Dr. rer. nat. ID: 74441
Anna-Franziska Worthmann
Publications
- 2024
Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
Bay, B., Fuh, M. M., Rohde, J., Worthmann, A., Goßling, A., Arnold, N., Koester, L., Lorenz, T., Blaum, C., Kirchhof, P., Blankenberg, S., Seiffert, M., Brunner, F. J., Waldeyer, C. & Heeren, J., 26.06.2024, In: LIPIDS HEALTH DIS. 23, 1, p. 197Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages
Liebold, I., Al Jawazneh, A., Casar, C., Lanzloth, C., Leyk, S., Hamley, M., Wong, M. N., Kylies, D., Gräfe, S. K., Edenhofer, I., Aranda-Pardos, I., Kriwet, M., Haas, H., Krause, J., Hadjilaou, A., Schromm, A. B., Richardt, U., Eggert, P., Tappe, D., Weidemann, S. A., Ghosh, S., Krebs, C. F., A-Gonzalez, N., Worthmann, A., Lohse, A. W., Huber, S., Rothlin, C. V., Puelles, V. G., Jacobs, T., Gagliani, N. & Bosurgi, L., 05.04.2024, In: SCIENCE. 384, 6691, p. eabo7027Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Worthmann, A., Ridder, J., Piel, S. Y. L., Evangelakos, I., Musfeldt, M., Voß, H., O'Farrell, M., Fischer, A. W., Adak, S., Sundd, M., Siffeti, H., Haumann, F., Kloth, K., Bierhals, T., Heine, M., Pertzborn, P., Pauly, M., Scholz, J-J., Kundu, S., Fuh, M. M., Neu, A., Tödter, K., Hempel, M., Knippschild, U., Semenkovich, C. F., Schlüter, H., Heeren, J., Scheja, L., Kubisch, C. & Schlein, C., 02.01.2024, In: NAT COMMUN. 15, 1, p. 45Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The short-chain fatty acid receptors Gpr41/43 regulate bone mass by promoting adipogenic differentiation of mesenchymal stem cells
Behler-Janbeck, F., Baranowsky, A., Schinke, T., Jaeckstein, M. Y., Worthmann, A., Fuh, M. M., Gunasekaran, K., Tiegs, G., Amling, M., Schinke, T. & Heeren, J., 2024, In: FRONT ENDOCRINOL. 15, p. 1392418Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice
Benzi, A., Heine, M., Spinelli, S., Salis, A., Worthmann, A., Diercks, B., Astigiano, C., Pérez Mato, R., Memushaj, A., Sturla, L., Vellone, V., Damonte, G., Jaeckstein, M. Y., Koch-Nolte, F., Mittrücker, H-W., Guse, A. H., De Flora, A., Heeren, J. & Bruzzone, S., 2024, In: FRONT ENDOCRINOL. 14, p. 1251351Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2023
A liquid chromatography-tandem mass spectrometry based method for the quantification of adenosine nucleotides and NAD precursors and products in various biological samples
Hiefner, J., Rische, J., Bunders, M. J. & Worthmann, A., 20.09.2023, In: FRONT IMMUNOL. 14, p. 1250762Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Short-term dietary changes can result in mucosal and systemic immune depression
Siracusa, F., Schaltenberg, N., Kumar, Y., Lesker, T. R., Steglich, B., Liwinski, T., Cortesi, F., Frommann, L., Diercks, B-P., Bönisch, F., Fischer, A. W., Scognamiglio, P., Pauly, M. J., Casar, C., Cohen, Y., Pelczar, P., Agalioti, T., Delfs, F., Worthmann, A., Wahib, R., Jagemann, B., Mittrücker, H-W., Kretz, O., Guse, A. H., Izbicki, J. R., Lassen, K. G., Strowig, T., Schweizer, M., Villablanca, E. J., Elinav, E., Huber, S., Heeren, J. & Gagliani, N., 09.2023, In: NAT IMMUNOL. 24, 9, p. 1473-1486 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD
Liebold, I., Meyer, S., Heine, M., Kuhl, A., Witt, J., Eissing, L., Fischer, A. W., Koop, A. C., Kluwe, J., Wiesch, J. S. Z., Wehmeyer, M., Knippschild, U., Scheja, L., Heeren, J., Bosurgi, L. & Worthmann, A., 17.01.2023, In: CELLS-BASEL. 12, 3, 341.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2022
Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice
Evangelakos, I., Kuhl, A., Baguhl, M., Schlein, C., John, C., Rohde, J. K., Heine, M. & Worthmann, A-F., 11.04.2022, In: FRONT CELL DEV BIOL. 10, 10, p. 836741 836741.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A Gas Chromatography Mass Spectrometry-Based Method for the Quantification of Short Chain Fatty Acids
Rohde, J. K., Fuh, M. M., Evangelakos, I., Pauly, M. J., Schaltenberg, N., Siracusa, F., Gagliani, N., Tödter, K., Heeren, J. & Worthmann, A., 11.02.2022, In: METABOLITES. 12, 2, 170.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Susceptibility to diet-induced obesity at thermoneutral conditions is independent of UCP1
Dieckmann, S., Strohmeyer, A., Willershäuser, M., Maurer, S. F., Wurst, W., Marschall, S., de Angelis, M. H., Kühn, R., Worthmann, A., Fuh, M. M., Heeren, J., Köhler, N., Pauling, J. K. & Klingenspor, M., 01.02.2022, In: AM J PHYSIOL-ENDOC M. 322, 2, p. E85-E100Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
MALDI MSI for a fresh view on atherosclerotic plaque lipids
Worthmann, A. & Bartelt, A., 02.2022, In: PFLUG ARCH EUR J PHY. 474, 2, p. 185-186 2 p.Research output: SCORING: Contribution to journal › Other (editorial matter etc.) › Research
- 2021
Oxysterol 7-α Hydroxylase (CYP7B1) Attenuates Metabolic-Associated Fatty Liver Disease in Mice at Thermoneutrality
Evangelakos, I., Schwinge, D., Worthmann, A., John, C., Roeder, N., Pertzborn, P., Behrens, J., Schramm, C., Scheja, L. & Heeren, J., 05.10.2021, In: CELLS-BASEL. 10, 10, p. 2656Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation
Fischer, A. W., Jaeckstein, M. Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns, O. T., Yuan, Y., Zhu, H., Chen, O., Ittrich, H., Nilsson, S. K., Stefanicka, P., Ukropec, J., Balaz, M., Dong, H., Sun, W., Reimer, R., Scheja, L. & Heeren, J., 02.03.2021, In: CELL METAB. 33, 3, p. 547-564.e7Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
Schlein, C., Fischer, A. W., Sass, F., Worthmann, A., Tödter, K., Jaeckstein, M. Y., Behrens, J., Lynes, M. D., Kiebish, M. A., Narain, N. R., Bussberg, V., Jespersen, N. Z., Nielsen, S., Scheele, C., Schweizer, M., Braren, I., Bartelt, A., Tseng, Y-H., Heeren, J. & Scheja, L., 12.01.2021, In: CELL REP. 34, 2, p. 108624Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Endothelial Lipase Is Involved in Cold-Induced High-Density Lipoprotein Turnover and Reverse Cholesterol Transport in Mice
Schaltenberg, N., John, C., Heine, M., Haumann, F., Rinninger, F., Scheja, L., Heeren, J. & Worthmann, A., 2021, In: FRONT CARDIOVASC MED. 8, p. 628235Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2020
Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature
Pauly, M. J., Rohde, J. K., John, C., Evangelakos, I., Koop, A. C., Pertzborn, P., Tödter, K., Scheja, L., Heeren, J. & Worthmann, A., 20.10.2020, In: NUTRIENTS. 12, 10Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2019
Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression
Worthmann, A., Schlein, C., Berbée, J. F. P., Rensen, P. C. N., Heeren, J. & Bartelt, A., 23.02.2019, In: NUTRIENTS. 11, 2Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2018
Assessment of Uptake and Biodistribution of Radiolabeled Cholesterol in Mice Using Gavaged Recombinant Triglyceride-rich Lipoprotein Particles (rTRL)
Worthmann, A., John, C. & Heeren, J., 05.07.2018, In: BIO-PROTOCOL. 8, 13, p. e2916Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2017
Metabolic Circuit Involving Free Fatty Acids, microRNA 122, and Triglyceride Synthesis in Liver and Muscle Tissues
Chai, C., Rivkin, M., Berkovits, L., Simerzin, A., Zorde-Khvalevsky, E., Rosenberg, N., Klein, S., Yaish, D., Durst, R., Shpitzen, S., Udi, S., Tam, J., Heeren, J., Worthmann, A., Schramm, C., Kluwe, J., Ravid, R., Hornstein, E., Giladi, H. & Galun, E., 11.2017, In: GASTROENTEROLOGY. 153, 5, p. 1404-1415Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O'Loughlin, E., Xu, Y., Fanek, Z., Greco, D. J., Smith, S. T., Tweet, G., Humulock, Z., Zrzavy, T., Conde-Sanroman, P., Gacias, M., Weng, Z., Chen, H., Tjon, E., Mazaheri, F., Hartmann, K., Madi, A., Ulrich, J. D., Glatzel, M., Worthmann, A., Heeren, J., Budnik, B., Lemere, C., Ikezu, T., Heppner, F. L., Litvak, V., Holtzman, D. M., Lassmann, H., Weiner, H. L., Ochando, J., Haass, C. & Butovsky, O., 19.09.2017, In: IMMUNITY. 47, 3, p. 566-581.e9Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
Worthmann, A., John, C., Rühlemann, M. C., Baguhl, M., Heinsen, F-A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., Fischer, M., Dandri, M., Kremoser, C., Scheja, L., Franke, A., Shaul, P. W. & Heeren, J., 07.2017, In: NAT MED. 23, 7, p. 839-849 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
Bartelt, A., John, C., Schaltenberg, N., Berbée, J. F. P., Worthmann, A., Cherradi, M. L., Schlein, C., Piepenburg, J., Boon, M. R., Rinninger, F., Heine, M., Toedter, K., Niemeier, A., Nilsson, S. K., Fischer, M., Wijers, S. L., van Marken Lichtenbelt, W. D., Scheja, L., Rensen, P. C. N. & Heeren, J., 19.04.2017, In: NAT COMMUN. 8, p. Art. 15010Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2015
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., Jung, C., Vazirpanah, N., Brouwers, L. P. J., Gordts, P. L. S. M., Esko, J. D., Hiemstra, P. S., Havekes, L. M., Scheja, L., Heeren, J. & Rensen, P. C. N., 2015, In: NAT COMMUN. 6, p. 6356Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2014
A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids
John, C., Werner, P., Worthmann, A., Wegner, K., Tödter, K., Scheja, L., Rohn, S., Heeren, J. & Fischer, M., 05.12.2014, In: J CHROMATOGR A. 1371, p. 184-195 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review