The T393C polymorphism of GNAS1 is a predictor for relapse and survival in resectable non-small cell lung cancer.

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The T393C polymorphism of GNAS1 is a predictor for relapse and survival in resectable non-small cell lung cancer. / Uzunoglu, Faik Güntac; Heumann, Asmus; Musici, Safije; Kutup, Asad; König, Alexandra; Roch, Nadine; Thomssen, Adriana; Dohrmann, Thorsten Wolfgang; Tsui, Tung Yu; Mann, Oliver; Izbicki, Jakob R.; Vashist, Yogesh.

In: LUNG CANCER, Vol. 79, No. 2, 2, 2013, p. 151-155.

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@article{2745e9358be14d4283504a6d682f5d5f,
title = "The T393C polymorphism of GNAS1 is a predictor for relapse and survival in resectable non-small cell lung cancer.",
abstract = "The GNAS1 T393C single nucleotide polymorphism (T393C-SNP) correlates with G?s mRNA stability and protein expression and augmented apoptosis. Genetic germ line variations as stable and reproducible markers potentially serve as prognostic marker in oncology. The aim of this study was to evaluate the potential prognostic value of T393C-SNP in complete resected non-small cell lung cancer (NSCLC).",
keywords = "Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Disease-Free Survival, Proportional Hazards Models, Retrospective Studies, Recurrence, Chi-Square Distribution, Homozygote, Polymorphism, Single Nucleotide, Kaplan-Meier Estimate, Tumor Markers, Biological/*genetics, Carcinoma, Non-Small-Cell Lung/*genetics/surgery, GTP-Binding Protein alpha Subunits, Gs/*genetics, Lung Neoplasms/*genetics/surgery, Adult, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Disease-Free Survival, Proportional Hazards Models, Retrospective Studies, Recurrence, Chi-Square Distribution, Homozygote, Polymorphism, Single Nucleotide, Kaplan-Meier Estimate, Tumor Markers, Biological/*genetics, Carcinoma, Non-Small-Cell Lung/*genetics/surgery, GTP-Binding Protein alpha Subunits, Gs/*genetics, Lung Neoplasms/*genetics/surgery",
author = "Uzunoglu, {Faik G{\"u}ntac} and Asmus Heumann and Safije Musici and Asad Kutup and Alexandra K{\"o}nig and Nadine Roch and Adriana Thomssen and Dohrmann, {Thorsten Wolfgang} and Tsui, {Tung Yu} and Oliver Mann and Izbicki, {Jakob R.} and Yogesh Vashist",
year = "2013",
language = "English",
volume = "79",
pages = "151--155",
journal = "LUNG CANCER",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - The T393C polymorphism of GNAS1 is a predictor for relapse and survival in resectable non-small cell lung cancer.

AU - Uzunoglu, Faik Güntac

AU - Heumann, Asmus

AU - Musici, Safije

AU - Kutup, Asad

AU - König, Alexandra

AU - Roch, Nadine

AU - Thomssen, Adriana

AU - Dohrmann, Thorsten Wolfgang

AU - Tsui, Tung Yu

AU - Mann, Oliver

AU - Izbicki, Jakob R.

AU - Vashist, Yogesh

PY - 2013

Y1 - 2013

N2 - The GNAS1 T393C single nucleotide polymorphism (T393C-SNP) correlates with G?s mRNA stability and protein expression and augmented apoptosis. Genetic germ line variations as stable and reproducible markers potentially serve as prognostic marker in oncology. The aim of this study was to evaluate the potential prognostic value of T393C-SNP in complete resected non-small cell lung cancer (NSCLC).

AB - The GNAS1 T393C single nucleotide polymorphism (T393C-SNP) correlates with G?s mRNA stability and protein expression and augmented apoptosis. Genetic germ line variations as stable and reproducible markers potentially serve as prognostic marker in oncology. The aim of this study was to evaluate the potential prognostic value of T393C-SNP in complete resected non-small cell lung cancer (NSCLC).

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Disease-Free Survival

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Recurrence

KW - Chi-Square Distribution

KW - Homozygote

KW - Polymorphism, Single Nucleotide

KW - Kaplan-Meier Estimate

KW - Tumor Markers, Biological/genetics

KW - Carcinoma, Non-Small-Cell Lung/genetics/surgery

KW - GTP-Binding Protein alpha Subunits, Gs/genetics

KW - Lung Neoplasms/genetics/surgery

KW - Adult

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Disease-Free Survival

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Recurrence

KW - Chi-Square Distribution

KW - Homozygote

KW - Polymorphism, Single Nucleotide

KW - Kaplan-Meier Estimate

KW - Tumor Markers, Biological/genetics

KW - Carcinoma, Non-Small-Cell Lung/genetics/surgery

KW - GTP-Binding Protein alpha Subunits, Gs/genetics

KW - Lung Neoplasms/genetics/surgery

M3 - SCORING: Journal article

VL - 79

SP - 151

EP - 155

JO - LUNG CANCER

JF - LUNG CANCER

SN - 0169-5002

IS - 2

M1 - 2

ER -