Dr.med. ID: 63283

Marc Lütgehetmann

graph of relations

Publications

  1. 2021
  2. Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report

    Apostolidou, S., Harbauer, T., Lasch, P., Biermann, D., Hempel, M., Lütgehetmann, M., Pfefferle, S., Herrmann, J., Rüffer, A., Reinshagen, K., Kozlik-Feldmann, R., Gieras, A., Kniep, I., Oh, J., Singer, D., Ebenebe, C. U. & Kobbe, R., 30.06.2021, In: CHILDREN-BASEL. 8, 7, 564.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  3. An automated room disinfection system using ozone is highly active against surrogates for SARS-CoV-2

    Franke, G., Knobling, B., Brill, F. H., Becker, B., Klupp, E. M., Belmar Campos, C., Pfefferle, S., Lütgehetmann, M. & Knobloch, J. K., 06.2021, In: J HOSP INFECT. 112, p. 108-113 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  4. Modifying a Diagnostic SARS-CoV-2 Spike PCR to Turn a Del69/70 Dropout into a Discriminatory On-Target Assay

    Nörz, D., Pfefferle, S., Grunwald, M., Fischer, N., Aepfelbacher, M. & Lütgehetmann, M., 06.2021, In: J MOL DIAGN. 23, 6, p. 777-778 2 p.

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  5. HEV-Associated Neuralgic Amyotrophy : A Multicentric Case Series

    Bannasch, J. H., Berger, B., Schwartkopp, C-P., Berning, M., Goetze, O., Panning, M., Fritz-Weltin, M., Trendelenburg, G., Gelderblom, M., Lütgehetmann, M., Stute, F., Horvatits, T., Dirks, M., Antoni, C., Behrendt, P. & Pischke, S., 30.05.2021, In: PATHOGENS. 10, 6, 672.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  6. Performance of the BD Phoenix CPO detect assay for detection and classification of carbapenemase-producing organisms

    Berneking, L., Both, A., Berinson, B., Hoffmann, A., Lütgehetmann, M., Aepfelbacher, M. & Rohde, H., 05.2021, In: EUR J CLIN MICROBIOL. 40, 5, p. 979-985 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  7. SARS-CoV-2-Zufallsentdeckungen bei Hamburger Todesfällen: ein epidemiologisches Monitoring während des dynamischen Infektionsgeschehens im Frühjahr 2020

    Klein, A., Langenwalder, F., Heinrich, F., Meißner, K., Schröder, A. S., Püschel, K., Ondruschka, B., Lütgehetmann, M. & Heinemann, A., 20.04.2021, In: RECHTSMEDIZIN. 31, p. 427-433 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  8. SARS-CoV-2 Reinfection in a Healthcare Worker Despite the Presence of Detectable Neutralizing Antibodies

    Brehm, T. T., Pfefferle, S., von Possel, R., Kobbe, R., Nörz, D., Schmiedel, S., Grundhoff, A., Olearo, F., Emmerich, P., Robitaille, A., Günther, T., Braun, P., Andersen, G., Knobloch, J. K., Addo, M. M., Lohse, A. W., Aepfelbacher, M., Fischer, N., Schulze Zur Wiesch, J. & Lütgehetmann, M., 12.04.2021, In: VIRUSES-BASEL. 13, 4, 661.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearch

  9. Presence of SARS-CoV-2 RNA in the Cornea of Viremic Patients With COVID-19

    Casagrande, M., Fitzek, A., Spitzer, M. S., Püschel, K., Glatzel, M., Krasemann, S., Nörz, D., Lütgehetmann, M., Pfefferle, S. & Schultheiss, M., 01.04.2021, In: JAMA OPHTHALMOL. 139, 4, p. 383-388 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  10. Clinical evaluation of a laboratory-developed quantitative BK virus-PCR assay using the cobas® omni Utility Channel

    Fritzsche, A., Berneking, L., Nörz, D., Reucher, S., Fischer, N., Roggenkamp, H., Aepfelbacher, M., Rohde, H., Pfefferle, S. & Lütgehetmann, M., 04.2021, In: J VIROL METHODS. 290, p. 114093

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  11. Severe liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?

    Roedl, K., Jarczak, D., Drolz, A., Wichmann, D., Boenisch, O., de Heer, G., Burdelski, C., Frings, D., Sensen, B., Nierhaus, A., Lütgehetmann, M., Kluge, S. & Fuhrmann, V., 15.03.2021, In: ANN INTENSIVE CARE. 11, 1, 44.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  12. Comparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza

    Brehm, T. T., van der Meirschen, M., Hennigs, A., Roedl, K., Jarczak, D., Wichmann, D., Frings, D., Nierhaus, A., Oqueka, T., Fiedler, W., Christopeit, M., Kraef, C., Schultze, A., Lütgehetmann, M., Addo, M. M., Schmiedel, S., Kluge, S. & Schulze Zur Wiesch, J., 11.03.2021, In: SCI REP-UK. 11, 1, 5803.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  13. Seroprevalence of SARS-CoV-2 antibodies among hospital workers in a German tertiary care center: A sequential follow-up study

    Brehm, T. T., Schwinge, D., Lampalzer, S., Schlicker, V., Küchen, J., Thompson, M., Ullrich, F., Huber, S., Schmiedel, S., Addo, M. M., Lütgehetmann, M., Knobloch, J. K., Schulze Zur Wiesch, J. & Lohse, A. W., 03.2021, In: INT J HYG ENVIR HEAL. 232, 113671.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  14. Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients

    Zhao, Y., Kilian, C., Turner, J. E., Bosurgi, L., Roedl, K., Bartsch, P., Gnirck, A. C., Cortesi, F., Schultheiß, C., Hellmig, M., Enk, L. U. B., Hausmann, F., Borchers, A., Wong, M. N., Paust, H. J., Siracusa, F., Scheibel, N., Herrmann, M., Rosati, E., Bacher, P., Kylies, D., Jarczak, D., Lütgehetmann, M., Pfefferle, S., Steurer, S., Zur Wiesch, J. S., Puelles, V. G., Sperhake, J. P., Addo, M. M., Lohse, A. W., Binder, M., Huber, S., Huber, T. B., Kluge, S., Bonn, S., Panzer, U., Gagliani, N. & Krebs, C. F., 23.02.2021, In: SCI IMMUNOL. 6, 56, eabf6692.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  15. Murine hepatocytes do not support persistence of Hepatitis D Virus mono-infection in vivo

    Giersch, K., Hermanussen, L., Volz, T., Kah, J., Allweiss, L., Casey, J., Sureau, C., Dandri, M. & Lütgehetmann, M., 02.2021, In: LIVER INT. 41, 2, p. 410-419 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  16. Viral Dynamics of SARS-CoV-2 in Critically Ill Allogeneic Hematopoietic Stem Cell Transplant Recipients and Immunocompetent Patients with COVID-19

    Roedl, K., Heidenreich, S., Pfefferle, S., Jarczak, D., Urbanowicz, T. T., Nörz, D., Aepfelbacher, M., Kröger, N., Kluge, S., Lütgehetmann, M., Christopeit, M. & Wichmann, D., 15.01.2021, In: AM J RESP CRIT CARE. 203, 2, p. 242-245 4 p.

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  17. Lower Levels of Transaminases but Higher Levels of Serum Creatinine in Patients with Acute Hepatitis E in Comparison to Patients with Hepatitis A

    Brehm, T. T., Mazaheri, O., Horvatits, T., Lütgehetmann, M., Schulze Zur Wiesch, J., Lohse, A. W., Polywka, S. & Pischke, S., 12.01.2021, In: PATHOGENS. 10, 1, p. 60

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  18. B cell analysis in SARS‐CoV‐2 versus malaria: Increased frequencies of plasmablasts and atypical memory B cells in COVID‐19

    Wildner, N. H., Ahmadi, P., Schulte, S., Brauneck, F., Kohsar, M., Lütgehetmann, M., Beisel, C., Addo, M. M., Haag, F. & Schulze zur Wiesch, J., 01.2021, In: J LEUKOCYTE BIOL. 109, 1, p. 77-90 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  19. Control of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients

    Woo, M. S., Steins, D., Häußler, V., Kohsar, M., Haag, F., Elias-Hamp, B., Heesen, C., Lütgehetmann, M., Schulze Zur Wiesch, J. & Friese, M. A., 01.2021, In: J NEUROL. 268, 1, p. 5-7 3 p.

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  20. Hepatitis delta virus propagation enabled by hepatitis C virus - scientifically intriguing; but is it relevant to clinical practice?

    Pflüger, L. S., Schulze Zur Wiesch, J., Polywka, S. & Lütgehetmann, M., 01.2021, In: J VIRAL HEPATITIS. 28, 1, p. 213-216 4 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  21. Postmortem Stability of SARS-CoV-2 in Nasopharyngeal Mucosa

    Heinrich, F., Meißner, K., Langenwalder, F., Püschel, K., Hoffmann, A., Lütgehetmann, M., Aepfelbacher, M., Bibiza-Freiwald, E., Pfefferle, S. & Heinemann, A., 01.2021, In: EMERG INFECT DIS. 27, 1, p. 329-331 3 p.

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  22. SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany

    Pfefferle, S., Günther, T., Kobbe, R., Czech-Sioli, M., Nörz, D., Santer, R., Oh, J., Kluge, S., Oestereich, L., Peldschus, K., Indenbirken, D., Huang, J., Grundhoff, A., Aepfelbacher, M., Knobloch, J. K., Lütgehetmann, M. & Fischer, N., 01.2021, In: CLIN MICROBIOL INFEC. 27, 1, p. 130.e5-130.e8

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  23. Inefficient Placental Virus Replication and Absence of Neonatal Cell-Specific Immunity Upon Sars-CoV-2 Infection During Pregnancy

    Tallarek, A-C., Urbschat, C., Fonseca Brito, L., Stanelle-Bertram, S., Krasemann, S., Frascaroli, G., Thiele, K., Wieczorek, A., Felber, N., Lütgehetmann, M., Markert, U. R., Hecher, K., Brune, W., Stahl, F., Gabriel, G., Diemert, A. & Arck, P. C., 2021, In: FRONT IMMUNOL. 12, p. 698578

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  24. Low incidence of COVID-19 in a prospective cohort of patients with liver cirrhosis and hepatocellular carcinoma treated at a tertiary medical center during the 2020 pandemic

    Fründt, T., Kuballa, L., Lütgehetman, M., Nörz, D., Arend, H., Brehm, T. T., Schulze Zur Wiesch, J., Horvatits, T., Horvatits, K., Huber, S., Wege, H. & Kluwe, J., 2021, In: PLOS ONE. 16, 12, p. e0258450

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  25. Strong Replication Interference Between Hepatitis Delta Viruses in Human Liver Chimeric Mice

    Giersch, K., Hermanussen, L., Volz, T., Volmari, A., Allweiss, L., Sureau, C., Casey, J., Huang, J., Fischer, N., Lütgehetmann, M. & Dandri, M., 2021, In: FRONT MICROBIOL. 12, p. 671466

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  26. 2020
  27. Challenges in treatment of patients with acute leukemia and COVID-19: a series of 12 patients

    Ghandili, S., Pfefferle, S., Roedl, K., Sonnemann, P., Karagiannis, P., Boenisch, O., Kluge, S., Schmiedel, S., Ittrich, H., Rohde, H., Lütgehetmann, M., Weisel, K., Bokemeyer, C., Wichmann, D., Fiedler, W., Jarczak, D. & Modemann, F., 08.12.2020, In: Blood Adv. 4, 23, p. 5936-5941 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  28. Neuropathology of patients with COVID-19 in Germany: a post-mortem case series

    Matschke, J., Lütgehetmann, M., Hagel, C., Sperhake, J. P., Schröder, A. S., Edler, C., Mushumba, H., Fitzek, A., Allweiss, L., Dandri, M., Dottermusch, M., Heinemann, A., Pfefferle, S., Schwabenland, M., Sumner Magruder, D., Bonn, S., Prinz, M., Gerloff, C., Püschel, K., Krasemann, S., Aepfelbacher, M. & Glatzel, M., 11.2020, In: LANCET NEUROL. 19, 11, p. 919-929 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  29. Antibiotic sensitivity in correlation to the origin of secondary peritonitis: a single center analysis

    Grotelüschen, R., Heidelmann, L. M., Lütgehetmann, M., Melling, N., Reeh, M., Ghadban, T., Dupree, A., Izbicki, J. R. & Bachmann, K. A., 29.10.2020, In: SCI REP-UK. 10, 1, p. 18588

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  30. Sustained response after remdesivir and convalescent plasma therapy in a B-cell depleted patient with protracted COVID-19

    Malsy, J., Veletzky, L., Heide, J., Hennigs, A., Gil-Ibanez, I., Stein, A., Lütgehetmann, M., Rosien, U., Jasper, D., Peine, S., Hiller, J., Haag, F., Schmiedel, S., Huber, S., Jordan, S., Addo, M. M. & Schulze Zur Wiesch, J., 26.10.2020, In: CLIN INFECT DIS. 73, 11, p. e4020–e4024

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  31. Significance of Anti-Nuclear Antibodies and Cryoglobulins in Patients with Acute and Chronic HEV Infection

    Horvatits, T., Schulze Zur Wiesch, J., Polywka, S., Buescher, G., Lütgehetmann, M., Hussey, E., Horvatits, K., Peine, S., Haag, F., Addo, M. M., Lohse, A. W., Weiler-Normann, C. & Pischke, S., 16.09.2020, In: PATHOGENS. 9, 9

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  32. Germany's first COVID-19 deceased:a 59-year-old man presenting with diffuse alveolar damage due to SARS-CoV-2 infection

    Heinrich, F., Sperhake, J-P., Heinemann, A., Mushumba, H., Lennartz, M., Nörz, D., Glatzel, M., Lütgehetmann, M. & Püschel, K., 04.09.2020, In: VIRCHOWS ARCH. 477, 3, p. 335-339 5 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  33. Autoantibodies to intracellular "rods and rings" structures in two patients with autoimmune hepatitis treated with azathioprine

    Galaski, J., Koop, A. C., Lütgehetmann, M., Lohse, A. W. & Weiler-Normann, C., 09.2020, In: AUTOIMMUNITY. 53, 6, p. 362-365 4 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  34. Clinical evaluation of five different automated SARS-CoV-2 serology assays in a cohort of hospitalized COVID-19 patients

    Pflüger, L. S., Bannasch, J. H., Brehm, T. T., Pfefferle, S., Hoffmann, A., Nörz, D., van der Meirschen, M., Kluge, S., Haddad, M., Pischke, S., Hiller, J., Addo, M. M., Lohse, A. W., Wiesch, J. S. Z., Peine, S., Aepfelbacher, M. & Lütgehetmann, M., 09.2020, In: J CLIN VIROL. 130, p. 104549

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  35. Correction to:Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany

    Edler, C., Schröder, A. S., Aepfelbacher, M., Fitzek, A., Heinemann, A., Heinrich, F., Klein, A., Langenwalder, F., Lütgehetmann, M., Meißner, K., Püschel, K., Schädler, J., Steurer, S., Mushumba, H. & Sperhake, J-P., 09.2020, In: INT J LEGAL MED. 134, 5, p. 1977

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  36. SARS-CoV-2 renal tropism associates with acute kidney injury

    Braun, F., Lütgehetmann, M., Pfefferle, S., Wong, M. N., Carsten, A., Lindenmeyer, M. T., Nörz, D., Heinrich, F., Meißner, K., Wichmann, D., Kluge, S., Gross, O., Pueschel, K., Schröder, A. S., Edler, C., Aepfelbacher, M., Puelles, V. G. & Huber, T. B., 29.08.2020, In: LANCET. 396, 10251, p. 597-598 2 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  37. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study

    Wichmann, D., Sperhake, J-P., Lütgehetmann, M., Steurer, S., Edler, C., Heinemann, A., Heinrich, F., Mushumba, H., Kniep, I., Schröder, A. S., Burdelski, C., de Heer, G., Nierhaus, A., Frings, D., Pfefferle, S., Becker, H., Bredereke-Wiedling, H., de Weerth, A., Paschen, H-R., Sheikhzadeh-Eggers, S., Stang, A., Schmiedel, S., Bokemeyer, C., Addo, M. M., Aepfelbacher, M., Püschel, K. & Kluge, S., 18.08.2020, In: ANN INTERN MED. 173, 4, p. 268-277 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  38. Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)

    Karakas, M., Jarczak, D., Becker, M., Roedl, K., Addo, M. M., Hein, F., Bergmann, A., Zimmermann, J., Simon, T-P., Marx, G., Lütgehetmann, M., Nierhaus, A. & Kluge, S., 11.08.2020, In: BIOMOLECULES. 10, 8, 1171.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  39. Multiorgan and Renal Tropism of SARS-CoV-2

    Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., Braun, F., Lu, S., Pfefferle, S., Schröder, A. S., Edler, C., Gross, O., Glatzel, M., Wichmann, D., Wiech, T., Kluge, S., Pueschel, K., Aepfelbacher, M. & Huber, T. B., 06.08.2020, In: NEW ENGL J MED. 383, 6, p. 590-592 3 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  40. Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes

    Tham, C. Y. L., Kah, J., Tan, A. T., Volz, T., Chia, A., Giersch, K., Ladiges, Y., Loglio, A., Borghi, M., Sureau, C., Lampertico, P., Lütgehetmann, M., Dandri-Petersen, M. & Bertoletti, A., 21.07.2020, In: CELL REP MED. 1, 4, p. 100060

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  41. Clinical evaluation of a SARS-CoV-2 RT-PCR assay on a fully automated system for rapid on-demand testing in the hospital setting

    Nörz, D., Fischer, N., Schultze, A., Kluge, S., Mayer-Runge, U., Aepfelbacher, M., Pfefferle, S. & Lütgehetmann, M., 07.2020, In: J CLIN VIROL. 128, p. 104390

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  42. Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany

    Edler, C., Schröder, A. S., Aepfelbacher, M., Fitzek, A., Heinemann, A., Heinrich, F., Klein, A., Langenwalder, F., Lütgehetmann, M., Meißner, K., Püschel, K., Schädler, J., Steurer, S., Mushumba, H. & Sperhake, J-P., 07.2020, In: INT J LEGAL MED. 134, 4, p. 1275-1284 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  43. Complete Genome Sequence of a SARS-CoV-2 Strain Isolated in Northern Germany

    Pfefferle, S., Huang, J., Nörz, D., Indenbirken, D., Lütgehetmann, M., Oestereich, L., Günther, T., Grundhoff, A., Aepfelbacher, M. & Fischer, N., 04.06.2020, In: MICROBIOL RESOUR ANN. 9, 23

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  44. No link between male infertility and HEV genotype 3 infection

    Horvatits, T., Varwig-Janssen, D., Schulze Zur Wiesch, J., Lübke, R., Reucher, S., Frerk, S., Addo, M. M., Schneider, S. W., Lohse, A. W., Luetgehetmann, M. & Pischke, S., 06.2020, In: GUT. 69, 6, p. 1150-1151 2 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  45. Risk factors for different intestinal pathogens among patients with traveler's diarrhea: A retrospective analysis at a German travel clinic (2009-2017)

    Brehm, T. T., Lütgehetmann, M., Tannich, E., Addo, M. M., Lohse, A. W., Rolling, T. & Vinnemeier, C. D., 01.05.2020, In: TRAVEL MED INFECT DI. 37, p. 101706

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  46. Detection of C. difficile toxin as a model assay for performing fully automated high-throughput RT-PCR on clinical stool samples

    Eigner, U., Nörz, D., Reucher, S., Furrer, J., Sun, J., Chu, K., Kolb, M., Hefner, N., Pfefferle, S. & Lütgehetmann, M., 05.2020, In: J MICROBIOL METH. 172, p. 105882

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review