The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.
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Abstract
Many autoimmune diseases are characterised by a female predominance. This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis.
Bibliographical data
| Original language | English |
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| Article number | 8 |
| ISSN | 0003-4967 |
| Publication status | Published - 2012 |
| pubmed | 22580585 |
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