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The German Hep-Net acute hepatitis C cohort: impact of viral and host factors on the initial presentation of acute hepatitis C virus infection.

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The German Hep-Net acute hepatitis C cohort: impact of viral and host factors on the initial presentation of acute hepatitis C virus infection. / Deterding, K; Wiegand, J; Grüner, N; Hahn, A; Jäckel, E; Jung, M C; Buggisch, Peter; Galle, P; Berg, T; Hinrichsen, H; Potthoff, A; Zeuzem, S; Cornberg, M; Manns, M; Wedemeyer, H.

In: Z GASTROENTEROL, Vol. 47, No. 6, 6, 2009, p. 531-540.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Deterding, K, Wiegand, J, Grüner, N, Hahn, A, Jäckel, E, Jung, MC, Buggisch, P, Galle, P, Berg, T, Hinrichsen, H, Potthoff, A, Zeuzem, S, Cornberg, M, Manns, M & Wedemeyer, H 2009, 'The German Hep-Net acute hepatitis C cohort: impact of viral and host factors on the initial presentation of acute hepatitis C virus infection.', Z GASTROENTEROL, vol. 47, no. 6, 6, pp. 531-540. <http://www.ncbi.nlm.nih.gov/pubmed/19533544?dopt=Citation>

APA

Deterding, K., Wiegand, J., Grüner, N., Hahn, A., Jäckel, E., Jung, M. C., Buggisch, P., Galle, P., Berg, T., Hinrichsen, H., Potthoff, A., Zeuzem, S., Cornberg, M., Manns, M., & Wedemeyer, H. (2009). The German Hep-Net acute hepatitis C cohort: impact of viral and host factors on the initial presentation of acute hepatitis C virus infection. Z GASTROENTEROL, 47(6), 531-540. [6]. http://www.ncbi.nlm.nih.gov/pubmed/19533544?dopt=Citation

Vancouver

Deterding K, Wiegand J, Grüner N, Hahn A, Jäckel E, Jung MC et al. The German Hep-Net acute hepatitis C cohort: impact of viral and host factors on the initial presentation of acute hepatitis C virus infection. Z GASTROENTEROL. 2009;47(6):531-540. 6.

Bibtex

@article{cefcb79621064c0d8427186eb02f9b31,
title = "The German Hep-Net acute hepatitis C cohort: impact of viral and host factors on the initial presentation of acute hepatitis C virus infection.",
abstract = "INTRODUCTION: The impacts of viral load, genotype, age, sex and BMI on the clinical course of acute hepatitis C are poorly defined. Here we studied 259 patients with acute HCV infection recruited in the German Hep-Net data base between 1998 and 2008. Antiviral treatment with interferon alpha was initiated in 171 patients (66 %) within 4 months after the diagnosis of acute hepatitis C. RESULTS: In this cohort (i) the mode of infection was associated with age as iv-drug users were significantly younger than non-iv-drug users while the proportion of patients who acquired HCV by medical procedures increased with age; (ii) patients younger than 30 years were more often infected with genotype 3 (26 % versus 8 % for patients older than 50 years; p = 0.03); (iii) 51 % of patients were icteric and 28 % presented with a 30-fold elevation of liver enzymes, however, no fulminant hepatic failure occurred; (iv) HCV genotype was not associated with disease severity and time to onset of symptoms; (v) low HCV viremia was associated with lower serum AST levels and a longer time from exposure to onset of symptoms; (vi) disease severity was independent from the mode of infection, age, sex and body mass index (BMI). CONCLUSIONS: In this large cohort of patients admitted for antiviral therapy, acute hepatitis C took a rather mild course of disease in the majority of patients. Disease severity was not associated with HCV genotype, viral load, age, sex and BMI.",
keywords = "Adult, Comorbidity, Humans, Male, Aged, Female, Middle Aged, numerical data, Risk Factors, Adolescent, Young Adult, Cohort Studies, Body Mass Index, Germany epidemiology, Risk Assessment, Age Distribution, Hepatitis C diagnosis, Sex Distribution, Substance Abuse, Intravenous epidemiology, Viral Load statistics, Adult, Comorbidity, Humans, Male, Aged, Female, Middle Aged, numerical data, Risk Factors, Adolescent, Young Adult, Cohort Studies, Body Mass Index, Germany epidemiology, Risk Assessment, Age Distribution, Hepatitis C diagnosis, Sex Distribution, Substance Abuse, Intravenous epidemiology, Viral Load statistics",
author = "K Deterding and J Wiegand and N Gr{\"u}ner and A Hahn and E J{\"a}ckel and Jung, {M C} and Peter Buggisch and P Galle and T Berg and H Hinrichsen and A Potthoff and S Zeuzem and M Cornberg and M Manns and H Wedemeyer",
year = "2009",
language = "Deutsch",
volume = "47",
pages = "531--540",
journal = "Z GASTROENTEROL",
issn = "0044-2771",
publisher = "Karl Demeter Verlag GmbH",
number = "6",

}

RIS

TY - JOUR

T1 - The German Hep-Net acute hepatitis C cohort: impact of viral and host factors on the initial presentation of acute hepatitis C virus infection.

AU - Deterding, K

AU - Wiegand, J

AU - Grüner, N

AU - Hahn, A

AU - Jäckel, E

AU - Jung, M C

AU - Buggisch, Peter

AU - Galle, P

AU - Berg, T

AU - Hinrichsen, H

AU - Potthoff, A

AU - Zeuzem, S

AU - Cornberg, M

AU - Manns, M

AU - Wedemeyer, H

PY - 2009

Y1 - 2009

N2 - INTRODUCTION: The impacts of viral load, genotype, age, sex and BMI on the clinical course of acute hepatitis C are poorly defined. Here we studied 259 patients with acute HCV infection recruited in the German Hep-Net data base between 1998 and 2008. Antiviral treatment with interferon alpha was initiated in 171 patients (66 %) within 4 months after the diagnosis of acute hepatitis C. RESULTS: In this cohort (i) the mode of infection was associated with age as iv-drug users were significantly younger than non-iv-drug users while the proportion of patients who acquired HCV by medical procedures increased with age; (ii) patients younger than 30 years were more often infected with genotype 3 (26 % versus 8 % for patients older than 50 years; p = 0.03); (iii) 51 % of patients were icteric and 28 % presented with a 30-fold elevation of liver enzymes, however, no fulminant hepatic failure occurred; (iv) HCV genotype was not associated with disease severity and time to onset of symptoms; (v) low HCV viremia was associated with lower serum AST levels and a longer time from exposure to onset of symptoms; (vi) disease severity was independent from the mode of infection, age, sex and body mass index (BMI). CONCLUSIONS: In this large cohort of patients admitted for antiviral therapy, acute hepatitis C took a rather mild course of disease in the majority of patients. Disease severity was not associated with HCV genotype, viral load, age, sex and BMI.

AB - INTRODUCTION: The impacts of viral load, genotype, age, sex and BMI on the clinical course of acute hepatitis C are poorly defined. Here we studied 259 patients with acute HCV infection recruited in the German Hep-Net data base between 1998 and 2008. Antiviral treatment with interferon alpha was initiated in 171 patients (66 %) within 4 months after the diagnosis of acute hepatitis C. RESULTS: In this cohort (i) the mode of infection was associated with age as iv-drug users were significantly younger than non-iv-drug users while the proportion of patients who acquired HCV by medical procedures increased with age; (ii) patients younger than 30 years were more often infected with genotype 3 (26 % versus 8 % for patients older than 50 years; p = 0.03); (iii) 51 % of patients were icteric and 28 % presented with a 30-fold elevation of liver enzymes, however, no fulminant hepatic failure occurred; (iv) HCV genotype was not associated with disease severity and time to onset of symptoms; (v) low HCV viremia was associated with lower serum AST levels and a longer time from exposure to onset of symptoms; (vi) disease severity was independent from the mode of infection, age, sex and body mass index (BMI). CONCLUSIONS: In this large cohort of patients admitted for antiviral therapy, acute hepatitis C took a rather mild course of disease in the majority of patients. Disease severity was not associated with HCV genotype, viral load, age, sex and BMI.

KW - Adult

KW - Comorbidity

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - numerical data

KW - Risk Factors

KW - Adolescent

KW - Young Adult

KW - Cohort Studies

KW - Body Mass Index

KW - Germany epidemiology

KW - Risk Assessment

KW - Age Distribution

KW - Hepatitis C diagnosis

KW - Sex Distribution

KW - Substance Abuse, Intravenous epidemiology

KW - Viral Load statistics

KW - Adult

KW - Comorbidity

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - numerical data

KW - Risk Factors

KW - Adolescent

KW - Young Adult

KW - Cohort Studies

KW - Body Mass Index

KW - Germany epidemiology

KW - Risk Assessment

KW - Age Distribution

KW - Hepatitis C diagnosis

KW - Sex Distribution

KW - Substance Abuse, Intravenous epidemiology

KW - Viral Load statistics

M3 - SCORING: Zeitschriftenaufsatz

VL - 47

SP - 531

EP - 540

JO - Z GASTROENTEROL

JF - Z GASTROENTEROL

SN - 0044-2771

IS - 6

M1 - 6

ER -