf and Christian Thumann and Zimmermann, {Wolfram H} and Roland Vetter and Tobias Graf and Andreas Luchner and Riegger, {G{\"u}nter Aj} and Heribert Schunkert and Thomas Eschenhagen and Joachim Weil",

year = "2012",

doi = "10.1186/1475-2840-11-57",

language = "English",

volume = "11",

pages = "57",

journal = "CARDIOVASC DIABETOL",

issn = "1475-2840",

publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.

AU - Fredersdorf, Sabine

AU - Thumann, Christian

AU - Zimmermann, Wolfram H

AU - Vetter, Roland

AU - Graf, Tobias

AU - Luchner, Andreas

AU - Riegger, Günter Aj

AU - Schunkert, Heribert

AU - Eschenhagen, Thomas

AU - Weil, Joachim

PY - 2012

Y1 - 2012

N2 - Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).

AB - Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).

KW - Animals

KW - Male

KW - Time Factors

KW - Cells, Cultured

KW - Disease Models, Animal

KW - Up-Regulation

KW - Rats

KW - Blotting, Northern

KW - Rats, Wistar

KW - Phosphorylation

KW - Blotting, Western

KW - Animals, Newborn

KW - Polymerase Chain Reaction

KW - Calcium/metabolism

KW - RNA, Messenger/metabolism

KW - Proto-Oncogene Proteins c-akt

KW - Insulin/pharmacology

KW - Calcium-Binding Proteins/genetics/metabolism

KW - Diabetes Mellitus, Type 2/blood/drug therapy/enzymology/genetics/physiopathology

KW - Gene Expression Regulation, Enzymologic/drug effects

KW - Hypoglycemic Agents/pharmacology

KW - Myocardial Contraction/drug effects

KW - Myocardium/enzymology

KW - Myocytes, Cardiac/drug effects/enzymology

KW - Rats, Zucker

KW - Sarcoplasmic Reticulum/enzymology

KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics/metabolism