Dr.med. ID: 63283
Marc Lütgehetmann
Publications
- 2020
Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system
Pfefferle, S., Reucher, S., Nörz, D. S. & Lütgehetmann, M., 04.03.2020, In: EUROSURVEILLANCE. 25, 9Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Implementation of the FilmArray ME panel in laboratory routine using a simple sample selection strategy for diagnosis of meningitis and encephalitis
Pfefferle, S., Christner, M., Aepfelbacher, M., Lütgehetmann, M. & Rohde, H., 22.02.2020, In: BMC INFECT DIS. 20, 1, p. 170Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection:longitudinal analysis of a German cohort:longitudinal analysis of a German cohort
Bockmann, J-H., Grube, M., Hamed, V., von Felden, J., Landahl, J., Wehmeyer, M., Giersch, K., Hall, M. T., Murray, J. M., Dandri, M., Lüth, S., Lohse, A. W., Lütgehetmann, M. & Schulze Zur Wiesch, J., 30.01.2020, In: BMC GASTROENTEROL. 20, 1, p. 24Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Evidence for systematic autopsies in COVID-19 positive deceased:Case report of the first German investigated COVID-19 death
Fitzek, A., Sperhake, J., Edler, C., Schröder, A. S., Heinemann, A., Heinrich, F., Ron, A., Mushumba, H., Lütgehetmann, M. & Püschel, K., 2020, In: RECHTSMEDIZIN. p. 1-6 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
DAMIAN an open source bioinformatics tool for fast, systematic and cohort based analysis of microorganisms in diagnostic samples
Alawi, M., Burkhardt, L., Indenbirken, D., Reumann, K., Christopeit, M., Kröger, N., Lütgehetmann, M., Aepfelbacher, M., Fischer, N. & Grundhoff, A., 14.11.2019, In: SCI REP-UK. 9, 1, p. 16841Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Fatal PCR-negative herpes simplex virus-1 encephalitis with GABAA receptor antibodies
Schuster, S., Abrante, L., Matschke, J., Lütgehetmann, M., Holst, B., Gelderblom, M., Braass, H., Leypoldt, F. & Magnus, T., 11.2019, In: NEUROL-NEUROIMMUNOL. 6, 6Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Microbial findings, sensitivity and outcome in patients with postoperative peritonitis a retrospective cohort study
Grotelueschen, R., Luetgehetmann, M., Erbes, J., Heidelmann, L. M., Grupp, K., Karstens, K., Ghadban, T., Reeh, M., Izbicki, J. R. & Bachmann, K., 10.2019, In: INT J SURG. 70, p. 63-69 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Clinical Perspective on Hepatitis E
Horvatits, T., Schulze Zur Wiesch, J., Lütgehetmann, M., Lohse, A. W. & Pischke, S., 05.07.2019, In: VIRUSES-BASEL. 11, 7Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Influence of local epidemiology on the performance of common colistin drug susceptibility testing methods
Asar, L., Pfefferle, S., Lütgehetmann, M., Hoffmann, A., Katchanov, J., Aepfelbacher, M., Rohde, H. & Maurer, F. P., 06.06.2019, In: PLOS ONE. 14, 6, p. e0217468Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
T cell receptor grafting allows virological control of Hepatitis B virus infection
Wisskirchen, K., Kah, J., Malo, A., Asen, T., Volz, T., Allweiss, L., Wettengel, J. M., Lütgehetmann, M., Urban, S., Bauer, T., Dandri, M. & Protzer, U., 30.04.2019, In: J CLIN INVEST. 129, 7, p. 2932-2945 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clinical evaluation of multiplex RT-PCR assays for the detection of influenza A/B and respiratory syncytial virus using a high throughput system
Eigner, U., Reucher, S., Hefner, N., Staffa-Peichl, S., Kolb, M., Betz, U., Holfelder, M., Spier, G., Pfefferle, S. & Lütgehetmann, M., 01.04.2019, In: J VIROL METHODS. 269, p. 49-54 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple's Disease
Moter, A., Janneck, M., Wolters, M., Iking-Konert, C., Wiessner, A., Loddenkemper, C., Hartleben, B., Lütgehetmann, M., Schmidt, J., Langbehn, U., Janssen, S., Geelhaar-Karsch, A., Schneider, T., Moos, V., Rohde, H., Kikhney, J. & Wiech, T., 19.03.2019, In: CLIN INFECT DIS. 68, 7, p. 1089-1097 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Chronic Hepatitis E in Rheumatology and Internal Medicine Patients: A Retrospective Multicenter European Cohort Study
Pischke, S., Peron, J-M., von Wulffen, M., von Felden, J., Höner Zu Siederdissen, C., Fournier, S., Lütgehetmann, M., Iking-Konert, C., Bettinger, D., Par, G., Thimme, R., Cantagrel, A., Lohse, A. W., Wedemeyer, H., de Man, R. & Mallet, V., 22.02.2019, In: VIRUSES-BASEL. 11, 2Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis
Lamprecht, P., Fischer, N., Huang, J., Burkhardt, L., Lütgehetmann, M., Arndt, F., Rolfs, I., Kerstein, A., Iking-Konert, C. & Laudien, M., 02.2019, In: J AUTOIMMUN. 97, p. 29-39 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Detection of a Broad Range of Low-Level Major Histocompatibility Complex Class II-Restricted, Hepatitis Delta Virus (HDV)-Specific T-Cell Responses Regardless of Clinical Status
Landahl, J., Bockmann, J. H., Scheurich, C., Ackermann, C., Matzat, V., Heide, J., Nuurei, T., D'Antonio, G., von Felden, J., Sette, A., Peine, S., Lohse, A. W., Lütgehetmann, M., Marget, M., Sidney, J. & Schulze Zur Wiesch, J., 29.01.2019, In: J INFECT DIS. 219, 4, p. 568-577 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo
Giersch, K., Bhadra, O. D., Volz, T., Allweiss, L., Riecken, K., Fehse, B., Lohse, A. W., Petersen, J., Sureau, C., Urban, S., Dandri, M. & Lütgehetmann, M., 01.2019, In: GUT. 68, 1, p. 150-157 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3 Regulatory T Cells
Mathies, F., Steffens, N., Kleinschmidt, D., Stuhlmann, F., Huber, F. J., Roy, U., Meyer, T., Luetgehetmann, M., von Petersdorff, M., Seiz, O., Herkel, J., Schramm, C., Flavell, R. A., Gagliani, N., Krebs, C., Panzer, U., Abdullah, Z., Strowig, T., Bedke, T. & Huber, S., 15.12.2018, In: J IMMUNOL. 201, 12, p. 3558-3568 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center.
Brehm, T. T., Schulze zur Wiesch, J., Lütgehetmann, M., Tappe, D., Eisermann, P., Lohse, A. W., Addo, M. M. & Schmiedel, S., 12.2018, In: INFECTION. 46, 6, p. 847-853 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lack of evidence for human serum albumin as major source of HEV infections
Horvatits, T., Westhölter, D., Peine, S., Schulze Zur Wiesch, J., Lohse, A. W., Lütgehetmann, M. & Pischke, S., 12.2018, In: TRANSFUSION MED. 28, 6, p. 470-471 2 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Hepatitis E seroprevalence in the Americas: A systematic review and meta-analysis
Horvatits, T., Ozga, A-K., Westhölter, D., Hartl, J., Manthey, C. F., Lütgehetmann, M., Rauch, G., Kriston, L., Lohse, A. W., Bendall, R., Wedemeyer, H., Dalton, H. R. & Pischke, S., 11.2018, In: LIVER INT. 38, 11, p. 1951-1964 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors
Kraef, C., Schlein, C., Hiller, J., Westhölter, D., Denzer, U., Horvatits, T., Peine, S., Lohse, A. W., Lütgehetmann, M., Polywka, S. & Pischke, S., 08.2018, In: J CLIN VIROL. 105, p. 26-30 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients
Westhölter, D., Hiller, J., Denzer, U., Polywka, S., Ayuk, F., Rybczynski, M., Horvatits, T., Gundlach, S., Blöcker, J., Schulze Zur Wiesch, J., Fischer, N., Addo, M. M., Peine, S., Göke, B., Lohse, A. W., Lütgehetmann, M. & Pischke, S., 07.2018, In: J HEPATOL. 69, 1, p. 36-42 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection
Winer, B. Y., Shirvani-Dastgerdi, E., Bram, Y., Sellau, J., Low, B. E., Johnson, H., Huang, T., Hrebikova, G., Heller, B., Sharon, Y., Giersch, K., Gerges, S., Seneca, K., Pais, M-A., Frankel, A. S., Chiriboga, L., Cullen, J., Nahass, R. G., Lutgehetmann, M., Toettcher, J. E., Wiles, M. V., Schwartz, R. E. & Ploss, A., 27.06.2018, In: SCI TRANSL MED. 10, 447, p. eaap9328Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Comprehensive Molecular Approach for Characterization of Hepatitis E Virus Genotype 3 Variants
Wang, B., Harms, D., Papp, C. P., Niendorf, S., Jacobsen, S., Lütgehetmann, M., Pischke, S., Wedermeyer, H., Hofmann, J. & Bock, C-T., 05.2018, In: J CLIN MICROBIOL. 56, 5, p. e01686-17Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A humanized mouse model of liver fibrosis following expansion of transplanted hepatic stellate cells
Benten, D., Kluwe, J., Wirth, J. W., Thiele, N. D., Follenzi, A., Bhargava, K. K., Palestro, C. J., Koepke, M., Tjandra, R., Volz, T., Lutgehetmann, M. & Gupta, S., 04.2018, In: LAB INVEST. 98, 4, p. 525-536 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hepatitis E: Still Waters Run Deep
von Wulffen, M., Westhölter, D., Lütgehetmann, M. & Pischke, S., 28.03.2018, In: J CLIN TRANSL HEPATO. 6, 1, p. 40-47 8 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
A Novel Orally Available Small Molecule That Inhibits Hepatitis B Virus Expression
Mueller, H., Wildum, S., Luangsay, S., Walther, J., Lopez, A., Tropberger, P., Ottaviani, G., Lu, W., John Parrott, N., Zhang, J. D., Schmucki, R., Racek, T., Hoflack, J-C., Kueng, E., Point, F., Zhou, X., Steiner, G., Lütgehetmann, M., Rapp, G., Volz, T., Dandri, M., Yang, S., Young, J. A. T. & Javanbakht, H., 03.2018, In: J HEPATOL. 68, 3, p. 412-420 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo
Allweiss, L., Volz, T., Giersch, K., Kah, J., Raffa, G., Petersen, J., Lohse, A. W., Beninati, C., Pollicino, T., Urban, S., Lütgehetmann, M. & Dandri, M., 03.2018, In: GUT. 67, 3, p. 542-552 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPA/SCID Mice With Humanized Livers and HBV Infection
Klumpp, K., Shimada, T., Allweiss, L., Volz, T., Lütgehetmann, M., Hartman, G., Flores, O. A., Lam, A. M. & Dandri-Petersen, M., 02.2018, In: GASTROENTEROLOGY. 154, 3, p. 652-662.e8Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft model
Thomaschewski, M., Riecken, K., Unrau, L., Volz, T., Cornils, K., Ittrich, H., Heim, D., Wege, H., Akgün, E., Lütgehetmann, M., Dieckhoff, J., Köpke, M., Dandri, M., Benten, D. & Fehse, B., 29.12.2017, In: ONCOTARGET. 8, 70, p. 115582-115595 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Two-tier approach combining molecular and culture-based techniques for optimized detection of vancomycin-resistant enterococci
Both, A., Franke, G. C., Mirwald, N., Lütgehetmann, M., Christner, M., Klupp, E-M., Belmar Campos, C., Büttner, H., Aepfelbacher, M. & Rohde, H., 12.2017, In: DIAGN MICR INFEC DIS. 89, 4, p. 253-257Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Comparison of one commercial and two in-house TaqMan multiplex real-time PCR assays for detection of enteropathogenic, enterotoxigenic and enteroaggregative Escherichia coli
Hahn, A., Lütgehetmann, M., Landt, O., Schwarz, N. G. & Frickmann, H., 11.2017, In: TROP MED INT HEALTH. 22, 11, p. 1371-1376 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection
Kah, J., Koh, S., Volz, T., Ceccarello, E., Allweiss, L., Lütgehetmann, M., Bertoletti, A. & Dandri, M., 01.08.2017, In: J CLIN INVEST. 127, 8, p. 3177-3188 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Heme oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice
Kah, J., Volz, T., Lütgehetmann, M., Groth, A., Lohse, A. W., Tiegs, G., Sass, G. & Dandri-Petersen, M., 08.2017, In: LIVER INT. 37, 8, p. 1128-1137Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice
Giersch, K., Homs, M., Volz, T., Helbig, M., Allweiss, L., Lohse, A. W., Petersen, J., Buti, M., Pollicino, T., Sureau, C., Dandri, M. & Lütgehetmann, M., 16.06.2017, In: SCI REP-UK. 7, 1, p. 3757Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization
Dahlke, C., Kasonta, R., Lunemann, S., Krähling, V., Zinser, M. E., Biedenkopf, N., Fehling, S. K., Ly, M. L., Rechtien, A., Stubbe, H. C., Olearo, F., Borregaard, S., Jambrecina, A., Stahl, F., Strecker, T., Eickmann, M., Lütgehetmann, M., Spohn, M., Schmiedel, S., Lohse, A. W., Becker, S., Addo, M. M. & VEBCON, 05.2017, In: EBIOMEDICINE. 19, p. 107-118Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Serum HBV pgRNA as a clinical marker for cccDNA activity
Giersch, K., Allweiss, L., Volz, T., Dandri-Petersen, M. & Lütgehetmann, M., 02.2017, In: J HEPATOL. 66, 2, p. 460-462Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Immunofluorescent Staining for the Detection of the Hepatitis B Core Antigen in Frozen Liver Sections of Human Liver Chimeric Mice
Allweiss, L., Lütgehetmann, M. & Dandri, M., 2017, In: Methods Mol Biol. 1540, p. 135-142 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2016
Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations
Schommers, P., Martrus, G., Matschl, U., Sirignano, M., Lütgehetmann, M., Richert, L., Hope, T. J., Fätkenheuer, G. & Altfeld, M., 15.08.2016, In: J VIROL. 90, 16, p. 7579-86 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Kinetics of HIV-1 latency reversal quantified on the single cell level using a novel flow-based technique
Martrus, G., Niehrs, A., Cornelis, R., Rechtien, A., García-Beltran, W., Lütgehetmann, M., Hoffmann, C. & Altfeld, M., 27.07.2016, In: J VIROL. 90, 20, p. 9018-9028Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Efficacy and safety of sofosbuvir/ledipasvir for the treatment of patients with hepatitis C virus re-infection after liver transplantation
Ciesek, S., Proske, V., Otto, B., Pischke, S., Costa, R., Lütgehetmann, M., Polywka, S., Klempnauer, J., Nashan, B., Manns, M. P., von Hahn, T., Lohse, A. W., Wedemeyer, H., Mix, H. & Sterneck, M., 06.2016, In: TRANSPL INFECT DIS. 18, 3, p. 326-32 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Blood-borne Hepatitis E Virus Transmission: A Relevant Risk for Immunosuppressed Patients
Pischke, S., Hiller, J., Lütgehetmann, M., Polywka, S., Rybczynski, M., Ayuketang, F. A. & Lohse, A. W., 13.05.2016, In: CLIN INFECT DIS. 63, 4, p. 569-570 2 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation
Allweiss, L., Gass, S., Giersch, K., Groth, A., Kah, J., Volz, T., Rapp, G., Schöbel, A., Lohse, A. W., Polywka, S., Pischke, S., Herker, E., Dandri-Petersen, M. & Lütgehetmann, M., 01.05.2016, In: J HEPATOL. 64, 5, p. 1033-1040Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer
Bierwolf, J., Volz, T., Lütgehetmann, M., Allweiss, L., Riecken, K., Warlich, M., Fehse, B., Kalff, J. C., Dandri-Petersen, M. & Pollok, J-M., 05.2016, In: TISSUE ENG PT A. 22, 9-10, p. 742-53 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Variability in long-term hepatitis B virus dynamics under antiviral therapy
Murray, J. M., Stancevic, O., Lütgehetmann, M., Wursthorn, K., Petersen, J. & Dandri-Petersen, M., 21.02.2016, In: J THEOR BIOL. 391, p. 74-80 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils
Kozik, J-H., Trautmann, T., Carambia, A., Preti, M., Lütgehetmann, M., Krech, T., Wiegard, C., Heeren, J. & Herkel, J., 2016, In: SCI REP-UK. 6, p. 28556Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection
Giersch, K., Allweiss, L., Volz, T., Helbig, M., Bierwolf, J., Lohse, A. W., Pollok, J. M., Petersen, J., Dandri-Petersen, M. & Lütgehetmann, M., 08.2015, In: J HEPATOL. 63, 2, p. 346-53 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Relevance of chronic hepatitis E in liver transplant recipients: a real-life setting
Galante, A., Pischke, S., Polywka, S., Lütgehetmann, M., Suneetha, P. V., Gisa, A., Hiller, J., Dienes, H. P., Nashan, B., Lohse, A. W. & Sterneck, M., 08.2015, In: TRANSPL INFECT DIS. 17, 4, p. 617-22 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Comparison of autochthonous and imported cases of hepatitis A or hepatitis E
Hartl, J., Kreuels, B., Polywka, S., Addo, M. M., Lütgehetmann, M., Dandri-Petersen, M., Dammermann, W., Sterneck, M., Lohse, A. W. & Pischke, S., 07.2015, In: Z GASTROENTEROL. 53, 7, p. 639-643Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples
Fischer, N., Indenbirken, D., Meyer, T., Lütgehetmann, M., Lellek, H., Spohn, M., Aepfelbacher, M., Alawi, M. & Grundhoff, A., 07.2015, In: J CLIN MICROBIOL. 53, 7, p. 2238-50 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review