Prof.Dr. ID: 59733
Manfred Jücker
Publications
- 2014
AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice
Grabinski, N., Möllmann, K., Milde-Langosch, K., Müller, V., Schumacher, U., Brandt, B., Pantel, K. & Jücker, M., 01.05.2014, In: CELL SIGNAL. 26, 5, p. 1021-9 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
"Alkohol und Nikotin"-Konzept und Evaluation eines interdisziplinären Wahlfachs mit OSPE im Studienabschnitt Medizin 1
Bergelt, C., Lauke-Wettwer, H., Petersen-Ewert, C., Jücker, M. & Bauer, C. K., 2014, In: GMS Z Med Ausbild. 31, 1, p. 1-20 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Education › peer-review
Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
Ewald, F., Nörz, D., Grottke, A., Hofmann, B. T., Nashan, B. & Jücker, M., 2014, In: INVEST NEW DRUG. 32, 6, p. 1144-54 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2013
Combined targeting of AKT and mTOR using MK-2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma
Ewald, F., Grabinski, N., Grottke, A., Windhorst, S., Nörz, D., Carstensen, L., Staufer, K., Hofmann, B. T., Diehl, F., David, K., Schumacher, U., Nashan, B. & Jücker, M., 01.11.2013, In: INT J CANCER. 133, 9, p. 2065-76 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2012
Activation of PI3K/Akt signaling by n-terminal SH2 domain mutants of the p85α regulatory subunit of PI3K is enhanced by deletion of its c-terminal SH2 domain.
Hofmann, B. T. & Jücker, M., 2012, In: CELL SIGNAL. 24, 10, p. 1950-1954 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells.
Grabinski, N., Ewald, F., Hofmann, B. T., Staufer, K., Schumacher, U., Nashan, B. & Jücker, M., 2012, In: MOL CANCER. 11, p. 85Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.
Brauer, H., Strauss, J., Wegner, W., Müller-Tidow, C., Horstmann, M. & Jücker, M., 2012, In: CELL SIGNAL. 24, 11, p. 2095-2101 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The inositol 5-phosphatase SHIP1 is a nucleo-cytoplasmic shuttling protein and enzymatically active in cell nuclei.
Nalaskowski, M., Metzner, A., Brehm, M., Labiadh, S., Brauer, H., Grabinski, N., Mayr, G. W. & Jücker, M., 2012, In: CELL SIGNAL. 24, 3, p. 621-628 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2011
Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells
Grabinski, N., Bartkowiak, K., Grupp, K., Brandt, B., Pantel, K. & Jücker, M., 12.2011, In: CELL SIGNAL. 23, 12, p. 1952-1960 9 p., 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Posttranscriptional regulation of the p85α adapter subunit of phosphatidylinositol 3-kinase in human leukemia cells
Hofmann, B. T., Hoxha, E., Mohr, E., Schulz, K. & Jücker, M., 01.03.2011, In: LEUKEMIA LYMPHOMA. 52, 3, p. 467-477 11 p., 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2009
Reduced proliferation of CD34(+) cells from patients with acute myeloid leukemia after gene transfer of INPP5D.
Metzner, A., Precht, C., Fehse, B., Fiedler, W., Stocking, C., Günther, A., Mayr, G. W. & Jücker, M., 2009, In: GENE THER. 16, 4, p. 570-573 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2008
Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.
Horn, S., Bergholz, U., Jücker, M., McCubrey, J. A., Trümper, L., Stocking, C. & Bäsecke, J., 2008, In: ONCOGENE. 27, 29, p. 4096-4106 29.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2007
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations.
Metzner, A., Horstmann, M., Fehse, B., Ortmeyer, G., Niemeyer, C. M., Stocking, C., Mayr, G. W. & Jücker, M., 2007, In: GENE THER. 14, 8, p. 699-703 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2003
An increase in the expression and total activity of endogenous p60(c-Src) in several factor-independent mutants of a human GM-CSF-dependent leukemia cell line (TF-1)
Horn, S., Meyer, J., Stocking, C., Ostertag, W. & Jücker, M., 16.10.2003, In: ONCOGENE. 22, 46, p. 7170-80 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2002
Hierarchy of stroma-derived factors in supporting growth of stroma-dependent hemopoietic cells membrane-bound SCF is sufficient to confer stroma competence to epithelial cells
Friel, J., Itoh, K., Bergholz, U., Jücker, M., Stocking, C., Harrison, P. & Ostertag, W., 01.03.2002, In: GROWTH FACTORS. 20, 1, p. 35-51 17 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2001
The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro
Horn, S., Meyer, J., Heukeshoven, J., Fehse, B., Schulze, C., Li, S., Frey, J., Poll, S., Stocking, C. & Jücker, M., 01.2001, In: LEUKEMIA. 15, 1, p. 112-20 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1996
Expression of the neural adhesion molecule L1 in the deafferented dentate gyrus
Jucker, M., D'Amato, F., Mondadori, C., Mohajeri, H., Magyar, J., Bartsch, U. & Schachner, M., 12.1996, In: NEUROSCIENCE. 75, 3, p. 703-15 13 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review