Can lesions to the motor cortex induce amyotrophic lateral sclerosis?
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Can lesions to the motor cortex induce amyotrophic lateral sclerosis? / Rosenbohm, Angela; Kassubek, Jan; Weydt, Patrick; Marroquin, Nicolai; Volk, Alexander; Kubisch, Christian; Huppertz, Hans-Jürgen; Weber, Markus; Andersen, Peter M; Weishaupt, Jochen H; Ludolph, Albert C; ALS Schwaben Register Group.
in: J NEUROL, Jahrgang 261, Nr. 2, 01.02.2014, S. 283-90.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Can lesions to the motor cortex induce amyotrophic lateral sclerosis?
AU - Rosenbohm, Angela
AU - Kassubek, Jan
AU - Weydt, Patrick
AU - Marroquin, Nicolai
AU - Volk, Alexander
AU - Kubisch, Christian
AU - Huppertz, Hans-Jürgen
AU - Weber, Markus
AU - Andersen, Peter M
AU - Weishaupt, Jochen H
AU - Ludolph, Albert C
AU - ALS Schwaben Register Group
PY - 2014/2/1
Y1 - 2014/2/1
N2 - A recent staging effort for amyotrophic lateral sclerosis (ALS) has demonstrated that the TDP-43 neuropathology may initiate focally in the motor cortex in the majority of patients. We searched our data bank for patients with lesions of the motor cortex which preceded disease onset. We performed a search of our patient- and MRI-data bank and screened 1,835 patients with amyotrophic lateral sclerosis for frontal lobe/motor cortex lesions. We found 18 patients with definite ALS who had documented and defined lesions of the motor cortex, which preceded the initial ALS symptoms by 8-42 years. In the vast majority (15/18) of the patients, the onset of ALS was closely related to the focal lesion since it started in a body region reflecting the damaged cortical area. The findings suggest that initial lesions to the motor cortex may be a contributing initiating factor in some patients with ALS or determine the site of onset in individuals pre-disposed to ALS.
AB - A recent staging effort for amyotrophic lateral sclerosis (ALS) has demonstrated that the TDP-43 neuropathology may initiate focally in the motor cortex in the majority of patients. We searched our data bank for patients with lesions of the motor cortex which preceded disease onset. We performed a search of our patient- and MRI-data bank and screened 1,835 patients with amyotrophic lateral sclerosis for frontal lobe/motor cortex lesions. We found 18 patients with definite ALS who had documented and defined lesions of the motor cortex, which preceded the initial ALS symptoms by 8-42 years. In the vast majority (15/18) of the patients, the onset of ALS was closely related to the focal lesion since it started in a body region reflecting the damaged cortical area. The findings suggest that initial lesions to the motor cortex may be a contributing initiating factor in some patients with ALS or determine the site of onset in individuals pre-disposed to ALS.
U2 - 10.1007/s00415-013-7185-7
DO - 10.1007/s00415-013-7185-7
M3 - SCORING: Journal article
C2 - 24253481
VL - 261
SP - 283
EP - 290
JO - J NEUROL
JF - J NEUROL
SN - 0340-5354
IS - 2
ER -