Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function.

  • van Dijk
  • J Sabine
  • E Rosalie Paalberends
  • Aref Najafi
  • Michelle Michels
  • Lucie Carrier
  • Lucie Carrier
  • Nicky M Boontje
  • Diederik W D Kuster
  • Marjon van Slegtenhorst
  • Dennis Dooijes
  • Dos Remedios Cris
  • Ten Cate
  • J Folkert
  • Ger J M Stienen
  • Jolanda van der Velden

Abstract

Hypertrophic cardiomyopathy (HCM), typically characterized by asymmetrical left ventricular hypertrophy, frequently is caused by mutations in sarcomeric proteins. We studied if changes in sarcomeric properties in HCM depend on the underlying protein mutation.

Bibliographical data

Original languageEnglish
Article number1
ISSN1941-3289
Publication statusPublished - 2012
pubmed 22178992