The T393C polymorphism of GNAS1 is a predictor for relapse and survival in resectable non-small cell lung cancer.
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The T393C polymorphism of GNAS1 is a predictor for relapse and survival in resectable non-small cell lung cancer. / Uzunoglu, Faik Güntac; Heumann, Asmus; Musici, Safije; Kutup, Asad; König, Alexandra; Roch, Nadine; Thomssen, Adriana; Dohrmann, Thorsten Wolfgang; Tsui, Tung Yu; Mann, Oliver; Izbicki, Jakob R.; Vashist, Yogesh.
in: LUNG CANCER, Jahrgang 79, Nr. 2, 2, 2013, S. 151-155.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The T393C polymorphism of GNAS1 is a predictor for relapse and survival in resectable non-small cell lung cancer.
AU - Uzunoglu, Faik Güntac
AU - Heumann, Asmus
AU - Musici, Safije
AU - Kutup, Asad
AU - König, Alexandra
AU - Roch, Nadine
AU - Thomssen, Adriana
AU - Dohrmann, Thorsten Wolfgang
AU - Tsui, Tung Yu
AU - Mann, Oliver
AU - Izbicki, Jakob R.
AU - Vashist, Yogesh
PY - 2013
Y1 - 2013
N2 - The GNAS1 T393C single nucleotide polymorphism (T393C-SNP) correlates with G?s mRNA stability and protein expression and augmented apoptosis. Genetic germ line variations as stable and reproducible markers potentially serve as prognostic marker in oncology. The aim of this study was to evaluate the potential prognostic value of T393C-SNP in complete resected non-small cell lung cancer (NSCLC).
AB - The GNAS1 T393C single nucleotide polymorphism (T393C-SNP) correlates with G?s mRNA stability and protein expression and augmented apoptosis. Genetic germ line variations as stable and reproducible markers potentially serve as prognostic marker in oncology. The aim of this study was to evaluate the potential prognostic value of T393C-SNP in complete resected non-small cell lung cancer (NSCLC).
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Disease-Free Survival
KW - Proportional Hazards Models
KW - Retrospective Studies
KW - Recurrence
KW - Chi-Square Distribution
KW - Homozygote
KW - Polymorphism, Single Nucleotide
KW - Kaplan-Meier Estimate
KW - Tumor Markers, Biological/genetics
KW - Carcinoma, Non-Small-Cell Lung/genetics/surgery
KW - GTP-Binding Protein alpha Subunits, Gs/genetics
KW - Lung Neoplasms/genetics/surgery
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Disease-Free Survival
KW - Proportional Hazards Models
KW - Retrospective Studies
KW - Recurrence
KW - Chi-Square Distribution
KW - Homozygote
KW - Polymorphism, Single Nucleotide
KW - Kaplan-Meier Estimate
KW - Tumor Markers, Biological/genetics
KW - Carcinoma, Non-Small-Cell Lung/genetics/surgery
KW - GTP-Binding Protein alpha Subunits, Gs/genetics
KW - Lung Neoplasms/genetics/surgery
M3 - SCORING: Journal article
VL - 79
SP - 151
EP - 155
JO - LUNG CANCER
JF - LUNG CANCER
SN - 0169-5002
IS - 2
M1 - 2
ER -