Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.
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Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. / Fredersdorf, Sabine; Thumann, Christian; Zimmermann, Wolfram H; Vetter, Roland; Graf, Tobias; Luchner, Andreas; Riegger, Günter Aj; Schunkert, Heribert; Eschenhagen, Thomas; Weil, Joachim.
in: CARDIOVASC DIABETOL, Jahrgang 11, 2012, S. 57.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.
AU - Fredersdorf, Sabine
AU - Thumann, Christian
AU - Zimmermann, Wolfram H
AU - Vetter, Roland
AU - Graf, Tobias
AU - Luchner, Andreas
AU - Riegger, Günter Aj
AU - Schunkert, Heribert
AU - Eschenhagen, Thomas
AU - Weil, Joachim
PY - 2012
Y1 - 2012
N2 - Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).
AB - Calcium (Ca2+) handling proteins are known to play a pivotal role in the pathophysiology of cardiomyopathy. However little is known about early changes in the diabetic heart and the impact of insulin treatment (Ins).
KW - Animals
KW - Male
KW - Time Factors
KW - Cells, Cultured
KW - Disease Models, Animal
KW - Up-Regulation
KW - Rats
KW - Blotting, Northern
KW - Rats, Wistar
KW - Phosphorylation
KW - Blotting, Western
KW - Animals, Newborn
KW - Polymerase Chain Reaction
KW - Calcium/metabolism
KW - RNA, Messenger/metabolism
KW - Proto-Oncogene Proteins c-akt
KW - Insulin/pharmacology
KW - Calcium-Binding Proteins/genetics/metabolism
KW - Diabetes Mellitus, Type 2/blood/drug therapy/enzymology/genetics/physiopathology
KW - Gene Expression Regulation, Enzymologic/drug effects
KW - Hypoglycemic Agents/pharmacology
KW - Myocardial Contraction/drug effects
KW - Myocardium/enzymology
KW - Myocytes, Cardiac/drug effects/enzymology
KW - Rats, Zucker
KW - Sarcoplasmic Reticulum/enzymology
KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics/metabolism
KW - Animals
KW - Male
KW - Time Factors
KW - Cells, Cultured
KW - Disease Models, Animal
KW - Up-Regulation
KW - Rats
KW - Blotting, Northern
KW - Rats, Wistar
KW - Phosphorylation
KW - Blotting, Western
KW - Animals, Newborn
KW - Polymerase Chain Reaction
KW - Calcium/metabolism
KW - RNA, Messenger/metabolism
KW - Proto-Oncogene Proteins c-akt
KW - Insulin/pharmacology
KW - Calcium-Binding Proteins/genetics/metabolism
KW - Diabetes Mellitus, Type 2/blood/drug therapy/enzymology/genetics/physiopathology
KW - Gene Expression Regulation, Enzymologic/drug effects
KW - Hypoglycemic Agents/pharmacology
KW - Myocardial Contraction/drug effects
KW - Myocardium/enzymology
KW - Myocytes, Cardiac/drug effects/enzymology
KW - Rats, Zucker
KW - Sarcoplasmic Reticulum/enzymology
KW - Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics/metabolism
U2 - 10.1186/1475-2840-11-57
DO - 10.1186/1475-2840-11-57
M3 - SCORING: Journal article
VL - 11
SP - 57
JO - CARDIOVASC DIABETOL
JF - CARDIOVASC DIABETOL
SN - 1475-2840
ER -