The putative oncogene CPI-17 is up-regulated in schwannoma

CPI-17 (PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A, 17 kDa) was previously described to act as an oncoprotein in the merlin pathway. The myosin phosphatase and its substrate merlin are part of a tumour suppressor cascade that can be blocked in two ways; by mutation of the NF2 gene encoding the tumour suppressor protein merlin and by up-regulation of the specific myosin phosphatase inhibitor, CPI-17. This article is protected by copyright. All rights reserved.