Department of Pediatric Hematology and Oncology
Publications
- 2012
Eradication of pulmonary aspergillosis in an adolescent patient undergoing three allogeneic stem cell transplantations for acute lymphoblastic leukemia.
Döring, M., Zierl, A., Mezger, M., Lang, P., Handgretinger, R. & Müller, I., 2012, In: Case Rep Transplant. 2012, p. 672923Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Familial and acquired hemophagocytic lymphohistiocytosis.
Janka-Schaub, G., 2012, In: ANNU REV MED. 63, p. 233-246Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Fatal EBV infection and variable clinical manifestations in an XLP-1 pedigree - rapid diagnosis of primary immunodeficiencies may save lives.
Sperl, D., Benesch, M., Urban, C., Lackner, H., Sovinz, P., Speicher, M. R., Uhrig, S., Schwarzbraun, T., Schwinger, W., Zur Stadt, U., Beutel, K., Janka-Schaub, G., Scarpatetti, M. & Seidel, M. G., 2012, In: KLIN PADIATR. 224, 6, p. 386-389 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial.
Lannering, B., Rutkowski, S., Doz, F., Pizer, B., Gustafsson, G., Navajas, A., Massimino, M., Reddingius, R., Benesch, M., Carrie, C., Taylor, R., Gandola, L., Björk-Eriksson, T., Giralt, J., Oldenburger, F., Pietsch, T., Figarella-Branger, D., Robson, K., Forni, M., Clifford, S. C., Warmuth-Metz, M., von Hoff, K., Faldum, A., Mosseri, V. & Kortmann, R., 2012, In: J CLIN ONCOL. 30, 26, p. 3187-3193 26.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
Ellinghaus, E., Stanulla, M., Richter, G., Ellinghaus, D., Te Kronnie, G., Cario, G., Cazzaniga, G., Horstmann, M., Panzer Grümayer, R., Cavé, H., Trka, J., Cinek, O., Teigler-Schlegel, A., ElSharawy, A., Häsler, R., Nebel, A., Meissner, B., Bartram, T., Lescai, F., Franceschi, C., Giordan, M., Nürnberg, P., Heinzow, B., Zimmermann, M., Schreiber, S., Schrappe, M. & Franke, A., 2012, In: LEUKEMIA. 26, 5, p. 902-909 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
IL-15-stimulated CD3/CD19-depleted stem-cell boosts in relapsed pediatric patients after haploidentical SCT.
Pfeiffer, M. M., Schumm, M., Müller, I., Handgretinger, R. & Lang, P., 2012, In: LEUKEMIA. 26, 11, p. 2435-2439 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study.
Biondi, A., Schrappe, M., Paola, D. L., Castor, A., Lucchini, G., Gandemer, V., Pieters, R., Stary, J., Escherich, G., Campbell, M., Li, C-K., Vora, A., Aricò, M., Röttgers, S., Saha, V. & Valsecchi, M. G., 2012, In: LANCET ONCOL. 13, 9, p. 936-945 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice.
Terziyska, N., Catarina, C. A., Groiss, V., Schneider, K., Farkasova, K., Ogris, M., Wagner, E., Ehrhardt, H., Brentjens, R. J., Zur Stadt, U., Horstmann, M., Quintanilla-Martinez, L. & Jeremias, I., 2012, In: PLOS ONE. 7, 12, p. 52798 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.
Brauer, H., Strauss, J., Wegner, W., Müller-Tidow, C., Horstmann, M. & Jücker, M., 2012, In: CELL SIGNAL. 24, 11, p. 2095-2101 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Medulloblastoma.
von Hoff, K. & Rutkowski, S., 2012, In: CURR TREAT OPTION NE. 14, 4, p. 416-426 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas.
Kool, M., Korshunov, A., Remke, M., Jones, D. T. W., Schlanstein, M., Northcott, P. A., Cho, Y-J., Koster, J., Antoinette, S. M., van Vuurden, D., Clifford, S. C., Pietsch, T., von Bueren, A., Rutkowski, S., Rutkowski, S., McCabe, M., Collins, V. P., Bäcklund, M. L., Haberler, C., Bourdeaut, F., Delattre, O., Doz, F., Ellison, D. W., Gilbertson, R. J., Pomeroy, S. L., Taylor, M. D., Lichter, P. & Pfister, S. M., 2012, In: ACTA NEUROPATHOL. 123, 4, p. 473-484 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Molecular subgroups of medulloblastoma: the current consensus.
Taylor, M. D., Northcott, P. A., Korshunov, A., Remke, M., Cho, Y-J., Clifford, S. C., Eberhart, C. G., Parsons, D. W., Rutkowski, S., Gajjar, A., Ellison, D. W., Lichter, P., Gilbertson, R. J., Pomeroy, S. L., Kool, M. & Pfister, S. M., 2012, In: ACTA NEUROPATHOL. 123, 4, p. 465-472 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Occurrence of acute lymphoblastic leukemia and juvenile myelomonocytic leukemia in a patient with Noonan syndrome carrying the germline PTPN11 mutation p.E139D.
Pauli, S., Steinemann, D., Dittmann, K., Wienands, J., Shoukier, M., Möschner, M., Burfeind, P., Manukjan, G., Göhring, G. & Escherich, G., 2012, In: AM J MED GENET A. 158A, 3, p. 652-658 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Outcomes after induction failure in childhood acute lymphoblastic leukemia.
Schrappe, M., Hunger, S. P., Pui, C-H., Saha, V., Gaynon, P. S., Baruchel, A., Conter, V., Otten, J., Ohara, A., Versluys, A. B., Escherich, G., Heyman, M., Silverman, L. B., Horibe, K., Mann, G., Camitta, B. M., Harbott, J., Riehm, H., Richards, S., Devidas, M. & Zimmermann, M., 2012, In: NEW ENGL J MED. 366, 15, p. 1371-1381 15.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
p53 expression predicts dismal outcome for medulloblastoma patients with metastatic disease.
Gessi, M., von Bueren, A., Rutkowski, S., Rutkowski, S. & Pietsch, T., 2012, In: J NEURO-ONCOL. 106, 1, p. 135-141 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pediatric high grade glioma of the spinal cord: results of the HIT-GBM database.
Wolff, B., Ng, A., Roth, D., Parthey, K., Warmuth-Metz, M., Eyrich, M., Kordes, U., Kortmann, R., Pietsch, T., Kramm, C. & Wolff, J. E., 2012, In: J NEURO-ONCOL. 107, 1, p. 139-146 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Proper cerebellar development requires expression of β1-integrin in Bergmann glia, but not in granule neurons.
Frick, A., Grammel, D., Schmidt, F., Pöschl, J., Priller, M., Pagella, P., von Bueren, A., André, O., Peraud, A., Tonn, J-C., Rutkowski, S., Rutkowski, S., Kretzschmar, H. A. & Schüller, U., 2012, In: GLIA. 60, 5, p. 820-832 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome.
Ronceray, L., Pötschger, U., Janka-Schaub, G., Gadner, H., Minkov, M., Hematology, G. S. F. P. & Group, O. L. C. H. S., 2012, In: J PEDIATR-US. 161, 1, p. 123-129 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Quantification of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) using amplicon-fusion-site polymerase chain reaction (AFS-PCR).
Weber, A., Taube, S., Zur Stadt, U., Horstmann, M., Krohn, K., Bradtke, J., Teigler-Schlegel, A., Leiblein, S. & Christiansen, H., 2012, In: EXP HEMATOL ONCOL. 1, 1, p. 33 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis.
Bode, S. F., Lehmberg, K., Maul-Pavicic, A., Vraetz, T., Janka-Schaub, G., Zur Stadt, U. & Ehl, S., 2012, In: ARTHRITIS RES THER. 14, 3, p. 213 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Reduced von Willebrand factor secretion is associated with loss of Weibel-Palade body formation.
Castaman, G., Giacomelli, S. H., Jacobi, P. M., Obser, T., Budde, U., Rodeghiero, F., Schneppenheim, R. & Haberichter, S. L., 2012, In: J THROMB HAEMOST. 10, 5, p. 951-958 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Risk factors for early death in children with haemophagocytic lymphohistiocytosis.
Trottestam, H., Berglöf, E., Horne, A., Onelöv, E., Beutel, K., Lehmberg, K., Sieni, E., Silfverberg, T., Aricò, M., Janka-Schaub, G. & Henter, J-I., 2012, In: ACTA PAEDIATR. 101, 3, p. 313-318 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Siglec-7 tetramers characterize B-cell subpopulations and leukemic blasts.
Gieseke, F., Mang, P., Viebahn, S., Sonntag, I., Kruchen, A., Erbacher, A., Pfeiffer, M., Handgretinger, R. & Müller, I., 2012, In: EUR J IMMUNOL. 42, 8, p. 2176-2186 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem.
Grammel, D., Warmuth-Metz, M., von Bueren, A., André, O., Kool, M., Pietsch, T., Kretzschmar, H. A., Rutkowski, S., Rutkowski, S., Pfister, S. M. & Schüller, U., 2012, In: ACTA NEUROPATHOL. 123, 4, p. 601-614 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Targeted therapeutics in treatment of children and young adults with solid tumors: an expert survey and review of the literature.
Grunewald, T. G. P., Greulich, N., Kontny, U., Frühwald, M., Rutkowski, S., Kordes, U., Scheurlen, W., Schmidt, W., Stachel, D., Metzler, M., Mittler, U., Graf, N., Benesch, M. & Burdach, S., 2012, In: KLIN PADIATR. 224, 3, p. 124-131 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The significance of PTEN and AKT aberrations in pediatric T-cell acute lymphoblastic leukemia.
Zuurbier, L., Petricoin, E. F., Vuerhard, M. J., Calvert, V., Kooi, C., Buijs-Gladdines, J. G. C. A. M., Smits, W. K., Sonneveld, E., Veerman, A. J. P., Kamps, W. A., Horstmann, M., Pieters, R. & Meijerink, J. P. P., 2012, In: HAEMATOLOGICA. 97, 9, p. 1405-1413 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Variant alleles of cytokine genes influence risk and clinical course of Langerhans cell histiocytosis.
Lehrnbecher, T., Salzmann-Manrique, E., Soerensen, J., Beutel, K., Janka-Schaub, G., Gadner, H. & Minkov, M., 2012, In: BRIT J HAEMATOL. 156, 1, p. 138-141 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients
Priller, M., Pöschl, J., Abrão, L., von Bueren, A. O., Cho, Y-J., Rutkowski, S., Kretzschmar, H. A. & Schüller, U., 01.11.2011, In: CLIN CANCER RES. 17, 21, p. 6791-801 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Regulation der primären Hämostase durch von-Willebrand-Faktor und ADAMTS13
Schneppenheim, R. & Budde, U., 01.11.2011, In: HAMOSTASEOLOGIE. 31, 4, p. 275-80 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors
Lorenz, A., Deutschmann, M., Ahlfeld, J., Prix, C., Koch, A., Smits, R., Fodde, R., Kretzschmar, H. A. & Schüller, U., 08.2011, In: MOL CELL BIOL. 31, 16, p. 3326-38 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
TH1 predominance is associated with improved survival in pediatric medulloblastoma patients
Wiegering, V., Eyrich, M., Rutkowski, S., Wölfl, M., Schlegel, P. G. & Winkler, B., 05.2011, In: CANCER IMMUNOL IMMUN. 60, 5, p. 693-703 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Glioblastoma in childhood – Treatment and outcome of 7 patients
Burkhardt, T., Emami, P., Kordes, U., Matschke, J., Regelsberger, J., Westphal, M. & Kammler, G., 01.04.2011, 62. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgen (PNCH).Research output: SCORING: Contribution to book/anthology › Conference contribution - Article for conference › Research
A comparison between two semi-quantitative bleeding scales for the diagnosis and assessment of bleeding severity in type 1 von Willebrand disease.
Tosetto, A., Rodeghiero, F., Castaman, G., Goodeve, A., Federici, A. B., Batlle, J., Meyer, D., Goudemand, J., Eikenboom, J., Schneppenheim, R., Budde, U., Ingerslev, J., Lethagen, S., Hill, F. G. H. & Peake, I., 2011, In: HAEMOPHILIA. 17, 1, p. 165-166 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A complex karyotype in an atypical teratoid/rhabdoid tumor: case report and review of the literature.
Coccé, M. C., Lubieniecki, F., Kordes, U., Alderete, D. & Gallego, M. S., 2011, In: J NEURO-ONCOL. 104, 1, p. 375-380 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
An aggressive systemic juvenile xanthogranuloma clonally related to a preceding T-cell acute lymphoblastic leukemia.
Perez-Becker, R., Szczepanowski, M., Leuschner, I., Janka-Schaub, G., Gokel, M., Imschweiler, T., Völpel, S., Niehues, T. & Klapper, W., 2011, In: PEDIATR BLOOD CANCER. 56, 5, p. 859-862 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology.
Gómez-Barrena, E., Rosset, P., Müller, I., Giordano, R., Bunu, C., Layrolle, P., Konttinen, Y. T. & Luyten, F. P., 2011, In: J CELL MOL MED. 15, 6, p. 1266-1286 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Characterisation of two novel large F8 deletions in patients with severe haemophilia A and factor VIII inhibitors.
Roth, L., Marschalek, R., Oldenburg, J., Oyen, F. & Schneppenheim, R., 2011, In: THROMB HAEMOSTASIS. 105, 2, p. 279-284 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Chemoimmunotherapy for hemophagocytic lymphohistiocytosis: long-term results of the HLH-94 treatment protocol.
Trottestam, H., Horne, A., Aricò, M., Egeler, R. M., Filipovich, A. H., Gadner, H., Imashuku, S., Ladisch, S., Webb, D., Janka-Schaub, G., Henter, J-I. & Society, H., 2011, In: BLOOD. 118, 17, p. 4577-4584 17.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Childhood medulloblastoma.
Massimino, M., Giangaspero, F., Garrè, M. L., Gandola, L., Poggi, G., Biassoni, V., Gatta, G. & Rutkowski, S., 2011, In: CRIT REV ONCOL HEMAT. 79, 41, p. 65-83 41.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients.
von Bueren, A., André, O., Oehler, C., von Hoff, K., von Hoff, K., Pruschy, M., Seifert, B., Gerber, N. U., Warmuth-Metz, M., Stearns, D., Eberhart, C. G., Rutkowski, S., Rutkowski, S. & Grotzer, M. A., 2011, In: BMC CANCER. 11, p. 74Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Common large partial VWF gene deletion does not cause alloantibody formation in the Hungarian type 3 von Willebrand disease population.
Mohl, A., Boda, Z., Jager, R., Losonczy, H., Marosi, A., Masszi, T., Nagy, E., Nemes, L., Obser, T., Oyen, F., Radványi, G., Schlammadinger, U., Szélessy, Z. S., Várkonyi, A., Vezendy, K., Vilimi, B., Schneppenheim, R. & Bodó, I., 2011, In: J THROMB HAEMOST. 9, 5, p. 945-952 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Curative treatment for central nervous system medulloepithelioma despite residual disease after resection. Report of two cases treated according to the GPHO Protocol HIT 2000 and review of the literature.
Müller, K., Zwiener, I., Welker, H., Maass, E., Bongartz, R., Berthold, F., Pietsch, T., Warmuth-Metz, M., von Bueren, A. & Rutkowski, S., 2011, In: STRAHLENTHER ONKOL. 187, 11, p. 757-762 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Ectopic craniopharyngioma.
Kordes, U., Flitsch, J., Hagel, C., Goebell, E., Schwarz, R., Herberhold, T., von Bueren, A., Rutkowski, S. & Müller, H. L., 2011, In: KLIN PADIATR. 223, 3, p. 176-177 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Expression of BARHL1 in medulloblastoma is associated with prolonged survival in mice and humans.
Pöschl, J., Lorenz, A., Hartmann, W., von Bueren, A., Kool, M., Li, S., Peraud, A., Tonn, J-C., Herms, J., Xiang, M., Rutkowski, S., Kretzschmar, H. A. & Schüller, U., 2011, In: ONCOGENE. 30, 47, p. 4721-4730 47.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database.
von Hoff, K., Hinkes, B., Dannenmann-Stern, E., von Bueren, A., André, O., Warmuth-Metz, M., Soerensen, N., Emser, A., Zwiener, I., Schlegel, P. G., Kuehl, J., Frühwald, M. C., Kortmann, R. D., Rutkowski, S. & Rutkowski, S., 2011, In: PEDIATR BLOOD CANCER. 57, 6, p. 978-985 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma.
Remke, M., Hielscher, T., Korshunov, A., Northcott, P. A., Bender, S., Kool, M., Westermann, F., Benner, A., Cin, H., Ryzhova, M., Sturm, D., Witt, H., Haag, D., Toedt, G., Wittmann, A., Schöttler, A., von Bueren, A., André, O., Rutkowski, S., Rutkowski, S., Scheurlen, W., Kulozik, A. E., Taylor, M. D., Lichter, P. & Pfister, S. M., 2011, In: J CLIN ONCOL. 29, 29, p. 3852-3861 29.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3.
Sieni, E., Cetica, V., Santoro, A., Beutel, K., Mastrodicasa, E., Meeths, M., Ciambotti, B., Brugnolo, F., Zur Stadt, U., Pende, D., Moretta, L., Griffiths, G. M., Henter, J-I., Janka-Schaub, G. & Aricò, M., 2011, In: J MED GENET. 48, 5, p. 343-352 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High-dose chemotherapy followed by autologous stem cell transplantation for metastatic rhabdomyosarcoma--a systematic review.
Peinemann, F., Kröger, N., Bartel, C., Grouven, U., Pittler, M., Erttmann, R. & Kulig, M., 2011, In: PLOS ONE. 6, 2, p. 17127 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High dose methotrexate for pediatric high grade glioma: results of the HIT-GBM-D Pilot study.
Wolff, J. E., Kortmann, R-D., Wolff, B., Pietsch, T., Peters, O., Schmid, H-J., Rutkowski, S., Warmuth-Metz, M. & Kramm, C., 2011, In: J NEURO-ONCOL. 102, 3, p. 433-442 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Increased cyclosporine concentrations in the absence of cyclosporine administration.
Peter, A., Shipkova, M., Wieland, E., Schleicher, E. & Müller, I., 2011, In: CLIN CHEM. 57, 5, p. 670-673 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review