The putative oncogene CPI-17 is up-regulated in schwannoma
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Abstract
CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) was previously described to act as an oncoprotein in the merlin pathway. The myosin phosphatase and its substrate merlin are part of a tumour suppressor cascade that can be blocked in two ways; by mutation of the NF2 gene encoding the tumour suppressor protein merlin and by up-regulation of the specific myosin phosphatase inhibitor, CPI-17. This article is protected by copyright. All rights reserved.
Bibliographical data
Original language | English |
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ISSN | 0305-1846 |
DOIs | |
Publication status | Published - 12.2016 |
Comment Deanary
Document Type:Letter
PubMed | 27248983 |
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