MD PI / Group Leader ID: 49836
Diego Sepulveda-Falla
Publications
- 2024
Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases
Song, F., Kovac, V., Mohammadi, B., Littau, J. L., Scharfenberg, F., Matamoros Angles, A., Vanni, I., Shafiq, M., Orge, L., Galliciotti, G., Djakkani, S., Linsenmeier, L., Černilec, M., Hartman, K., Jung, S., Tatzelt, J., Neumann, J. E., Damme, M., Tschirner, S. K., Lichtenthaler, S. F., Ricklefs, F. L., Sauvigny, T., Schmitz, M., Zerr, I., Puig, B., Tolosa, E., Ferrer, I., Magnus, T., Rupnik, M. S., Sepulveda-Falla, D., Matschke, J., Šmid, L. M., Bresjanac, M., Andreoletti, O., Krasemann, S., Foliaki, S. T., Nonno, R., Becker-Pauly, C., Monzo, C., Crozet, C., Haigh, C. L., Glatzel, M., Curin Serbec, V. & Altmeppen, H. C., 09.07.2024, In: ACTA NEUROPATHOL. 148, 1, p. 2Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease
Quiroz, Y. T., Aguillon, D., Aguirre-Acevedo, D. C., Vasquez, D., Zuluaga, Y., Baena, A. Y., Madrigal, L., Hincapié, L., Sanchez, J. S., Langella, S., Posada-Duque, R., Littau, J. L., Villalba-Moreno, N. D., Vila-Castelar, C., Ramirez Gomez, L., Garcia, G., Kaplan, E., Rassi Vargas, S., Ossa, J. A., Valderrama-Carmona, P., Perez-Corredor, P., Krasemann, S., Glatzel, M., Kosik, K. S., Johnson, K., Sperling, R. A., Reiman, E. M., Sepulveda-Falla, D., Lopera, F. & Arboleda-Velasquez, J. F., 20.06.2024, In: NEW ENGL J MED. 390, 23, p. 2156-2164 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Single-nucleus RNA sequencing demonstrates an autosomal dominant Alzheimer's disease profile and possible mechanisms of disease protection
Almeida, M. C., Eger, S. J., He, C., Audouard, M., Nikitina, A., Glasauer, S. M. K., Han, D., Mejía-Cupajita, B., Acosta-Uribe, J., Villalba-Moreno, N. D., Littau, J. L., Elcheikhali, M., Rivera, E. K., Carrettiero, D. C., Villegas-Lanau, C. A., Sepulveda-Falla, D., Lopera, F. & Kosik, K. S., 05.06.2024, In: NEURON. 112, 11, p. 1778-1794.e7Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The 2022 symposium on dementia and brain aging in low- and middle-income countries: Highlights on research, diagnosis, care, and impact
Kalaria, R., Maestre, G., Mahinrad, S., Acosta, D. M., Akinyemi, R. O., Alladi, S., Allegri, R. F., Arshad, F., Babalola, D. O., Baiyewu, O., Bak, T. H., Bellaj, T., Brodie-Mends, D. K., Carrillo, M. C., Celestin, K-K-M., Damasceno, A., de Silva, R. K., de Silva, R., Djibuti, M., Dreyer, A. J., Ellajosyula, R., Farombi, T. H., Friedland, R. P., Garza, N., Gbessemehlan, A., Georgiou, E. E-Z., Govia, I., Grinberg, L. T., Guerchet, M., Gugssa, S. A., Gumikiriza-Onoria, J. L., Hogervorst, E., Hornberger, M., Ibanez, A., Ihara, M., Issac, T. G., Jönsson, L., Karanja, W. M., Lee, J. H., Leroi, I., Livingston, G., Manes, F. F., Mbakile-Mahlanza, L., Miller, B. L., Musyimi, C. W., Mutiso, V. N., Nakasujja, N., Ndetei, D. M., Nightingale, S., Novotni, G., Nyamayaro, P., Nyame, S., Ogeng'o, J. A., Ogunniyi, A., de Oliveira, M. O., Okubadejo, N. U., Orrell, M., Paddick, S-M., Pericak-Vance, M. A., Pirtosek, Z., Potocnik, F. C. V., Raman, R., Rizig, M., Rosselli, M., Salokhiddinov, M., Satizabal, C. L., Sepulveda-Falla, D., Seshadri, S., Sexton, C. E., Skoog, I., George-Hyslop, P. H. S., Suemoto, C. K., Thapa, P., Udeh-Momoh, C. T., Valcour, V., Vance, J. M., Varghese, M., Vera, J. H., Walker, R. W., Zetterberg, H., Zewde, Y. Z. & Ismail, O., 06.2024, In: ALZHEIMERS DEMENT. 20, 6, p. 4290-4314 25 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Genetic modifiers of cognitive decline in PSEN1 E280A Alzheimer's disease
Sepulveda-Falla, D., Vélez, J. I., Acosta-Baena, N., Baena, A., Moreno, S., Krasemann, S., Lopera, F., Mastronardi, C. A. & Arcos-Burgos, M., 04.2024, In: ALZHEIMERS DEMENT. 20, 4, p. 2873-2885 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
APOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation
Marino, C., Perez-Corredor, P., O'Hare, M., Heuer, A., Chmielewska, N., Gordon, H., Chandrahas, A. S., Gonzalez-Buendia, L., Delgado-Tirado, S., Doan, T. H., Vanderleest, T. E., Arevalo-Alquichire, S., Obar, R. A., Ortiz-Cordero, C., Villegas, A., Sepulveda-Falla, D., Kim, L. A., Lopera, F., Mahley, R., Huang, Y., Quiroz, Y. T. & Arboleda-Velasquez, J. F., 02.2024, In: ALZHEIMERS DEMENT. 20, 2, p. 819-836 18 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer's cases
Perez-Corredor, P., Vanderleest, T. E., Vacano, G. N., Sanchez, J. S., Villalba-Moreno, N. D., Marino, C., Krasemann, S., Mendivil-Perez, M. A., Aguillón, D., Jiménez-Del-Río, M., Baena, A., Sepulveda-Falla, D., Lopera, F., Quiroz, Y. T., Arboleda-Velasquez, J. F. & Mazzarino, R. C., 2024, In: FRONT MOL NEUROSCI. 17, p. 1373568Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2023
Comorbidities in Early-Onset Sporadic versus Presenilin-1 Mutation-Associated Alzheimer's Disease Dementia: Evidence for Dependency on Alzheimer's Disease Neuropathological Changes
Sepulveda-Falla, D., Villegas Lanau, C. A., White, C., Serrano, G. E., Acosta-Uribe, J., Mejía-Cupajita, B., Villalba-Moreno, N. D., Lu, P., Glatzel, M., Kofler, J. K., Ghetti, B., Frosch, M. P., Lopera Restrepo, F., Kosik, K. S. & Beach, T. G., 16.08.2023, In: medRxiv.Research output: SCORING: Contribution to journal › Preprint › Research
Resistant and Resilient mutations in protection against familial Alzheimer's disease: learning from nature
Sepulveda-Falla, D., 01.06.2023, In: MOL NEURODEGENER. 18, 1, p. 36Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics
Panahi, M., Hase, Y., Gallart-Palau, X., Mitra, S., Watanabe, A., Low, R. C., Yamamoto, Y., Sepulveda-Falla, D., Hainsworth, A. H., Ihara, M., Sze, S. K., Viitanen, M., Behbahani, H. & Kalaria, R. N., 08.05.2023, In: ACTA NEUROPATHOL COM. 11, 1, p. 76Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous man
Lopera, F., Marino, C., Chandrahas, A. S., O'Hare, M., Villalba-Moreno, N. D., Aguillon, D., Baena, A., Sanchez, J. S., Vila-Castelar, C., Ramirez Gomez, L., Chmielewska, N., Oliveira, G. M., Littau, J. L., Hartmann, K., Park, K., Krasemann, S., Glatzel, M., Schoemaker, D., Gonzalez-Buendia, L., Delgado-Tirado, S., Arevalo-Alquichire, S., Saez-Torres, K. L., Amarnani, D., Kim, L. A., Mazzarino, R. C., Gordon, H., Bocanegra, Y., Villegas, A., Gai, X., Bootwalla, M., Ji, J., Shen, L., Kosik, K. S., Su, Y., Chen, Y., Schultz, A., Sperling, R. A., Johnson, K., Reiman, E. M., Sepulveda-Falla, D., Arboleda-Velasquez, J. F. & Quiroz, Y. T., 05.2023, In: NAT MED. 29, 5, p. 1243-1252 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs
Maestre, G., Carrillo, M., Kalaria, R., Acosta, D., Adams, L., Adoukonou, T., Akinwande, K., Akinyemi, J., Akinyemi, R., Akpa, O., Alladi, S., Allegri, R., Arizaga, R., Arshad, F., Arulogun, O., Babalola, D., Baiyewu, O., Bak, T., Bellaj, T., Boshe, J., Brayne, C., Brodie-Mends, D., Brown, R., Cahn, J., Cyrille, N., Damasceno, A., de Silva, R., de Silva, R., Djibuti, M., Dreyer, A. J., Ellajosyula, R., Farombi, T., Fongang, B., Forner, S., Friedland, R., Garza, N., Gbessemehlan, A., Georgiou, E. E-Z., Gouider, R., Govia, I., Grinberg, L., Guerchet, M., Gugssa, S., Gumikiriza-Onoria, J. L., Gustafson, D., Hogervorst, E., Hornberger, M., Ibanez, A., Ihara, M., Ismail, O., Issac, T., Jönsson, L., Kaputu, C., Karanja, W., Karungi, J., Tshala-Katumbay, D., Kunkle, B., Lee, J. H., Leroi, I., Lewis, R., Livingston, G., Lopera, F., Lwere, K., Manes, F., Mbakile-Mahlanza, L., Mena, P., Miller, B., Millogo, A., Mohamed, A., Musyimi, C., Mutiso, V., Nakasujja, N., Ndetei, D., Nightingale, S., Njamnshi, A. K., Novotni, G., Nyamayaro, P., Nyame, S., Ogeng'o, J., Ogunniyi, A., Okada De Oliveira, M., Okubadejo, N., Orrell, M., Orunmuyi, A., Owolabi, M., Paddick, S., A Pericak-Vance, M., Pirtosek, Z., Potocnik, F., Preston, B., Raman, R., Ranchod, K., Rizig, M., Rosselli, M., Deepa, R., Roy, U., Salokhiddinov, M., Sano, M., Sarfo, F., Satizabal, C. L., Sepulveda-Falla, D., Seshadri, S., Sexton, C., Skoog, I., St George-Hyslop, P., Suemoto, C., Tanner, J., Thapa, P., Toure, K., Ucheagwu, V., Udeh-Momoh, C., Valcour, V., Vance, J., Varghese, M., Vera, J., Walker, R., Weidner, W., Sebastian, W., Whitehead Gay, P., Zetterberg, H., Zewde, Y. & African Dementia Consortium, 11.03.2023, In: ALZHEIMERS DEMENT. 19, 3, p. 1105-1108 4 p.Research output: SCORING: Contribution to journal › Editorial › Research
Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection
Henao-Restrepo, J., López-Murillo, C., Valderrama-Carmona, P., Orozco-Santa, N., Gomez, J., Gutiérrez-Vargas, J., Moraga, R., Toledo, J., Littau, J. L., Härtel, S., Arboleda-Velásquez, J. F., Sepulveda-Falla, D., Lopera, F., Cardona-Gómez, G. P., Villegas, A. & Posada-Duque, R., 03.2023, In: BRAIN PATHOL. 33, 2, p. e13119Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Early Depressive Symptoms Predict Faster Dementia Progression in Autosomal-Dominant Alzheimer's Disease
Acosta-Baena, N., Lopera-Gómez, C. M., Jaramillo-Elorza, M. C., Velilla-Jiménez, L., Villegas-Lanau, C. A., Sepúlveda-Falla, D., Arcos-Burgos, M. & Lopera, F., 2023, In: J ALZHEIMERS DIS. 92, 3, p. 911-923 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2022
Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease
Littau, J. L., Velilla, L., Hase, Y., Villalba-Moreno, N. D., Hagel, C., Drexler, D., Osorio Restrepo, S., Villegas, A., Lopera, F., Vargas, S., Glatzel, M., Krasemann, S., Quiroz, Y. T., Arboleda-Velasquez, J. F., Kalaria, R. & Sepulveda-Falla, D., 11.2022, In: BRAIN PATHOL. 32, 6, p. e13097Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Loss of Homeostatic Microglia Signature in Prion Diseases
Wang, Y., Hartmann, K., Thies, E., Mohammadi, B., Altmeppen, H., Sepulveda-Falla, D., Glatzel, M. & Krasemann, S., 21.09.2022, In: CELLS-BASEL. 11, 19, 2948.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia
Sepulveda-Falla, D., Sanchez, J. S., Almeida, M. C., Boassa, D., Acosta-Uribe, J., Vila-Castelar, C., Ramirez-Gomez, L., Baena, A., Aguillon, D., Villalba-Moreno, N. D., Littau, J. L., Villegas, A., Beach, T. G., White, C. L., Ellisman, M., Krasemann, S., Glatzel, M., Johnson, K. A., Sperling, R. A., Reiman, E. M., Arboleda-Velasquez, J. F., Kosik, K. S., Lopera, F. & Quiroz, Y. T., 09.2022, In: ACTA NEUROPATHOL. 144, 3, p. 589-601 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
Krasemann, S., Haferkamp, U., Pfefferle, S., Woo, M. S., Heinrich, F., Schweizer, M., Appelt-Menzel, A., Cubukova, A., Barenberg, J., Leu, J., Hartmann, K., Thies, E., Littau, J. L., Sepulveda-Falla, D., Zhang, L., Ton, K., Liang, Y., Matschke, J., Ricklefs, F., Sauvigny, T., Sperhake, J., Fitzek, A., Gerhartl, A., Brachner, A., Geiger, N., König, E-M., Bodem, J., Franzenburg, S., Franke, A., Moese, S., Müller, F-J., Geisslinger, G., Claussen, C., Kannt, A., Zaliani, A., Gribbon, P., Ondruschka, B., Neuhaus, W., Friese, M. A., Glatzel, M. & Pless, O., 08.02.2022, In: STEM CELL REP. 17, 2, p. 307-320 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Reactive Astrocytes Contribute to Alzheimer's Disease-Related Neurotoxicity and Synaptotoxicity in a Neuron-Astrocyte Co-culture Assay
Wasilewski, D., Villalba-Moreno, N. D., Stange, I., Glatzel, M., Sepulveda-Falla, D. & Krasemann, S., 21.01.2022, In: FRONT CELL NEUROSCI. 15, 739411.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2021
Cerebral Small Vessel Disease in Sporadic and Familial Alzheimer Disease
Kalaria, R. N. & Sepulveda-Falla, D., 11.2021, In: AM J PATHOL. 191, 11, p. 1888-1905 18 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators
O'Hare, M., Amarnani, D., Whitmore, H. A. B., An, M., Marino, C., Ramos, L., Delgado-Tirado, S., Hu, X., Chmielewska, N., Chandrahas, A., Fitzek, A., Heinrich, F., Steurer, S., Ondruschka, B., Glatzel, M., Krasemann, S., Sepulveda-Falla, D., Lagares, D., Pedron, J., Bushweller, J. H., Liu, P., Arboleda-Velasquez, J. F. & Kim, L. A., 07.2021, In: AM J PATHOL. 191, 7, p. 1193-1208 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Protein Predictive Modeling and Simulation of Mutations of Presenilin-1 Familial Alzheimer's Disease on the Orthosteric Site
Soto-Ospina, A., Araque Marín, P., Bedoya, G., Sepulveda-Falla, D. & Villegas Lanau, A., 02.06.2021, In: FRONT MOL BIOSCI. 8, 649990.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease
Sepulveda-Falla, D., Chavez-Gutierrez, L., Portelius, E., Vélez, J. I., Dujardin, S., Barrera-Ocampo, A., Dinkel, F., Hagel, C., Puig, B., Mastronardi, C., Lopera, F., Hyman, B. T., Blennow, K., Arcos-Burgos, M., de Strooper, B. & Glatzel, M., 02.2021, In: ACTA NEUROPATHOL. 141, 2, p. 217-233 17 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
Cerebrospinal Fluid Mitochondrial DNA in Rapid and Slow Progressive Forms of Alzheimer's Disease
Podlesniy, P., Llorens, F., Puigròs, M., Serra, N., Sepúlveda-Falla, D., Schmidt, C., Hermann, P., Zerr, I. & Trullas, R., 31.08.2020, In: INT J MOL SCI. 21, 17Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders
Palmqvist, S., Janelidze, S., Quiroz, Y. T., Zetterberg, H., Lopera, F., Stomrud, E., Su, Y., Chen, Y., Serrano, G. E., Leuzy, A., Mattsson-Carlgren, N., Strandberg, O., Smith, R., Villegas, A., Sepulveda-Falla, D., Chai, X., Proctor, N. K., Beach, T. G., Blennow, K., Dage, J. L., Reiman, E. M. & Hansson, O., 25.08.2020, In: JAMA-J AM MED ASSOC. 324, 8, p. 772-781 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease
Sabogal-Guáqueta, A. M., Arias-Londoño, J. D., Gutierrez-Vargas, J., Sepulveda-Falla, D., Glatzel, M., Villegas-Lanau, A. & Cardona-Gómez, G. P., 01.08.2020, In: BBA-MOL BASIS DIS. 1866, 8, p. 165797Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer's Disease Patients
Dinkel, F., Trujillo-Rodriguez, D., Villegas, A., Streffer, J., Mercken, M., Lopera, F., Glatzel, M. & Sepulveda-Falla, D., 28.07.2020, In: FRONT AGING NEUROSCI. 12, p. 220Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study
Quiroz, Y. T., Zetterberg, H., Reiman, E. M., Chen, Y., Su, Y., Fox-Fuller, J. T., Garcia, G., Villegas, A., Sepulveda-Falla, D., Villada, M., Arboleda-Velasquez, J. F., Guzmán-Vélez, E., Vila-Castelar, C., Gordon, B. A., Schultz, S. A., Protas, H. D., Ghisays, V., Giraldo, M., Tirado, V., Baena, A., Munoz, C., Rios-Romenets, S., Tariot, P. N., Blennow, K. & Lopera, F., 06.2020, In: LANCET NEUROL. 19, 6, p. 513-521 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis
Rojas-Charry, L., Calero-Martinez, S., Morganti, C., Morciano, G., Park, K., Hagel, C., Marciniak, S. J., Glatzel, M., Pinton, P. & Sepulveda-Falla, D., 15.04.2020, In: SCI REP-UK. 10, 1, p. 6455Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin
Hermann, M., Reumann, R., Schostak, K., Kement, D., Gelderblom, M., Bernreuther, C., Frischknecht, R., Schipanski, A., Marik, S., Krasemann, S., Sepulveda-Falla, D., Schweizer, M., Magnus, T., Glatzel, M. & Galliciotti, G., 01.2020, In: MOL CELL NEUROSCI. 102, p. 103420Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
Hartmann, K., Sepulveda-Falla, D., Rose, I. V. L., Madore, C., Muth, C., Matschke, J., Butovsky, O., Liddelow, S., Glatzel, M. & Krasemann, S., 22.05.2019, In: ACTA NEUROPATHOL COM. 7, 1, p. 83Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Neural Plasticity during Aging
Arcos-Burgos, M., Lopera, F., Sepulveda-Falla, D. & Mastronardi, C., 26.03.2019, In: NEURAL PLAST. 2019, p. 6042132Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
The Colombian-German network for neurodegenerative research: UndoAD
Sepulveda-Falla, D., Villegas, A., Lopera, F. & Glatzel, M., 01.2019, In: LANCET NEUROL. 18, 1, p. 29Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro
Muth, C., Hartmann, A., Sepulveda-Falla, D., Glatzel, M. & Krasemann, S., 2019, In: FRONT CELL NEUROSCI. 13, p. 181Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Distinct microglia profile in Creutzfeldt-Jakob disease and Alzheimer's disease is independent of disease kinetics
Krbot, K., Hermann, P., Skorić, M. K., Zerr, I., Sepulveda-Falla, D., Goebel, S., Matschke, J., Krasemann, S. & Glatzel, M., 12.2018, In: NEUROPATHOLOGY. 38, 6, p. 591-600 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease
Rasmussen, J., Mahler, J., Beschorner, N., Kaeser, S. A., Häsler, L. M., Baumann, F., Nyström, S., Portelius, E., Blennow, K., Lashley, T., Fox, N. C., Sepulveda-Falla, D., Glatzel, M., Oblak, A. L., Ghetti, B., Nilsson, K. P. R., Hammarström, P., Staufenbiel, M., Walker, L. C. & Jucker, M., 05.12.2017, In: P NATL ACAD SCI USA. 114, 49, p. 13018-13023 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Losing sleep over mitochondria: A new player in the pathophysiology of Fatal Familial Insomnia
Glatzel, M. & Sepulveda-Falla, D., 01.2017, In: BRAIN PATHOL. 27, 1, p. 107-108Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
- 2016
Mutations modifying sporadic Alzheimer's disease age of onset
Vélez, J. I., Lopera, F., Patel, H. R., Johar, A. S., Cai, Y., Rivera, D., Tobón, C., Villegas, A., Sepulveda-Falla, D., Lehmann, S. G., Easteal, S., Mastronardi, C. A. & Arcos-Burgos, M., 12.2016, In: AM J MED GENET B. 171, 8, p. 1116-1130 15 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Amyloid-β Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease
Barrera-Ocampo, A., Arlt, S., Matschke, J., Hartmann, U., Puig Martorell, B., Ferrer, I., Zürbig, P., Glatzel, M., Sepulveda-Falla, D. & Jahn, H., 02.08.2016, In: J NEUROPATH EXP NEUR. 75, 9, p. 903-916Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease
Vélez, J. I., Lopera, F., Sepulveda-Falla, D., Patel, H. R., Johar, A. S., Chuah, A., Tobón, C., Rivera, D., Villegas, A., Cai, Y., Peng, K., Arkell, R., Castellanos, F. X., Andrews, S. J., Silva Lara, M. F., Creagh, P. K., Easteal, S., de Leon, J., Wong, M. L., Licinio, J., Mastronardi, C. A. & Arcos-Burgos, M., 01.07.2016, In: MOL PSYCHIATR. 21, 7, p. 916-24Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma
Friedrich, C., von Bueren, A. O., Kolevatova, L., Bernreuther, C., Grob, T., Sepulveda-Falla, D., van den Boom, L., Westphal, M., Simon, R. & Glatzel, M., 02.2016, In: CHILD NERV SYST. 32, 2, p. 281-90Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
Qualitative changes in human γ-secretase underlie familial Alzheimer's disease
Szaruga, M., Veugelen, S., Benurwar, M., Lismont, S., Sepulveda-Falla, D., Lleo, A., Ryan, N. S., Lashley, T., Fox, N. C., Murayama, S., Gijsen, H., De Strooper, B. & Chávez-Gutiérrez, L., 19.10.2015, In: J EXP MED. 212, 12, p. 2003-2013Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis
Sepulveda-Falla, D., Barrera-Ocampo, A. A., Hagel, C., Korwitz, A., Vinueza-Veloz, M. F., Zhou, K., Schonewille, M., Zhou, H., Velazquez-Perez, L., Rodriguez-Labrada, R., Villegas, A., Ferrer, I., Lopera, F., Langer, T., De Zeeuw, C. I. & Glatzel, M., 01.04.2014, In: J CLIN INVEST. 124, 4, p. 1552-67 16 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer's disease
Dohler, F., Sepulveda-Falla, D., Krasemann, S., Altmeppen, H., Schlüter, H., Hildebrand, D., Zerr, I., Matschke, J. & Glatzel, M., 01.03.2014, In: BRAIN. 137, Pt 3, p. 873-86 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Immune activation in amyloid-β-related angiitis correlates with decreased parenchymal amyloid-β plaque load
Bogner, S., Bernreuther, C., Matschke, J., Barrera-Ocampo, A. A., Sepulveda-Falla, D., Leypoldt, F., Magnus, T., Haag, F., Bergmann, M., Brück, W., Vogelgesang, S. & Glatzel, M., 01.01.2014, In: NEURODEGENER DIS. 13, 1, p. 38-44 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Specific de-SUMOylation triggered by acquisition of spatial learning is related to epigenetic changes in the rat hippocampus
Castro Gomez, M. S., Barrera-Ocampo, A. A., Machado-Rodriguez, G., Castro-Alvarez, J. F., Glatzel, M., Giraldo, M. & Sepulveda-Falla, D., 04.12.2013, In: NEUROREPORT. 24, 17, p. 976-81 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease.
Pera, M., Alcolea, D., Sánchez-Valle, R., Guardia-Laguarta, C., Colom-Cadena, M., Badiola, N., Suárez-Calvet, M., Lladó, A., Barrera-Ocampo, A. A., Sepulveda-Falla, D., Blesa, R., Molinuevo, J. L., Clarimón, J., Ferrer, I., Gelpi, E. & Lleó, A., 2013, In: ACTA NEUROPATHOL. 125, 2, p. 201-213 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2012
Phenotypic profile of early-onset familial Alzheimer's disease caused by presenilin-1 E280A mutation.
Sepulveda-Falla, D., Glatzel, M. & Lopera, F., 2012, In: J ALZHEIMERS DIS. 32, 1, p. 1-12 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease.
Sepulveda-Falla, D., Matschke, J., Bernreuther, C., Hagel, C., Puig Martorell, B., Villegas, A., Garcia, G., Zea, J., Gomez-Mancilla, B., Ferrer, I., Lopera, F. & Glatzel, M., 2011, In: BRAIN PATHOL. 21, 4, p. 452-463 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study.
Acosta-Baena, N., Sepulveda-Falla, D., Lopera-Gómez, C. M., Jaramillo-Elorza, M. C., Moreno, S., Aguirre-Acevedo, D. C., Saldarriaga, A. & Lopera, F., 2011, In: LANCET NEUROL. 10, 3, p. 213-220 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review