The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.
Beteiligte Einrichtungen
Abstract
Many autoimmune diseases are characterised by a female predominance. This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis.
Bibliografische Daten
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 8 |
| ISSN | 0003-4967 |
| Status | Veröffentlicht - 2012 |
| pubmed | 22580585 |
|---|
