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Can lesions to the motor cortex induce amyotrophic lateral sclerosis?

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Can lesions to the motor cortex induce amyotrophic lateral sclerosis? / Rosenbohm, Angela; Kassubek, Jan; Weydt, Patrick; Marroquin, Nicolai; Volk, Alexander; Kubisch, Christian; Huppertz, Hans-Jürgen; Weber, Markus; Andersen, Peter M; Weishaupt, Jochen H; Ludolph, Albert C; ALS Schwaben Register Group.

In: J NEUROL, Vol. 261, No. 2, 01.02.2014, p. 283-90.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rosenbohm, A, Kassubek, J, Weydt, P, Marroquin, N, Volk, A, Kubisch, C, Huppertz, H-J, Weber, M, Andersen, PM, Weishaupt, JH, Ludolph, AC & ALS Schwaben Register Group 2014, 'Can lesions to the motor cortex induce amyotrophic lateral sclerosis?', J NEUROL, vol. 261, no. 2, pp. 283-90. https://doi.org/10.1007/s00415-013-7185-7

APA

Rosenbohm, A., Kassubek, J., Weydt, P., Marroquin, N., Volk, A., Kubisch, C., Huppertz, H-J., Weber, M., Andersen, P. M., Weishaupt, J. H., Ludolph, A. C., & ALS Schwaben Register Group (2014). Can lesions to the motor cortex induce amyotrophic lateral sclerosis? J NEUROL, 261(2), 283-90. https://doi.org/10.1007/s00415-013-7185-7

Vancouver

Rosenbohm A, Kassubek J, Weydt P, Marroquin N, Volk A, Kubisch C et al. Can lesions to the motor cortex induce amyotrophic lateral sclerosis? J NEUROL. 2014 Feb 1;261(2):283-90. https://doi.org/10.1007/s00415-013-7185-7

Bibtex

@article{377cc92f482d446b849cc86329cafde0,
title = "Can lesions to the motor cortex induce amyotrophic lateral sclerosis?",
abstract = "A recent staging effort for amyotrophic lateral sclerosis (ALS) has demonstrated that the TDP-43 neuropathology may initiate focally in the motor cortex in the majority of patients. We searched our data bank for patients with lesions of the motor cortex which preceded disease onset. We performed a search of our patient- and MRI-data bank and screened 1,835 patients with amyotrophic lateral sclerosis for frontal lobe/motor cortex lesions. We found 18 patients with definite ALS who had documented and defined lesions of the motor cortex, which preceded the initial ALS symptoms by 8-42 years. In the vast majority (15/18) of the patients, the onset of ALS was closely related to the focal lesion since it started in a body region reflecting the damaged cortical area. The findings suggest that initial lesions to the motor cortex may be a contributing initiating factor in some patients with ALS or determine the site of onset in individuals pre-disposed to ALS.",
author = "Angela Rosenbohm and Jan Kassubek and Patrick Weydt and Nicolai Marroquin and Alexander Volk and Christian Kubisch and Hans-J{\"u}rgen Huppertz and Markus Weber and Andersen, {Peter M} and Weishaupt, {Jochen H} and Ludolph, {Albert C} and {ALS Schwaben Register Group}",
year = "2014",
month = feb,
day = "1",
doi = "10.1007/s00415-013-7185-7",
language = "English",
volume = "261",
pages = "283--90",
journal = "J NEUROL",
issn = "0340-5354",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - Can lesions to the motor cortex induce amyotrophic lateral sclerosis?

AU - Rosenbohm, Angela

AU - Kassubek, Jan

AU - Weydt, Patrick

AU - Marroquin, Nicolai

AU - Volk, Alexander

AU - Kubisch, Christian

AU - Huppertz, Hans-Jürgen

AU - Weber, Markus

AU - Andersen, Peter M

AU - Weishaupt, Jochen H

AU - Ludolph, Albert C

AU - ALS Schwaben Register Group

PY - 2014/2/1

Y1 - 2014/2/1

N2 - A recent staging effort for amyotrophic lateral sclerosis (ALS) has demonstrated that the TDP-43 neuropathology may initiate focally in the motor cortex in the majority of patients. We searched our data bank for patients with lesions of the motor cortex which preceded disease onset. We performed a search of our patient- and MRI-data bank and screened 1,835 patients with amyotrophic lateral sclerosis for frontal lobe/motor cortex lesions. We found 18 patients with definite ALS who had documented and defined lesions of the motor cortex, which preceded the initial ALS symptoms by 8-42 years. In the vast majority (15/18) of the patients, the onset of ALS was closely related to the focal lesion since it started in a body region reflecting the damaged cortical area. The findings suggest that initial lesions to the motor cortex may be a contributing initiating factor in some patients with ALS or determine the site of onset in individuals pre-disposed to ALS.

AB - A recent staging effort for amyotrophic lateral sclerosis (ALS) has demonstrated that the TDP-43 neuropathology may initiate focally in the motor cortex in the majority of patients. We searched our data bank for patients with lesions of the motor cortex which preceded disease onset. We performed a search of our patient- and MRI-data bank and screened 1,835 patients with amyotrophic lateral sclerosis for frontal lobe/motor cortex lesions. We found 18 patients with definite ALS who had documented and defined lesions of the motor cortex, which preceded the initial ALS symptoms by 8-42 years. In the vast majority (15/18) of the patients, the onset of ALS was closely related to the focal lesion since it started in a body region reflecting the damaged cortical area. The findings suggest that initial lesions to the motor cortex may be a contributing initiating factor in some patients with ALS or determine the site of onset in individuals pre-disposed to ALS.

U2 - 10.1007/s00415-013-7185-7

DO - 10.1007/s00415-013-7185-7

M3 - SCORING: Journal article

C2 - 24253481

VL - 261

SP - 283

EP - 290

JO - J NEUROL

JF - J NEUROL

SN - 0340-5354

IS - 2

ER -