The podosome cap: past, present, perspective

Stefan Linder; Pasquale Cervero

doi:10.1016/j.ejcb.2020.151087

The podosome cap: past, present, perspective

Standard

The podosome cap: past, present, perspective. / Linder, Stefan ; Cervero, Pasquale.

In: EUR J CELL BIOL, Vol. 99, No. 5, 06.2020, p. 151087.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Linder, S & Cervero, P 2020, 'The podosome cap: past, present, perspective', EUR J CELL BIOL, vol. 99, no. 5, pp. 151087. https://doi.org/10.1016/j.ejcb.2020.151087

APA

Linder, S., & Cervero, P. (2020). The podosome cap: past, present, perspective. EUR J CELL BIOL, 99(5), 151087. https://doi.org/10.1016/j.ejcb.2020.151087

Vancouver

Linder S , Cervero P. The podosome cap: past, present, perspective. EUR J CELL BIOL. 2020 Jun;99(5):151087. https://doi.org/10.1016/j.ejcb.2020.151087

Bibtex

@article{9246dcc92378430781456f9bc5d99515,

title = "The podosome cap: past, present, perspective",

abstract = "Podosomes are prominent actin-based adhesion structures in a variety of cell types. They feature an extensive repertoire of functions, which requires exquisite spatiotemporal fine-tuning. Accordingly, podosomes consist of hundreds of different components, which fulfill specific structural and regulatory functions. Moreover, it has become apparent that podosome architecture is more intricate than previously believed. The classical model of an actin-rich core surrounded by a ring structure containing adhesion plaque proteins thus had to be expanded, and several additional substructures have been described, most notably the podosome cap on top of the actin-rich core. Here, we discuss the known components of the podosome cap, the history of their detection and their potential regulatory roles in podosome turnover and function. We also point out strategies for identifying further cap components and present a new model for the podosome cap as a multilayered module that fine-tunes actomyosin contractility, a central requirement for podosome architecture, dynamics and function.",

keywords = "Actins/metabolism, Actomyosin/metabolism, Humans, Microfilament Proteins/metabolism, Podosomes/metabolism",

author = "Stefan Linder and Pasquale Cervero",

year = "2020",

month = jun,

doi = "10.1016/j.ejcb.2020.151087",

language = "English",

volume = "99",

pages = "151087",

journal = "EUR J CELL BIOL",

issn = "0171-9335",

publisher = "Urban und Fischer Verlag GmbH und Co. KG",

number = "5",

}

RIS

TY - JOUR

T1 - The podosome cap: past, present, perspective

AU - Linder, Stefan

AU - Cervero, Pasquale

PY - 2020/6

Y1 - 2020/6

N2 - Podosomes are prominent actin-based adhesion structures in a variety of cell types. They feature an extensive repertoire of functions, which requires exquisite spatiotemporal fine-tuning. Accordingly, podosomes consist of hundreds of different components, which fulfill specific structural and regulatory functions. Moreover, it has become apparent that podosome architecture is more intricate than previously believed. The classical model of an actin-rich core surrounded by a ring structure containing adhesion plaque proteins thus had to be expanded, and several additional substructures have been described, most notably the podosome cap on top of the actin-rich core. Here, we discuss the known components of the podosome cap, the history of their detection and their potential regulatory roles in podosome turnover and function. We also point out strategies for identifying further cap components and present a new model for the podosome cap as a multilayered module that fine-tunes actomyosin contractility, a central requirement for podosome architecture, dynamics and function.

AB - Podosomes are prominent actin-based adhesion structures in a variety of cell types. They feature an extensive repertoire of functions, which requires exquisite spatiotemporal fine-tuning. Accordingly, podosomes consist of hundreds of different components, which fulfill specific structural and regulatory functions. Moreover, it has become apparent that podosome architecture is more intricate than previously believed. The classical model of an actin-rich core surrounded by a ring structure containing adhesion plaque proteins thus had to be expanded, and several additional substructures have been described, most notably the podosome cap on top of the actin-rich core. Here, we discuss the known components of the podosome cap, the history of their detection and their potential regulatory roles in podosome turnover and function. We also point out strategies for identifying further cap components and present a new model for the podosome cap as a multilayered module that fine-tunes actomyosin contractility, a central requirement for podosome architecture, dynamics and function.

KW - Actins/metabolism

KW - Actomyosin/metabolism

KW - Humans

KW - Microfilament Proteins/metabolism

KW - Podosomes/metabolism

U2 - 10.1016/j.ejcb.2020.151087

DO - 10.1016/j.ejcb.2020.151087

M3 - SCORING: Review article

C2 - 32646641

VL - 99

SP - 151087

JO - EUR J CELL BIOL

JF - EUR J CELL BIOL

SN - 0171-9335

IS - 5

ER -