Variants in STAT5B associate with serum TC and LDL-C levels.

  • Jan Kornfeld
  • Aaron Isaacs
  • Veronique Vitart
  • J Andrew Pospisilik
  • Thomas Meitinger
  • Ulf Gyllensten
  • James F Wilson
  • Igor Rudan
  • Harry Campbell
  • Josef M Penninger
  • Veronika Sexl
  • Richard Moriggl
  • Cornelia van Duijn
  • Peter P Pramstaller
  • Andrew A Hicks

Related Research units

Abstract

Known genetic variants influencing serum lipid levels do not adequately account for the observed population variability of these phenotypes. The GH/signal transducers and activators of transcription (STAT) signaling pathway is an evolutionary conserved system that exerts strong effects on metabolism, including that of lipids.

Bibliographical data

Original languageEnglish
Article number9
ISSN0021-972X
Publication statusPublished - 2011
pubmed 21752895