Department of Tumor Biology
Publications
- 2011
Circulating tumors cells as biomarkers: progress toward biomarker qualification.
Danila, D. C., Pantel, K., Fleisher, M. & Scher, H. I., 2011, In: CANCER J. 17, 6, p. 438-450 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase.
Schultze, A. & Fiedler, W., 2011, In: ANTI-CANCER AGENT ME. 11, 7, p. 593-599 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clinical relevance and biology of circulating tumor cells.
Bednarz, N., Alix-Panabières, C. & Pantel, K., 2011, In: BREAST CANCER RES. 13, 6, p. 228 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Controversies in clinical cancer dormancy.
Uhr, J. W. & Pantel, K., 2011, In: P NATL ACAD SCI USA. 108, 30, p. 12396-12400 30.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Detection and clinical relevance of early disseminated breast cancer cells depend on their cytokeratin expression pattern.
Harms-Effenberger, K., Borgen, E., Zu Eulenburg, C. G., Bartkowiak, K., Grosser, A., Synnestvedt, M., Kaaresen, R., Brandt, B., Nesland, J. M., Pantel, K. & Naume, B., 2011, In: BREAST CANCER RES TR. 125, 3, p. 729-738 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Detection of circulating tumor cells by RT-PCR significantly associated with poor prognosis in breast cancer.
Zhang, L., Wu, G. & Pantel, K., 2011, In: BREAST CANCER RES TR. 130, 1, p. 359-364 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Detection of circulating tumour cells in peripheral blood of patients with advanced non-metastatic bladder cancer.
Rink, M., Chun, F., Minner, S. J. P., Friedrich, M., Mauermann, O., Heinzer, H., Huland, H., Fisch, M., Pantel, K. & Riethdorf, S., 2011, In: BJU INT. 107, 10, p. 1668-1675 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ.
Sänger, N., Harms-Effenberger, K., Riethdorf, S., Viviane, V. H., Gauwerky, J., Wiegratz, I., Strebhardt, K., Kaufmann, M. & Pantel, K., 2011, In: INT J CANCER. 129, 10, p. 2522-2526 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
ERG status is unrelated to PSA recurrence in radically operated prostate cancer in the absence of antihormonal therapy.
Minner, S. J. P., Enodien, M., Sirma, H., Lübke, A., Krohn, A., Mayer, P. S., Simon, R., Tennstedt, P., Müller, J., Scholz, L., Brase, J. C., Liu, A. Y., Schlüter, H., Pantel, K., Schumacher, U., Bokemeyer, C., Steuber, T., Graefen, M., Sauter, G. & Schlomm, T., 2011, In: CLIN CANCER RES. 17, 18, p. 5878-5888 18.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Evaluation of cell-free tumour DNA and RNA in patients with breast cancer and benign breast disease.
Schwarzenbach, H., Müller, V., Milde-Langosch, K., Steinbach, B. & Pantel, K., 2011, In: MOL BIOSYST. 7, 10, p. 2848-2854 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
External quality assurance of circulating tumor cell enumeration using the CellSearch(®) system: a feasibility study.
Kraan, J., Sleijfer, S., Strijbos, M. H., Ignatiadis, M., Peeters, D., Pierga, J-Y., Farace, F., Riethdorf, S., Fehm, T., Zorzino, L., Tibbe, A. G. J., Maestro, M., Gisbert-Criado, R., Denton, G., Bono, D., Johann, S., Dive, C., Foekens, J. A. & Gratama, J. W., 2011, In: CYTOM PART B-CLIN CY. 80, 2, p. 112-118 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genomic profiling of cell-free DNA in blood and bone marrow of prostate cancer patients.
Schwarzenbach, H., Chun, F., Isbarn, H., Huland, H. & Pantel, K., 2011, In: J CANCER RES CLIN. 137, 5, p. 811-819 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors.
Joosse, S., Brandwijk, K. I. M., Mulder, L., Wesseling, J., Hannemann, J. & Nederlof, P. M., 2011, In: GENE CHROMOSOME CANC. 50, 2, p. 71-81 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impact of physical activity and doping on epigenetic gene regulation.
Schwarzenbach, H., 2011, In: DRUG TEST ANAL. 3, 10, p. 682-687 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impact of platinum-based chemotherapy on circulating nucleic acid levels, protease activities in blood and disseminated tumor cells in bone marrow of ovarian cancer patients.
Wimberger, P., Roth, C., Pantel, K., Kasimir-Bauer, S., Kimmig, R. & Schwarzenbach, H., 2011, In: INT J CANCER. 128, 11, p. 2572-2580 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice.
Mueller, K. M., Kornfeld, J., Friedbichler, K., Blaas, L., Egger, G., Esterbauer, H., Hasselblatt, P., Schlederer, M., Haindl, S., Wagner, K-U., Engblom, D., Haemmerle, G., Kratky, D., Sexl, V., Kenner, L., Kozlov, A. V., Terracciano, L., Zechner, R., Schuetz, G., Casanova, E., Pospisilik, J. A., Heim, M. H. & Moriggl, R., 2011, In: HEPATOLOGY. 54, 4, p. 1398-1409 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Indicators of homologous recombination deficiency in breast cancer and association with response to neoadjuvant chemotherapy.
Lips, E. H., Mulder, L., Hannemann, J., Laddach, N., Vrancken Peeters, M. T. F. D., van de Vijver, M. J., Wesseling, J., Nederlof, P. M. & Rodenhuis, S., 2011, In: ANN ONCOL. 22, 4, p. 870-876 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Influence of whole arm loss of chromosome 16q on gene expression patterns in oestrogen receptor-positive, invasive breast cancer.
Hungermann, D., Schmidt, H., Natrajan, R., Tidow, N., Poos, K., Reis-Filho, J. S., Brandt, B., Buerger, H. & Korsching, E., 2011, In: J PATHOL. 224, 4, p. 517-528 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.
Maxwell, C. A., Benítez, J., Gómez-Baldó, L., Osorio, A., Bonifaci, N., Fernández-Ramires, R., Costes, S. V., Guinó, E., Chen, H., Evans, G. J. R., Mohan, P., Català, I., Petit, A., Aguilar, H., Villanueva, A., Aytes, A., Serra-Musach, J., Rennert, G., Lejbkowicz, F., Peterlongo, P., Manoukian, S., Peissel, B., Ripamonti, C. B., Bonanni, B., Viel, A., Allavena, A., Bernard, L., Radice, P., Friedman, E., Kaufman, B., Laitman, Y., Dubrovsky, M., Milgrom, R., Jakubowska, A., Cybulski, C., Gorski, B., Jaworska, K., Durda, K., Sukiennicki, G., Lubiński, J., Shugart, Y. Y., Domchek, S. M., Letrero, R., Weber, B. L., Hogervorst, F. B. L., Rookus, M. A., Collee, J. M., Devilee, P., Ligtenberg, M. J., Luijt, R. B. V. D., Aalfs, C. M., Waisfisz, Q., Wijnen, J., Roozendaal, C. E. P. V., HEBON, U., EMBRACE, U., Easton, D. F., Peock, S., Cook, M., Oliver, C., Frost, D., Harrington, P., Evans, D. G., Lalloo, F., Eeles, R., Izatt, L., Chu, C., Eccles, D., Douglas, F., Brewer, C., Nevanlinna, H., Heikkinen, T., Couch, F. J., Lindor, N. M., Wang, X., Godwin, A. K., Caligo, M. A., Lombardi, G., Loman, N., Karlsson, P., Ehrencrona, H., Wachenfeldt, A. V., SWE-BRCA, U., Barkardottir, R. B., Hamann, U., Rashid, M. U., Lasa, A., Caldés, T., Andrés, R., Schmitt, M., Assmann, V., Stevens, K., Offit, K., Curado, J., Tilgner, H., Guigó, R., Aiza, G., Brunet, J., Castellsagué, J., Martrat, G., Urruticoechea, A., Blanco, I., Tihomirova, L., Goldgar, D. E., Buys, S., John, E. M., Miron, A., Southey, M., Daly, M. B., BCFR, U., Schmutzler, R. K., Wappenschmidt, B., Meindl, A., Arnold, N., Deissler, H., Varon-Mateeva, R., Sutter, C., Niederacher, D., Imyamitov, E., Sinilnikova, O. M., Stoppa-Lyonne, D., Mazoyer, S., Verny-Pierre, C., Castera, L., de Pauw, A., Bignon, Y-J., Uhrhammer, N., Peyrat, J-P., Vennin, P., Sandra, F. F., Collonge-Rame, M-A., Mortemousque, I., Collaborators, GEMO. S., Spurdle, A. B., Beesley, J., Chen, X., Healey, S., Barcellos-Hoff, M. H., Vidal, M., Gruber, S. B., Lázaro, C., Capellá, G., McGuffog, L., Nathanson, K. L., Antoniou, A. C., Chenevix-Trench, G., Fleisch, M. C., Moreno, V. & Pujana, M. A., 2011, In: PLOS BIOL. 9, 11, p. 1001199 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Loss of heterozygosity proximal to the M6P/IGF2R locus is predictive for the presence of disseminated tumor cells in the bone marrow of ovarian cancer patients before and after chemotherapy.
Kuhlmann, J. D., Schwarzenbach, H., Otterbach, F., Heubner, M., Wimberger, P., Worm, K-H., Kimmig, R. & Kasimir-Bauer, S., 2011, In: GENE CHROMOSOME CANC. 50, 8, p. 598-605 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia.
Schmidt, T., Behzad, K. M., Loges, S., Cauwenberghs, S., Fraisl, P., Maes, C., Jonckx, B., Kim, D. K., Kleppe, M., Tjwa, M., Schenk, T., Vinckier, S., Fragoso, R., Maria, D. M., Beel, K., Dias, S., Verfaillie, C., Clark, R. E., Brümmendorf, T. H., Vandenberghe, P., Rafii, S., Holyoake, T., Hochhaus, A., Cools, J., Karin, M., Carmeliet, G., Dewerchin, M. & Carmeliet, P., 2011, In: CANCER CELL. 19, 6, p. 740-753 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Molecular mechanisms of metastasis.
Hoon, D. S. B., Ferris, R., Tanaka, R., Chong, K. K., Alix-Panabières, C. & Pantel, K., 2011, In: J SURG ONCOL. 103, 6, p. 508-517 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Monitoring of loss of heterozygosity in serum microsatellite DNA among patients with gastrointestinal stromal tumors indicates tumor recurrence.
Rawnaq, T., Schwarzenbach, H., Schurr, P., Freise, K., Brandl, S., Izbicki, J. R. & Kaifi, J., 2011, In: J SURG RES. 169, 1, p. 31-35 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis.
Janni, W., Vogl, F. D., Wiedswang, G., Synnestvedt, M., Fehm, T., Jückstock, J., Borgen, E., Rack, B., Braun, S., Sommer, H., Solomayer, E., Pantel, K., Nesland, J., Friese, K. & Naume, B., 2011, In: CLIN CANCER RES. 17, 9, p. 2967-2976 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prediction of BRCA status
Joosse, S. & Hannemann, J., 2011, In: Int J Clin Rev. 07, p. 9Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prediction of BRCA status
Joosse, S. & Hannemann, J., 2011, In: CML - Breast Cancer. 23, 2, p. 41-50 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer.
Müller, V., Riethdorf, S., Rack, B., Janni, W., Fasching, P. A., Solomayer, E., Aktas, B., Kasimir-Bauer, S., Zeitz, J., Pantel, K., Fehm, T. & Group, DETECT. S., 2011, In: BREAST CANCER RES. 13, 4, p. 71 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prospective multi-centre study to validate chromogenic in situ hybridisation for the assessment of HER2 gene amplification in specimens from adjuvant and metastatic breast cancer patients.
Riethdorf, S., Hoegel, B., John, B., Ott, G., Fritz, P., Thon, S., Löning, T. & Pantel, K., 2011, In: J CANCER RES CLIN. 137, 2, p. 261-269 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prostate Cancer - From Bench to Bedside
Schwarzenbach, H., 2011, Prostate Cancer - From Bench to Bedside: Clinical relevance of circulating nucleic acids in blood of prostate cancer patients. 1 ed. InTec, p. 115-132Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
Quantitative high-resolution genomic analysis of single cancer cells.
Hannemann, J., Meyer-Staeckling, S., Kemming, D., Alpers, I., Joosse, S., Pospisil, H., Kurtz, S., Görndt, J., Püschel, K., Riethdorf, S., Pantel, K. & Brandt, B., 2011, In: PLOS ONE. 6, 11, p. 26362 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer.
Roth, C., Kasimir-Bauer, S., Pantel, K. & Schwarzenbach, H., 2011, In: MOL ONCOL. 5, 3, p. 281-291 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study.
Karkera, J., Steiner, H., Li, W., Skradski, V., Moser, P. L., Riethdorf, S., Reddy, M., Puchalski, T., Safer, K., Prabhakar, U., Pantel, K., Qi, M. & Culig, Z., 2011, In: PROSTATE. 71, 13, p. 1455-1465 13.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer.
Vashist, Y., Kutup, A., Musici, S., Yekebas, E. F., Mina, S., Uzunoglu, F. G., Zehler, O., König, A., Cataldegirmen, G., Bockhorn, M., Harms-Effenberger, K., Kalinin, V., Pantel, K. & Izbicki, J. R., 2011, In: MOL CELL ONCOL. 34, 4, p. 281-288 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Variants in STAT5B associate with serum TC and LDL-C levels.
Kornfeld, J., Isaacs, A., Vitart, V., Pospisilik, J. A., Meitinger, T., Gyllensten, U., Wilson, J. F., Rudan, I., Campbell, H., Penninger, J. M., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, P. P. & Hicks, A. A., 2011, In: J CLIN ENDOCR METAB. 96, 9, p. 1496-1501 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
VCAM-1 promotes osteolytic expansion of indolent bone micrometastasis of breast cancer by engaging α4β1-positive osteoclast progenitors.
Lu, X., Mu, E., Wei, Y., Riethdorf, S., Yang, Q., Yuan, M., Yan, J., Hua, Y., Tiede, B. J., Lu, X., Haffty, B. G., Pantel, K., Massagué, J. & Kang, Y., 2011, In: CANCER CELL. 20, 6, p. 701-714 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2010
Metabolic sensing by p53: keeping the balance between life and death
Tolstonog, G. V. & Deppert, W., 27.07.2010, In: P NATL ACAD SCI USA. 107, 30, p. 13193-4 2 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Advancing personalized cancer therapy by detection and characterization of circulating carcinoma cells.
Riethdorf, S. & Pantel, K., 2010, In: ANN NY ACAD SCI. 1210, p. 66-77Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A SURFACE PLASMON RESONANCE/MASS SPECTROMETRY INTERFACE FOR MAXIMUM SENSITIVITY
Dankbar, N., Gedig, E. & König, S., 2010, In: Biomacromol Mass Spectrom. 2, 2, p. 77-85 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
BRCA1 loss preexisting in small subpopulations of prostate cancer is associated with advanced disease and metastatic spread to lymph nodes and peripheral blood
Bednarz, N., Eltze, E., Semjonow, A., Rink, M., Andreas, A., Mulder, L., Hannemann, J., Fisch, M., Pantel, K., Weier, H-U. G., Bielawski, K. P. & Brandt, B., 2010, In: CLIN CANCER RES. 16, 13, p. 3340-3348 9 p., 13.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer.
Roth, C., Rack, B., Müller, V., Janni, W., Pantel, K. & Schwarzenbach, H., 2010, In: BREAST CANCER RES. 12, 6, p. 90 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Circulating tumour cells in cancer patients: challenges and perspectives.
Pantel, K. & Alix-Panabières, C., 2010, In: TRENDS MOL MED. 16, 9, p. 398-406 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Concordance of clinical and molecular breast cancer subtyping in the context of preoperative chemotherapy response.
de Ronde Jorma, J., Hannemann, J., Halfwerk, H., Mulder, L., Straver, M. E., Peeters, V., Marie-Jeanne, T. F. D., Wesseling, J., van de Vijver, M., Wessels, L. F. A. & Rodenhuis, S., 2010, In: BREAST CANCER RES TR. 119, 1, p. 119-126 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.
Holstege, H., van Beers, E., Velds, A., Liu, X., Joosse, S., Klarenbeek, S., Schut, E., Kerkhoven, R., Klijn, C. N., Wessels, L. F. A., Nederlof, P. M. & Jonkers, J., 2010, In: BMC CANCER. 10, p. 455Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial.
Riethdorf, S., Müller, V., Zhang, L., Rau, T., Loibl, S., Komor, M., Roller, M., Huober, J., Fehm, T., Schrader, I., Hilfrich, J., Holms, F., Tesch, H., Eidtmann, H., Untch, M., von Minckwitz, G. & Pantel, K., 2010, In: CLIN CANCER RES. 16, 9, p. 2634-2645 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Detection of a BSA-Biotin-Conjugate by a Novel Immunosensor
Lok Hang, MAK., Meinhard, KNOLL., Dankbar, N., Tanja, FISBECK. & Andreas, GORSCHLÜTER., 2010, In: Sensors & Transducers. 113, 2, p. 140-149 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients.
Bartkowiak, K., Harms-Effenberger, K., Harder, S., Andreas, A., Buck, F., Peter-Katalinic, J., Pantel, K. & Brandt, B., 2010, In: J PROTEOME RES. 9, 6, p. 3158-3168 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Floral homeotic C function genes repress specific B function genes in the carpel whorl of the basal eudicot California poppy (Eschscholzia californica).
Yellina, A. L., Orashakova, S., Lange, S., Erdmann, R., Leebens-Mack, J. & Becker, A., 2010, In: Evodevo. 1, p. 13Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
GORDITA (AGL63) is a young paralog of the Arabidopsis thaliana B(sister) MADS box gene ABS (TT16) that has undergone neofunctionalization.
Erdmann, R., Gramzow, L., Melzer, R., Theissen, G. & Becker, A., 2010, In: Plant J. 63, 6, p. 914-924 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
HER2 status of circulating tumor cells in patients with metastatic breast cancer: a prospective, multicenter trial.
Fehm, T., Müller, V., Aktas, B., Janni, W., Schneeweiss, A., Stickeler, E., Lattrich, C., Löhberg, C. R., Solomayer, E., Rack, B., Riethdorf, S., Klein, C., Schindlbeck, C., Brocker, K., Kasimir-Bauer, S., Wallwiener, D. & Pantel, K., 2010, In: BREAST CANCER RES TR. 124, 2, p. 403-412 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Increase in circulating microRNA levels in blood of ovarian cancer patients
Roth, C., Kasimir-Bauer, S., Heubner, M., Pantel, K. & Schwarzenbach, H., 2010, Circulating nucleic acids in plasma and serum. Gahan, P. (ed.). 1. ed. Springer, Vol. Ad. Exp. Med. Biol.. p. 63-71Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review