Department of Pediatric Hematology and Oncology
Publications
- 2009
ITI with high-dose FIX and combined immunosuppressive therapy in a patient with severe haemophilia B and inhibitor.
Beutel, K., Hauch, H., Rischewski, J., Kordes, U., Schneppenheim, J. & Schneppenheim, R., 2009, In: HAMOSTASEOLOGIE. 29, 2, p. 155-157 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Molecular analysis and clinical aspects of four patients with Chédiak-Higashi syndrome (CHS).
Scherber, E., Beutel, K., Ganschow, R., Schulz, A., Janka-Schaub, G. & Zur Stadt, U., 2009, In: CLIN GENET.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Neuroonkologie
Kammler, G., Kordes, U., Hornung, D., LINHART, D. & Hagel, C., 2009, Neuropädiatrie - Evidenzbasierte Therapie. Elsevier, p. 215-239 25 p.Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
New insights to the MLL recombinome of acute leukemias.
Meyer, C., Kowarz, E., Hofmann, J., Renneville, A., Zuna, J., Trka, J., Ben Abdelali, R., Macintyre, E., De Braekeleer, E., De Braekeleer, M., Delabesse, E., de Oliveira, M. P., Cavé, H., Clappier, E., van Dongen, J. J. M., Balgobind, B. V., van den Heuvel-Eibrink, M. M., Beverloo, H. B., Panzer-Grümayer, R., Teigler-Schlegel, A., Harbott, J., Kjeldsen, E., Schnittger, S., Koehl, U., Gruhn, B., Heidenreich, O., Chan, L. C., Yip, S. F., Krzywinski, M., Eckert, C., Möricke, A., Schrappe, M., Alonso, C. N., Schäfer, B. W., Krauter, J., Lee, D. A., Zur Stadt, U., Te Kronnie, G., Sutton, R., Izraeli, S., Trakhtenbrot, L., Lo Nigro, L., Tsaur, G., Fechina, L., Szczepanski, T., Strehl, S., Ilencikova, D., Molkentin, M., Burmeister, T., Dingermann, T., Klingebiel, T. & Marschalek, R., 2009, In: LEUKEMIA. 23, 8, p. 1490-1499 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Outcome of congenital acute lymphoblastic leukemia treated on the Interfant-99 protocol.
Linden, V. D., Marieke, H., Valsecchi, M. G., Paola, D. L., Janka-Schaub, G., Janka, G., Leblanc, T. M., Felice, M., Andrea, B., Campbell, M., Hann, I., Rubnitz, J. E., Stary, J., Szczepanski, T., Vora, A., Ferster, A., Hovi, L., Silverman, L. B. & Pieters, R., 2009, In: BLOOD. 114, 18, p. 3764-3768 18.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Paediatric haemostaseology.
Schneppenheim, R., 2009, In: HAMOSTASEOLOGIE. 29, 2, p. 133 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pancytopenia in a 4-year-old boy. 22q11.2 microdeletion syndrome.
Lehmberg, K., Rohr, J., Schneppenheim, R., Sommerfeld, K. & Janka-Schaub, G., 2009, In: ACTA PAEDIATR. 98, 5, p. 769-770, 912-914 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Patients with early relapse of primary hemophagocytic syndromes or with persistent CNS involvement may benefit from immediate hematopoietic stem cell transplantation.
Sparber-Sauer, M., Hönig, M., Schulz, A. S., Zur Stadt, U., Schütz, C., Debatin, K. M. & Friedrich, W., 2009, In: BONE MARROW TRANSPL. 44, 6, p. 333-338 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pharmacokinetics of high-dose methotrexate in infants treated for acute lymphoblastic leukemia.
Lönnerholm, G., Valsecchi, M. G., Paola, D. L., Schrappe, M., Hovi, L., Campbell, M., Mann, G., Janka-Schaub, G., Li, C-K., Stary, J., Hann, I. & Pieters, R., 2009, In: PEDIATR BLOOD CANCER. 52, 5, p. 596-601 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group.
Bader, P., Kreyenberg, H., Henze, G. H. R., Eckert, C., Reising, M., Willasch, A., Barth, A., Borkhardt, A., Peters, C., Handgretinger, R., Sykora, K-W., Holter, W., Kabisch, H., Klingebiel, T. & von Stackelberg, A., 2009, In: J CLIN ONCOL. 27, 3, p. 377-384 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition.
Bug, S., Dürig, J., Oyen, F., Klein-Hitpass, L., Martin-Subero, J. I., Harder, L., Baudis, M., Arnold, N., Kordes, U., Dührsen, U., Schneppenheim, R. & Siebert, R., 2009, In: CANCER GENET-NY. 192, 1, p. 44-47 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Response to DDAVP in children with von Willebrand disease type 2.
Schneppenheim, R., Budde, U., Beutel, K., Hassenpflug, W-A., Hauch, H., Obser, T., Oyen, F., Schneppenheim, S. & Schrum, J., 2009, In: HAMOSTASEOLOGIE. 29, 2, p. 143-148 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
RNA interference-mediated c-MYC inhibition prevents cell growth and decreases sensitivity to radio- and chemotherapy in childhood medulloblastoma cells.
von Bueren, A., André, O., Shalaby, T., Oehler-Jänne, C., Arnold, L., Stearns, D., Eberhart, C. G., Arcaro, A., Pruschy, M. & Grotzer, M. A., 2009, In: BMC CANCER. 9, p. 10Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Second allogeneic stem cell transplantation in myeloid malignancies.
Hartwig, M., Ocheni, S., Asenova, S., Wiedemann, B., Zabelina, T., Ayuketang Ayuk, F., Kabisch, H., Erttmann, R., Kröger, N., Zander, A. R. & Bacher, U., 2009, In: ACTA HAEMATOL-BASEL. 122, 4, p. 185-192 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Shear-induced unfolding activates von Willebrand factor A2 domain for proteolysis.
Schneppenheim, R., Baldauf, C., Stacklies, W., Obser, T., Pieconka, A., Schneppenheim, S., Budde, U., Zhou, J. & Gräter, F., 2009, In: J THROMB HAEMOST. 7, 12, p. 2096-2105 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Standardized MRD quantification in European ALL trials: Proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008.
Brüggemann, M., Schrauder, A., Raff, T., Pfeifer, H., Dworzak, M., Ottmann, O. G., Asnafi, V., Baruchel, A., Bassan, R., Benoit, Y., Biondi, A., Cavé, H., Dombret, H., Fielding, A. K., Foà, R., Gökbuget, N., Goldstone, A. H., Goulden, N., Henze, G., Hoelzer, D., Janka-Schaub, G., Macintyre, E. A., Pieters, R., Rambaldi, A., Ribera, J-M., Schmiegelow, K., Spinelli, O., Stary, J., von Stackelberg, A., Kneba, M., Schrappe, M. & van Dongen, J. J. M., 2009, In: LEUKEMIA.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The CD70/CD27 pathway is critical for stimulation of an effective cytotoxic T cell response against B cell precursor acute lymphoblastic leukemia.
Glouchkova, L., Ackermann, B., Zibert, A., Meisel, R., Siepermann, M., Janka-Schaub, G., Goebel, U., Troeger, A. & Dilloo, D., 2009, In: J IMMUNOL. 182, 1, p. 718-725 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The problem of novel FVIII missense mutations for haemophilia A genetic counseling.
Schneppenheim, R., Schröder, J., Obser, T., Oyen, F., Schneppenheim, S. & Oldenburg, J., 2009, In: HAMOSTASEOLOGIE. 29, 2, p. 158-160 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Treatment of the X-linked lymphoproliferative, Griscelli and Chédiak-Higashi syndromes by HLH directed therapy.
Trottestam, H., Beutel, K., Meeths, M., Carlsen, N., Heilmann, C., Pasi, S., Webb, D., Hasle, H. & Henter, J-I., 2009, In: PEDIATR BLOOD CANCER. 52, 2, p. 268-272 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Variations in the ratio between von Willebrand factor and its cleaving protease during systemic inflammation and association with severity and prognosis of organ failure.
Claus, R. A., Bockmeyer, C. L., Ulrich, B., Kentouche, K., Sossdorf, M., Hilberg, T., Schneppenheim, R., Reinhart, K., Bauer, M., Brunkhorst, F. M. & Lösche, W., 2009, In: THROMB HAEMOSTASIS. 101, 2, p. 239-247 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
WT1 mutations in T-ALL.
Tosello, V., Mansour, M. R., Barnes, K., Paganin, M., Sulis, M. L., Jenkinson, S., Allen, C. G., Gale, R. E., Linch, D. C., Palomero, T., Real, P., Murty, V., Yao, X., Richards, S. M., Goldstone, A., Rowe, J., Basso, G., Wiernik, P. H., Paietta, E., Pieters, R., Horstmann, M., Meijerink, J. P. P. & Ferrando, A. A., 2009, In: BLOOD. 114, 5, p. 1038-1045 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2008
Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors
Fuchs, J., Seitz, G., Ellerkamp, V., Dietz, K., Bosk, A., Müller, I., Warmann, S. W. & Schäfer, J. F., 12.2008, In: J SURG ONCOL. 17, 4, p. 323-30 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mesenchymal stem cell therapy for degenerative inflammatory disorders
Müller, I., Lymperi, S. & Dazzi, F., 12.2008, In: CURR OPIN ORGAN TRAN. 13, 6, p. 639-44 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Secretion of angiogenic proteins by human multipotent mesenchymal stromal cells and their clinical potential in the treatment of avascular osteonecrosis
Müller, I., Vaegler, M., Holzwarth, C., Tzaribatchev, N., Pfister, S. M., Schütt, B., Reize, P., Greil, J., Handgretinger, R. & Rudert, M., 11.2008, In: LEUKEMIA. 22, 11, p. 2054-61 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study [corrected].
Bhojwani, D., Kang, H., Menezes, R. X., Yang, W., Sather, H., Moskowitz, N. P., Min, D-J., Potter, J. W., Harvey, R., Hunger, S. P., Seibel, N., Raetz, E. A., Pieters, R., Horstmann, M. A., Relling, M. V., den Boer, M. L., Willman, C. L., Carroll, W. L. & Children's Oncology Group Study, 20.09.2008, In: J CLIN ONCOL. 26, 27, p. 4376-4384 9 p., 27.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
WT1 protein expression in slowly proliferating myeloid leukemic cell lines is scarce throughout the cell cycle with a minimum in G0/G1 phase
Kerst, G., Bergold, N., Viebahn, S., Gieseke, F., Kalinova, M., Trka, J., Handgretinger, R. & Müller, I., 09.2008, In: Leukemia research. 32, 9, p. 1393-9 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
Schüller, U., Heine, V. M., Mao, J., Kho, A. T., Dillon, A. K., Han, Y-G., Huillard, E., Sun, T., Ligon, A. H., Qian, Y., Ma, Q., Alvarez-Buylla, A., McMahon, A. P., Rowitch, D. H. & Ligon, K. L., 12.08.2008, In: CANCER CELL. 14, 2, p. 123-34 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells
Yang, Z-J., Ellis, T., Markant, S. L., Read, T-A., Kessler, J. D., Bourboulas, M., Schüller, U., Machold, R., Fishell, G., Rowitch, D. H., Wainwright, B. J. & Wechsler-Reya, R. J., 12.08.2008, In: CANCER CELL. 14, 2, p. 135-45 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Drug delivery in acute myeloid leukemia
Kohlschütter, J., Michelfelder, S. & Trepel, M., 06.2008, In: EXPERT OPIN DRUG DEL. 5, 6, p. 653-63 11 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Identification of type 1 von Willebrand disease patients with reduced von Willebrand factor survival by assay of the VWF propeptide in the European study: molecular and clinical markers for the diagnosis and management of type 1 VWD (MCMDM-1VWD).
Haberichter, S. L., Castaman, G., Budde, U., Peake, I., Goodeve, A., Rodeghiero, F., Federici, A. B., Batlle, J., Meyer, D., Mazurier, C., Goudemand, J., Eikenboom, J., Schneppenheim, R., Ingerslev, J., Vorlova, Z., Habart, D., Holmberg, L., Lethagen, S., Pasi, J., Hill, F. G. H. & Montgomery, R. R., 15.05.2008, In: BLOOD. 111, 10, p. 4979-4985 7 p., 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
WT1 protein expression in childhood acute leukemia
Kerst, G., Bergold, N., Gieseke, F., Coustan-Smith, E., Lang, P., Kalinova, M., Handgretinger, R., Trka, J. & Müller, I., 05.2008, In: AM J HEMATOL. 83, 5, p. 382-6 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Absence of mutations in the AKT1 oncogene in glioblastomas and medulloblastomas
Schüller, U., Ruiter, M., Herms, J., Kretzschmar, H. A. & Grasbon-Frodl, E., 03.2008, In: ACTA NEUROPATHOL. 115, 3, p. 367-8 2 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mesenchymal stromal cells: a novel treatment option for steroid-induced avascular osteonecrosis
Tzaribachev, N., Vaegler, M., Schaefer, J., Reize, P., Rudert, M., Handgretinger, R. & Müller, I., 03.2008, In: CAN MED ASSOC J. 10, 3, p. 232-4 3 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Efficient in vitro generation of adult multipotent cells from mobilized peripheral blood CD133+ cells
Kuçi, S., Kuçi, Z., Schmid, S., Seitz, G., Müller, I., Dufke, A., Leimig, T., Murti, G., Jurecic, R., Schumm, M., Lang, P., Bruchelt, G., Bader, P., Klingebiel, T., Niethammer, D. & Handgretinger, R., 02.2008, In: CELL PROLIFERAT. 41, 1, p. 12-27 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impairment of intellectual functions after surgery and posterior fossa irradiation in children with ependymoma is related to age and neurologic complications
von Hoff, K., Kieffer, V., Habrand, J-L., Kalifa, C., Dellatolas, G. & Grill, J., 01.01.2008, In: BMC CANCER. 8, p. 15Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
An Alu-mediated novel large deletion is the most frequent cause of type 3 von Willebrand disease in Hungary.
Mohl, A., Marschalek, R., Masszi, T., Nagy, E., Obser, T., Oyen, F., Sallai, K., Bodó, I. & Schneppenheim, R., 2008, In: J THROMB HAEMOST. 6, 10, p. 1729-1735 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Analysis of the CC chemokine receptor 5Delta32 polymorphism in pediatric liver transplant recipients.
Fischer-Maas, L., Schneppenheim, R., Oyen, F., Grabhorn, E., Briem-Richter, A., Fischer, L. & Ganschow, R., 2008, In: PEDIATR TRANSPLANT. 12, 7, p. 769-772 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Anti-thymocyte globulin overcomes the negative impact of HLA mismatching in transplantation from unrelated donors.
Ayuketang Ayuk, F., Diyachenko, G., Zabelina, T., Panse, J., Wolschke, C., Eiermann, T., Binder, T., Fehse, B., Erttmann, R., Kabisch, H., Bacher, U., Kröger, N. & Zander, A. R., 2008, In: EXP HEMATOL. 36, 8, p. 1047-1054 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cooperative genetic defects in TLX3 rearranged pediatric T-ALL.
Van Vlierberghe, P., Homminga, I., Zuurbier, L., Gladdines-Buijs, J., van Wering, E. R., Horstmann, M., Beverloo, H. B., Pieters, R. & Meijerink, J. P. P., 2008, In: LEUKEMIA. 22, 4, p. 762-770 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Detailed von Willebrand factor multimer analysis in patients with von Willebrand disease in the European study, molecular and clinical markers for the diagnosis and management of type 1 von Willebrand disease (MCMDM-1VWD).
Budde, U., Schneppenheim, R., Eikenboom, J., Goodeve, A., Will, K., Drewke, E., Castaman, G., Rodeghiero, F., Federici, A. B., Batlle, J., Pérez, A., Meyer, D., Mazurier, C., Goudemand, J., Ingerslev, J., Habart, D., Vorlova, Z., Holmberg, L., Lethagen, S., Pasi, J., Hill, F. & Peake, I., 2008, In: J THROMB HAEMOST. 6, 5, p. 762-771 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
EBV reactivation and post transplant lymphoproliferative disorders following allogeneic SCT.
Ocheni, S., Kröger, N., Zabelina, T., Sobottka, I., Ayuketang Ayuk, F., Wolschke, C., Muth, A., Lellek, H., Petersen, L., Erttmann, R., Kabisch, H., Zander, A. R. & Bacher, U., 2008, In: BONE MARROW TRANSPL. 42, 3, p. 181-186 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Emergence of linezolid resistance in a methicillin resistant Staphylococcus aureus strain.
Hentschke, M., Saager, B., Horstkotte, M. A., Scherpe, S., Wolters, M., Kabisch, H., Grosse, R., Heisig, P., Aepfelbacher, M. & Rohde, H., 2008, In: INFECTION. 36, 1, p. 85-87 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Erythrocytapheresis: Do Not Forget a Useful Therapy!
Ullrich, H., Fischer, R., Grosse, R., Kordes, U., Schubert, C., Altstadt, B. & Andreu, G., 2008, In: TRANSFUS MED HEMOTH. 35, 1, p. 24-30 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Frequency and spectrum of central nervous system involvement in 193 children with haemophagocytic lymphohistiocytosis.
Horne, A., Trottestam, H., Aricò, M., Egeler, R. M., Filipovich, A. H., Gadner, H., Imashuku, S., Ladisch, S., Webb, D., Janka-Schaub, G. & Henter, J-I., 2008, In: BRIT J HAEMATOL. 140, 3, p. 327-335 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic defects in von Willebrand disease type 3 in Indian and Greek patients.
Gupta, P. K., Saxena, R., Adamtziki, E., Budde, U., Oyen, F., Obser, T. & Schneppenheim, R., 2008, In: BLOOD CELL MOL DIS. 41, 2, p. 219-222 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis due to perforin mutations.
Trizzino, A., Zur Stadt, U., Ueda, I., Risma, K., Janka, G., Ishii, E., Beutel, K., Sumegi, J., Cannella, S., Pende, D., Mian, A., Henter, J-I., Janka-Schaub, G., Santoro, A., Filipovich, A. & Aricò, M., 2008, In: J MED GENET. 45, 1, p. 15-21 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia.
von Stackelberg, A., Hartmann, R., Bührer, C., Fengler, R., Janka-Schaub, G., Reiter, A., Mann, G., Schmiegelow, K., Ratei, R., Klingebiel, T., Ritter, J. & Henze, G., 2008, In: BLOOD. 111, 5, p. 2573-2580 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High expression of CD40 on B-cell precursor acute lymphoblastic leukemia blasts is an independent risk factor associated with improved survival and enhanced capacity to up-regulate the death receptor CD95.
Troeger, A., Glouchkova, L., Ackermann, B., Escherich, G., Meisel, R., Hanenberg, H., Boer, D., Monique, L., Janka-Schaub, G., Janka-Schaub, G. E., Goebel, U., Laws, H-J. & Dilloo, D., 2008, In: BLOOD. 112, 4, p. 1028-1034 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impact of reduction of therapy on infectious complications in childhood acute lymphoblastic leukemia.
Graubner, U. B., Porzig, S., Jorch, N., Kolb, R., Wessalowski, R., Escherich, G. & Janka-Schaub, G., 2008, In: PEDIATR BLOOD CANCER. 50, 2, p. 259-263 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Impaired capacity for acute endogenous fibrinolysis in smokers is restored by ascorbic acid.
Kähler, J., Koeke, K., Karstens, M., Schneppenheim, R., Meinertz, T. & Heitzer, T., 2008, In: FREE RADICAL BIO MED. 44, 3, p. 315-321 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review