Department of Pediatric Hematology and Oncology

Publications

  1. 2005
  2. Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas

    Schüller, U., Koch, A., Hartmann, W., Garrè, M. L., Goodyer, C. G., Cama, A., Sörensen, N., Wiestler, O. D. & Pietsch, T., 20.10.2005, In: INT J CANCER. 117, 1, p. 82-9 8 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  3. Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate

    McKinnell, C., Sharpe, R. M., Mahood, K., Hallmark, N., Scott, H., Ivell, R., Staub, C., Jégou, B., Haag, F., Koch-Nolte, F. & Hartung, S., 01.10.2005, In: ENDOCRINOLOGY. 146, 10, p. 4536-44 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  4. Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor

    De Gendt, K., Atanassova, N., Tan, K. A. L., de França, L. R., Parreira, G. G., McKinnell, C., Sharpe, R. M., Saunders, P. T. K., Mason, J. I., Hartung, S., Ivell, R., Denolet, E. & Verhoeven, G., 01.09.2005, In: ENDOCRINOLOGY. 146, 9, p. 4117-26 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  5. DHPLC based fraction collection of TCR-gamma rearrangements in childhood ALL: direct sequencing of products amplified by a single or a multiplex PCR approach.

    Zur Stadt, U., Isbarn, H., Schneppenheim, R. & Kabisch, H., 08.2005, In: INT J ONCOL. 27, 2, p. 547-552 6 p., 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  6. Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction

    Schilbach, K., Kerst, G., Walter, S., Eyrich, M., Wernet, D., Handgretinger, R., Xie, W., Rammensee, H-G., Müller, I., Bühring, H-J. & Niethammer, D., 01.07.2005, In: BLOOD. 106, 1, p. 144-9 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  7. Elevated expression of Wnt antagonists is a common event in hepatoblastomas

    Koch, A., Waha, A., Hartmann, W., Hrychyk, A., Schüller, U., Waha, A., Wharton, K. A., Fuchs, S. Y., von Schweinitz, D. & Pietsch, T., 15.06.2005, In: CLIN CANCER RES. 11, 12, p. 4295-304 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  8. Haemophilia A: from mutation analysis to new therapies

    Graw, J., Brackmann, H-H., Oldenburg, J., Schneppenheim, R., Spannagl, M. & Schwaab, R., 06.2005, In: NAT GENET. 6, 6, p. 488-501 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  9. Hämophilie B (Faktor-IX-Mangel) mit begleitender Faktor-XII-Erniedrigung bei einem Mischlingskater

    Lutze, G., Kutschmann, K., Fürst, K. & Schneppenheim, R., 28.05.2005, In: BERL MUNCH TIERARZTL. 118, 5-6, p. 255-60 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  10. Insulin-like factor 3 - where are we now?

    Ivell, R., Hartung, S. & Anand-Ivell, R., 01.05.2005, In: ANN NY ACAD SCI. 1041, p. 486-96 11 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearch

  11. The evolving classification of von Willebrand disease

    Schneppenheim, R., 01.04.2005, In: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 16 Suppl 1, p. S3-S10

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  12. Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells

    Hartmann, W., Koch, A., Brune, H., Waha, A., Schüller, U., Dani, I., Denkhaus, D., Langmann, W., Bode, U., Wiestler, O. D., Schilling, K. & Pietsch, T., 04.2005, In: AM J PATHOL. 166, 4, p. 1153-62 10 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  13. Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR

    Kerst, G., Kreyenberg, H., Roth, C., Well, C., Dietz, K., Coustan-Smith, E., Campana, D., Koscielniak, E., Niemeyer, C., Schlegel, P. G., Müller, I., Niethammer, D. & Bader, P., 03.2005, In: BRIT J HAEMATOL. 128, 6, p. 774-82 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  14. Hemophagocytic lymphohistiocytosis

    Janka-Schaub, G., 01.01.2005, In: HEMATOLOGY. 10 Suppl 1, p. 104-7 4 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  15. Phenotypic and genotypic diagnosis of von Willebrand disease: a 2004 update

    Schneppenheim, R. & Budde, U., 01.2005, In: SEMIN HEMATOL. 42, 1, p. 15-28 14 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  16. Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.

    Horstmann, M., Hassenpflug, W-A., Udo, Z. S., Escherich, G., Janka-Schaub, G. & Kabisch, H., 2005, In: HAEMATOLOGICA. 90, 12, p. 1701-1703 12.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  17. Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia.

    Stams, W. A. G., Boer, D., Monique, L., Holleman, A., Appel, I. M., Beverloo, H. B., Janka-Schaub, G., Elisabeth, R., Janka-Schaub, G. E., Evans, W. E. & Pieters, R., 2005, In: BLOOD. 105, 11, p. 4223-4225 11.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  18. [Bacterial infections in pediatric cancer patients]

    Simon, A., Beutel, K., Marklein, G. & Fleischhack, G., 2005, In: KLIN PADIATR. 217, 1, p. 17-36 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  19. Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia.

    Holleman, A., Boer, D., Monique, L., Kazemier, K. M., Beverloo, H. B., Janka-Schaub, G., Anne, R. M., Janka-Schaub, G. E. & Pieters, R., 2005, In: BLOOD. 106, 5, p. 1817-1823 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  20. Decreased plasma concentration of von Willebrand factor antigen (VWF:Ag) in patients with glycogen storage disease type Ia

    Mühlhausen, C., Schneppenheim, R., Budde, U., Merkel, M., Muschol, N., Ullrich, K. & Santer, R., 2005, In: J INHERIT METAB DIS. 28, 6, p. 945-950 6 p., 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  21. [Diagnostics and management of central venous line infections in pediatric cancer patients]

    Beutel, K. & Simon, A., 2005, In: KLIN PADIATR. 217, 1, p. 91-100 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  22. Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia.

    Stams, U., Wendy, A. G., Den, B., Monique, L., Beverloo, U., Berna, H., Kazemier, U., Karin, M., Wering, V., Elisabeth, R., Janka-Schaub, G., Gritta, E., Pieters, U. & Rob, U., 2005, In: HAEMATOLOGICA. 90, 12, p. 1697-1699 12.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  23. Expression levels of TEL, AML1, and the fusion products TEL-AML1 and AML1-TEL versus drug sensitivity and clinical outcome in t(12;21)-positive pediatric acute lymphoblastic leukemia.

    Stams, U., Wendy, A. G., Den, B., Monique, L., Beverloo, U., Berna, H., Meijerink, U., Jules, P. P., Wering, V., Elisabeth, R., Janka-Schaub, G., Gritta, E., Pieters, U. & Rob, U., 2005, In: CLIN CANCER RES. 11, 8, p. 2974-2980 8.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  24. Familial and acquired hemophagocytic lymphohistiocytosis.

    Janka-Schaub, G. & Udo, Z. S., 2005, In: HEMATOL-AM SOC HEMAT. p. 82-88

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  25. Gene conversions are a common cause of von Willebrand disease.

    Gupta, P. K., Adamtziki, E., Budde, U., Jaiprakash, M., Kumar, H., Harbeck-Seu, A., Kannan, M., Oyen, F., Obser, T., Wedekind, I., Saxena, R. & Schneppenheim, R., 2005, In: BRIT J HAEMATOL. 130, 5, p. 752-758 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  26. Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis.

    Horne, A., Janka-Schaub, G., Maarten Egeler, R., Gadner, H., Imashuku, S., Ladisch, S., Locatelli, F., Montgomery, S. M., Webb, D., Winiarski, J., Filipovich, A. H. & Henter, J-I., 2005, In: BRIT J HAEMATOL. 129, 5, p. 622-630 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  27. Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.

    Lugthart, S., Cheok, M. H., Boer, D., Monique, L., Yang, W., Holleman, A., Cheng, C., Pui, C-H., Janka-Schaub, G., Janka-Schaub, G. E., Pieters, R. & Evans, W. E., 2005, In: CANCER CELL. 7, 4, p. 375-386 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  28. Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival.

    Führer, M., Rampf, U., Baumann, I., Faldum, A., Niemeyer, C., Janka-Schaub, G., Friedrich, W., Ebell, W., Borkhardt, A. & Bender-Goetze, C., 2005, In: BLOOD. 106, 6, p. 2102-2104 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  29. Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes.

    Khalil, M. N., Erb, N., Khalil, P. N., Escherich, G. & Janka-Schaub, G. E., 2005, In: J CHROMATOGR B. 821, 1, p. 105-111 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  30. Langerhans cell histiocytosis in neonates.

    Minkov, M., Prosch, H., Steiner, M., Grois, N., Pötschger, U., Kaatsch, P., Janka-Schaub, G. & Gadner, H., 2005, In: PEDIATR BLOOD CANCER. 45, 6, p. 802-807 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  31. Ligands for the peroxisome proliferator-activated receptor-gamma have inhibitory effects on growth of human neuroblastoma cells in vitro.

    Valentiner, U., Carlsson, M., Erttmann, R., Hildebrandt, H. & Schumacher, U., 2005, In: TOXICOLOGY. 213, 1-2, p. 157-168 1-2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  32. Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11.

    Udo, Z. S., Schmidt, S., Kasper, B., Beutel, K., Diler, A. S., Henter, J-I., Kabisch, H., Schneppenheim, R., Nürnberg, P., Janka-Schaub, G. & Hennies, H. C., 2005, In: HUM MOL GENET. 14, 6, p. 827-834 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  33. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87.

    Einsiedel, H. G., von Stackelberg, A., Hartmann, R., Fengler, R., Schrappe, M., Janka-Schaub, G., Mann, G., Hählen, K., Göbel, U., Klingebiel, T., Ludwig, W-D. & Henze, G., 2005, In: J CLIN ONCOL. 23, 31, p. 7942-7950 31.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  34. Long-term treatment with deferiprone in a L1 veteran.

    Meo, A., Ruggeri, A., Rosa, L., Angela, M., Kordes, U., Kordes, U. & Fischer, R., 2005, In: EUR J HAEMATOL. 74, 6, p. 523-525 6.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  35. Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial.

    Berthold, F., Boos, J., Burdach, S., Erttmann, R., Henze, G., Hermann, J., Klingebiel, T., Kremens, B., Schilling, F. H., Schrappe, M., Simon, T. & Hero, B., 2005, In: LANCET ONCOL. 6, 9, p. 649-658 9.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  36. Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major.

    Grosse, R., Lund, U., Caruso, V., Fischer, R., Janka-Schaub, G., Magnano, C., Engelhardt, R., Dürken, M. & Nielsen, P., 2005, In: ANN NY ACAD SCI. 1054, p. 429-432

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  37. Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes.

    Hellwinkel, O., Müller, J., Pollmann, A. & Kabisch, H., 2005, In: J GENE MED. 7, 4, p. 407-419 4.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  38. Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia.

    Meier, M., den Boer, M. L., Hall, A. G., Irving, J. A. E., Passier, M., Minto, L., van Wering, E. R., Janka-Schaub, G. & Pieters, R., 2005, In: LEUKEMIA. 19, 11, p. 1887-1895 11.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  39. Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells.

    Bardenheuer, W., Lehmberg, K., Rattmann, I., Brueckner, A., Schneider, A., Sorg, U. R., Seeber, S., Moritz, T. & Flasshove, M., 2005, In: LEUKEMIA. 19, 12, p. 2281-2288 12.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  40. Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse.

    Kordes, U., Cheng, Y-C. & Scotting, P. J., 2005, In: DEV BRAIN RES. 157, 2, p. 209-213 2.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  41. Subtyping of natural killer cell cytotoxicity deficiencies in haemophagocytic lymphohistocytosis provides therapeutic guidance.

    Horne, A., Zheng, C., Lorenz, I., Löfstedt, M., Montgomery, S. M., Janka-Schaub, G., Henter, J-I. & Marion Schneider, E., 2005, In: BRIT J HAEMATOL. 129, 5, p. 658-666 5.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  42. Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia.

    Stam, R. W., Boer, D., Monique, L., Schneider, P., Horstmann, M., Horstmann, M., Beverloo, H. B., van der Voort, E., Valsecchi, M. G., de Lorenzo, P., Sallan, S. E., Armstrong, S. A. & Pieters, R., 2005, In: BLOOD. 106, 7, p. 2484-2490 7.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  43. The seventh international childhood acute lymphoblastic leukemia workshop report: Palermo, Italy, January 29--30, 2005.

    Aricó, M., Baruchel, A., Bertrand, Y., Biondi, A., Conter, V., Eden, T., Gadner, H., Gaynon, P., Horibe, K., Hunger, S. P., Janka-Schaub, G., Masera, G., Nachman, J., Pieters, R., Schrappe, M., Schmiegelow, K., Valsecchi, M. G. & Pui, C-H., 2005, In: LEUKEMIA. 19, 7, p. 1145-1152 7.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  44. [Viral infections in pediatric cancer patients]

    Schuster, F. R., Simon, A., Laws, H-J., Beutel, K., Groll, A. H., Jäger, G. & Schuster, V., 2005, In: KLIN PADIATR. 217, 1, p. 67-84 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  45. 2004
  46. Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation

    Otto, M., Barfield, R. C., Iyengar, R., Gatewood, J., Müller, I., Holladay, M. S., Houston, J., Leung, W. & Handgretinger, R., 23.12.2004, In: J IMMUNOTHER. 28, 1, p. 73-8 6 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  47. Bcl-2 expression inversely correlates with tumour cell differentiation in medulloblastoma

    Schüller, U., Schober, F., Kretzschmar, H. A. & Herms, J., 10.2004, In: NEUROPATH APPL NEURO. 30, 5, p. 513-21 9 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  48. Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)

    Licht, C., Stapenhorst, L., Simon, T., Budde, U., Schneppenheim, R. & Hoppe, B., 01.09.2004, In: KIDNEY INT. 66, 3, p. 955-8 4 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  49. Recombinant expression of mutations causing von Willebrand disease type Normandy: characterization of a combined defect of factor VIII binding and multimerization.

    Schneppenheim, R., Lenk, H., Obser, T., Oldenburg, J., Oyen, F., Schneppenheim, S., Schwaab, R., Will, K. & Budde, U., 07.2004, In: THROMB HAEMOSTASIS. 92, 1, p. 36-41 6 p., 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  50. Glycosylation and lectins-examples of immunesurveillance and immune evasion

    Müller, I., Jenner, J., Handgretinger, R., Riberdy, J. & Kerst, G., 04.2004, In: HISTOL HISTOPATHOL. 19, 2, p. 527-33 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  51. Diagnose der thrombotisch-thrombozytopenischen Purpura

    Budde, U., Angerhaus, D., Obser, T. & Schneppenheim, R., 01.02.2004, In: HAMOSTASEOLOGIE. 24, 1, p. 65-70 6 p., 1.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

  52. Molekulare Genetik des von-Willebrand-Syndroms

    Schneppenheim, R., 01.02.2004, In: HAMOSTASEOLOGIE. 24, 1, p. 37-43 7 p.

    Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review