Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis.

  • Wolfgang Janni
  • Florian D Vogl
  • Gro Wiedswang
  • Marit Synnestvedt
  • Tanja Fehm
  • Julia Jückstock
  • Elin Borgen
  • Brigitte Rack
  • Stephan Braun
  • Harald Sommer
  • Erich Solomayer
  • Klaus Pantel
  • Jahn Nesland
  • Klaus Friese
  • Bjørn Naume

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Abstract

The prognostic significance of disseminated tumor cells (DTC) in bone marrow (BM) of breast cancer patients at the time of primary diagnosis has been confirmed by a large pooled analysis. In view of the lack of early indicators for secondary adjuvant treatment, we here evaluated whether the persistence of DTCs after adjuvant therapy increases the risk of subsequent relapse and death.

Bibliographical data

Original languageEnglish
Article number9
ISSN1078-0432
Publication statusPublished - 2011
pubmed 21415211