The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.

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The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY. / Sasidhar, Manda V; Itoh, Noriko; Gold, Stefan; Lawson, Gregory W; Voskuhl, Rhonda R.

In: ANN RHEUM DIS, Vol. 71, No. 8, 8, 2012, p. 1418-1422.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

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Sasidhar MV, Itoh N, Gold S, Lawson GW, Voskuhl RR. The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY. ANN RHEUM DIS. 2012;71(8):1418-1422. 8.

Bibtex

@article{d48189daaec34b04a4ec05ff7c8135a6,
title = "The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.",
abstract = "Many autoimmune diseases are characterised by a female predominance. This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis.",
keywords = "Animals, Male, Female, Mice, Up-Regulation, Mice, Transgenic, Biological Markers/metabolism, Chromosome Duplication, Longevity, T-Lymphocytes/immunology, Antigens, CD3/immunology, Spleen/immunology, Antigens, CD28/immunology, CD40 Ligand/metabolism, Kidney, Kidney Diseases, Lupus Erythematosus, Systemic/*genetics/immunology/metabolism, *Sex Chromosome Aberrations, Sex Chromosome Disorders/*genetics, X Chromosome/*genetics, Y Chromosome/*genetics, Animals, Male, Female, Mice, Up-Regulation, Mice, Transgenic, Biological Markers/metabolism, Chromosome Duplication, Longevity, T-Lymphocytes/immunology, Antigens, CD3/immunology, Spleen/immunology, Antigens, CD28/immunology, CD40 Ligand/metabolism, Kidney, Kidney Diseases, Lupus Erythematosus, Systemic/*genetics/immunology/metabolism, *Sex Chromosome Aberrations, Sex Chromosome Disorders/*genetics, X Chromosome/*genetics, Y Chromosome/*genetics",
author = "Sasidhar, {Manda V} and Noriko Itoh and Stefan Gold and Lawson, {Gregory W} and Voskuhl, {Rhonda R}",
year = "2012",
language = "English",
volume = "71",
pages = "1418--1422",
journal = "ANN RHEUM DIS",
issn = "0003-4967",
publisher = "BMJ PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.

AU - Sasidhar, Manda V

AU - Itoh, Noriko

AU - Gold, Stefan

AU - Lawson, Gregory W

AU - Voskuhl, Rhonda R

PY - 2012

Y1 - 2012

N2 - Many autoimmune diseases are characterised by a female predominance. This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis.

AB - Many autoimmune diseases are characterised by a female predominance. This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis.

KW - Animals

KW - Male

KW - Female

KW - Mice

KW - Up-Regulation

KW - Mice, Transgenic

KW - Biological Markers/metabolism

KW - Chromosome Duplication

KW - Longevity

KW - T-Lymphocytes/immunology

KW - Antigens, CD3/immunology

KW - Spleen/immunology

KW - Antigens, CD28/immunology

KW - CD40 Ligand/metabolism

KW - Kidney

KW - Kidney Diseases

KW - Lupus Erythematosus, Systemic/genetics/immunology/metabolism

KW - Sex Chromosome Aberrations

KW - Sex Chromosome Disorders/genetics

KW - X Chromosome/genetics

KW - Y Chromosome/genetics

KW - Animals

KW - Male

KW - Female

KW - Mice

KW - Up-Regulation

KW - Mice, Transgenic

KW - Biological Markers/metabolism

KW - Chromosome Duplication

KW - Longevity

KW - T-Lymphocytes/immunology

KW - Antigens, CD3/immunology

KW - Spleen/immunology

KW - Antigens, CD28/immunology

KW - CD40 Ligand/metabolism

KW - Kidney

KW - Kidney Diseases

KW - Lupus Erythematosus, Systemic/genetics/immunology/metabolism

KW - Sex Chromosome Aberrations

KW - Sex Chromosome Disorders/genetics

KW - X Chromosome/genetics

KW - Y Chromosome/genetics

M3 - SCORING: Journal article

VL - 71

SP - 1418

EP - 1422

JO - ANN RHEUM DIS

JF - ANN RHEUM DIS

SN - 0003-4967

IS - 8

M1 - 8

ER -