The podosome cap: past, present, perspective
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The podosome cap: past, present, perspective. / Linder, Stefan; Cervero, Pasquale.
in: EUR J CELL BIOL, Jahrgang 99, Nr. 5, 06.2020, S. 151087.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - The podosome cap: past, present, perspective
AU - Linder, Stefan
AU - Cervero, Pasquale
N1 - Copyright © 2020 Elsevier GmbH. All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Podosomes are prominent actin-based adhesion structures in a variety of cell types. They feature an extensive repertoire of functions, which requires exquisite spatiotemporal fine-tuning. Accordingly, podosomes consist of hundreds of different components, which fulfill specific structural and regulatory functions. Moreover, it has become apparent that podosome architecture is more intricate than previously believed. The classical model of an actin-rich core surrounded by a ring structure containing adhesion plaque proteins thus had to be expanded, and several additional substructures have been described, most notably the podosome cap on top of the actin-rich core. Here, we discuss the known components of the podosome cap, the history of their detection and their potential regulatory roles in podosome turnover and function. We also point out strategies for identifying further cap components and present a new model for the podosome cap as a multilayered module that fine-tunes actomyosin contractility, a central requirement for podosome architecture, dynamics and function.
AB - Podosomes are prominent actin-based adhesion structures in a variety of cell types. They feature an extensive repertoire of functions, which requires exquisite spatiotemporal fine-tuning. Accordingly, podosomes consist of hundreds of different components, which fulfill specific structural and regulatory functions. Moreover, it has become apparent that podosome architecture is more intricate than previously believed. The classical model of an actin-rich core surrounded by a ring structure containing adhesion plaque proteins thus had to be expanded, and several additional substructures have been described, most notably the podosome cap on top of the actin-rich core. Here, we discuss the known components of the podosome cap, the history of their detection and their potential regulatory roles in podosome turnover and function. We also point out strategies for identifying further cap components and present a new model for the podosome cap as a multilayered module that fine-tunes actomyosin contractility, a central requirement for podosome architecture, dynamics and function.
KW - Actins/metabolism
KW - Actomyosin/metabolism
KW - Humans
KW - Microfilament Proteins/metabolism
KW - Podosomes/metabolism
U2 - 10.1016/j.ejcb.2020.151087
DO - 10.1016/j.ejcb.2020.151087
M3 - SCORING: Review article
C2 - 32646641
VL - 99
SP - 151087
JO - EUR J CELL BIOL
JF - EUR J CELL BIOL
SN - 0171-9335
IS - 5
ER -