Department of Biochemistry and Molecular Cell Biology
Publications
Fat Quantification in Dual-Layer Detector Spectral Computed Tomography: Experimental Development and First In-Patient Validation
Molwitz, I., Campbell, G. M., Yamamura, J., Knopp, T., Toedter, K., Fischer, R., Wang, Z. J., Busch, A., Ozga, A-K., Zhang, S., Lindner, T., Sevecke, F., Grosser, M., Adam, G. & Szwargulski, P., 01.07.2022, In: INVEST RADIOL. 57, 7, p. 463-469 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Worthmann, A., Ridder, J., Piel, S. Y. L., Evangelakos, I., Musfeldt, M., Voß, H., O'Farrell, M., Fischer, A. W., Adak, S., Sundd, M., Siffeti, H., Haumann, F., Kloth, K., Bierhals, T., Heine, M., Pertzborn, P., Pauly, M., Scholz, J-J., Kundu, S., Fuh, M. M., Neu, A., Tödter, K., Hempel, M., Knippschild, U., Semenkovich, C. F., Schlüter, H., Heeren, J., Scheja, L., Kubisch, C. & Schlein, C., 02.01.2024, In: NAT COMMUN. 15, 1, p. 45Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
Schlein, C., Talukdar, S., Heine, M., Fischer, A. W., Krott, L. M., Nilsson, S. K., Brenner, M. B., Heeren, J. & Scheja, L., 08.03.2016, In: CELL METAB. 23, 3, p. 441-53 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Final-year medical students' self-assessment of facets of competence for beginning residents
Bußenius, L., Harendza, S., van den Bussche, H. & Selch, S., 07.02.2022, In: BMC MED EDUC. 22, 1, 82.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
FoxO transcription factors are required for hepatic HDL-cholesterol clearance
Lee, S. X., Heine, M., Schlein, C., Ramakrishnan, R., Liu, J., Belnavis, G., Haimi, I., Fischer, A. W., Ginsberg, H., Heeren, J., Rinninger, F. & Haeusler, R. A., 02.04.2018, In: J CLIN INVEST. 128, 4, p. 1615-1626 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Fragebogenbasierte Anforderungsanalyse für das Berufsbild des Anästhesiologen
Gassner, S., Oubaid, V., Hampe, W., Zöllner, C. & Kubitz, J. C., 2018, In: ANASTH INTENSIVMED. 59, p. 114-120Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus.
Musunuru, K., Strong, A., Frank-Kamenetsky, M., Lee, N. E., Ahfeldt, T., Sachs, K. V., Li, X., Li, H., Kuperwasser, N., Ruda, V. M., Pirruccello, J. P., Muchmore, B., Prokunina-Olsson, L., Hall, J. L., Schadt, E. E., Morales, C. R., Lund-Katz, S., Phillips, M. C., Wong, J., Cantley, W., Racie, T., Ejebe, K. G., Orho-Melander, M., Melander, O., Koteliansky, V., Fitzgerald, K., Krauss, R. M., Cowan, C. A., Kathiresan, S. & Rader, D. J., 2010, In: NATURE. 466, 7307, p. 714-719 7307.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor
Wolf, I. M. A., Diercks, B-P., Gattkowski, E., Czarniak, F., Kempski, J., Werner, R., Schetelig, D., Mittrücker, H-W., Schumacher, V., von Osten, M., Lodygin, D., Flügel, A., Fliegert, R. & Guse, A. H., 13.10.2015, In: SCI SIGNAL. 8, 398, p. Art. ra102 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Full focus on calcium
Parys, J. B. & Guse, A. H., 17.09.2019, In: SCIENCE SIGNALING. 12, 599Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Functional ryanodine receptor expression is required for NAADP-mediated local Ca2+ signaling in T-lymphocytes
Dammermann, W. & Guse, A. H., 03.06.2005, In: J BIOL CHEM. 280, 22, p. 21394-9 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Function of the neuropeptide head activator for early neural and neuroendocrine development.
Hampe, W., Hermans-Borgmeyer, I. & Schaller, H. C., 1999, In: Results Probl Cell Differ. 26, p. 323-337Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gadospin f-enhanced magnetic resonance imaging for diagnosis and monitoring of atherosclerosis: validation with transmission electron microscopy and x-ray fluorescence imaging in the apolipoprotein e-deficient mouse
Jung, C., Dučić, T., Reimer, R., Koziolek, E., Kording, F., Heine, M., Adam, G., Ittrich, H. & Kaul, M. G., 2014, In: MOL IMAGING. 13, p. 1-10 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
General population’s knowledge about the anatomical locations of organs and medical terms today and 50 years ago: a replication study
Harendza, S., Münter, A., Bußenius, L. & Bittner, A., 22.07.2021, In: GMS Journal for Medical Education. 38, 5, p. Doc94 Doc94.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Generation and characterization of antagonistic anti-human CD39 nanobodies
Menzel, S., Duan, Y., Hambach, J., Albrecht, B., Wendt-Cousin, D., Winzer, R., Tolosa, E., Rissiek, A., Guse, A. H., Haag, F., Magnus, T., Koch-Nolte, F. & Rissiek, B., 2024, In: FRONT IMMUNOL. 15, p. 1328306Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
Wagner, T., Bartelt, A., Schlein, C. & Heeren, J., 2015, In: PLOS ONE. 10, 12, e0145102.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease.
Linsel-Nitschke, P., Heeren, J., Aherrahrou, Z., Bruse, P., Gieger, C., Illig, T., Prokisch, H., Heim, K., Doering, A., Peters, A., Meitinger, T., Wichmann, H-E., Hinney, A., Reinehr, T., Roth, C., Ortlepp, J. R., Soufi, M., Sattler, A. M., Schaefer, J., Stark, K., Hengstenberg, C., Schaefer, A., Schreiber, S., Kronenberg, F., Samani, N. J., Schunkert, H. & Erdmann, J., 2010, In: ATHEROSCLEROSIS. 208, 1, p. 183-189 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genome-wide methylation profiling of glioblastoma cell-derived extracellular vesicle DNA allows tumor classification
Maire, C. L., Fuh, M. M., Kaulich, K., Fita, K. D., Stevic, I., Heiland, D. H., Welsh, J. A., Jones, J. C., Görgens, A., Ricklefs, T., Dührsen, L., Sauvigny, T., Joosse, S. A., Reifenberger, G., Pantel, K., Glatzel, M., Miklosi, A. G., Felce, J. H., Caselli, M., Pereno, V., Reimer, R., Schlüter, H., Westphal, M., Schüller, U., Lamszus, K. & Ricklefs, F. L., 01.07.2021, In: NEURO-ONCOLOGY. 23, 7, p. 1087-1099 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
German Physicians and Medical Students Do Not Represent the Population They Serve
Groene, O., Huelmann, T., Hampe, W. & Emami, P., 06.06.2023, In: HEALTHCARE-BASEL. 11, 12, 1662.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Glucocorticoid-Induced Obesity Develops Independently of UCP1
Luijten, I. H. N., Brooks, K., Boulet, N., Shabalina, I. G., Jaiprakash, A., Carlsson, B., Fischer, A. W., Cannon, B. & Nedergaard, J., 07.05.2019, In: CELL REP. 27, 6, p. 1686-1698.e5Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
GMA-Jahrestagung 2014 in Hamburg - Ankündigung
Hampe, W. & Kuhnigk, O., 15.05.2014, In: GMS Z Med Ausbild. 31, 2 Doc13, p. 1-4Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Transfer
GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors.
Wittenberger, T., Hellebrand, S., Munck, A., Kreienkamp, H-J., Schaller, H. C. & Hampe, W., 2002, In: BMC GENOMICS. 3, 1, p. 17 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
GTP-induced fusion of isolated pancreatic microsomal vesicles is increased by acidification of the vesicle lumen.
Hampe, W., Zimmermann, P. & Schulz, I., 1990, In: FEBS LETT. 271, 1-2, p. 62-66 1-2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Guidelines for mouse and human DC functional assays
Clausen, B., Amon, L., Backer, R., Berod, L., Bopp, T., Brand, A., Burgdorf, S., Chen, L., Da, M., Distler, U., Dress, R. J., Dudziak, D., Dutertre, C-A., Eich, C., Gabele, A., Geiger, M., Ginhoux, F., Giusiano, L., Godoy, G. J., Hamouda, A., Hatscher, L., Heger, L., Heidkamp, G., Hernandez, L. C., Jacobi, L., Kaszubowski, T., Kong, W. T., Lehmann, C., Lopez Lopez, T., Mahnke, K., Nitsche, D., Renkawitz, J., Reza, R., Saez, P., Schlautmann, L., Schmitt, M., Seicher, A., Sielaff, M., Sparwasser, T., Stoitzer, P., Tchitashvili, G., Tenzer, S., Tochoedo, N., Vurnek, D., Zink, F. & Hieronymus, T., 23.12.2023, In: EUR J IMMUNOL. 53, 12, p. e2249925Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Health Literacy: Literature review for the German National Health Literacy Action Plan
Groene, O., 2016.Research output: Working paper › Research communication reports
Hepatic lipase is expressed by osteoblasts and modulates bone remodeling in obesity
Bartelt, A., Beil, T., Müller, B., Koehne, T., Yorgan, T. A., Heine, M., Yilmaz, T., Ruether, W., Heeren, J., Schinke, T. & Niemeier, A., 01.05.2014, In: BONE. 62, p. 90-98 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis
Schneegans, S., Löptien, J., Mojzisch, A., Loreth, D., Kretz, O., Raschdorf, C., Hanssen, A., Gocke, A., Siebels, B., Gunasekaran, K., Ding, Y., Oliveira-Ferrer, L., Brylka, L., Schinke, T., Schlüter, H., Paatero, I., Voß, H., Werner, S., Pantel, K. & Wikman, H., 11.04.2024, In: J EXP CLIN CANC RES. 43, 1, p. 110Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus.
Twisk, J., Hoekman, M. F., Mager, W. H., Moorman, A. F., de Boer, P. A., Scheja, L., Princen, H. M. & Gebhardt, R., 1995, In: J CLIN INVEST. 95, 3, p. 1235-1243 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice
Rinninger, F., Heine, M., Singaraja, R., Hayden, M., Brundert, M., Ramakrishnan, R. & Heeren, J., 01.09.2014, In: J LIPID RES. 55, 9, p. 1914-1924 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High interstitial fluid pressure is associated with low tumour penetration of diagnostic monoclonal antibodies applied for molecular imaging purposes.
Heine, M., Freund, B., Nielsen, P., Jung, C., Reimer, R., Hohenberg, H., Zangemeister-Wittke, U., Wester, H-J., Lüers, G. & Schumacher, U., 2012, In: PLOS ONE. 7, 5, p. 36258 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.
Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y-H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., Daley, G. Q., Brack, A. S., Collins, J. J., Cowan, C., Schlaeger, T. M. & Rossi, D. J., 2010, In: CELL STEM CELL. 7, 5, p. 618-630 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High Metabolic Function and Resilience of NKG2A-Educated NK Cells
Highton, A. J., Diercks, B-P., Möckl, F., Martrus, G., Sauter, J., Schmidt, A. H., Bunders, M. J., Körner, C., Guse, A. H. & Altfeld, M., 2020, In: FRONT IMMUNOL. 11, 559576.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High-Resolution Calcium Imaging Method for Local Calcium Signaling
Diercks, B-P., Werner, R., Schetelig, D., Wolf, I. & Guse, A., 2019, Calcium-Binding Proteins of the EF-Hand Superfamily. 1 ed. Humana Press, Vol. 1929. p. 27-39 13 p.Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
High resolution structure of streptavidin in complex with a novel high affinity peptide tag mimicking the biotin binding motif.
Perbandt, M., Bruns, O., Vallazza, M., Lamla, T., Betzel, C. & Erdmann, V. A., 2007, In: PROTEINS. 67, 4, p. 1147-1153 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Histological Analysis
Johansson, C. B., Jimbo, R. & Röser, K., 2011, Comprehensive Biomaterials. Ducheyne, P., Healy, K. E., Hutmacher, D. W., Grainger, D. W. & Kirkpatrick, C. J. (eds.). 1 ed. Elsevier Limited, Vol. 3. p. 215-233 19 p. 3.313.Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
Histological Analysis
Johansson, C. B., Röser, K., Jimbo, R., Hammarström Johansson, P., Larsson, L. & Östberg, A. K., 2017, Comprehensive Biomaterials II. Ducheyne, P., Healy, K., Hutmacher, D. E., Grainger, D. W. & Kirkpatrick, C. J. (eds.). 2 ed. Oxford, Vol. 3. p. 335-363 29 p. 3.16Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation
Roggenkamp, H. G., Khansahib, I., Hernandez C, L. C., Zhang, Y., Lodygin, D., Krüger, A., Gu, F., Möckl, F., Löhndorf, A., Wolters, V., Woike, D., Rosche, A., Bauche, A., Schetelig, D., Werner, R., Schlüter, H., Failla, A. V., Meier, C., Fliegert, R., Walseth, T. F., Flügel, A., Diercks, B-P. & Guse, A. H., 23.03.2021, In: SCI SIGNAL. 14, 675Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Homepages of German medical faculties--an overview.
Kuhnigk, O., Tiller, D., Harendza, S. & Hampe, W., 2012, In: GMS Z Med Ausbild. 29, 4, p. 59 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
Albers, K., Schlein, C., Wenner, K., Lohse, P., Bartelt, A., Heeren, J., Santer, R. & Merkel, M., 01.03.2014, In: ATHEROSCLEROSIS. 233, 1, p. 97-103 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Host cell responses to Chlamydia pneumoniae in gamma interferon-induced persistence overlap those of productive infection and are linked to genes involved in apoptosis, cell cycle, and metabolism.
Eickhoff, M., Thalmann, J., Hess, S., Martin, M., Laue, T., Kruppa, J., Brandes, G. & Klos, A., 2007, In: INFECT IMMUN. 75, 6, p. 2853-2863 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
How good are medical students at communicating risk? An implementation study at three German medical schools
Groene, O., Bergelt, C. & Ehrhardt, M., 01.2022, In: PATIENT EDUC COUNS. 105, 1, p. 128-135 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum.
Munck, A., Böhm, C., Seibel, N. M., Zara, H. H. & Hampe, W., 2005, In: FEBS J. 272, 7, p. 1718-1726 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo.
Dieckmann, M., Beil, F. T., Müller, B., Bartelt, A., Marshall, R. P., Köhne, T., Amling, M., Ruether, W., Cooper, J. A., Humphries, S. E., Herz, J. & Niemeier, A., 2013, In: J BONE MINER RES. 28, 2, p. 236-245 10 p., 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Human beta 2-adrenergic receptor produced in stably transformed insect cells is functionally coupled via endogenous GTP-binding protein to adenylyl cyclase.
Kleymann, G., Boege, F., Hahn, M., Hampe, W., Vasudevan, S. & Reiländer, H., 1993, In: EUR J BIOCHEM. 213, 2, p. 797-804 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro
Ahmadi, P., Yan, M., Bauche, A., Smeets, R., Müller, C. E., Koch-Nolte, F., Haag, F., Fliegert, R., Kluwe, L., Schulze Zur Wiesch, J. & Hartjen, P., 10.2022, In: CELL IMMUNOL. 380, 104589.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Human Fetal TNF-α-Cytokine-Producing CD4 Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life
Schreurs, R. R. C. E., Baumdick, M. E., Sagebiel, A. F., Kaufmann, M., Mokry, M., Klarenbeek, P. L., Schaltenberg, N., Steinert, F. L., van Rijn, J. M., Drewniak, A., The, S-M. M. L., Bakx, R., Derikx, J. P. M., de Vries, N., Corpeleijn, W. E., Pals, S. T., Gagliani, N., Friese, M. A., Middendorp, S., Nieuwenhuis, E. E. S., Reinshagen, K., Geijtenbeek, T. B. H., van Goudoever, J. B. & Bunders, M. J., 19.02.2019, In: IMMUNITY. 50, 2, p. 462-476.e8Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Human mesenchymal stem cells are not of donor origin in patients with severe aplastic anemia who underwent sex-mismatched allogeneic bone marrow transplant
Stute, N., Fehse, B., Schröder, J., Arps, S., Adamietz, P., Held, K. R. & Zander, A. R., 12.2002, In: J HEMATOTH STEM CELL. 11, 6, p. 977-984 8 p.Research output: SCORING: Contribution to journal › Short publication › Research › peer-review
Hydrolysis and rearrangement reactions of riboflavin phosphates. An explicit kinetic study.
Nielsen, P., Harksen, J. & Bacher, A., 1985, In: EUR J BIOCHEM. 152, 2, p. 465-473 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hypertriglyceridemia in obese subjects: caused by reduced apolipoprotein A5 plasma levels?
Heeren, J. & Merkel, M., 2010, In: ATHEROSCLEROSIS. 212, 2, p. 386-387 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Identification and characterization of SorCS, a third member of a novel receptor family.
Hermey, G., Riedel, I. B., Hampe, W., Schaller, H. C. & Hermans-Borgmeyer, I., 1999, In: BIOCHEM BIOPH RES CO. 266, 2, p. 347-351 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Identification of a cis-acting element and a novel trans-acting factor of the glutamine synthetase gene in liver cells.
Gaunitz, F., Weber, S., Scheja, L. & Gebhardt, R., 2001, In: BIOCHEM BIOPH RES CO. 284, 2, p. 377-383 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review