Department of Stem Cell Transplantation
Publications
- 2006
Oral valganciclovir leads to higher exposure to ganciclovir than intravenous ganciclovir in patients following allogeneic stem cell transplantation.
Einsele, H., Reusser, P., Bornhäuser, M., Kalhs, P., Ehninger, G., Hebart, H., Chalandon, Y., Kröger, N., Hertenstein, B. & Rohde, F., 2006, In: BLOOD. 107, 7, p. 3002-3008 7.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)--novel predictors for response and survival in gastric cancer patients.
Goekkurt, E., Hoehn, S., Wolschke, C., Wittmer, C., Stueber, C., Hossfeld, D. K. & Stoehlmacher, J., 2006, In: BRIT J CANCER. 94, 2, p. 281-286 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients.
Kröger, N., Milde-Langosch, K., Riethdorf, S., Schmoor, C., Schumacher, M., Zander, A. R. & Löning, T., 2006, In: CLIN CANCER RES. 12, 1, p. 159-168 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Prognostic factors for donor lymphocyte infusions following non-myeloablative allogeneic stem cell transplantation in multiple myeloma.
van de Donk, N. W. C. J., Kröger, N., Hegenbart, U., Corradini, P., San Miguel, J. F., Goldschmidt, H., Perez-Simon, J. A., Zijlmans, M., Raymakers, R. A., Montefusco, V., Ayuketang Ayuk, F., van Oers, M. H. J., Nagler, A., Verdonck, L. F. & Lokhorst, H. M., 2006, In: BONE MARROW TRANSPL. 37, 12, p. 1135-1141 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Randomized trial of single compared with tandem high-dose chemotherapy followed by autologous stem-cell transplantation in patients with chemotherapy-sensitive metastatic breast cancer.
Kröger, N., Frick, M., Gluz, O., Mohrmann, S., Metzner, B., Jackisch, C., Ko, Y., Lindemann, H-W., Meier, C. R., Lohrmann, H. P., Ruffert, U., Hänel, M., Bodenstein, H., Neubauer, A., Ehninger, G., Wolf, H-H., Kolbe, K., Burock, K., Zander, A. R. & Nitz, U., 2006, In: J CLIN ONCOL. 24, 24, p. 3919-3926 24.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS).
Kröger, N., Shimoni, A., Zabelina, T., Schieder, H., Panse, J., Ayuketang Ayuk, F., Wolschke, C., Renges, H., Dahlke, J., Atanackovic, D., Nagler, A. & Zander, A. R., 2006, In: BONE MARROW TRANSPL. 37, 4, p. 339-344 4.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Remarkable activity of novel agents bortezomib and thalidomide in patients not responding to donor lymphocyte infusions following nonmyeloablative allogeneic stem cell transplantation in multiple myeloma.
Donk, V. D., Kröger, N., Kröger, N., Hegenbart, U., Corradini, P., Miguel, S., Jesus, F., Goldschmidt, H., Perez-Simon, J. A., Zijlmans, M., Ayuketang Ayuk, F., Montefusco, V., Ayuk, F. A., Oers, V., Marinus, H. J., Nagler, A., Verdonck, L. F. & Lokhorst, H. M., 2006, In: BLOOD. 107, 8, p. 3415-3416 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Retroviral vector insertions in T-lymphocytes used for suicide gene therapy occur in gene groups with specific molecular functions.
Giordano, F. A., Fehse, B., Hotz-Wagenblatt, A., Jonnakuty, S., Del Val, C., Appelt, J-U., Nagy, K. Z., Kuehlcke, K., Naundorf, S., Zander, A. R., Zeller, W. J., Ho, A. D., Fruehauf, S. & Laufs, S., 2006, In: BONE MARROW TRANSPL. 38, 3, p. 229-235 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Sensitive balance of suppressing and activating effects of mesenchymal stem cells on T-cell proliferation.
Fang, L., Lange, C., Engel, M., Zander, A. R. & Fehse, B., 2006, In: TRANSPLANTATION. 82, 10, p. 1370-1373 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
The role of stem cell source in autologous hematopoietic stem cell transplantation for patients with myelodysplastic syndromes.
de Witte, T., Brand, R., van Biezen, A., Delforge, M., Biersack, H., Or, R., Meloni, G., Bandini, B., Sierra, J., Kröger, N., Gratwohl, A. & Niederwieser, D., 2006, In: HAEMATOLOGICA. 91, 6, p. 750-756 6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2005
A comparison between three graft manipulation methods for haploidentical stem cell transplantation in pediatric patients: preliminary results of a pilot study
Lang, P., Schumm, M., Greil, J., Bader, P., Klingebiel, T., Müller, I., Feuchtinger, T., Pfeiffer, M., Schlegel, P-G., Niethammer, D. & Handgretinger, R., 25.11.2005, In: KLIN PADIATR. 217, 6, p. 334-8 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats
Lange, C., Tögel, F., Ittrich, H., Clayton, F., Nolte-Ernsting, C., Zander, A. R. & Westenfelder, C., 01.10.2005, In: KIDNEY INT. 68, 4, p. 1613-7 5 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Untersuchungen zur Markierung von mesenchymalen Stammzellen mit unterschiedlichen superparamagnetischen Eisenoxidpartikeln und Nachweisbarkeit in der MRT bei 3T
Ittrich, H., Lange, C., Dahnke, H., Zander, A. R., Adam, G. & Nolte Ernsting, C., 01.08.2005, In: ROFO-FORTSCHR RONTG. 177, 8, p. 1151-1163 13 p., 8.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
DHPLC based fraction collection of TCR-gamma rearrangements in childhood ALL: direct sequencing of products amplified by a single or a multiplex PCR approach.
Zur Stadt, U., Isbarn, H., Schneppenheim, R. & Kabisch, H., 08.2005, In: INT J ONCOL. 27, 2, p. 547-552 6 p., 2.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms
Tögel, F., Hu, Z., Weiss, K., Isaac, J., Lange, C. & Westenfelder, C., 01.07.2005, In: AM J PHYSIOL-RENAL. 289, 1, p. F31-42Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction
Schilbach, K., Kerst, G., Walter, S., Eyrich, M., Wernet, D., Handgretinger, R., Xie, W., Rammensee, H-G., Müller, I., Bühring, H-J. & Niethammer, D., 01.07.2005, In: BLOOD. 106, 1, p. 144-9 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis
Modlich, U., Kustikova, O. S., Schmidt, M., Rudolph, C., Meyer, J., Li, Z., Kamino, K., von Neuhoff, N., Schlegelberger, B., Kuehlcke, K., Bunting, K. D., Schmidt, S., Deichmann, A., von Kalle, C., Fehse, B. & Baum, C., 01.06.2005, In: BLOOD. 105, 11, p. 4235-46 12 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Reduction of myocardial scar size after implantation of mesenchymal stem cells in rats: what is the mechanism?
Jaquet, K., Krause, K. T., Denschel, J., Faessler, P., Nauerz, M., Geidel, S., Boczor, S., Lange, C., Stute, N., Zander, A. & Kuck, K-H., 01.06.2005, In: STEM CELLS DEV. 14, 3, p. 299-309 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking
Kustikova, O., Fehse, B., Modlich, U., Yang, M., Düllmann, J., Kamino, K., von Neuhoff, N., Schlegelberger, B., Li, Z. & Baum, C., 20.05.2005, In: SCIENCE. 308, 5725, p. 1171-4 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR
Kerst, G., Kreyenberg, H., Roth, C., Well, C., Dietz, K., Coustan-Smith, E., Campana, D., Koscielniak, E., Niemeyer, C., Schlegel, P. G., Müller, I., Niethammer, D. & Bader, P., 03.2005, In: BRIT J HAEMATOL. 128, 6, p. 774-82 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Antithymocyte globulin induces ex vivo and in vivo depletion of myeloid and plasmacytoid dendritic cells
Fang, L., Fehse, B., Engel, M., Zander, A. & Kröger, N., 15.02.2005, In: TRANSPLANTATION. 79, 3, p. 369-371 3 p.Research output: SCORING: Contribution to journal › Short publication › Research › peer-review
Analysis of progenitor cell mobilization and erythropoietin plasma levels in patients with acute myocardial infarction
Krause, K., Fehse, B., Jaquet, K., Lange, C., Kyriazis, K., Boczor, S., Zander, A. & Kuck, K-H., 01.01.2005, In: EXP CLIN CARDIOL. 10, 2, p. 104-7 4 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
After major ABO-mismatched allogeneic hematopoietic progenitor cell transplantation, erythroid engraftment occurs later in patients with donor blood group A than donor blood group B.
Schetelig, J., Breitschaft, A., Kröger, N., Zabelina, T., Ebell, W., Bornhäuser, M., Haack, A., Ehninger, G., Salama, A. & Siegert, W., 2005, In: TRANSFUSION. 45, 5, p. 779-787 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Aldehyde dehydrogenase activity as a marker for the quality of hematopoietic stem cell transplants.
Lioznov, M., Freiberger, P., Kröger, N., Zander, A. R. & Fehse, B., 2005, In: BONE MARROW TRANSPL. 35, 9, p. 909-914 9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Antithymocyte globulin induces complement-dependent cell lysis and caspase-dependent apoptosis in myeloma cells.
Ayuketang Ayuk, F., Fang, L., Fehse, B., Zander, A. R. & Kröger, N., 2005, In: EXP HEMATOL. 33, 12, p. 1531-1536 12.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Comparison between antithymocyte globulin and alemtuzumab and the possible impact of KIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients with multiple myeloma.
Kröger, N., Shaw, B., Iacobelli, S., Zabelina, T., Peggs, K., Shimoni, A., Nagler, A., Binder, T., Eiermann, T., Madrigal, A., Schwerdtfeger, R., Kiehl, M., Sayer, H. G., Beyer, J., Bornhäuser, M., Ayuketang Ayuk, F., Zander, A. R. & Marks, D. I., 2005, In: BRIT J HAEMATOL. 129, 5, p. 631-643 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Dynamics of bone marrow changes in patients with chronic idiopathic myelofibrosis following allogeneic stem cell transplantation.
Thiele, J., Kvasnicka, H. M., Dietrich, H., Stein, G., Hann, M., Kaminski, A., Rathjen, N., Metz, K. A., Beelen, D. W., Ditschkowski, M., Zander, A. & Kröger, N., 2005, In: HISTOL HISTOPATHOL. 20, 3, p. 879-889 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age >55 years) with hematologic malignancies: older age is no longer a contraindication when using reduced intensity conditioning.
Shimoni, A., Kröger, N-M., Zabelina, T., Ayuketang Ayuk, F., Hardan, I., Yeshurun, M., Shem-Tov, N., Avigdor, A., Ben-Bassat, I., Zander, A. & Nagler, A., 2005, In: LEUKEMIA. 19, 1, p. 7-12 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Hepatocytic gene expression in cultured rat mesenchymal stem cells.
Lange, C., Bassler, P., Lioznov, M., Bruns, H., Kluth, D., Zander, A. R. & Fiegel, H. C., 2005, In: TRANSPL P. 37, 1, p. 276-279 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
High-potential human mesenchymal stem cells.
Lange, C., Schroeder, J., Stute, N., Lioznov, M. & Zander, A. R., 2005, In: STEM CELLS DEV. 14, 1, p. 70-80 1.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Improving the ex vivo retroviral-mediated suicide-gene transfer process in T lymphocytes to preserve immune function
Robinet, E., Fehse, B., Ebeling, S., Sauce, D., Ferrand, C. & Tiberghien, P., 2005, In: CYTOTHERAPY. 7, 2, p. 150-7 8 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Liver-specific gene expression in mesenchymal stem cells is induced by liver cells.
Lange, C., Bassler, P., Lioznov, M., Bruns, H., Kluth, D., Zander, A-R. & Fiegel, H-C., 2005, In: WORLD J GASTROENTERO. 11, 29, p. 4497-4504 29.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Pilot study of reduced-intensity conditioning followed by allogeneic stem cell transplantation from related and unrelated donors in patients with myelofibrosis.
Kröger, N., Zabelina, T., Schieder, H., Panse, J., Ayuk, F., Stute, N., Fehse, N., Waschke, O., Fehse, B., Kvasnicka, H. M., Thiele, J. & Zander, A., 2005, In: BRIT J HAEMATOL. 128, 5, p. 690-697 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2004
Human gammadelta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation
Otto, M., Barfield, R. C., Iyengar, R., Gatewood, J., Müller, I., Holladay, M. S., Houston, J., Leung, W. & Handgretinger, R., 23.12.2004, In: J IMMUNOTHER. 28, 1, p. 73-8 6 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Autologous serum for isolation and expansion of human mesenchymal stem cells for clinical use
Stute, N., Holtz, K., Bubenheim, M., Lange, C., Blake, F. & Zander, A. R., 01.12.2004, In: Experimental hematology. 32, 12, p. 1212-25 14 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Tumor cells escape suicide gene therapy by genetic and epigenetic instability
Frank, O., Rudolph, C., Heberlein, C., von Neuhoff, N., Schröck, E., Schambach, A., Schlegelberger, B., Fehse, B., Ostertag, W., Stocking, C. & Baum, C., 01.12.2004, In: BLOOD. 104, 12, p. 3543-9 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Self-inactivating retroviral vectors with improved RNA processing
Kraunus, J., Schaumann, D. H. S., Meyer, J., Modlich, U., Fehse, B., Brandenburg, G., von Laer, D., Klump, H., Schambach, A., Bohne, J. & Baum, C., 11.2004, In: GENE THER. 11, 21, p. 1568-78 11 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Stem cell clonality and genotoxicity in hematopoietic cells: gene activation side effects should be avoidable
von Kalle, C., Fehse, B., Layh-Schmitt, G., Schmidt, M., Kelly, P. & Baum, C., 10.2004, In: SEMIN HEMATOL. 41, 4, p. 303-18 16 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Pois(s)on--it's a question of dose
Fehse, B., Kustikova, O. S., Bubenheim, M. & Baum, C., 06.2004, In: GENE THER. 11, 11, p. 879-81 3 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Simplified generation of high-titer retrovirus producer cells for clinically relevant retroviral vectors by reversible inclusion of a lox-P-flanked marker gene
Loew, R., Selevsek, N., Fehse, B., von Laer, D., Baum, C., Fauser, A. & Kuehlcke, K., 05.2004, In: MOL THER. 9, 5, p. 738-46 9 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Glycosylation and lectins-examples of immunesurveillance and immune evasion
Müller, I., Jenner, J., Handgretinger, R., Riberdy, J. & Kerst, G., 04.2004, In: HISTOL HISTOPATHOL. 19, 2, p. 527-33 7 p.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Chance or necessity? Insertional mutagenesis in gene therapy and its consequences
Baum, C., von Kalle, C., Staal, F. J. T., Li, Z., Fehse, B., Schmidt, M., Weerkamp, F., Karlsson, S., Wagemaker, G. & Williams, D. A., 01.2004, In: MOL THER. 9, 1, p. 5-13 9 p.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation.
Kröger, N-M., Schilling, G., Einsele, H., Liebisch, P., Shimoni, A., Nagler, A., Perez-Simon, J. A., Miguel, S., Jesus, F., Kiehl, M., Fauser, A., Schwerdtfeger, R., Wandt, H., Sayer, H. G., Myint, H., Zabelina, T., Zabelina, T., Dierlamm, J., Hinke, A. & Zander, A., 2004, In: BLOOD. 103, 11, p. 4056-4061 11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Efficacy and toxicity of low-dose escalating donor lymphocyte infusion given after reduced intensity conditioning allograft for multiple myeloma.
Ayuketang Ayuk, F., Shimoni, A., Nagler, A., Schwerdtfeger, R., Kiehl, M., Sayer, H. G., Zabelina, T., Zander, A. R. & Kröger, N., 2004, In: LEUKEMIA. 18, 3, p. 659-662 3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Evidence for increased risk of secondary graft failure after in vivo depletion of suicide gene-modified T lymphocytes transplanted in conjunction with CD34+-enriched blood stem cells.
Fehse, B., Ayuketang Ayuk, F., Kröger, N., Fang, L., Kühlcke, K., Heinzelmann, M., Zabelina, T., Fauser, A. A. & Zander, A. R., 2004, In: BLOOD. 104, 10, p. 3408-3409 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Low-dose thalidomide and donor lymphocyte infusion as adoptive immunotherapy after allogeneic stem cell transplantation in patients with multiple myeloma.
Kröger, N-M., Shimoni, A., Zagrivnaja, M., Ayuketang Ayuk, F., Lioznov, M., Schieder, H., Renges, H-H., Fehse, B., Zabelina, T., Nagler, A. & Zander, A., 2004, In: BLOOD. 104, 10, p. 3361-3363 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Outcome of allogeneic hematopoietic stem-cell transplantation in adult patients with acute lymphoblastic leukemia: no difference in related compared with unrelated transplant in first complete remission.
Kiehl, M. G., Kraut, L., Schwerdtfeger, R., Hertenstein, B., Remberger, M., Kröger, N., Stelljes, M., Bornhaeuser, M., Martin, H., Scheid, C., Ganser, A., Zander, A. R., Kienast, J., Ehninger, G., Hoelzer, D., Diehl, V., Fauser, A. A. & Ringden, O., 2004, In: J CLIN ONCOL. 22, 14, p. 2816-2825 14.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Reduced-intensity conditioning with busulfan and fludarabine with or without antithymocyte globulin in HLA-identical sibling transplantation--a retrospective analysis.
Schetelig, J., Bornhäuser, M., Kiehl, M., Schwerdtfeger, R., Kröger, N., Runde, V., Zabelina, T., Held, T. K., Thiede, C., Fauser, A. A., Beelen, D., Zander, A., Ehninger, G. & Siegert, W., 2004, In: BONE MARROW TRANSPL. 33, 5, p. 483-490 5.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Relapse to prior autograft and chronic graft-versus-host disease are the strongest prognostic factors for outcome of melphalan/fludarabine-based dose-reduced allogeneic stem cell transplantation in patients with multiple myeloma.
Kröger, N-M., Perez-Simon, J. A., Myint, H., Klingemann, H., Shimoni, A., Nagler, A., Martino, R., Alegre, A., Tomas, J. F., Schwerdtfeger, R., Kiehl, M., Fauser, A., Sayer, H. G., Leon, A., Beyer, J., Zabelina, T., Ayuketang Ayuk, F., Miguel, S., Jesus, F., Brand, R. & Zander, A., 2004, In: BIOL BLOOD MARROW TR. 10, 10, p. 698-708 10.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
- 2003
Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population
Kustikova, O. S., Wahlers, A., Kuhlcke, K., Stahle, B., Zander, A. R., Baum, C. & Fehse, B., 01.12.2003, In: BLOOD. 102, 12, p. 3934-7 4 p.Research output: SCORING: Contribution to journal › Short publication › Research › peer-review