Department of Stem Cell Transplantation
Publications
- 2003
Predictable and efficient retroviral gene transfer into murine bone marrow repopulating cells using a defined vector dose
Li, Z., Schwieger, M., Lange, C., Kraunus, J., Sun, H., van den Akker, E., Modlich, U., Serinsöz, E., Will, E., von Laer, D., Stocking, C., Fehse, B., Schiedlmeier, B. & Baum, C., 01.12.2003, In: Experimental hematology. 31, 12, p. 1206-14 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mutagenesis by retroviral transgene insertion: risk assessment and potential alternatives
Baum, C. & Fehse, B., 10.2003, In: Current opinion in molecular therapeutics. 5, 5, p. 458-62 5 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Minor histocompatibility antigens on canine hemopoietic progenitor cells
Weber, M., Lange, C., Günther, W., Franz, M., Kremmer, E. & Kolb, H-J., 15.06.2003, In: J IMMUNOL. 170, 12, p. 5861-8 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Receptor activator of nuclear factor kappaB ligand plays a nonredundant role in doxorubicin-induced apoptosis
Müller, I., Pfister, S. M., Grohs, U., Zweigner, J., Handgretinger, R., Niethammer, D. & Bruchelt, G., 15.04.2003, In: CANCER RES. 63, 8, p. 1772-5 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Side effects of retroviral gene transfer into hematopoietic stem cells
Baum, C., Düllmann, J., Li, Z., Fehse, B., Meyer, J., Williams, D. A. & von Kalle, C., 15.03.2003, In: BLOOD. 101, 6, p. 2099-114 16 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
ATG as part of the conditioning regimen reduces transplant-related mortality (TRM) and improves overall survival after unrelated stem cell transplantation in patients with chronic myelogenous leukemia (CML).
Zander, A. R., Kröger, N., Schleuning, M., Finke, J., Zabelina, T., Beelen, D., Schwerdtfeger, R., Baurmann, H., Bornhäuser, M., Ehninger, G., Fauser, A. A., Kiehl, M., Trenschel, R., Ottinger, H. D., Bertz, H., Berger, J., Kolb, H-J. & Schaefer, U. W., 2003, In: BONE MARROW TRANSPL. 32, 4, p. 355-361 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Characterization of cell types during rat liver development.
Fiegel, H. C., Park, J. J. H., Lioznov, M., Martin, A., Jaeschke-Melli, S., Kaufmann, P. M., Fehse, B., Zander, A. R. & Kluth, D., 2003, In: HEPATOLOGY. 37, 1, p. 148-154 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hepatic lineages isolated from developing rat liver show different ways of maturation.
Fiegel, H. C., Kluth, J., Lioznov, M., Holzhüter, S., Fehse, B., Zander, A. & Kluth, D., 2003, In: BIOCHEM BIOPH RES CO. 305, 1, p. 46-53 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation.
Fehse, N., Fehse, B., Kröger, N-M., Zabelina, T., Freiberger, P., Krüger, W., Kabisch, H., Erttmann, R. & Zander, A., 2003, In: J HEMATOTH STEM CELL. 12, 2, p. 237-242 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Liver-specific gene expression in cultured human hematopoietic stem cells.
Fiegel, H. C., Lioznov, M., Cortes-Dericks, L., Lange, C., Kluth, D., Fehse, B. & Zander, A. R., 2003, In: STEM CELLS. 21, 1, p. 98-104 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Myeloablative intensified conditioning regimen with in vivo T-cell depletion (ATG) followed by allografting in patients with advanced multiple myeloma. A phase I/II study of the German Study-group Multiple Myeloma (DSMM).
Kröger, N-M., Einsele, H., Wolff, D., Casper, J., Freund, M., Derigs, G., Wandt, H., Schäfer-Eckart, K., Wittkowsky, G., Schmitz, N., Krüger, W., Zabelina, T., Renges, H., Ayuketang Ayuk, F., Krüll, A. & Zander, A., 2003, In: BONE MARROW TRANSPL. 31, 11, p. 973-979 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Non-overt disseminated intravascular coagulation in patients during treatment with antithymocyte globulin for unrelated allogeneic hematopoietic stem cell transplantation.
Weber, M., Kröger, N., Langer, F., Hansen, A., Zabelina, T., Eifrig, B., Hossfeld, D. K. & Zander, A. R., 2003, In: BONE MARROW TRANSPL. 31, 9, p. 817-822 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2002
A novel 'sort-suicide' fusion gene vector for T cell manipulation
Fehse, B., Kustikova, O. S., Li, Z., Wahlers, A., Bohn, W., Beyer, W. R., Chalmers, D., Tiberghien, P., Kühlcke, K., Zander, A. R. & Baum, C., 12.2002, In: GENE THER. 9, 23, p. 1633-1638 6 p.Research output: SCORING: Contribution to journal › Short publication › Research › peer-review
Human mesenchymal stem cells are not of donor origin in patients with severe aplastic anemia who underwent sex-mismatched allogeneic bone marrow transplant
Stute, N., Fehse, B., Schröder, J., Arps, S., Adamietz, P., Held, K. R. & Zander, A. R., 12.2002, In: J HEMATOTH STEM CELL. 11, 6, p. 977-984 8 p.Research output: SCORING: Contribution to journal › Short publication › Research › peer-review
Molecular methods for detection and quantification of myeloma cells after bone marrow transplantation: comparison between real-time quantitative and nested PCR
Tögel, F., Kröger, N., Korioth, F., Fehse, B. & Zander, A. R., 12.2002, In: J HEMATOTH STEM CELL. 11, 6, p. 971-976 6 p.Research output: SCORING: Contribution to journal › Short publication › Research › peer-review
Interleukin-10 modulation of alloreactivity and graft-versus-host reactions
Wang, X-N., Lange, C., Schulz, U., Sviland, L., Eissner, G., Oliver, K. M., Jackson, G. H., Holler, E. & Dickinson, A. M., 27.09.2002, In: TRANSPLANTATION. 74, 6, p. 772-8 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Persisting multilineage transgene expression in the clonal progeny of a hematopoietic stem cell
Li, Z., Fehse, B., Schiedlmeier, B., Düllmann, J., Frank, O., Zander, A. R., Ostertag, W. & Baum, C., 09.2002, In: LEUKEMIA. 16, 9, p. 1655-63 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Upstream conserved sequences of mouse leukemia viruses are important for high transgene expression in lymphoid and hematopoietic cells
Wahlers, A., Kustikova, O., Zipfel, P. F., Itoh, K., Koester, M., Heberlein, C., Li, Z., Schiedlmeier, B., Skerka, C., Fehse, B. & Baum, C., 09.2002, In: MOL THER. 6, 3, p. 313-320 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Murine leukemia induced by retroviral gene marking
Li, Z., Düllmann, J., Schiedlmeier, B., Schmidt, M., von Kalle, C., Meyer, J., Forster, M., Stocking, C., Wahlers, A., Frank, O., Ostertag, W., Kühlcke, K., Eckert, H-G., Fehse, B. & Baum, C., 19.04.2002, In: SCIENCE. 296, 5567, p. 497Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Allogeneic stem cell transplantation of adult chronic myelomonocytic leukaemia. A report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT).
Kröger, N., Zabelina, T., Guardiola, P., Volker, R., Sierra, J., Anja, V. B., Niederwieser, D., Zander, A. R. & Theo, D. W., 2002, In: BRIT J HAEMATOL. 118, 1, p. 67-73 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Allogeneic transplantation after reduced conditioning in high risk patients is complicated by a high incidence of acute and chronic graft-versus-host disease.
Schetelig, J., Kröger, N-M., Held, T. K., Christian, T., Krusch, A., Zabelina, T., Dubiel, M., Rick, O., Bornhäuser, M., Ehninger, G., Zander, A. & Siegert, W., 2002, In: HAEMATOLOGICA. 87, 3, p. 299-305 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma.
Kröger, N-M., Schwerdtfeger, R., Kiehl, M., Sayer, H. G., Renges, H-H., Zabelina, T., Fehse, B., Tögel, F., Wittkowsky, G., Kuse, R. & Zander, A., 2002, In: BLOOD. 100, 3, p. 755-760 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Binding of activated platelets to WBCs in vivo after transfusion.
Gutensohn, K., Geidel, K., Brockmann, M., Siemensen, M., Krueger, W., Kröger, N. & Kuehnl, P., 2002, In: TRANSFUSION. 42, 10, p. 1373-1380 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Dose-reduced conditioning regimen followed by allogeneic stem cell transplantation in patients with myelofibrosis with myeloid metaplasia.
Hessling, J., Kröger, N-M., Werner, M., Zabelina, T., Hansen, A., Kordes, U., Ayuketang Ayuk, F., Renges, H-H., Panse, J., Erttmann, R. & Zander, A., 2002, In: BRIT J HAEMATOL. 119, 3, p. 769-772 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Highly efficient retroviral gene transfer based on centrifugation-mediated vector preloading of tissue culture vessels.
Kühlcke, K., Fehse, B., Schilz, A., Loges, S., Lindemann, C., Ayuketang Ayuk, F., Lehmann, F., Stute, N., Fauser, A. A., Zander, A. R. & Eckert, H-G., 2002, In: MOL THER. 5, 4, p. 473-478 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
In vivo T cell depletion with pretransplant anti-thymocyte globulin reduces graft-versus-host disease without increasing relapse in good risk myeloid leukemia patients after stem cell transplantation from matched related donors.
Kröger, N., Zabelina, T., Krüger, W., Renges, H., Stute, N., Rischewski, J., Sonnenberg, S., Ayuk, F., Ayuketang Ayuk, F., Schade, U., Fiegel, H., Erttmann, R., Löliger, C. & Zander, A. R., 2002, In: BONE MARROW TRANSPL. 29, 8, p. 683-689 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus antithymocyte globulin.
Kröger, N., Zabelina, T., Renges, H., Krüger, W., Kordes, U., Rischewski, J., Schrum, J., Horstmann, M., Ayuketang Ayuk, F., Erttmann, R., Kabisch, H. & Zander, A. R., 2002, In: ANN HEMATOL. 81, 11, p. 627-631 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Platelet function testing in apheresis products: flow cytometric, resonance thrombographic (RTG) and rotational thrombelastographic (roTEG) analyses.
Gutensohn, K., Geidel, K., Kröger, N., Eifrig, B., Crespeigne, N. & Kuehnl, P., 2002, In: TRANSFUS APHER SCI. 26, 3, p. 147-155 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Radiotherapy after high-dose chemotherapy and peripheral blood stem cell support in high-risk breast cancer.
Hoeller, U., Juergen, H., Kröger, N., Krueger, W., Jaenicke, F. & Alberti, W., 2002, In: INT J RADIAT ONCOL. 53, 5, p. 1234-1239 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Reconstitution of mRNA editing in yeast using a Gal4-apoB-Gal80 fusion transcript as the selectable marker.
Lellek, H., Welker, S., Diehl, I., Kirsten, R. & Greeve, J., 2002, In: J BIOL CHEM. 277, 26, p. 23638-23644 26.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
[Unrelated donor stem cell transplantation in children: low toxicity using a GvHD-prophylaxis regimen with CSA, MTX, metronidazole,iv-immunoglobulin and ATG]
Graf Finckenstein, F., Zabelina, T., Dürken, M., Dahlke, J., Kröger, N., Krüger, W., Janka-Schaub, G., Erttmann, R., Zander, A. R. & Kabisch, H., 2002, In: KLIN PADIATR. 214, 4, p. 206-211 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Unrelated stem cell transplantation in multiple myeloma after a reduced-intensity conditioning with pretransplantation antithymocyte globulin is highly effective with low transplantation-related mortality.
Kröger, N., Sayer, H. G., Schwerdtfeger, R., Kiehl, M., Nagler, A., Renges, H., Zabelina, T., Fehse, B., Ayuketang Ayuk, F., Wittkowsky, G., Schmitz, N. & Zander, A. R., 2002, In: BLOOD. 100, 12, p. 3919-3924 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2001
Noncutaneous varicella-zoster virus (VZV) infection with fatal liver failure in a child with acute lymphoblastic leukemia (ALL)
Müller, I., Aepinus, C., Beck, R., Bültmann, B., Niethammer, D. & Klingebiel, T., 08.2001, In: Med Pediatr Oncol. 37, 2, p. 145-7 3 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Mass-spectrometry-linked screening of protein fractions for enzymatic activities--a tool for functional genomics
Jankowski, J., Stephan, N., Knobloch, M., Fischer, S., Schmaltz, D., Zidek, W. & Schlüter, H., 03.2001, In: ANAL BIOCHEM. 290, 2, p. 324-9 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Membrane-anchored peptide inhibits human immunodeficiency virus entry
Hildinger, M., Dittmar, M. T., Schult-Dietrich, P., Fehse, B., Schnierle, B. S., Thaler, S., Stiegler, G., Welker, R. & von Laer, D., 03.2001, In: J VIROL. 75, 6, p. 3038-42 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro
Horn, S., Meyer, J., Heukeshoven, J., Fehse, B., Schulze, C., Li, S., Frey, J., Poll, S., Stocking, C. & Jücker, M., 01.2001, In: LEUKEMIA. 15, 1, p. 112-20 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
A fludarabine-based dose-reduced conditioning regimen followed by allogeneic stem cell transplantation from related or unrelated donors in patients with myelodysplastic syndrome.
Kröger, N., Schetelig, J., Zabelina, T., Krüger, W., Renges, H., Stute, N., Schrum, J., Kabisch, H., Siegert, W. & Zander, A. R., 2001, In: BONE MARROW TRANSPL. 28, 7, p. 643-647 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Anti-thymocyte-globulin as part of the preparative regimen prevents graft failure and severe graft versus host disease (GvHD) in allogeneic stem cell transplantation from unrelated donors.
Kröger, N., Zabelina, T., Krüger, W., Renges, H., Stute, N., Dürken, M., Graf von Finkenstein, F., Erttmann, R., Kabisch, H., Schafhausen, P., Jaburg, N., Löliger, C. & Zander, A. R., 2001, In: ANN HEMATOL. 80, 4, p. 209-215 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Comparison of total body irradiation vs busulfan in combination with cyclophosphamide as conditioning for unrelated stem cell transplantation in CML patients.
Kröger, N., Zabelina, T., Krüger, W., Renges, H., Stute, N., Kabisch, H., Jaburg, N., Löliger, C., Krüll, A. & Zander, A. R., 2001, In: BONE MARROW TRANSPL. 27, 4, p. 349-354 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Donor lymphocyte infusion enhances remission status in patients with persistent disease after allografting for multiple myeloma.
Kröger, N., Krüger, W., Renges, H., Zabelina, T., Stute, N., Jung, R., Wittkowsky, G., Kuse, R. & Zander, A., 2001, In: BRIT J HAEMATOL. 112, 2, p. 421-423 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Patient cytomegalovirus seropositivity with or without reactivation is the most important prognostic factor for survival and treatment-related mortality in stem cell transplantation from unrelated donors using pretransplant in vivo T-cell depletion with anti-thymocyte globulin.
Kröger, N., Zabelina, T., Krüger, W., Renges, H., Stute, N., Schrum, J., Kabisch, H., Schafhausen, P., Jaburg, N., Löliger, C., Schäfer, P., Hinke, A. & Zander, A. R., 2001, In: BRIT J HAEMATOL. 113, 4, p. 1060-1071 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Real-time quantitative Y chromosome-specific PCR (QYCS-PCR) for monitoring hematopoietic chimerism after sex-mismatched allogeneic stem cell transplantation.
Fehse, B., Chukhlovin, A., Kühlcke, K., Marinetz, O., Vorwig, O., Renges, H., Krüger, W., Zabelina, T., Dudina, O., Finckenstein, F. G., Kröger, N., Kabisch, H., Hochhaus, A. & Zander, A. R., 2001, In: J HEMATOTH STEM CELL. 10, 3, p. 419-425 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
T lymphocytes as targets of gene transfer with Moloney-type retroviral vectors.
Ayuketang Ayuk, F., Zander, A. R. & Fehse, B., 2001, In: CURR GENE THER. 1, 4, p. 325-337 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2000
Generation of functionally mature dendritic cells from the multipotential stem cell line FDCP-mix
Schroeder, T., Strehl, J., Lange, C. & Just, U., 01.12.2000, In: BRIT J HAEMATOL. 111, 3, p. 890-7 8 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
In vitro-generated stem cell leukaemia showing altered cell cycle progression with distinct signalling of the tyrosine-phosphorylated rasGAP-associated p62(dok) protein
Huss, R., Weissinger, E. M., Lange, C., Gatsios, P., Eissner, G., Kolb, H. J., Diebold, J., Heinrich, P. C. & Graeve, L., 01.11.2000, In: J PATHOL. 192, 3, p. 363-72 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Quiescence of CD34-negative haematopoietic stem cells is mediated by downregulation of Cyclin B and no stat activation
Huss, R., Gatsios, P., Graeve, L., Lange, C., Eissner, G., Kolb, H. J., Thalmeier, K. & Heinrich, P. C., 01.08.2000, In: CYTOKINE. 12, 8, p. 1195-204 10 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
CD34 splice variant: an attractive marker for selection of gene-modified cells
Fehse, B., Richters, A., Putimtseva-Scharf, K., Klump, H., Li, Z., Ostertag, W., Zander, A. R. & Baum, C., 05.2000, In: MOL THER. 1, 5 Pt 1, p. 448-456 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Evidence of peripheral blood-derived, plastic-adherent CD34(-/low) hematopoietic stem cell clones with mesenchymal stem cell characteristics
Huss, R., Lange, C., Weissinger, E. M., Kolb, H. J. & Thalmeier, K., 01.01.2000, In: STEM CELLS. 18, 4, p. 252-60 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Dose-dependent effect of etoposide in combination with busulfan plus cyclophosphamide as conditioning for stem cell transplantation in patients with acute myeloid leukemia.
Kröger, N., Zabelina, T., Sonnenberg, S., Krüger, W., Renges, H., Stute, N., Finkenstein, F., Mayer, U., Holstein, K., Fiedler, W., Colberg, H., Sonnen, R., Kuse, R., Braumann, D., Metzner, B., Del Valle, F., Erttmann, R., Kabisch, H. & Zander, A. R., 2000, In: BONE MARROW TRANSPL. 26, 7, p. 711-716 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Extracorporeal plateletpheresis induces the interaction of activated platelets with white blood cells.
Gutensohn, K., Alisch, A., Krueger, W., Kröger, N. & Kuehnl, P., 2000, In: VOX SANG. 78, 2, p. 101-105 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review