Research ExplorerScientific StaffHermann Clemens Altmeppen

Dipl. Hum.-Biol. Dr. rer. nat. ID: 32498

Hermann Clemens Altmeppen

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Phone: 040-7410-58750

Research Interests

My current research focusses on how proteolytic processing events on key proteins impact on neurodegenerative diseases such as rare and transmissible prion diseases or Alzheimer`s disease, the most frequent cause of dementia.

Research Interests

Fields of specific interest:

Neurodegeneration, Cell biology, Infectious diseases, Proteolytic processing

Publications

Inducing prion protein shedding as a neuroprotective and regenerative approach in pathological conditions of the brain: from theory to facts

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Vagus nerve inflammation contributes to dysautonomia in COVID-19

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Anchorless risk or released benefit? An updated view on the ADAM10-mediated shedding of the prion protein

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

An optimized western blot assay provides a comprehensive assessment of the physiological endoproteolytic processing of the prion protein

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Loss of Homeostatic Microglia Signature in Prion Diseases

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Autosomal dominantly inherited myopathy likely caused by the TNNT1 variant p.(Asp65Ala)

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

The prion protein and its ligands: Insights into structure-function relationships

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Multiplexed mRNA analysis of brain-derived extracellular vesicles upon experimental stroke in mice reveals increased mRNA content with potential relevance to inflammation and recovery processes

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

NeuroCOVID: Insights into Neuroinvasion and Pathophysiology

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

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activities

Research Grant of the "Werner Otto Stiftung"

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

Research Grant of the American “Creutzfeldt-Jakob Disease Foundation, Inc.”: for the project “Targeting the endogenous proteolytic processing of PrPC as a therapeutic strategy against prion diseases”

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

Admission to/Member of the Collaborative Research Center CRC877 (SFB877) “Proteolysis as a regulatory event in pathophysiology” (Kiel & Hamburg, 2nd Funding period) with the project A12 on “ADAM10-mediated shedding of the prion protein”

Activity: Other › Distinctions, awards, fellowships and visits - Other › Research

Young Scientists Research Grant of the Medical Faculty, University Medical Center Hamburg Eppendorf (UKE)

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

“Werner Otto Stipendium”

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

Leibniz Center Infection (LCI) Graduate School “Modell Systems for Infectious Diseases”: Doktorandenstipendium

Activity: Other › Distinctions, awards, fellowships and visits - Prizes, scholarships, distinctions, appointments › Research

View all (6)