Department of Pediatric Hematology and Oncology
Publications
- 2005
Subtype-specific expression and genetic alterations of the chemokinereceptor gene CXCR4 in medulloblastomas
Schüller, U., Koch, A., Hartmann, W., Garrè, M. L., Goodyer, C. G., Cama, A., Sörensen, N., Wiestler, O. D. & Pietsch, T., 20.10.2005, In: INT J CANCER. 117, 1, p. 82-9 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate
McKinnell, C., Sharpe, R. M., Mahood, K., Hallmark, N., Scott, H., Ivell, R., Staub, C., Jégou, B., Haag, F., Koch-Nolte, F. & Hartung, S., 01.10.2005, In: ENDOCRINOLOGY. 146, 10, p. 4536-44 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor
De Gendt, K., Atanassova, N., Tan, K. A. L., de França, L. R., Parreira, G. G., McKinnell, C., Sharpe, R. M., Saunders, P. T. K., Mason, J. I., Hartung, S., Ivell, R., Denolet, E. & Verhoeven, G., 01.09.2005, In: ENDOCRINOLOGY. 146, 9, p. 4117-26 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
DHPLC based fraction collection of TCR-gamma rearrangements in childhood ALL: direct sequencing of products amplified by a single or a multiplex PCR approach.
Zur Stadt, U., Isbarn, H., Schneppenheim, R. & Kabisch, H., 08.2005, In: INT J ONCOL. 27, 2, p. 547-552 6 p., 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction
Schilbach, K., Kerst, G., Walter, S., Eyrich, M., Wernet, D., Handgretinger, R., Xie, W., Rammensee, H-G., Müller, I., Bühring, H-J. & Niethammer, D., 01.07.2005, In: BLOOD. 106, 1, p. 144-9 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Elevated expression of Wnt antagonists is a common event in hepatoblastomas
Koch, A., Waha, A., Hartmann, W., Hrychyk, A., Schüller, U., Waha, A., Wharton, K. A., Fuchs, S. Y., von Schweinitz, D. & Pietsch, T., 15.06.2005, In: CLIN CANCER RES. 11, 12, p. 4295-304 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Haemophilia A: from mutation analysis to new therapies
Graw, J., Brackmann, H-H., Oldenburg, J., Schneppenheim, R., Spannagl, M. & Schwaab, R., 06.2005, In: NAT GENET. 6, 6, p. 488-501 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hämophilie B (Faktor-IX-Mangel) mit begleitender Faktor-XII-Erniedrigung bei einem Mischlingskater
Lutze, G., Kutschmann, K., Fürst, K. & Schneppenheim, R., 28.05.2005, In: BERL MUNCH TIERARZTL. 118, 5-6, p. 255-60 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Insulin-like factor 3 - where are we now?
Ivell, R., Hartung, S. & Anand-Ivell, R., 01.05.2005, In: ANN NY ACAD SCI. 1041, p. 486-96 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
The evolving classification of von Willebrand disease
Schneppenheim, R., 01.04.2005, In: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 16 Suppl 1, p. S3-S10Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells
Hartmann, W., Koch, A., Brune, H., Waha, A., Schüller, U., Dani, I., Denkhaus, D., Langmann, W., Bode, U., Wiestler, O. D., Schilling, K. & Pietsch, T., 04.2005, In: AM J PATHOL. 166, 4, p. 1153-62 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR
Kerst, G., Kreyenberg, H., Roth, C., Well, C., Dietz, K., Coustan-Smith, E., Campana, D., Koscielniak, E., Niemeyer, C., Schlegel, P. G., Müller, I., Niethammer, D. & Bader, P., 03.2005, In: BRIT J HAEMATOL. 128, 6, p. 774-82 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hemophagocytic lymphohistiocytosis
Janka-Schaub, G., 01.01.2005, In: HEMATOLOGY. 10 Suppl 1, p. 104-7 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Phenotypic and genotypic diagnosis of von Willebrand disease: a 2004 update
Schneppenheim, R. & Budde, U., 01.2005, In: SEMIN HEMATOL. 42, 1, p. 15-28 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children.
Horstmann, M., Hassenpflug, W-A., Udo, Z. S., Escherich, G., Janka-Schaub, G. & Kabisch, H., 2005, In: HAEMATOLOGICA. 90, 12, p. 1701-1703 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia.
Stams, W. A. G., Boer, D., Monique, L., Holleman, A., Appel, I. M., Beverloo, H. B., Janka-Schaub, G., Elisabeth, R., Janka-Schaub, G. E., Evans, W. E. & Pieters, R., 2005, In: BLOOD. 105, 11, p. 4223-4225 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
[Bacterial infections in pediatric cancer patients]
Simon, A., Beutel, K., Marklein, G. & Fleischhack, G., 2005, In: KLIN PADIATR. 217, 1, p. 17-36 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia.
Holleman, A., Boer, D., Monique, L., Kazemier, K. M., Beverloo, H. B., Janka-Schaub, G., Anne, R. M., Janka-Schaub, G. E. & Pieters, R., 2005, In: BLOOD. 106, 5, p. 1817-1823 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Decreased plasma concentration of von Willebrand factor antigen (VWF:Ag) in patients with glycogen storage disease type Ia
Mühlhausen, C., Schneppenheim, R., Budde, U., Merkel, M., Muschol, N., Ullrich, K. & Santer, R., 2005, In: J INHERIT METAB DIS. 28, 6, p. 945-950 6 p., 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
[Diagnostics and management of central venous line infections in pediatric cancer patients]
Beutel, K. & Simon, A., 2005, In: KLIN PADIATR. 217, 1, p. 91-100 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Effect of the histone deacetylase inhibitor depsipeptide on B-cell differentiation in both TEL-AML1-positive and negative childhood acute lymphoblastic leukemia.
Stams, U., Wendy, A. G., Den, B., Monique, L., Beverloo, U., Berna, H., Kazemier, U., Karin, M., Wering, V., Elisabeth, R., Janka-Schaub, G., Gritta, E., Pieters, U. & Rob, U., 2005, In: HAEMATOLOGICA. 90, 12, p. 1697-1699 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Expression levels of TEL, AML1, and the fusion products TEL-AML1 and AML1-TEL versus drug sensitivity and clinical outcome in t(12;21)-positive pediatric acute lymphoblastic leukemia.
Stams, U., Wendy, A. G., Den, B., Monique, L., Beverloo, U., Berna, H., Meijerink, U., Jules, P. P., Wering, V., Elisabeth, R., Janka-Schaub, G., Gritta, E., Pieters, U. & Rob, U., 2005, In: CLIN CANCER RES. 11, 8, p. 2974-2980 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Familial and acquired hemophagocytic lymphohistiocytosis.
Janka-Schaub, G. & Udo, Z. S., 2005, In: HEMATOL-AM SOC HEMAT. p. 82-88Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gene conversions are a common cause of von Willebrand disease.
Gupta, P. K., Adamtziki, E., Budde, U., Jaiprakash, M., Kumar, H., Harbeck-Seu, A., Kannan, M., Oyen, F., Obser, T., Wedekind, I., Saxena, R. & Schneppenheim, R., 2005, In: BRIT J HAEMATOL. 130, 5, p. 752-758 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis.
Horne, A., Janka-Schaub, G., Maarten Egeler, R., Gadner, H., Imashuku, S., Ladisch, S., Locatelli, F., Montgomery, S. M., Webb, D., Winiarski, J., Filipovich, A. H. & Henter, J-I., 2005, In: BRIT J HAEMATOL. 129, 5, p. 622-630 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia.
Lugthart, S., Cheok, M. H., Boer, D., Monique, L., Yang, W., Holleman, A., Cheng, C., Pui, C-H., Janka-Schaub, G., Janka-Schaub, G. E., Pieters, R. & Evans, W. E., 2005, In: CANCER CELL. 7, 4, p. 375-386 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival.
Führer, M., Rampf, U., Baumann, I., Faldum, A., Niemeyer, C., Janka-Schaub, G., Friedrich, W., Ebell, W., Borkhardt, A. & Bender-Goetze, C., 2005, In: BLOOD. 106, 6, p. 2102-2104 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes.
Khalil, M. N., Erb, N., Khalil, P. N., Escherich, G. & Janka-Schaub, G. E., 2005, In: J CHROMATOGR B. 821, 1, p. 105-111 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Langerhans cell histiocytosis in neonates.
Minkov, M., Prosch, H., Steiner, M., Grois, N., Pötschger, U., Kaatsch, P., Janka-Schaub, G. & Gadner, H., 2005, In: PEDIATR BLOOD CANCER. 45, 6, p. 802-807 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Ligands for the peroxisome proliferator-activated receptor-gamma have inhibitory effects on growth of human neuroblastoma cells in vitro.
Valentiner, U., Carlsson, M., Erttmann, R., Hildebrandt, H. & Schumacher, U., 2005, In: TOXICOLOGY. 213, 1-2, p. 157-168 1-2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11.
Udo, Z. S., Schmidt, S., Kasper, B., Beutel, K., Diler, A. S., Henter, J-I., Kabisch, H., Schneppenheim, R., Nürnberg, P., Janka-Schaub, G. & Hennies, H. C., 2005, In: HUM MOL GENET. 14, 6, p. 827-834 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Münster Group 87.
Einsiedel, H. G., von Stackelberg, A., Hartmann, R., Fengler, R., Schrappe, M., Janka-Schaub, G., Mann, G., Hählen, K., Göbel, U., Klingebiel, T., Ludwig, W-D. & Henze, G., 2005, In: J CLIN ONCOL. 23, 31, p. 7942-7950 31.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Long-term treatment with deferiprone in a L1 veteran.
Meo, A., Ruggeri, A., Rosa, L., Angela, M., Kordes, U., Kordes, U. & Fischer, R., 2005, In: EUR J HAEMATOL. 74, 6, p. 523-525 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial.
Berthold, F., Boos, J., Burdach, S., Erttmann, R., Henze, G., Hermann, J., Klingebiel, T., Kremens, B., Schilling, F. H., Schrappe, M., Simon, T. & Hero, B., 2005, In: LANCET ONCOL. 6, 9, p. 649-658 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major.
Grosse, R., Lund, U., Caruso, V., Fischer, R., Janka-Schaub, G., Magnano, C., Engelhardt, R., Dürken, M. & Nielsen, P., 2005, In: ANN NY ACAD SCI. 1054, p. 429-432Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes.
Hellwinkel, O., Müller, J., Pollmann, A. & Kabisch, H., 2005, In: J GENE MED. 7, 4, p. 407-419 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia.
Meier, M., den Boer, M. L., Hall, A. G., Irving, J. A. E., Passier, M., Minto, L., van Wering, E. R., Janka-Schaub, G. & Pieters, R., 2005, In: LEUKEMIA. 19, 11, p. 1887-1895 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells.
Bardenheuer, W., Lehmberg, K., Rattmann, I., Brueckner, A., Schneider, A., Sorg, U. R., Seeber, S., Moritz, T. & Flasshove, M., 2005, In: LEUKEMIA. 19, 12, p. 2281-2288 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Sox group E gene expression distinguishes different types and maturational stages of glial cells in developing chick and mouse.
Kordes, U., Cheng, Y-C. & Scotting, P. J., 2005, In: DEV BRAIN RES. 157, 2, p. 209-213 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Subtyping of natural killer cell cytotoxicity deficiencies in haemophagocytic lymphohistocytosis provides therapeutic guidance.
Horne, A., Zheng, C., Lorenz, I., Löfstedt, M., Montgomery, S. M., Janka-Schaub, G., Henter, J-I. & Marion Schneider, E., 2005, In: BRIT J HAEMATOL. 129, 5, p. 658-666 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia.
Stam, R. W., Boer, D., Monique, L., Schneider, P., Horstmann, M., Horstmann, M., Beverloo, H. B., van der Voort, E., Valsecchi, M. G., de Lorenzo, P., Sallan, S. E., Armstrong, S. A. & Pieters, R., 2005, In: BLOOD. 106, 7, p. 2484-2490 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The seventh international childhood acute lymphoblastic leukemia workshop report: Palermo, Italy, January 29--30, 2005.
Aricó, M., Baruchel, A., Bertrand, Y., Biondi, A., Conter, V., Eden, T., Gadner, H., Gaynon, P., Horibe, K., Hunger, S. P., Janka-Schaub, G., Masera, G., Nachman, J., Pieters, R., Schrappe, M., Schmiegelow, K., Valsecchi, M. G. & Pui, C-H., 2005, In: LEUKEMIA. 19, 7, p. 1145-1152 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
[Viral infections in pediatric cancer patients]
Schuster, F. R., Simon, A., Laws, H-J., Beutel, K., Groll, A. H., Jäger, G. & Schuster, V., 2005, In: KLIN PADIATR. 217, 1, p. 67-84 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2004
Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation
Otto, M., Barfield, R. C., Iyengar, R., Gatewood, J., Müller, I., Holladay, M. S., Houston, J., Leung, W. & Handgretinger, R., 23.12.2004, In: J IMMUNOTHER. 28, 1, p. 73-8 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Bcl-2 expression inversely correlates with tumour cell differentiation in medulloblastoma
Schüller, U., Schober, F., Kretzschmar, H. A. & Herms, J., 10.2004, In: NEUROPATH APPL NEURO. 30, 5, p. 513-21 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)
Licht, C., Stapenhorst, L., Simon, T., Budde, U., Schneppenheim, R. & Hoppe, B., 01.09.2004, In: KIDNEY INT. 66, 3, p. 955-8 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Recombinant expression of mutations causing von Willebrand disease type Normandy: characterization of a combined defect of factor VIII binding and multimerization.
Schneppenheim, R., Lenk, H., Obser, T., Oldenburg, J., Oyen, F., Schneppenheim, S., Schwaab, R., Will, K. & Budde, U., 07.2004, In: THROMB HAEMOSTASIS. 92, 1, p. 36-41 6 p., 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Glycosylation and lectins-examples of immunesurveillance and immune evasion
Müller, I., Jenner, J., Handgretinger, R., Riberdy, J. & Kerst, G., 04.2004, In: HISTOL HISTOPATHOL. 19, 2, p. 527-33 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Diagnose der thrombotisch-thrombozytopenischen Purpura
Budde, U., Angerhaus, D., Obser, T. & Schneppenheim, R., 01.02.2004, In: HAMOSTASEOLOGIE. 24, 1, p. 65-70 6 p., 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Molekulare Genetik des von-Willebrand-Syndroms
Schneppenheim, R., 01.02.2004, In: HAMOSTASEOLOGIE. 24, 1, p. 37-43 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review