Research ExplorerScientific StaffManfred Jücker Publications

Prof.Dr. ID: 59733

Manfred Jücker

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Publications

  1. 2024

  2. K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3

    Geißert, R., Lammert, A., Wirth, S., Hönig, R., Lohfink, D., Unger, M., Pek, D., Schlüter, K., Scheftschik, T., Smit, D. J., Jücker, M., Menke, A. & Giehl, K., 30.01.2024, In: CELL COMMUN SIGNAL. 22, 1, p. 85

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  3. 2023

  4. Generating Patient-Derived HCC Cell Lines Suitable for Predictive In Vitro and In Vivo Drug Screening by Orthotopic Transplantation

    Staffeldt, L., Mattert, G., Riecken, K., Rövenstrunk, G., Volkmar, A., Heumann, A., Moustafa, M., Jücker, M., Fehse, B., Schumacher, U., Lüth, S. & Kah, J., 30.12.2023, In: CELLS-BASEL. 13, 1, 82.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  5. Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases

    Ehm, P. A. H., Linnebacher, M., Block, A., Rehbach, C. & Jücker, M., 08.2023, In: CELL SIGNAL. 108, p. 110720

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  6. Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis

    Kempska, J., Oliveira-Ferrer, L., Grottke, A., Qi, M., Alawi, M., Meyer, F., Borgmann, K., Hamester, F., Eylmann, K., Rossberg, M., Smit, D. J., Jücker, M., Laakmann, E., Witzel, I., Schmalfeldt, B., Müller, V. & Legler, K., 06.07.2023, In: FRONT ONCOL. 13, p. 1129682 1129682.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  7. SHIP1 Is Present but Strongly Downregulated in T-ALL, and after Restoration Suppresses Leukemia Growth in a T-ALL Xenotransplantation Mouse Model

    Ehm, P., Rietow, R., Wegner, W., Bußmann, L., Kriegs, M., Dierck, K., Horn, S., Streichert, T., Horstmann, M. & Jücker, M., 06.07.2023, In: CELLS-BASEL. 12, 13, p. 1798

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  8. Activated Src kinases downstream of BCR-ABL and Flt3 induces proteasomal degradation of SHIP1 by phosphorylation of tyrosine 1021

    Ehm, P., Bettin, B. & Jücker, M., 06.2023, In: BBA-MOL CELL RES. 1870, 5, 119467.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  9. Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo

    Genduso, S., Freytag, V., Schetler, D., Kirchner, L., Schiecke, A., Maar, H., Wicklein, D., Gebauer, F., Bröker, K., Stürken, C., Milde-Langosch, K., Oliveira-Ferrer, L., Ricklefs, F. L., Ewald, F., Wolters-Eisfeld, G., Riecken, K., Unrau, L., Krause, L., Bohnenberger, H., Offermann, A., Perner, S., Sebens, S., Lamszus, K., Diehl, L., Linder, S., Jücker, M., Schumacher, U. & Lange, T., 17.03.2023, In: J HEMATOL ONCOL. 16, 1, 23.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  10. The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism

    Tian, L-Y., Smit, D. J. & Jücker, M., 31.01.2023, In: INT J MOL SCI. 24, 3, 2652.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  11. Reduced expression and activity of patient-derived SHIP1 phosphatase domain mutants

    Ehm, P., Nelson, N., Giehler, S., Schaks, M., Bettin, B., Kirchmair, J. & Jücker, M., 01.2023, In: CELL SIGNAL. 101, 110485.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  12. 2022

  13. JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative Neoplasm (MPN)

    Glück, M., Dally, L., Jücker, M. & Ehm, P., 08.2022, In: INT J BIOCHEM CELL B. 149, 106229.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  14. Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer

    Elakad, O., Häupl, B., Labitzky, V., Yao, S., Küffer, S., von Hammerstein-Equord, A., Danner, B. C., Jücker, M., Urlaub, H., Lange, T., Ströbel, P., Oellerich, T. & Bohnenberger, H., 19.07.2022, In: NPJ PRECIS ONCOL. 6, 1, 52.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  15. Investigation of the function of the PI3-Kinase / AKT signaling pathway for leukemogenesis and therapy of acute childhood lymphoblastic leukemia (ALL)

    Ehm, P., Grottke, A., Bettin, B. & Jücker, M., 05.2022, In: CELL SIGNAL. 93, 110301.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  16. Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM+ and CD90+ Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model

    Moustafa, M., Dähling, K-K., Günther, A., Riebandt, L., Smit, D. J., Riecken, K., Schröder, C., Zhuang, R., Krech, T., Kriegs, M., Fehse, B., Izbicki, J., Fischer, L., Nashan, B., Li, J. & Jücker, M., 08.04.2022, In: CANCERS. 14, 8, 1882.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  17. The Functional Role of Extracellular Matrix Proteins in Cancer

    Popova, N. V. & Jücker, M., 04.01.2022, In: CANCERS. 14, 1, 238.

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  18. AKT Isoforms as a Target in Cancer and Immunotherapy

    Smit, D. J. & Jücker, M., 2022, PI3K and AKT Isoforms in Immunity. Dominguez-Villar, M. (ed.). 1 ed. Cham: Springer, p. 409-436 27 p. (Current Topics in Microbiology and Immunology; vol. 436).

    Research output: SCORING: Contribution to book/anthology › Chapter › Research › peer-review

  19. 2021

  20. AKT1 and PTEN show the highest affinities among phosphoinositide binding proteins for the second messengers PtdIns(3,4,5)P3 and PtdIns(3,4)P2

    Nelson, N., Razeto, A., Gilardi, A., Grättinger, M., Kirchmair, J. & Jücker, M., 03.09.2021, In: BIOCHEM BIOPH RES CO. 568, p. 110-115 6 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  21. Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer

    Hofmann, B. T., Picksak, A-S., Kwiatkowski, M., Grupp, K., Jücker, M., Bachmann, K., Mercanoglu, B., Izbicki, J. R., Kahlert, C., Bockhorn, M., Güngör, C., Ewald, F. & Wolters-Eisfeld, G., 18.08.2021, In: GLYCOBIOLOGY. 2021, cwab088.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  22. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

    Ecker, V., Stumpf, M., Brandmeier, L., Neumayer, T., Pfeuffer, L., Engleitner, T., Ringshausen, I., Nelson, N., Jücker, M., Wanninger, S., Zenz, T., Wendtner, C., Manske, K., Steiger, K., Rad, R., Müschen, M., Ruland, J. & Buchner, M., 10.06.2021, In: NAT COMMUN. 12, 1, p. 3526

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  23. Circulating tumor cells as a promising target for individualized drug susceptibility tests in cancer therapy

    Smit, D. J., Pantel, K. & Jücker, M., 06.2021, In: BIOCHEM PHARMACOL. 188, p. 114589

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  24. AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review

    Hinz, N. & Jücker, M., 11.05.2021, In: CANCERS. 13, 10, p. 2287

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  25. Combined Targeting of AKT and mTOR Synergistically Inhibits Formation of Primary Colorectal Carcinoma Tumouroids In Vitro: A 3D Tumour Model for Pre-therapeutic Drug Screening

    Nörz, D., Mullins, C. S., Smit, D. J., Linnebacher, M., Hagel, G., Mirdogan, A., Siekiera, J., Ehm, P., Izbicki, J. R., Block, A., Thastrup, O. & Jücker, M., 05.2021, In: ANTICANCER RES. 41, 5, p. 2257-2275 19 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  26. Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis

    Hinz, N., Baranowsky, A., Horn, M., Kriegs, M., Sibbertsen, F., Smit, D. J., Clezardin, P., Lange, T., Schinke, T. & Jücker, M., 18.02.2021, In: CELLS-BASEL. 10, 2, 430.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  27. The Role of mTOR Signaling as a Therapeutic Target in Cancer

    Popova, N. V. & Jücker, M., 09.02.2021, In: INT J MOL SCI. 22, 4, p. 1743

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  28. 2020

  29. Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer

    Voß, H., Wurlitzer, M., Smit, D. J., Ewald, F., Alawi, M., Spohn, M., Indenbirken, D., Omidi, M., David, K., Juhl, H., Simon, R., Sauter, G., Fischer, L., Izbicki, J. R., Molloy, M. P., Nashan, B., Schlüter, H. & Jücker, M., 12.2020, In: CLIN EXP METASTAS. 37, 6, p. 649-656 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  30. High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors

    Smit, D. J., Cayrefourcq, L., Haider, M-T., Hinz, N., Pantel, K., Alix-Panabières, C. & Jücker, M., 20.09.2020, In: CELLS-BASEL. 9, 9

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  31. Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity

    Koch, C., Kuske, A., Joosse, S. A., Yigit, G., Sflomos, G., Thaler, S., Smit, D. J., Werner, S., Borgmann, K., Gärtner, S., Mossahebi Mohammadi, P., Battista, L., Cayrefourcq, L., Altmüller, J., Salinas-Riester, G., Raithatha, K., Zibat, A., Goy, Y., Ott, L., Bartkowiak, K., Tan, T. Z., Zhou, Q., Speicher, M. R., Müller, V., Gorges, T. M., Jücker, M., Thiery, J-P., Brisken, C., Riethdorf, S., Alix-Panabières, C. & Pantel, K., 07.09.2020, In: EMBO MOL MED. 12, 9, e11908.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  32. Ectopic Expression of Hematopoietic SHIP1 in Human Colorectal Cancer

    Schaks, M., Allgoewer, K., Nelson, N., Ehm, P., Heumann, A., Ewald, F., Schumacher, U., Simon, R., Sauter, G. & Jücker, M., 15.07.2020, In: BIOMEDICINES. 8, 7

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  33. Characterization of the substrate specificity of the inositol 5-phosphatase SHIP1

    Nelson, N., Wundenberg, T., Lin, H., Rehbach, C., Horn, S., Windhorst, S. & Jücker, M., 02.04.2020, In: BIOCHEM BIOPH RES CO. 524, 2, p. 366-370 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  34. Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo

    Schulte, A., Ewald, F., Spyra, M., Smit, D. J., Jiang, W., Salamon, J., Jücker, M. & Mautner, V-F., 24.02.2020, In: INT J MOL SCI. 21, 4

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  35. Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice

    Labitzky, V., Baranowsky, A., Maar, H., Hanika, S., Starzonek, S., Ahlers, A-K., Stübke, K., Koziolek, E. J., Heine, M., Schäfer, P., Windhorst, S., Jücker, M., Riecken, K., Amling, M., Schinke, T., Schumacher, U., Valentiner, U. & Lange, T., 07.02.2020, In: CANCERS. 12, 2

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  36. PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer

    Marquard, F. E. & Jücker, M., 02.2020, In: BIOCHEM PHARMACOL. 172, p. 113729

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  37. 2019

  38. Distinct functions of AKT isoforms in breast cancer: a comprehensive review

    Hinz, N. & Jücker, M., 21.11.2019, In: CELL COMMUN SIGNAL. 17, 1, p. 154

    Research output: SCORING: Contribution to journal › SCORING: Review article › Research

  39. Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins

    Ehm, P. A. H., Lange, F., Hentschel, C., Jepsen, A., Glück, M., Nelson, N., Bettin, B., de Bruyn Kops, C., Kirchmair, J., Nalaskowski, M. & Jücker, M., 11.2019, In: CELL SIGNAL. 63, p. 109380

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  40. 2018

  41. Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells

    Nalaskowski, M. M., Ehm, P., Rehbach, C., Nelson, N., Täger, M., Modest, K. & Jücker, M., 09.2018, In: CELL SIGNAL. 49, p. 87-94 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  42. 2017

  43. SHIP1, but not an AML-derived SHIP1 mutant, suppresses myeloid leukemia growth in a xenotransplantation mouse model

    Täger, M., Horn, S., Latuske, E., Ehm, P., Schaks, M., Nalaskowski, M., Fehse, B., Fiedler, W., Stocking, C., Wellbrock, J. & Jücker, M., 11.2017, In: GENE THER. 24, 11, p. 749-753 5 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  44. Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing

    Volksdorf, T., Heilmann, J., Eming, S. A., Schawjinski, K., Zorn-Kruppa, M., Ueck, C., Vidal-Y-Sy, S., Windhorst, S., Jücker, M., Moll, I. & Brandner, J. M., 06.2017, In: AM J PATHOL. 187, 6, p. 1301-1312

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  45. Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia

    Latuske, E-M., Stamm, H., Klokow, M., Vohwinkel, G., Muschhammer, J., Bokemeyer, C., Jücker, M., Kebenko, M., Fiedler, W. & Wellbrock, J., 25.04.2017, In: ONCOTARGET. 8, 17, p. 29187-29201

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  46. PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression

    Hohensee, I., Chuang, H-N., Grottke, A., Werner, S., Schulte, A., Horn, S., Lamszus, K., Bartkowiak, K., Witzel, I., Westphal, M., Matschke, J., Glatzel, M., Jücker, M., Pukrop, T., Pantel, K. & Wikman, H., 01.2017, In: ONCOTARGET. 8, 4, p. 6155-6168

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  47. Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells

    Toulany, M., Maier, J., Iida, M., Rebholz, S., Holler, M., Grottke, A., Jüker, M., Wheeler, D. L., Rothbauer, U. & Rodemann, H. P., 2017, In: CELL DEATH DISCOV. 3, p. 17072

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  48. 2016

  49. Akt isoform specific effects in ovarian cancer progression

    Linnerth-Petrik, N. M., Santry, L. A., Moorehead, R., Jücker, M., Wootton, S. K. & Petrik, J., 15.11.2016, In: ONCOTARGET. 7, 46, p. 74820-74833 14 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  50. Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4

    Grottke, A., Ewald, F., Lange, T., Nörz, D., Herzberger, C., Bach, J., Grabinski, N., Gräser, L., Höppner, F., Nashan, B., Schumacher, U. & Jücker, M., 2016, In: PLOS ONE. 11, 1, p. e0146370

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  51. Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells

    Holler, M., Grottke, A., Mueck, K., Manes, J., Jücker, M., Rodemann, H. P. & Toulany, M., 2016, In: PLOS ONE. 11, 5, p. e0154745

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  52. 2015

  53. Discontinuing MEK inhibitors in tumor cells with an acquired resistance increases migration and invasion

    Nörz, D., Grottke, A., Bach, J., Herzberger, C., Hofmann, B. T., Nashan, B., Jücker, M. & Ewald, F., 11.2015, In: CELL SIGNAL. 27, 11, p. 2191-200 10 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  54. Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects

    Wellbrock, J., Latuske, E., Köhler, J., Wagner, K., Stamm, H., Vettorazzi, E., Vohwinkel, G., Klokow, M., Uibeleisen, R., Ehm, P., Riecken, K., Loges, S., Thol, F., Schubert, C., Amling, M., Jücker, M., Bokemeyer, C., Heuser, M., Krauter, J. & Fiedler, W., 05.03.2015, In: CLIN CANCER RES.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  55. The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies

    Ehm, P., Nalaskowski, M. M., Wundenberg, T. & Jücker, M., 03.2015, In: NUCLEUS-PHILA. 6, 2, p. 154-64 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  56. ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: Identification of novel targets for concerted therapy concepts

    Kebenko, M., Drenckhan, A., Gros, S. J., Jücker, M., Grabinski, N., Ewald, F., Grottke, A., Schultze, A., Izbicki, J. R., Bokemeyer, C., Wellbrock, J. & Fiedler, W., 01.02.2015, In: CELL SIGNAL. 27, 2, p. 373-81 9 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  57. COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

    Hofmann, B. T., Schlüter, L., Lange, P., Mercanoglu, B., Ewald, F., Fölster, A., Picksak, A-S., Harder, S., El Gammal, A. T., Grupp, K., Güngör, C., Drenckhan, A., Schlüter, H., Wagener, C., Izbicki, J. R., Jücker, M., Bockhorn, M. & Wolters-Eisfeld, G., 01.01.2015, In: MOL CANCER. 14, 1, p. 109

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  58. Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic acid induced 2

    Werner, S., Brors, B., Eick, J., Marques, E., Pogenberg, V., Parret, A., Kemming, D., Wood, A. W., Edgren, H., Neubauer, H., Streichert, T., Riethdorf, S., Bedi, U., Baccelli, I., Jücker, M., Eils, R., Fehm, T., Trumpp, A., Johnsen, S. A., Klefstrom, J., Wilmanns, M., Müller, V., Pantel, K. & Wikman-Kocher, H., 2015, In: CANCER DISCOV. 5, 5, p. 506-19

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  59. Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma

    Ewald, F., Nörz, D., Grottke, A., Bach, J., Herzberger, C., Hofmann, B. T., Nashan, B. & Jücker, M., 2015, In: J CANCER. 6, 12, p. 1195-205 11 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

  60. 2014

  61. H2S preconditioning of human adipose tissue-derived stem cells increases their efficacy in an in vitro model of cell therapy for simulated ischemia

    Dongó, E., Benkő, Z., Csizmazia, Á., Marosi, G., Grottke, A., Jücker, M., Schumacher, U. & Kiss, L., 15.09.2014, In: LIFE SCI. 113, 1-2, p. 14-21 8 p.

    Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

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