Research ExplorerScientific StaffGiovanna Galliciotti

Dr. ID: 38947

Giovanna Galliciotti

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Affiliations
Emails
Phone: 54424Fax: 55696
ORCID: 0000-0002-2697-2364

Research Interests

My research is focused on development, plasticity and degeneration of the nervous system. In the last years, I investigated different aspects of neuroserpin, a serine protease inhibitor of the central and peripheral nervous system. Neuroserpin regulates the activity of the serine protease tissue plasminogen activator, and is critically involved in the pathophysiology of stroke, epilepsy, schizophrenia and fear disorders. Together with my collaborators, I demonstrated a role for neuroserpin in developmental neurogenesis, in maturation of dendritic spines during synaptogenesis and in synaptic plasticity. Moreover, I investigated pathomechanisms of a neurodegenerative disease called Familial encephalopathy with neuroserpin inclusion bodies (FENIB), caused by point mutations in neuroserpin and characterized by intraneuronal deposition of neuroserpin polymers leading to neuronal death and dementia.

Publications

Neuroserpin Gene Therapy Inhibits Retinal Ganglion Cell Apoptosis and Promotes Functional Preservation in Glaucoma

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Elucidating the pathological mechanisms of neurodegeneration in the lethal serpinopathy FENIB

Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research

Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Young COVID-19 Patients Show a Higher Degree of Microglial Activation When Compared to Controls

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Neuroserpin: structure, function, physiology and pathology

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Neuroserpin Is Strongly Expressed in the Developing and Adult Mouse Neocortex but Its Absence Does Not Perturb Cortical Lamination and Synaptic Proteome

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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