The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.
Standard
The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY. / Sasidhar, Manda V; Itoh, Noriko; Gold, Stefan; Lawson, Gregory W; Voskuhl, Rhonda R.
in: ANN RHEUM DIS, Jahrgang 71, Nr. 8, 8, 2012, S. 1418-1422.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.
AU - Sasidhar, Manda V
AU - Itoh, Noriko
AU - Gold, Stefan
AU - Lawson, Gregory W
AU - Voskuhl, Rhonda R
PY - 2012
Y1 - 2012
N2 - Many autoimmune diseases are characterised by a female predominance. This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis.
AB - Many autoimmune diseases are characterised by a female predominance. This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis.
KW - Animals
KW - Male
KW - Female
KW - Mice
KW - Up-Regulation
KW - Mice, Transgenic
KW - Biological Markers/metabolism
KW - Chromosome Duplication
KW - Longevity
KW - T-Lymphocytes/immunology
KW - Antigens, CD3/immunology
KW - Spleen/immunology
KW - Antigens, CD28/immunology
KW - CD40 Ligand/metabolism
KW - Kidney
KW - Kidney Diseases
KW - Lupus Erythematosus, Systemic/genetics/immunology/metabolism
KW - Sex Chromosome Aberrations
KW - Sex Chromosome Disorders/genetics
KW - X Chromosome/genetics
KW - Y Chromosome/genetics
KW - Animals
KW - Male
KW - Female
KW - Mice
KW - Up-Regulation
KW - Mice, Transgenic
KW - Biological Markers/metabolism
KW - Chromosome Duplication
KW - Longevity
KW - T-Lymphocytes/immunology
KW - Antigens, CD3/immunology
KW - Spleen/immunology
KW - Antigens, CD28/immunology
KW - CD40 Ligand/metabolism
KW - Kidney
KW - Kidney Diseases
KW - Lupus Erythematosus, Systemic/genetics/immunology/metabolism
KW - Sex Chromosome Aberrations
KW - Sex Chromosome Disorders/genetics
KW - X Chromosome/genetics
KW - Y Chromosome/genetics
M3 - SCORING: Journal article
VL - 71
SP - 1418
EP - 1422
JO - ANN RHEUM DIS
JF - ANN RHEUM DIS
SN - 0003-4967
IS - 8
M1 - 8
ER -