Dr.med. ID: 63283

Marc Lütgehetmann

graph of relations

Publications

  1. 2020
  2. Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system

    Pfefferle, S., Reucher, S., Nörz, D. S. & Lütgehetmann, M., 04.03.2020, In: EUROSURVEILLANCE. 25, 9

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  3. High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection:longitudinal analysis of a German cohort:longitudinal analysis of a German cohort

    Bockmann, J-H., Grube, M., Hamed, V., von Felden, J., Landahl, J., Wehmeyer, M., Giersch, K., Hall, M. T., Murray, J. M., Dandri, M., Lüth, S., Lohse, A. W., Lütgehetmann, M. & Schulze Zur Wiesch, J., 30.01.2020, In: BMC GASTROENTEROL. 20, 1, p. 24

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  4. Evidence for systematic autopsies in COVID-19 positive deceased:Case report of the first German investigated COVID-19 death

    Fitzek, A., Sperhake, J., Edler, C., Schröder, A. S., Heinemann, A., Heinrich, F., Ron, A., Mushumba, H., Lütgehetmann, M. & Püschel, K., 2020, In: RECHTSMEDIZIN. p. 1-6 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  5. 2019
  6. DAMIAN an open source bioinformatics tool for fast, systematic and cohort based analysis of microorganisms in diagnostic samples

    Alawi, M., Burkhardt, L., Indenbirken, D., Reumann, K., Christopeit, M., Kröger, N., Lütgehetmann, M., Aepfelbacher, M., Fischer, N. & Grundhoff, A., 14.11.2019, In: SCI REP-UK. 9, 1, p. 16841

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  7. Fatal PCR-negative herpes simplex virus-1 encephalitis with GABAA receptor antibodies

    Schuster, S., Abrante, L., Matschke, J., Lütgehetmann, M., Holst, B., Gelderblom, M., Braass, H., Leypoldt, F. & Magnus, T., 11.2019, In: NEUROL-NEUROIMMUNOL. 6, 6

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  8. Microbial findings, sensitivity and outcome in patients with postoperative peritonitis a retrospective cohort study

    Grotelueschen, R., Luetgehetmann, M., Erbes, J., Heidelmann, L. M., Grupp, K., Karstens, K., Ghadban, T., Reeh, M., Izbicki, J. R. & Bachmann, K., 10.2019, In: INT J SURG. 70, p. 63-69 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  9. The Clinical Perspective on Hepatitis E

    Horvatits, T., Schulze Zur Wiesch, J., Lütgehetmann, M., Lohse, A. W. & Pischke, S., 05.07.2019, In: VIRUSES-BASEL. 11, 7

    Research output: SCORING: Contribution to journalSCORING: Review articleResearch

  10. Influence of local epidemiology on the performance of common colistin drug susceptibility testing methods

    Asar, L., Pfefferle, S., Lütgehetmann, M., Hoffmann, A., Katchanov, J., Aepfelbacher, M., Rohde, H. & Maurer, F. P., 06.06.2019, In: PLOS ONE. 14, 6, p. e0217468

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  11. T cell receptor grafting allows virological control of Hepatitis B virus infection

    Wisskirchen, K., Kah, J., Malo, A., Asen, T., Volz, T., Allweiss, L., Wettengel, J. M., Lütgehetmann, M., Urban, S., Bauer, T., Dandri, M. & Protzer, U., 30.04.2019, In: J CLIN INVEST. 129, 7, p. 2932-2945 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  12. Clinical evaluation of multiplex RT-PCR assays for the detection of influenza A/B and respiratory syncytial virus using a high throughput system

    Eigner, U., Reucher, S., Hefner, N., Staffa-Peichl, S., Kolb, M., Betz, U., Holfelder, M., Spier, G., Pfefferle, S. & Lütgehetmann, M., 01.04.2019, In: J VIROL METHODS. 269, p. 49-54 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  13. Potential Role for Urine Polymerase Chain Reaction in the Diagnosis of Whipple's Disease

    Moter, A., Janneck, M., Wolters, M., Iking-Konert, C., Wiessner, A., Loddenkemper, C., Hartleben, B., Lütgehetmann, M., Schmidt, J., Langbehn, U., Janssen, S., Geelhaar-Karsch, A., Schneider, T., Moos, V., Rohde, H., Kikhney, J. & Wiech, T., 19.03.2019, In: CLIN INFECT DIS. 68, 7, p. 1089-1097 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  14. Chronic Hepatitis E in Rheumatology and Internal Medicine Patients: A Retrospective Multicenter European Cohort Study

    Pischke, S., Peron, J-M., von Wulffen, M., von Felden, J., Höner Zu Siederdissen, C., Fournier, S., Lütgehetmann, M., Iking-Konert, C., Bettinger, D., Par, G., Thimme, R., Cantagrel, A., Lohse, A. W., Wedemeyer, H., de Man, R. & Mallet, V., 22.02.2019, In: VIRUSES-BASEL. 11, 2

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  15. Changes in the composition of the upper respiratory tract microbial community in granulomatosis with polyangiitis

    Lamprecht, P., Fischer, N., Huang, J., Burkhardt, L., Lütgehetmann, M., Arndt, F., Rolfs, I., Kerstein, A., Iking-Konert, C. & Laudien, M., 02.2019, In: J AUTOIMMUN. 97, p. 29-39 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  16. Detection of a Broad Range of Low-Level Major Histocompatibility Complex Class II-Restricted, Hepatitis Delta Virus (HDV)-Specific T-Cell Responses Regardless of Clinical Status

    Landahl, J., Bockmann, J. H., Scheurich, C., Ackermann, C., Matzat, V., Heide, J., Nuurei, T., D'Antonio, G., von Felden, J., Sette, A., Peine, S., Lohse, A. W., Lütgehetmann, M., Marget, M., Sidney, J. & Schulze Zur Wiesch, J., 29.01.2019, In: J INFECT DIS. 219, 4, p. 568-577 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  17. Hepatitis delta virus persists during liver regeneration and is amplified through cell division both in vitro and in vivo

    Giersch, K., Bhadra, O. D., Volz, T., Allweiss, L., Riecken, K., Fehse, B., Lohse, A. W., Petersen, J., Sureau, C., Urban, S., Dandri, M. & Lütgehetmann, M., 01.2019, In: GUT. 68, 1, p. 150-157 8 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  18. 2018
  19. Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3 Regulatory T Cells

    Mathies, F., Steffens, N., Kleinschmidt, D., Stuhlmann, F., Huber, F. J., Roy, U., Meyer, T., Luetgehetmann, M., von Petersdorff, M., Seiz, O., Herkel, J., Schramm, C., Flavell, R. A., Gagliani, N., Krebs, C., Panzer, U., Abdullah, Z., Strowig, T., Bedke, T. & Huber, S., 15.12.2018, In: J IMMUNOL. 201, 12, p. 3558-3568 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  20. Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center.

    Brehm, T. T., Schulze zur Wiesch, J., Lütgehetmann, M., Tappe, D., Eisermann, P., Lohse, A. W., Addo, M. M. & Schmiedel, S., 12.2018, In: INFECTION. 46, 6, p. 847-853 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  21. Lack of evidence for human serum albumin as major source of HEV infections

    Horvatits, T., Westhölter, D., Peine, S., Schulze Zur Wiesch, J., Lohse, A. W., Lütgehetmann, M. & Pischke, S., 12.2018, In: TRANSFUSION MED. 28, 6, p. 470-471 2 p.

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  22. Hepatitis E seroprevalence in the Americas: A systematic review and meta-analysis

    Horvatits, T., Ozga, A-K., Westhölter, D., Hartl, J., Manthey, C. F., Lütgehetmann, M., Rauch, G., Kriston, L., Lohse, A. W., Bendall, R., Wedemeyer, H., Dalton, H. R. & Pischke, S., 11.2018, In: LIVER INT. 38, 11, p. 1951-1964 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  23. Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors

    Kraef, C., Schlein, C., Hiller, J., Westhölter, D., Denzer, U., Horvatits, T., Peine, S., Lohse, A. W., Lütgehetmann, M., Polywka, S. & Pischke, S., 08.2018, In: J CLIN VIROL. 105, p. 26-30 5 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  24. HEV-positive blood donations represent a relevant infection risk for immunosuppressed recipients

    Westhölter, D., Hiller, J., Denzer, U., Polywka, S., Ayuk, F., Rybczynski, M., Horvatits, T., Gundlach, S., Blöcker, J., Schulze Zur Wiesch, J., Fischer, N., Addo, M. M., Peine, S., Göke, B., Lohse, A. W., Lütgehetmann, M. & Pischke, S., 07.2018, In: J HEPATOL. 69, 1, p. 36-42 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  25. Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection

    Winer, B. Y., Shirvani-Dastgerdi, E., Bram, Y., Sellau, J., Low, B. E., Johnson, H., Huang, T., Hrebikova, G., Heller, B., Sharon, Y., Giersch, K., Gerges, S., Seneca, K., Pais, M-A., Frankel, A. S., Chiriboga, L., Cullen, J., Nahass, R. G., Lutgehetmann, M., Toettcher, J. E., Wiles, M. V., Schwartz, R. E. & Ploss, A., 27.06.2018, In: SCI TRANSL MED. 10, 447, p. eaap9328

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  26. Comprehensive Molecular Approach for Characterization of Hepatitis E Virus Genotype 3 Variants

    Wang, B., Harms, D., Papp, C. P., Niendorf, S., Jacobsen, S., Lütgehetmann, M., Pischke, S., Wedermeyer, H., Hofmann, J. & Bock, C-T., 05.2018, In: J CLIN MICROBIOL. 56, 5, p. e01686-17

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  27. A humanized mouse model of liver fibrosis following expansion of transplanted hepatic stellate cells

    Benten, D., Kluwe, J., Wirth, J. W., Thiele, N. D., Follenzi, A., Bhargava, K. K., Palestro, C. J., Koepke, M., Tjandra, R., Volz, T., Lutgehetmann, M. & Gupta, S., 04.2018, In: LAB INVEST. 98, 4, p. 525-536 12 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  28. Hepatitis E: Still Waters Run Deep

    von Wulffen, M., Westhölter, D., Lütgehetmann, M. & Pischke, S., 28.03.2018, In: J CLIN TRANSL HEPATO. 6, 1, p. 40-47 8 p.

    Research output: SCORING: Contribution to journalSCORING: Review articleResearch

  29. A Novel Orally Available Small Molecule That Inhibits Hepatitis B Virus Expression

    Mueller, H., Wildum, S., Luangsay, S., Walther, J., Lopez, A., Tropberger, P., Ottaviani, G., Lu, W., John Parrott, N., Zhang, J. D., Schmucki, R., Racek, T., Hoflack, J-C., Kueng, E., Point, F., Zhou, X., Steiner, G., Lütgehetmann, M., Rapp, G., Volz, T., Dandri, M., Yang, S., Young, J. A. T. & Javanbakht, H., 03.2018, In: J HEPATOL. 68, 3, p. 412-420 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  30. Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo

    Allweiss, L., Volz, T., Giersch, K., Kah, J., Raffa, G., Petersen, J., Lohse, A. W., Beninati, C., Pollicino, T., Urban, S., Lütgehetmann, M. & Dandri, M., 03.2018, In: GUT. 67, 3, p. 542-552 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  31. Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPA/SCID Mice With Humanized Livers and HBV Infection

    Klumpp, K., Shimada, T., Allweiss, L., Volz, T., Lütgehetmann, M., Hartman, G., Flores, O. A., Lam, A. M. & Dandri-Petersen, M., 02.2018, In: GASTROENTEROLOGY. 154, 3, p. 652-662.e8

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  32. 2017
  33. Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft model

    Thomaschewski, M., Riecken, K., Unrau, L., Volz, T., Cornils, K., Ittrich, H., Heim, D., Wege, H., Akgün, E., Lütgehetmann, M., Dieckhoff, J., Köpke, M., Dandri, M., Benten, D. & Fehse, B., 29.12.2017, In: ONCOTARGET. 8, 70, p. 115582-115595 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  34. Two-tier approach combining molecular and culture-based techniques for optimized detection of vancomycin-resistant enterococci

    Both, A., Franke, G. C., Mirwald, N., Lütgehetmann, M., Christner, M., Klupp, E-M., Belmar Campos, C., Büttner, H., Aepfelbacher, M. & Rohde, H., 12.2017, In: DIAGN MICR INFEC DIS. 89, 4, p. 253-257

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  35. Comparison of one commercial and two in-house TaqMan multiplex real-time PCR assays for detection of enteropathogenic, enterotoxigenic and enteroaggregative Escherichia coli

    Hahn, A., Lütgehetmann, M., Landt, O., Schwarz, N. G. & Frickmann, H., 11.2017, In: TROP MED INT HEALTH. 22, 11, p. 1371-1376 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  36. Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection

    Kah, J., Koh, S., Volz, T., Ceccarello, E., Allweiss, L., Lütgehetmann, M., Bertoletti, A. & Dandri, M., 01.08.2017, In: J CLIN INVEST. 127, 8, p. 3177-3188 12 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  37. Heme oxygenase-1 polymorphisms can affect HCV replication and treatment responses with different efficacy in humanized mice

    Kah, J., Volz, T., Lütgehetmann, M., Groth, A., Lohse, A. W., Tiegs, G., Sass, G. & Dandri-Petersen, M., 08.2017, In: LIVER INT. 37, 8, p. 1128-1137

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  38. Both interferon alpha and lambda can reduce all intrahepatic HDV infection markers in HBV/HDV infected humanized mice

    Giersch, K., Homs, M., Volz, T., Helbig, M., Allweiss, L., Lohse, A. W., Petersen, J., Buti, M., Pollicino, T., Sureau, C., Dandri, M. & Lütgehetmann, M., 16.06.2017, In: SCI REP-UK. 7, 1, p. 3757

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  39. Dose-dependent T-cell Dynamics and Cytokine Cascade Following rVSV-ZEBOV Immunization

    Dahlke, C., Kasonta, R., Lunemann, S., Krähling, V., Zinser, M. E., Biedenkopf, N., Fehling, S. K., Ly, M. L., Rechtien, A., Stubbe, H. C., Olearo, F., Borregaard, S., Jambrecina, A., Stahl, F., Strecker, T., Eickmann, M., Lütgehetmann, M., Spohn, M., Schmiedel, S., Lohse, A. W., Becker, S., Addo, M. M. & VEBCON, 05.2017, In: EBIOMEDICINE. 19, p. 107-118

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  40. Serum HBV pgRNA as a clinical marker for cccDNA activity

    Giersch, K., Allweiss, L., Volz, T., Dandri-Petersen, M. & Lütgehetmann, M., 02.2017, In: J HEPATOL. 66, 2, p. 460-462

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  41. Immunofluorescent Staining for the Detection of the Hepatitis B Core Antigen in Frozen Liver Sections of Human Liver Chimeric Mice

    Allweiss, L., Lütgehetmann, M. & Dandri, M., 2017, In: Methods Mol Biol. 1540, p. 135-142 8 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  42. 2016
  43. Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations

    Schommers, P., Martrus, G., Matschl, U., Sirignano, M., Lütgehetmann, M., Richert, L., Hope, T. J., Fätkenheuer, G. & Altfeld, M., 15.08.2016, In: J VIROL. 90, 16, p. 7579-86 8 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  44. Kinetics of HIV-1 latency reversal quantified on the single cell level using a novel flow-based technique

    Martrus, G., Niehrs, A., Cornelis, R., Rechtien, A., García-Beltran, W., Lütgehetmann, M., Hoffmann, C. & Altfeld, M., 27.07.2016, In: J VIROL. 90, 20, p. 9018-9028

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  45. Efficacy and safety of sofosbuvir/ledipasvir for the treatment of patients with hepatitis C virus re-infection after liver transplantation

    Ciesek, S., Proske, V., Otto, B., Pischke, S., Costa, R., Lütgehetmann, M., Polywka, S., Klempnauer, J., Nashan, B., Manns, M. P., von Hahn, T., Lohse, A. W., Wedemeyer, H., Mix, H. & Sterneck, M., 06.2016, In: TRANSPL INFECT DIS. 18, 3, p. 326-32 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  46. Blood-borne Hepatitis E Virus Transmission: A Relevant Risk for Immunosuppressed Patients

    Pischke, S., Hiller, J., Lütgehetmann, M., Polywka, S., Rybczynski, M., Ayuketang, F. A. & Lohse, A. W., 13.05.2016, In: CLIN INFECT DIS. 63, 4, p. 569-570 2 p.

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  47. Human liver chimeric mice as a new model of chronic hepatitis E virus infection and preclinical drug evaluation

    Allweiss, L., Gass, S., Giersch, K., Groth, A., Kah, J., Volz, T., Rapp, G., Schöbel, A., Lohse, A. W., Polywka, S., Pischke, S., Herker, E., Dandri-Petersen, M. & Lütgehetmann, M., 01.05.2016, In: J HEPATOL. 64, 5, p. 1033-1040

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  48. Primary Human Hepatocytes Repopulate Livers of Mice After In Vitro Culturing and Lentiviral-Mediated Gene Transfer

    Bierwolf, J., Volz, T., Lütgehetmann, M., Allweiss, L., Riecken, K., Warlich, M., Fehse, B., Kalff, J. C., Dandri-Petersen, M. & Pollok, J-M., 05.2016, In: TISSUE ENG PT A. 22, 9-10, p. 742-53 12 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  49. Variability in long-term hepatitis B virus dynamics under antiviral therapy

    Murray, J. M., Stancevic, O., Lütgehetmann, M., Wursthorn, K., Petersen, J. & Dandri-Petersen, M., 21.02.2016, In: J THEOR BIOL. 391, p. 74-80 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  50. Attenuated viral hepatitis in Trem1-/- mice is associated with reduced inflammatory activity of neutrophils

    Kozik, J-H., Trautmann, T., Carambia, A., Preti, M., Lütgehetmann, M., Krech, T., Wiegard, C., Heeren, J. & Herkel, J., 2016, In: SCI REP-UK. 6, p. 28556

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  51. 2015
  52. Hepatitis Delta co-infection in humanized mice leads to pronounced induction of innate immune responses in comparison to HBV mono-infection

    Giersch, K., Allweiss, L., Volz, T., Helbig, M., Bierwolf, J., Lohse, A. W., Pollok, J. M., Petersen, J., Dandri-Petersen, M. & Lütgehetmann, M., 08.2015, In: J HEPATOL. 63, 2, p. 346-53 8 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  53. Relevance of chronic hepatitis E in liver transplant recipients: a real-life setting

    Galante, A., Pischke, S., Polywka, S., Lütgehetmann, M., Suneetha, P. V., Gisa, A., Hiller, J., Dienes, H. P., Nashan, B., Lohse, A. W. & Sterneck, M., 08.2015, In: TRANSPL INFECT DIS. 17, 4, p. 617-22 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  54. Comparison of autochthonous and imported cases of hepatitis A or hepatitis E

    Hartl, J., Kreuels, B., Polywka, S., Addo, M. M., Lütgehetmann, M., Dandri-Petersen, M., Dammermann, W., Sterneck, M., Lohse, A. W. & Pischke, S., 07.2015, In: Z GASTROENTEROL. 53, 7, p. 639-643

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  55. Evaluation of Unbiased Next-Generation Sequencing of RNA (RNA-seq) as a Diagnostic Method in Influenza Virus-Positive Respiratory Samples

    Fischer, N., Indenbirken, D., Meyer, T., Lütgehetmann, M., Lellek, H., Spohn, M., Aepfelbacher, M., Alawi, M. & Grundhoff, A., 07.2015, In: J CLIN MICROBIOL. 53, 7, p. 2238-50 13 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review