Pre-dementia clinical stages in presenilin 1 E280A familial early-onset Alzheimer's disease: a retrospective cohort study.

  • Natalia Acosta-Baena
  • Diego Sepulveda-Falla
  • Carlos Mario Lopera-Gómez
  • Mario César Jaramillo-Elorza
  • Sonia Moreno
  • Daniel Camilo Aguirre-Acevedo
  • Amanda Saldarriaga
  • Francisco Lopera

Abstract

Mild cognitive impairment (MCI) and pre-MCI have been proposed as stages preceding Alzheimer's disease (AD) dementia. We assessed descendants of individuals with a mutation in presenilin 1 (PSEN1) that causes familial AD, with the aim of identifying distinct stages of clinical progression to AD dementia.

Bibliographical data

Original languageGerman
Article number3
ISSN1474-4422
Publication statusPublished - 2011
pubmed 21296022