Dr. ID: 64460
Lan Kluwe
Publications
- 2010
Extended runs of homozygosity at 17q11.2: an association with type-2 NF1 deletions?
Roehl, A. C., Cooper, D. N., Kluwe, L., Helbrich, A., Wimmer, K., Högel, J., Mautner, V. F. & Kehrer-Sawatzki, H., 2010, In: HUM MUTAT. 31, 3, p. 325-334 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin.
Hummel, T. R., Jessen, W. J., Miller, S. J., Kluwe, L., Mautner, V. F., Wallace, M. R., Lázaro, C., Page, G. P., Worley, P. F., Aronow, B. J., Schorry, E. K. & Ratner, N., 2010, In: CLIN CANCER RES. 16, 20, p. 5048-5057 20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Imatinib mesylate (Glivec) inhibits Schwann cell viability and reduces the size of human plexiform neurofibroma in a xenograft model.
Demestre, M., Herzberg, J., Holtkamp, N., Hagel, C., Reuss, D., Friedrich, R. E., Kluwe, L., Andreas, V. D., Mautner, V. F. & Kurtz, A., 2010, In: J NEURO-ONCOL. 98, 1, p. 11-19 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Intrachromosomal mitotic nonallelic homologous recombination is the major molecular mechanism underlying type-2 NF1 deletions.
Roehl, A. C., Vogt, J., Mussotter, T., Zickler, A. N., Spöti, H., Högel, J., Chuzhanova, N. A., Wimmer, K., Kluwe, L., Mautner, V. F., Cooper, D. N. & Kehrer-Sawatzki, H., 2010, In: HUM MUTAT. 31, 10, p. 1163-1173 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Large intragenic deletions of the NF2 gene: breakpoints and associated phenotypes.
Abo-Dalo, B., Kutsche, K., Mautner, V. F. & Kluwe, L., 2010, In: GENE CHROMOSOME CANC. 49, 2, p. 171-175 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2009
CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice.
Demestre, M., Messerli, S. M., Celli, N., Shahhossini, M., Kluwe, L., Mautner, V. F. & Maruta, H., 2009, In: PHYTOTHER RES. 23, 2, p. 226-230 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genome-wide high-resolution analysis of DNA copy number alterations in NF1-associated malignant peripheral nerve sheath tumors using 32K BAC array.
Mantripragada, K. K., Ståhl, D., Díaz, T., Patridge, C., Menzel, U., Andersson, R., Kluwe, L., Kluwe, L., Mautner, V. F., Mautner, V., Dumanski, J. P. & Upadhyaya, M., 2009, In: GENE CHROMOSOME CANC. 48, 10, p. 897-907 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mechanisms of loss of heterozygosity in neurofibromatosis type 1-associated plexiform neurofibromas.
Steinmann, K., Kluwe, L., Friedrich, R., Mautner, V. F., Cooper, D. N. & Kehrer-Sawatzki, H., 2009, In: J INVEST DERMATOL. 129, 3, p. 615-621 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Ral overactivation in malignant peripheral nerve sheath tumors.
Vidya, B., Yamoutpoor, F., Pan, W., Dudek, A. Z., Esfandyari, T., Piedra, M., Babovick-Vuksanovic, D., Woo, R. A., Mautner, V. F., Kluwe, L., Vries, D., George, H., Thomas, S. L., Kurtz, A., Parada, L. F. & Farassati, F., 2009, In: MOL CELL BIOL. 29, 14, p. 3964-3974 14.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The spectrum of somatic and germline NF1 mutations in NF1 patients with spinal neurofibromas.
Upadhyaya, M., Spurlock, G., Kluwe, L., Chuzhanova, N., Bennett, E., Thomas, N., Guha, A. & Mautner, V. F., 2009, In: NEUROGENETICS. 10, 3, p. 251-263 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2008
Absence of cutaneous neurofibromas in an NF1 patient with an atypical deletion partially overlapping the common 1.4 Mb microdeleted region.
Kehrer-Sawatzki, H., Schmid, E., Fünsterer, C., Kluwe, L. & Mautner, V. F., 2008, In: AM J MED GENET A. 146, 6, p. 691-699 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Alterations in the SMARCB1 (INI1) tumor suppressor gene in familial schwannomatosis.
Boyd, C., Smith, M. J., Kluwe, L., Balogh, A., Maccollin, M. & Plotkin, S. R., 2008, In: CLIN GENET. 74, 4, p. 358-366 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Assessment of benign tumor burden by whole-body MRI in patients with neurofibromatosis 1.
Mautner, V. F., Asuagbor, F. A., Dombi, E., Fünsterer, C., Kluwe, L., Wenzel, R., Widemann, B. C. & Friedman, J. M., 2008, In: NEURO-ONCOLOGY. 10, 4, p. 593-598 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Copy number variations in the NF1 gene region are infrequent and do not predispose to recurrent type-1 deletions.
Steinmann, K., Kluwe, L., Cooper, D. N., Brems, H., Thomas, D. R., Legius, E., Mautner, V. F. & Kehrer-Sawatzki, H., 2008, In: EUR J HUM GENET. 16, 5, p. 572-580 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Correlation of nonsense and frameshift mutations with severity of retinal abnormalities in neurofibromatosis 2.
Feucht, M., Kluwe, L., Mautner, V. F. & Richard, G., 2008, In: ARCH OPHTHALMOL-CHIC. 126, 10, p. 1376-1380 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Germline and somatic NF1 gene mutations in plexiform neurofibromas.
Upadhyaya, M., Spurlock, G., Monem, B., Thomas, N., Friedrich, R., Kluwe, L. & Mautner, V. F., 2008, In: HUM MUTAT. 29, 8, p. 103-111 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).
Upadhyaya, M., Kluwe, L., Spurlock, G., Monem, B., Majounie, E., Mantripragada, K., Ruggieri, M., Chuzhanova, N., Evans, D. G., Ferner, R., Thomas, N., Guha, A. & Mautner, V. F., 2008, In: HUM MUTAT. 29, 1, p. 74-82 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization.
Mantripragada, K. K., Spurlock, G., Kluwe, L., Chuzhanova, N., Ferner, R. E., Frayling, I. M., Dumanski, J. P., Guha, A., Mautner, V. F. & Upadhyaya, M., 2008, In: CLIN CANCER RES. 14, 4, p. 1015-1024 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals.
Mantripragada, K. K., Caley, M., Stephens, P., Jones, C. J., Kluwe, L., Guha, A., Mautner, V. F. & Upadhyaya, M., 2008, In: GENE CHROMOSOME CANC. 47, 3, p. 238-246 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2007
Histopathology and clinical outcome of NF1-associated vs. sporadic malignant peripheral nerve sheath tumors.
Hagel, C., Zils, U., Peiper, M., Kluwe, L., Gotthard, S., Friedrich, R., Zurakowski, D., von Deimling, A. & Mautner, V. F., 2007, In: J NEURO-ONCOL. 82, 2, p. 187-192 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Type 2 NF1 deletions are highly unusual by virtue of the absence of nonallelic homologous recombination hotspots and an apparent preference for female mitotic recombination.
Steinmann, K., Cooper, D. N., Kluwe, L., Chuzhanova, N. A., Senger, C., Serra, E., Lazaro, C., Gilaberte, M., Wimmer, K., Mautner, V. F. & Kehrer-Sawatzki, H., 2007, In: AM J HUM GENET. 81, 6, p. 1201-1220 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2006
Conservation of hotspots for recombination in low-copy repeats associated with the NF1 microdeletion.
Raedt, T. D., Stephens, M., Heyns, I., Brems, H., Thijs, D., Messiaen, L., Stephens, K., Lazaro, C., Wimmer, K., Kehrer-Sawatzki, H., Vidaud, D., Kluwe, L., Marynen, P. & Legius, E., 2006, In: NAT GENET. 38, 12, p. 1419-1423 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues.
Miller, S. J., Rangwala, F., Williams, J., Ackerman, P., Kong, S., Jegga, A. G., Kaiser, S., Aronow, B. J., Frahm, S., Kluwe, L., Mautner, V. F., Upadhyaya, M., Muir, D., Wallace, M., Hagen, J., Quelle, D. E., Watson, M. A., Perry, A., Gutmann, D. H. & Ratner, N., 2006, In: CANCER RES. 66, 5, p. 2584-2591 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
MRI growth patterns of plexiform neurofibromas in patients with neurofibromatosis type 1.
Mautner, V. F., Hartmann, M., Kluwe, L., Friedrich, R. & Fünsterer, C., 2006, In: NEURORADIOLOGY. 48, 3, p. 160-165 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotype.
Aghi, M., Kluwe, L., Webster, M. T., Jacoby, L. B., Barker, F. G., Ojemann, R. G., Mautner, V. F. & MacCollin, M., 2006, In: J NEUROSURG. 104, 2, p. 201-207 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Vitamin D deficiency associated with number of neurofibromas in neurofibromatosis 1.
Lammert, M., Friedman, J. M., Roth, H. J., Friedrich, R., Kluwe, L., Atkins, D., Schooler, T. & Mautner, V. F., 2006, In: J MED GENET. 43, 10, p. 810-813 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2005
Malignant peripheral nerve sheath tumors (MPNST) in neurofibromatosis type 1 (NF1): diagnostic findings on magnetic resonance images and mutation analysis of the NF1 gene
Friedrich, R. E., Kluwe, L., Fünsterer, C. & Mautner, V. F., 2005, In: ANTICANCER RES. 25, 3A, p. 1699-702 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2004
Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated tumors
Kurtz, A., Lueth, M., Kluwe, L., Zhang, T., Foster, R., Mautner, V-F., Hartmann, M., Tan, D-J., Martuza, R. L., Friedrich, R. E., Driever, P. H. & Wong, L-J. C., 01.08.2004, In: MOL CANCER RES. 2, 8, p. 433-41 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients
Frahm, S., Mautner, V-F., Brems, H., Legius, E., Debiec-Rychter, M., Friedrich, R. E., Knöfel, W. T., Peiper, M. & Kluwe, L., 01.06.2004, In: NEUROBIOL DIS. 16, 1, p. 85-91 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients
Frahm, S., Kurtz, A., Kluwe, L., Farassati, F., Friedrich, R. E. & Mautner, V. F., 17.05.2004, In: CANCER CELL INT. 4, 1, p. 4Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Screening 500 unselected neurofibromatosis 1 patients for deletions of the NF1 gene
Kluwe, L., Siebert, R., Gesk, S., Friedrich, R. E., Tinschert, S., Kehrer-Sawatzki, H. & Mautner, V-F., 01.02.2004, In: HUM MUTAT. 23, 2, p. 111-6 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2003
Constitutional NF1 mutations in neurofibromatosis 1 patients with malignant peripheral nerve sheath tumors
Kluwe, L., Friedrich, R. E., Peiper, M., Friedman, J. & Mautner, V-F., 01.11.2003, In: HUM MUTAT. 22, 5, p. 420Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Molecular study of frequency of mosaicism in neurofibromatosis 2 patients with bilateral vestibular schwannomas
Kluwe, L., Mautner, V., Heinrich, B., Dezube, R., Jacoby, L. B., Friedrich, R. E. & MacCollin, M., 01.02.2003, In: J MED GENET. 40, 2, p. 109-14 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Ki-67 proliferation-index (MIB-1) of neurofibromas in neurofibromatosis type 1 patients
Friedrich, R. E., Hagel, C., Brehme, Z., Kluwe, L. & Mautner, V. F., 2003, In: ANTICANCER RES. 23, 2A, p. 953-5 3 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2002
Polyneuropathy in neurofibromatosis 2: clinical findings, molecular genetics and neuropathological alterations in sural nerve biopsy specimens
Hagel, C., Lindenau, M., Lamszus, K., Kluwe, L., Stavrou, D. & Mautner, V-F., 08.2002, In: ACTA NEUROPATHOL. 104, 2, p. 179-87 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
NF1 mutations in neurofibromatosis 1 patients with plexiform neurofibromas
Kluwe, L., Friedrich, R. E., Korf, B., Fahsold, R. & Mautner, V-F., 01.03.2002, In: HUM MUTAT. 19, 3, p. 309Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Presymptomatic diagnosis for children of sporadic neurofibromatosis 2 patients: a method based on tumor analysis
Kluwe, L., Friedrich, R. E., Tatagiba, M. & Mautner, V. F., 2002, In: GENET MED. 4, 1, p. 27-30 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2001
Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas
Kluwe, L., Hagel, C., Tatagiba, M., Thomas, S., Stavrou, D., Ostertag, H., von Deimling, A. & Mautner, V. F., 01.09.2001, In: J NEUROPATH EXP NEUR. 60, 9, p. 917-20 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2000
Mutations and allelic loss of the NF2 gene in neurofibromatosis 2-associated skin tumors
Kluwe, L., Friedrich, R. E., Hagel, C., Lindenau, M. & Mautner, V. F., 01.05.2000, In: J INVEST DERMATOL. 114, 5, p. 1017-21 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1999
Allelic loss of the NF1 gene in NF1-associated plexiform neurofibromas
Kluwe, L., Friedrich, R. E. & Mautner, V. F., 01.08.1999, In: CANCER GENET-NY. 113, 1, p. 65-9 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 1998
Trk A, B, and C are commonly expressed in human astrocytes and astrocytic gliomas but not by human oligodendrocytes and oligodendroglioma
Wang, Y., Hagel, C., Hamel, W., Müller, S., Kluwe, L. & Westphal, M., 01.10.1998, In: ACTA NEUROPATHOL. 96, 4, p. 357-64 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients
Rosenbaum, C., Kluwe, L., Mautner, V. F., Friedrich, R. E., Müller, H. W. & Hanemann, C. O., 01.07.1998, In: NEUROBIOL DIS. 5, 1, p. 55-64 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review