Terminal differentiation, advanced organotypic maturation, and modeling of hypertrophic growth in engineered heart tissue.

  • Malte Tiburcy
  • Michael Didié
  • Oliver Boy
  • Peter Christalla
  • Stephan Döker
  • Hiroshi Naito
  • Bijoy Chandapillai Karikkineth
  • Ali El-Armouche
  • Michael Grimm
  • Monika Nose
  • Thomas Eschenhagen
  • Anke Zieseniss
  • Doerthe M Katschinksi
  • Nazha Hamdani
  • Wolfgang A Linke
  • Xiaoke Yin
  • Manuel Mayr
  • Wolfram-Hubertus Zimmermann

Abstract

Cardiac tissue engineering should provide "realistic" in vitro heart muscle models and surrogate tissue for myocardial repair. For either application, engineered myocardium should display features of native myocardium, including terminal differentiation, organotypic maturation, and hypertrophic growth.

Bibliographical data

Original languageEnglish
Article number10
ISSN0009-7330
Publication statusPublished - 2011
pubmed 21921264