Center for Internal Medicine

Publications

  1. 2014
  2. The diagnosis and treatment of cholangiocarcinoma

    Vogel, A., Wege, H., Caca, K., Nashan, B. & Neumann, U., 2014, In: DTSCH ARZTEBL INT. 111, 44, p. 748-54 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  3. The Impact of Self-Reported Childhood Trauma on Emotion Regulation in Borderline Personality Disorder and Major Depression

    Carvalho Fernando, S., Beblo, T., Schlosser, N., Terfehr, K., Otte, C., Löwe, B., Wolf, O. T., Spitzer, C., Driessen, M. & Wingenfeld, K., 2014, In: J TRAUMA DISSOCIATIO. 15, 4, p. 384-401

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  4. Was sagt den Erfolg stationärer Therapie für Patientinnen mit Anorexia nervosa voraus?

    Kästner, D., Gumz, A., Osen, B., Voderholzer, U., Wollburg, E., Karacic, M., Meyer, B., Rose, M. & Löwe, B., 2014, DGPPN Kongress 2014.

    Research output: SCORING: Contribution to book/anthologyConference contribution - PosterResearch

  5. Westliche Humanexperimente in der DDR und die Deklaration von Helsinki. Neue Forschungsergebnisse zur Ethik

    Erices, R., Gumz, A. & Frewer, A., 2014, Forschung als Herausforderung für Ethik und Menschenrechte. 50 Jahre Deklaration von Helsinki (1964-2014): Jahrbuch Medizin-Ethik 27. Frewer, A. (ed.). 1 ed. Deutscher Ärzte-Verlag, 11 p.

    Research output: SCORING: Contribution to book/anthologySCORING: Contribution to collected editions/anthologiesResearch

  6. Why is diagnosing a somatoform disorder so difficult? A systematic review examining the current barriers in primary care

    Murray, A., Toussaint, A-K., Althaus, A. & Löwe, B., 2014, Not Applicable.

    Research output: SCORING: Contribution to book/anthologyConference contribution - Other conference contributionsResearchpeer-review

  7. Wichtige Blickdiagnose in den Tropen: Pellagra durch Mangelernährung - Verwirrtheit, Durchfall und Hautveränderungen bei 42-jähriger Malawierin

    Rothe, C., 2014, In: FLUGMEDIZIN TROPENME. 21, 1, p. 12-13

    Research output: SCORING: Contribution to journalSCORING: Journal articleEducation

  8. 2013
  9. IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation

    Turner, J. E., Morrison, P. J., Wilhelm, C., Wilson, M., Ahlfors, H., Renauld, J-C., Panzer, U., Helmby, H. & Stockinger, B., 16.12.2013, In: J EXP MED. 210, 13, p. 2951-65 15 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  10. Neuropsychological functioning in posttraumatic stress disorder following forced displacement in older adults and their offspring

    Jelinek, L., Wittekind, C. E., Moritz, S., Kellner, M. & Muhtz, C., 15.12.2013, In: PSYCHIAT RES. 210, 2, p. 584-9 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  11. Uptake kinetics and nanotoxicity of silica nanoparticles are cell type dependent

    Blechinger, J., Bauer, A. T., Torrano, A. A., Gorzelanny, C., Bräuchle, C. & Schneider, S. W., 09.12.2013, In: SMALL. 9, 23, p. 3970-80, 3906

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  12. Kolokalisation von FGF9 und FGFR3 in adulten humanen Spermatogonien

    von Kopylow, K., Spiess, A-N., Schulze, W. & Kirchhoff, C., 04.12.2013, In: J Reprodmed Endokrinol. 10 , 5-6, p. 330 1 p., P083.

    Research output: SCORING: Contribution to journalNewspaper articlesTransfer

  13. An argument-based approach to the validation of UHTRUST: can we measure how recent graduates can be trusted with unfamiliar tasks?

    Wijnen-Meijer, M., Van der Schaaf, M., Booij, E., Harendza, S., Boscardin, C., Van Wijngaarden, J. & Ten Cate, T. J., 01.12.2013, In: ADV HEALTH SCI EDUC. 18, 5, p. 1009-27 19 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  14. Effectiveness and safety of minilaparoscopy-guided spleen biopsy: a retrospective series of 57 cases

    Werner, T., Koch, J. & Denzer, U. W., 01.12.2013, In: SURG ENDOSC. 27, 12, p. 4743

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  15. Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells

    Burghardt, S., Erhardt, A., Claass, B., Huber, S., Adler, G., Jacobs, T., Chalaris, A., Schmidt-Arras, D., Rose-John, S., Karimi, K. & Tiegs, G., 01.12.2013, In: J IMMUNOL. 191, 11, p. 5574-82 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  16. Laparoscopic Heller myotomy versus endoscopic balloon dilatation for the treatment of achalasia: a network meta-analysis

    Schoenberg, M. B., Marx, S., Kersten, J. F., Rösch, T., Belle, S., Kähler, G., Vassiliou, M. C., Lüth, S. & von Renteln, D., 01.12.2013, In: ANN SURG. 258, 6, p. 943-52 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  17. MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN

    Krebs, C. F., Kapffer, S., Paust, H-J., Schmidt, T., Bennstein, S. B., Peters, A., Stege, G., Brix, S. R., Meyer-Schwesinger, C., Müller, R-U., Turner, J. E., Steinmetz, O. M., Wolf, G., Stahl, R. A. K. & Panzer, U., 01.12.2013, In: J AM SOC NEPHROL. 24, 12, p. 1955-65 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  18. Some unusual cystic lesions of the liver

    Wehmeyer, M. H., Lohse, A. W. & Schramm, C., 01.12.2013, In: GASTROENTEROLOGY. 145, 6, p. e1-2

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  19. Def-6, a novel regulator of small GTPases in podocytes, acts downstream of atypical protein kinase C (aPKC) λ/ι

    Worthmann, K., Leitges, M., Teng, B., Sestu, M., Tossidou, I., Samson, T., Haller, H., Huber, T. B. & Schiffer, M., 12.2013, In: AM J PATHOL. 183, 6, p. 1945-59 15 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  20. New Approaches to Diagnosing Male Infertility: Part I: Microarray Analysis of Testicular Biopsy Specimens from Men with Intact and Impaired Spermatogenesis.

    Spiess, A-N. & Schulze, W., 12.2013, Atlas on the Human Testis: Normal Morphology and Pathology . Jezek, D. (ed.). 1 ed. Springer, Vol. 1. p. 253-261 8 p. 16

    Research output: SCORING: Contribution to book/anthologySCORING: Contribution to collected editions/anthologiesTransferpeer-review

  21. When choice matters: task-dependent memory effects in older adulthood

    Depping, M. K. & Freund, A. M., 12.2013, In: PSYCHOL AGING. 28, 4, p. 923-36

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  22. Anthracyclines induce DNA damage response-mediated protection against severe sepsis

    Figueiredo, N., Chora, A., Raquel, H., Pejanovic, N., Pereira, P., Hartleben, B., Neves-Costa, A., Moita, C., Pedroso, D., Pinto, A., Marques, S., Faridi, H., Costa, P., Gozzelino, R., Zhao, J. L., Soares, M. P., Gama-Carvalho, M., Martinez, J., Zhang, Q., Döring, G., Grompe, M., Simas, J. P., Huber, T. B., Baltimore, D., Gupta, V., Green, D. R., Ferreira, J. A. & Moita, L. F., 14.11.2013, In: IMMUNITY. 39, 5, p. 874-84 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  23. Associations between immune depression and cardiovascular events in HIV infection

    Sabin, C. A., Ryom, L., De Wit, S., Mocroft, A., Phillips, A. N., Worm, S. W., Weber, R., D'Arminio Monforte, A., Reiss, P., Kamara, D., El-Sadr, W., Pradier, C., Dabis, F., Law, M., Lundgren, J. & D:A:D study Group, 13.11.2013, In: AIDS. 27, 17, p. 2735-48 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  24. Virtuelle Patienten: Wie werden sie aus Sicht von Medizinstudierenden am besten eingesetzt?

    Riemer, M. & Abendroth, M., 13.11.2013, In: GMS Med Inform Biom E. 9(4), Doc19, 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  25. Actinic keratosis among seafarers

    Oldenburg, M., Kuechmeister, B., Ohnemus, U., Baur, X. & Moll, I., 01.11.2013, In: ARCH DERMATOL RES. 305, 9, p. 787-96 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  26. Acute glucocorticoid effects on response inhibition in borderline personality disorder

    Carvalho Fernando, S., Beblo, T., Schlosser, N., Terfehr, K., Wolf, O. T., Otte, C., Löwe, B., Spitzer, C., Driessen, M. & Wingenfeld, K., 01.11.2013, In: PSYCHONEUROENDOCRINO. 38, 11, p. 2780-8 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  27. A new endoscopically implantable device (SatiSphere) for treatment of obesity--efficacy, safety, and metabolic effects on glucose, insulin, and GLP-1 levels

    Sauer, N., Rösch, T., Pezold, J., Reining, F., Anders, M., Groth, S., Schachschal, G., Mann, O. & Aberle, J., 01.11.2013, In: OBES SURG. 23, 11, p. 1727-33 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  28. Association between childhood trauma and low hair cortisol in depressed patients and healthy control subjects

    Hinkelmann, K., Muhtz, C., Dettenborn-Betz, L., Agorastos, A., Wingenfeld, K., Spitzer, C., Gao, W., Kirschbaum, C., Wiedemann, K. & Otte, C., 01.11.2013, In: BIOL PSYCHIAT. 74, 9, p. e15-7

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  29. Association between cortisol awakening response and memory function in major depression

    Hinkelmann, K., Muhtz, C., Dettenborn-Betz, L., Agorastos, A., Moritz, S., Wingenfeld, K., Spitzer, C., Gold, S. M., Wiedemann, K. & Otte, C., 01.11.2013, In: PSYCHOL MED. 43, 11, p. 2255-63 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  30. Bericht der AG Dermatopathologie vom 97. Jahrestag der DGP in Heidelberg

    Meister, P. & Moll, I., 01.11.2013, In: PATHOLOGE. 34 Suppl 2, p. 282-3 2 p.

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  31. Cognitive biases in patients with chronic obstructive pulmonary disease and depression--a pilot study

    Fritzsche, A., Watz, H., Magnussen, H., Tuinmann, G., Löwe, B. & von Leupoldt, A., 01.11.2013, In: BRIT J HEALTH PSYCH. 18, 4, p. 827-43 17 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  32. Diagnostik und Therapie des hepatozellulären Karzinoms

    Greten, T. F., Malek, N. P., Schmidt, S., Arends, J., Bartenstein, P., Bechstein, W., Bernatik, T., Bitzer, M., Chavan, A., Dollinger, M., Domagk, D., Drognitz, O., Düx, M., Farkas, S., Folprecht, G., Galle, P., Geißler, M., Gerken, G., Habermehl, D., Helmberger, T., Herfarth, K., Hoffmann, R. T., Holtmann, M., Huppert, P., Jakobs, T., Keller, M., Klempnauer, J., Kolligs, F., Körber, J., Lang, H., Lehner, F., Lordick, F., Lubienski, A., Manns, M. P., Mahnken, A., Möhler, M., Mönch, C., Neuhaus, P., Niederau, C., Ocker, M., Otto, G., Pereira, P., Pott, G., Riemer, J., Ringe, K., Ritterbusch, U., Rummeny, E., Schirmacher, P., Schlitt, H. J., Schlottmann, K., Schmitz, V., Schuler, A., Schulze-Bergkamen, H., von Schweinitz, D., Seehofer, D., Sitter, H., Straßburg, C. P., Stroszczynski, C., Strobel, D., Tannapfel, A., Trojan, J., van Thiel, I., Vogel, A., Wacker, F., Wedemeyer, H., Wege, H., Weinmann, A., Wittekind, C., Wörmann, B. & Zech, C. J., 01.11.2013, In: Z GASTROENTEROL. 51, 11, p. 1269-326 58 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  33. Die psychische Gesundheit von Kindern, Jugendlichen und jungen Erwachsenen--Teil 1: Häufigkeit, Störungspersistenz, Belastungsfaktoren, Service-Inanspruchnahme und Behandlungsverzögerung mit Konsequenzen

    Lambert, M., Bock, T., Naber, D., Löwe, B., Schulte-Markwort, M., Schäfer, I., Gumz, A., Degkwitz, P., Schulte, B., König, H. H., Konnopka, A., Bauer, M., Bechdolf, A., Correll, C., Juckel, G., Klosterkötter, J., Leopold, K., Pfennig, A. & Karow, A., 01.11.2013, In: FORTSCHR NEUROL PSYC. 81, 11, p. 614-27 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  34. Die psychische Gesundheit von Kindern, Jugendlichen und jungen Erwachsenen--Teil 2: Krankheitslast, Defizite des deutschen Versorgungssystems, Effektivität und Effizienz von "Early Intervention Services"

    Karow, A., Bock, T., Naber, D., Löwe, B., Schulte-Markwort, M., Schäfer, I., Gumz, A., Degkwitz, P., Schulte, B., König, H. H., Konnopka, A., Bauer, M., Bechdolf, A., Correll, C., Juckel, G., Klosterkötter, J., Leopold, K., Pfennig, A. & Lambert, M., 01.11.2013, In: FORTSCHR NEUROL PSYC. 81, 11, p. 628-38 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  35. Effect of medical education on students' attitudes toward psychiatry and individuals with mental disorders

    Hofmann, M., Harendza, S., Meyer, J., Drabik, A., Reimer, J. & Kuhnigk, O., 01.11.2013, In: ACAD PSYCHIATR. 37, 6, p. 380-4 5 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  36. Essential facets of competence that enable trust in medical graduates: a ranking study among physician educators in two countries

    Wijnen-Meijer, M., van der Schaaf, M., Nillesen, K., Harendza, S. & Ten Cate, O., 01.11.2013, In: PERSPECT MED EDUC. 2, 5-6, p. 290-7 8 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  37. Presence of EpCAM-positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma

    Schulze, K., Gasch, C., Staufer, K., Nashan, B., Lohse, A. W., Pantel, K., Riethdorf, S. & Wege, H., 01.11.2013, In: INT J CANCER. 133, 9, p. 2165-71 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  38. Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA

    Grint, D., Peters, L., Schwarze-Zander, C., Beniowski, M., Pradier, C., Battegay, M., Jevtovic, D., Soriano, V., Lundgren, J. D., Rockstroh, J. K., Kirk, O., Mocroft, A. & EuroSIDA in EuroCoord, 01.11.2013, In: HIV MED. 14, 10, p. 614-23 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  39. TGF-β1 and TNF-α differentially regulate Twist1 mediated resistance towards BRAF/MEK inhibition in melanoma

    Menon, D. R., Wels, C., Bonyadi Rad, E., Joshi, S., Knausz, H., Lade-Keller, J., Brandner, J. M. & Schaider, H., 01.11.2013, In: PIGM CELL MELANOMA R. 26, 6, p. 912-6 5 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  40. The CTLA-4 +49GG genotype is associated with susceptibility for nephrotic kidney diseases

    Spink, C., Stege, G., Tenbrock, K. & Harendza, S., 01.11.2013, In: NEPHROL DIAL TRANSPL. 28, 11, p. 2800-5 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  41. The role of MDSCs in hepatocellular carcinoma--in vivo veritas?

    Schrader, J., 01.11.2013, In: J HEPATOL. 59, 5, p. 921-3 3 p.

    Research output: SCORING: Contribution to journalOther (editorial matter etc.)Research

  42. Aus vier mach zwei: Neuklassifikation von Somatisierungsstörung, undifferenzierter somatoformer Störung, Schmerzstörung und Hypochondrie im DSM-5

    Lau, K., Löwe, B., Langs, G. & Voigt, K., 11.2013, In: PSYCHOTHERAPEUT. 58, 6, p. 545-551 545 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  43. Elevated hepatic chemerin mRNA expression in human non-alcoholic fatty liver disease

    Döcke, S., Lock, J. F., Birkenfeld, A. L., Hoppe, S., Lieske, S., Rieger, A., Raschzok, N., Sauer, I. M., Florian, S., Osterhoff, M. A., Heller, R., Herrmann, K., Lindenmüller, S., Horn, P., Bauer, M., Weickert, M. O., Neuhaus, P., Stockmann, M., Möhlig, M., Pfeiffer, A. F. H. & von Loeffelholz, C., 11.2013, In: EUR J ENDOCRINOL. 169, 5, p. 547-57 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  44. Proteinuria impairs podocyte regeneration by sequestering retinoic acid

    Peired, A., Angelotti, M. L., Ronconi, E., la Marca, G., Mazzinghi, B., Sisti, A., Lombardi, D., Giocaliere, E., Della Bona, M., Villanelli, F., Parente, E., Ballerini, L., Sagrinati, C., Wanner, N., Huber, T. B., Liapis, H., Lazzeri, E., Lasagni, L. & Romagnani, P., 11.2013, In: J AM SOC NEPHROL. 24, 11, p. 1756-68 13 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  45. Toll like receptor 2 agonists lipoteichoic acid and peptidoglycan are able to enhance antigen specific IFNγ release in whole blood during recall antigen responses

    Dammermann, W., Wollenberg, L., Bentzien, F., Lohse, A. & Lüth, S., 31.10.2013, In: J IMMUNOL METHODS. 396, 1-2, p. 107-15 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  46. Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls

    Schlosser, N., Wolf, O. T., Fernando, S. C., Terfehr, K., Otte, C., Spitzer, C., Beblo, T., Driessen, M., Löwe, B. & Wingenfeld, K., 30.10.2013, In: PSYCHIAT RES. 209, 3, p. 439-46 8 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  47. Interleukin-6-Blockade als potenzielles therapeutisches Target bei entzündlich-rheumatischen Erkrankungen

    Iking-Konert, C., Bartz-Bazzanella, P., Falagan, D., Hofman, M. W., Schwarting, A. & Dörner, T., 30.10.2013, In: Z RHEUMATOL.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  48. Aberrant ZNF423 impedes B cell differentiation and is linked to adverse outcome of ETV6-RUNX1 negative B precursor acute lymphoblastic leukemia

    Harder, L., Eschenburg, G., Zech, A., Kriebitzsch, N., Otto, B., Streichert, T., Behlich, A-S., Dierck, K., Klingler, B., Hansen, A., Stanulla, M., Zimmermann, M., Kremmer, E., Stocking, C. & Horstmann, M. A., 21.10.2013, In: J EXP MED. 210, 11, p. 2289-304 16 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  49. Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1

    Thies, B., Meyer-Schwesinger, C., Lamp, J., Schweizer, M., Koeller, D. M., Ullrich, K., Braulke, T. & Mühlhausen, C., 01.10.2013, In: BBA-MOL BASIS DIS. 1832, 10, p. 1463-72 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  50. Antiviral effect, safety, and pharmacokinetics of five-day oral administration of Deleobuvir (BI 207127), an investigational hepatitis C virus RNA polymerase inhibitor, in patients with chronic hepatitis C

    Larrey, D., Lohse, A. W., Trepo, C., Bronowicki, J-P., Arastéh, K., Bourlière, M., Calleja, J. L., Stern, J. O., Nehmiz, G., Abdallah, N., Berger, K. L., Marquis, M., Steffgen, J., Kukolj, G. & BI 207127 Study Group, 01.10.2013, In: ANTIMICROB AGENTS CH. 57, 10, p. 4727-35 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  51. Decreased frequency of CD73+CD8+ T cells of HIV-infected patients correlates with immune activation and T cell exhaustion

    Tóth, I., Le, A. Q., Hartjen, P., Thomssen, A., Matzat, V., Lehmann, C., Scheurich, C., Beisel, C., Busch, C. P., Degen, O., Lohse, A. W., Eiermann, T., Fätkenheuer, G., Meyer-Olson, D., Bockhorn, M., Hauber, J., Lunzen, J. & Schulze Zur Wiesch, J., 01.10.2013, In: J LEUKOCYTE BIOL. 94, 4, p. 551-61 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  52. Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression

    Hochheiser, K., Heuser, C., Krause, T. A., Teteris, S., Ilias, A., Weisheit, C., Hoss, F., Tittel, A. P., Knolle, P. A., Panzer, U., Engel, D. R., Tharaux, P-L. & Kurts, C., 01.10.2013, In: J CLIN INVEST. 123, 10, p. 4242-54 13 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review